-
1
-
-
84918815964
-
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
-
Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2015;136:E359-86.
-
(2015)
International Journal of Cancer
, vol.136
, pp. E359-E386
-
-
Ferlay, J.1
Soerjomataram, I.2
Dikshit, R.3
-
3
-
-
34548462932
-
The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours
-
Groome PA, Bolejack V, Crowley JJ, et al. The IASLC Lung Cancer Staging Project: validation of the proposals for revision of the T, N, and M descriptors and consequent stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol. 2007;2:694-705.
-
(2007)
J Thorac Oncol
, vol.2
, pp. 694-705
-
-
Groome, P.A.1
Bolejack, V.2
Crowley, J.J.3
-
4
-
-
84931340760
-
Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
-
Chan BA, Hughes BG. Targeted therapy for non-small cell lung cancer: current standards and the promise of the future. Transl Lung Cancer Res. 2015;4:36-54.
-
(2015)
Transl Lung Cancer Res
, vol.4
, pp. 36-54
-
-
Chan, B.A.1
Hughes, B.G.2
-
6
-
-
84892485531
-
Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer
-
Brahmer JR, Pardoll DM. Immune checkpoint inhibitors: making immunotherapy a reality for the treatment of lung cancer. Cancer Immunology Research. 2013;1:85-91.
-
(2013)
Cancer Immunology Research
, vol.1
, pp. 85-91
-
-
Brahmer, J.R.1
Pardoll, D.M.2
-
7
-
-
84904024273
-
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
-
Taube JM, Klein A, Brahmer JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 2014;20:5064-74.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5064-5074
-
-
Taube, J.M.1
Klein, A.2
Brahmer, J.R.3
-
8
-
-
84989844879
-
T-cell exhaustion in the tumor microenvironment
-
Jiang Y, Li Y, Zhu B. T-cell exhaustion in the tumor microenvironment. Cell Death Dis. 2015;6:e1792.
-
(2015)
Cell Death Dis
, vol.6
-
-
Jiang, Y.1
Li, Y.2
Zhu, B.3
-
9
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28:3167-75.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
10
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
11
-
-
84936749833
-
Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced Non-small-cell lung cancer
-
Gettinger SN, Horn L, Gandhi L, et al. Overall survival and long-term safety of nivolumab (anti-programmed death 1 antibody, BMS-936558, ONO-4538) in patients with previously treated advanced Non-small-cell lung cancer. J Clin Oncol. 2015;33:2004-12.
-
(2015)
J Clin Oncol
, vol.33
, pp. 2004-2012
-
-
Gettinger, S.N.1
Horn, L.2
Gandhi, L.3
-
12
-
-
73149092567
-
Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
-
Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clinical Cancer Research. 2009;15:7412-20.
-
(2009)
Clinical Cancer Research
, vol.15
, pp. 7412-7420
-
-
Wolchok, J.D.1
Hoos, A.2
O'Day, S.3
-
13
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial
-
Rizvi NA, Mazieres J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16:257-65.
-
(2015)
Lancet Oncol
, vol.16
, pp. 257-265
-
-
Rizvi, N.A.1
Mazieres, J.2
Planchard, D.3
-
14
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. New England Journal of Medicine. 2015;373:123-35.
-
(2015)
New England Journal of Medicine
, vol.373
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
15
-
-
84944937210
-
Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
-
Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med. 2015;373:1627-39.
-
(2015)
N Engl J Med
, vol.373
, pp. 1627-1639
-
-
Borghaei, H.1
Paz-Ares, L.2
Horn, L.3
-
17
-
-
84950117835
-
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
-
Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2016;387:1540-50.
-
(2016)
Lancet
, vol.387
, pp. 1540-1550
-
-
Herbst, R.S.1
Baas, P.2
Kim, D.W.3
-
18
-
-
33645736792
-
Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
-
Thompson RH, Kuntz SM, Leibovich BC, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res. 2006;66:3381-5.
-
(2006)
Cancer Res
, vol.66
, pp. 3381-3385
-
-
Thompson, R.H.1
Kuntz, S.M.2
Leibovich, B.C.3
-
19
-
-
84937204733
-
Abstract CT105: MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): Antitumor activity and association with tumor PD-L1 expression
-
Gandhi L, Balmanoukian A, Hui R, et al. Abstract CT105: MK-3475 (anti-PD-1 monoclonal antibody) for non-small cell lung cancer (NSCLC): Antitumor activity and association with tumor PD-L1 expression. Cancer Research. 2014;74:CT105.
-
(2014)
Cancer Research
, vol.74
-
-
Gandhi, L.1
Balmanoukian, A.2
Hui, R.3
-
20
-
-
84962038946
-
Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial
-
Fehrenbacher L, Spira A, Ballinger M, et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet. 2016.
-
(2016)
Lancet
-
-
Fehrenbacher, L.1
Spira, A.2
Ballinger, M.3
-
21
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515:563-7.
-
(2014)
Nature
, vol.515
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
-
22
-
-
80052476869
-
High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
-
Mu CY, Huang JA, Chen Y, Chen C, Zhang XG. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Medical Oncology. 2011;28:682-8.
-
(2011)
Medical Oncology
, vol.28
, pp. 682-688
-
-
Mu, C.Y.1
Huang, J.A.2
Chen, Y.3
Chen, C.4
Zhang, X.G.5
-
23
-
-
84891534246
-
Programmed death ligand-1 expression in non-small cell lung cancer
-
Velcheti V, Schalper KA, Carvajal DE, et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest. 2014;94:107-16.
-
(2014)
Lab Invest
, vol.94
, pp. 107-116
-
-
Velcheti, V.1
Schalper, K.A.2
Carvajal, D.E.3
-
24
-
-
61549122071
-
Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
-
Gao Q, Wang XY, Qiu SJ, et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res. 2009;15:971-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 971-979
-
-
Gao, Q.1
Wang, X.Y.2
Qiu, S.J.3
-
25
-
-
84897404380
-
Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
-
Yang CY, Lin MW, Chang YL, Wu CT, Yang PC. Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. Eur J Cancer. 2014;50:1361-9.
-
(2014)
Eur J Cancer
, vol.50
, pp. 1361-1369
-
-
Yang, C.Y.1
Lin, M.W.2
Chang, Y.L.3
Wu, C.T.4
Yang, P.C.5
-
26
-
-
84920655625
-
PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
-
D'Incecco A, Andreozzi M, Ludovini V, et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. British Journal of Cancer. 2015;112:95-102.
-
(2015)
British Journal of Cancer
, vol.112
, pp. 95-102
-
-
D'Incecco, A.1
Andreozzi, M.2
Ludovini, V.3
-
27
-
-
84923072443
-
Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
-
Azuma K, Ota K, Kawahara A, et al. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Ann Oncol. 2014;25:1935-40.
-
(2014)
Ann Oncol
, vol.25
, pp. 1935-1940
-
-
Azuma, K.1
Ota, K.2
Kawahara, A.3
-
28
-
-
84873666114
-
Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study
-
Chen YB, Mu CY, Huang JA. Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study. Tumori. 2012;98:751-5.
-
(2012)
Tumori
, vol.98
, pp. 751-755
-
-
Chen, Y.B.1
Mu, C.Y.2
Huang, J.A.3
-
29
-
-
84929939531
-
The prognostic value of PD-L1 expression for non-small cell lung cancer patients: a meta-analysis
-
Wang A, Wang HY, Liu Y, et al. The prognostic value of PD-L1 expression for non-small cell lung cancer patients: a meta-analysis. Eur J Surg Oncol. 2015;41:450-6.
-
(2015)
Eur. J. Surg. Oncol.
, vol.41
, pp. 450-456
-
-
Wang, A.1
Wang, H.Y.2
Liu, Y.3
-
30
-
-
84928615785
-
Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis
-
Pan ZK, Ye F, Wu X, An HX, Wu JX. Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis. Journal of Thoracic Disease. 2015;7:462-70.
-
(2015)
Journal of Thoracic Disease
, vol.7
, pp. 462-470
-
-
Pan, Z.K.1
Ye, F.2
Wu, X.3
An, H.X.4
Wu, J.X.5
-
31
-
-
84949663097
-
Prognostic value of programmed cell death-ligand 1 expression in patients with non-small-cell lung cancer: evidence from an updated meta-analysis
-
Zhong A, Xing Y, Pan X, Shi M, Xu H. Prognostic value of programmed cell death-ligand 1 expression in patients with non-small-cell lung cancer: evidence from an updated meta-analysis. OncoTargets and Therapy. 2015;8:3595-601.
-
(2015)
OncoTargets and Therapy
, vol.8
, pp. 3595-3601
-
-
Zhong, A.1
Xing, Y.2
Pan, X.3
Shi, M.4
Xu, H.5
-
32
-
-
84941647041
-
PD-L1 over-expression and survival in patients with non-small cell lung cancer: a meta-analysis
-
Zhou ZJ, Zhan P, Song Y. PD-L1 over-expression and survival in patients with non-small cell lung cancer: a meta-analysis. Transl Lung Cancer Res. 2015;4:203-8.
-
(2015)
Transl Lung Cancer Res
, vol.4
, pp. 203-208
-
-
Zhou, Z.J.1
Zhan, P.2
Song, Y.3
-
33
-
-
84964858970
-
Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients
-
Ilie M, Hofman V, Dietel M, Soria JC, Hofman P. Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients. Virchows Arch. 2016.
-
(2016)
Virchows Arch
-
-
Ilie, M.1
Hofman, V.2
Dietel, M.3
Soria, J.C.4
Hofman, P.5
-
34
-
-
84937544496
-
Assays for predicting and monitoring responses to lung cancer immunotherapy
-
Teixidó C, Karachaliou N, González-Cao M, Morales-Espinosa D, Rosell R. Assays for predicting and monitoring responses to lung cancer immunotherapy. Cancer Biology & Medicine. 2015;12:87-95.
-
(2015)
Cancer Biology & Medicine
, vol.12
, pp. 87-95
-
-
Teixidó, C.1
Karachaliou, N.2
González-Cao, M.3
Morales-Espinosa, D.4
Rosell, R.5
-
35
-
-
84995409729
-
Atezolizumab monotherapy vs docetaxel in 2L/3L non-small cell lung cancer: Primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR)
-
Vienna: European Cancer Congress
-
Vansteenkiste J, Fehrenbacher L, Spira A, et al. Atezolizumab monotherapy vs docetaxel in 2L/3L non-small cell lung cancer: Primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR). Vienna: European Cancer Congress; 2015.
-
(2015)
-
-
Vansteenkiste, J.1
Fehrenbacher, L.2
Spira, A.3
-
36
-
-
84998798002
-
PD-L1 IHC assays for lung cancer: results from phase 1 of the "blueprint PD-L1 assay comparison project"
-
New Orleans: AACR Annual Meeting
-
Hirsch FR, McElhinny A, Stanforth D, et al. PD-L1 IHC assays for lung cancer: results from phase 1 of the "blueprint PD-L1 assay comparison project". New Orleans: AACR Annual Meeting; 2016.
-
(2016)
-
-
Hirsch, F.R.1
McElhinny, A.2
Stanforth, D.3
-
37
-
-
84998970044
-
Spatiotemporal effects on Programmed Death Ligand 1 (PD-L1) expression and Immunophenotype of Non-small Cell Lung Cancer (NSCLC) (ID1609)
-
Denver: 2015 World Conference on Lung Cancer
-
Desai N. Spatiotemporal effects on Programmed Death Ligand 1 (PD-L1) expression and Immunophenotype of Non-small Cell Lung Cancer (NSCLC) (ID1609). Denver: 2015 World Conference on Lung Cancer; 2015.
-
(2015)
-
-
Desai, N.1
-
38
-
-
84998663951
-
Evaluation of PD-L1 expression in metachronous tumor samples and FDG-PET as a predictive biomarker in Ph2 study (FIR) of Atezolizumab (MPDL3280A) (ID2207).
-
Denver: 2015 World Conference on Lung Cancer;
-
Kowanetz M. Evaluation of PD-L1 expression in metachronous tumor samples and FDG-PET as a predictive biomarker in Ph2 study (FIR) of Atezolizumab (MPDL3280A) (ID2207). Denver: 2015 World Conference on Lung Cancer; 2015.
-
(2015)
-
-
Kowanetz, M.1
-
39
-
-
84998570171
-
Predictive biomarker testing for programmed cell death 1 inhibition in Non-small cell lung cancer (ID 1081).
-
Denver: 2015 World Conference on Lung Cancer
-
Sheffield BS, Geller G, Pleasance E, et al. Predictive biomarker testing for programmed cell death 1 inhibition in Non-small cell lung cancer (ID 1081). Denver: 2015 World Conference on Lung Cancer; 2015.
-
(2015)
-
-
Sheffield, B.S.1
Geller, G.2
Pleasance, E.3
-
40
-
-
84998823200
-
Programmed Death Ligand-1 (PDL-1) expression in Non-Small Cell Lung Cancer (NSCLC): analysis of a large early stage cohort; and concordance of expression in paired primary-nodal and primary-metastasis tumour samples (ID 3226)
-
Denver: 2015 World Conference on Lung Cancer
-
Mitchell P, Murone C, Asadi K, Harbison CT, Knight S, John T. Programmed Death Ligand-1 (PDL-1) expression in Non-Small Cell Lung Cancer (NSCLC): analysis of a large early stage cohort; and concordance of expression in paired primary-nodal and primary-metastasis tumour samples (ID 3226). Denver: 2015 World Conference on Lung Cancer; 2015.
-
(2015)
-
-
Mitchell, P.1
Murone, C.2
Asadi, K.3
Harbison, C.T.4
Knight, S.5
John, T.6
-
41
-
-
84956607290
-
Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer
-
Sheng J, Fang W, Yu J, et al. Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer. Scientific Reports. 2016;6:20090.
-
(2016)
Scientific Reports
, vol.6
, pp. 20090
-
-
Sheng, J.1
Fang, W.2
Yu, J.3
-
42
-
-
84926525215
-
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer
-
Twyman-Saint Victor C, Rech AJ, Maity A, et al. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature. 2015;520:373-7.
-
(2015)
Nature
, vol.520
, pp. 373-377
-
-
Twyman-Saint Victor, C.1
Rech, A.J.2
Maity, A.3
-
43
-
-
84893876109
-
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
-
Deng L, Liang H, Burnette B, et al. Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. The Journal of Clinical Investigation. 2014;124:687-95.
-
(2014)
The Journal of Clinical Investigation.
, vol.124
, pp. 687-695
-
-
Deng, L.1
Liang, H.2
Burnette, B.3
-
44
-
-
84998971770
-
Radiation therapy induces an adaptive upregulation of PD-L1 on tumor cells which may limit the efficacy of the anti-tumor immune response but can be circumvented by anti-PD-L1
-
Illidge T, Lipowska-Bhalla G, Cheadle E, et al. Radiation therapy induces an adaptive upregulation of PD-L1 on tumor cells which may limit the efficacy of the anti-tumor immune response but can be circumvented by anti-PD-L1. Int J Radiat Oncol Biol Phys. 2014;90:S776.
-
(2014)
Int J Radiat Oncol Biol Phys.
, vol.90
, pp. S776
-
-
Illidge, T.1
Lipowska-Bhalla, G.2
Cheadle, E.3
-
45
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014;371:2189-99.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
46
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015;348:124-8.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
47
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. New England Journal of Medicine. 2015;372:2509-20.
-
(2015)
New England Journal of Medicine
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
48
-
-
84931444036
-
POLE proofreading mutations elicit an antitumor immune response in endometrial cancer
-
van Gool IC, Eggink FA, Freeman-Mills L, et al. POLE proofreading mutations elicit an antitumor immune response in endometrial cancer. Clin Cancer Res. 2015;21:3347-55.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3347-3355
-
-
Gool, I.C.1
Eggink, F.A.2
Freeman-Mills, L.3
-
49
-
-
84937246543
-
Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?
-
Apetoh L, Ladoire S, Coukos G, Ghiringhelli F. Combining immunotherapy and anticancer agents: the right path to achieve cancer cure? Ann Oncol. 2015;26(9):1813-823.
-
(2015)
Ann Oncol
, vol.26
, Issue.9
, pp. 1813-1823
-
-
Apetoh, L.1
Ladoire, S.2
Coukos, G.3
Ghiringhelli, F.4
-
50
-
-
84890111958
-
Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
-
Bracci L, Schiavoni G, Sistigu A, Belardelli F. Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer. Cell Death Differ. 2014;21:15-25.
-
(2014)
Cell Death Differ
, vol.21
, pp. 15-25
-
-
Bracci, L.1
Schiavoni, G.2
Sistigu, A.3
Belardelli, F.4
-
51
-
-
84938309673
-
Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients with advanced NSCLC
-
Antonia S, Goldberg SB, Balmanoukian AS, et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-L1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients with advanced NSCLC. J Clin Oncol. 2015;33(suppl):abstr 3014.
-
(2015)
J Clin Oncol
, vol.33
-
-
Antonia, S.1
Goldberg, S.B.2
Balmanoukian, A.S.3
-
52
-
-
84908269560
-
Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase I results
-
Antonia S, Gettinger SN, Chow L, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) and ipilimumab in first-line NSCLC: Interim phase I results. J Clin Oncol. 2014;32:suppl; abstr 8023.
-
(2014)
J Clin Oncol
, vol.32
-
-
Antonia, S.1
Gettinger, S.N.2
Chow, L.3
-
53
-
-
84960498096
-
Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study
-
Antonia S, Goldberg SB, Balmanoukian A, et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study. Lancet Oncol. 2016;17:299-308.
-
(2016)
Lancet Oncol.
, vol.17
, pp. 299-308
-
-
Antonia, S.1
Goldberg, S.B.2
Balmanoukian, A.3
-
54
-
-
84984681480
-
CheckMate 012: Safety and efficacy of first-line (1 L) nivolumab (nivo; N) and ipilimumab (ipi; I) in advanced (adv) NSCLC (Abstract 3001)
-
Hellmann MD, Gettinger SN, Goldman JW, et al. CheckMate 012: Safety and efficacy of first-line (1 L) nivolumab (nivo; N) and ipilimumab (ipi; I) in advanced (adv) NSCLC (Abstract 3001). J Clin Oncol. 2016;34:suppl; abstr 3001.
-
(2016)
J Clin Oncol
, vol.34
-
-
Hellmann, M.D.1
Gettinger, S.N.2
Goldman, J.W.3
-
55
-
-
84949095628
-
An ongoing phase IIIb/IV safety trial of nivolumab (NIVO) in patients (pts) with advanced or metastatic non-small-cell lung cancer (NSCLC) who progressed after receiving 1 or more prior systemic regimens
-
Bauer TM, McCleod M, Chandler JC, et al. An ongoing phase IIIb/IV safety trial of nivolumab (NIVO) in patients (pts) with advanced or metastatic non-small-cell lung cancer (NSCLC) who progressed after receiving 1 or more prior systemic regimens. J Clin Oncol. 2015;33:suppl; abstr 3013.
-
(2015)
J Clin Oncol
, vol.33
-
-
Bauer, T.M.1
McCleod, M.2
Chandler, J.C.3
-
56
-
-
84907558390
-
Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial
-
Hodi FS, Sznol M, Kluger HM, et al. Long-term survival of ipilimumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial. J Clin Oncol. 2014;32:suppl; abstr 9002.
-
(2014)
J Clin Oncol
, vol.32
-
-
Hodi, F.S.1
Sznol, M.2
Kluger, H.M.3
-
57
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372:320-30.
-
(2015)
N Engl J Med
, vol.372
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
-
58
-
-
84931083080
-
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
-
Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015;16:375-84.
-
(2015)
Lancet Oncol
, vol.16
, pp. 375-384
-
-
Weber, J.S.1
D'Angelo, S.P.2
Minor, D.3
-
60
-
-
84907973066
-
Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475
-
Kefford R, Ribas A, Hamid O, et al. Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. J Clin Oncol 2014;32:suppl; abstr 3005.
-
(2014)
J Clin Oncol
, vol.32
-
-
Kefford, R.1
Ribas, A.2
Hamid, O.3
-
61
-
-
84936821511
-
Efficacy based on tumor PD-L1 expression in KEYNOTE-002, a randomized comparison of pembrolizumab (pembro; MK-3475) versus chemotherapy in patients (pts) with ipilimumab-refractory (IPI-R) advanced melanoma (MEL)
-
Puzanov I, Dummer R, Schachter J, et al. Efficacy based on tumor PD-L1 expression in KEYNOTE-002, a randomized comparison of pembrolizumab (pembro; MK-3475) versus chemotherapy in patients (pts) with ipilimumab-refractory (IPI-R) advanced melanoma (MEL). J Clin Oncol. 2015;33:suppl; abstr 3012.
-
(2015)
J Clin Oncol
, vol.33
-
-
Puzanov, I.1
Dummer, R.2
Schachter, J.3
-
63
-
-
84947444410
-
Clinical activity and safety from a phase II study (FIR) of MPDL3280A (anti-PDL1) in PD-L1-selected patients with non-small cell lung cancer (NSCLC)
-
Spigel DR, Chaft JE, Gettinger SN, et al. Clinical activity and safety from a phase II study (FIR) of MPDL3280A (anti-PDL1) in PD-L1-selected patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33:suppl; abstr 8028.
-
(2015)
J Clin Oncol
, vol.33
-
-
Spigel, D.R.1
Chaft, J.E.2
Gettinger, S.N.3
-
64
-
-
84942138309
-
Efficacy, safety and predictive biomarker results from a randomized phase II study comparing MPDL3280A vs docetaxel in 2 L/3L NSCLC (POPLAR)
-
Spira A, Park K, Mazieres J, et al. Efficacy, safety and predictive biomarker results from a randomized phase II study comparing MPDL3280A vs docetaxel in 2 L/3L NSCLC (POPLAR). J Clin Oncol. 2015;33:suppl; abstr 8010.
-
(2015)
J Clin Oncol
, vol.33
-
-
Spira, A.1
Park, K.2
Mazieres, J.3
-
65
-
-
84995404301
-
Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC)
-
Vienna: European Cancer Congress
-
Besse B, Johnson M, Janne M, et al. Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected non-small cell lung cancer (NSCLC). Vienna: European Cancer Congress; 2015.
-
(2015)
-
-
Besse, B.1
Johnson, M.2
Janne, M.3
-
66
-
-
84923078390
-
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature. 2014;515:558-62.
-
(2014)
Nature
, vol.515
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
-
67
-
-
84959577118
-
Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial
-
10031.
-
Rosenberg JE, Hoffman-Censits J, Powles T, et al. Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial. Lancet. 2016;387(10031):1909-920.
-
(2016)
Lancet
, vol.387
, pp. 1909-1920
-
-
Rosenberg, J.E.1
Hoffman-Censits, J.2
Powles, T.3
-
68
-
-
84944734156
-
Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)
-
Rizvi N, Brahmer J, Ou SI, et al. Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33:suppl;abstr 8032.
-
(2015)
J Clin Oncol
, vol.33
-
-
Rizvi, N.1
Brahmer, J.2
Ou, S.I.3
-
69
-
-
84941080042
-
Safety and efficacy of MEDI4736, an anti-PD-L1 antibody, in patients from a squamous cell carcinoma of the head and neck (SCCHN) expansion cohort
-
Segal NH, Ou SI, Balmanoukian AS, et al. Safety and efficacy of MEDI4736, an anti-PD-L1 antibody, in patients from a squamous cell carcinoma of the head and neck (SCCHN) expansion cohort. J Clin Oncol. 2015;33:suppl; abstr 3011.
-
(2015)
J Clin Oncol
, vol.33
-
-
Segal, N.H.1
Ou, S.I.2
Balmanoukian, A.S.3
-
70
-
-
84944751040
-
Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: A phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy
-
Gulley JL, Spigel DR, Kelly K, et al. Avelumab (MSB0010718C), an anti-PD-L1 antibody, in advanced NSCLC patients: A phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy. J Clin Oncol. 2015;33:suppl; abstr 8034.
-
(2015)
J Clin Oncol
, vol.33
-
-
Gulley, J.L.1
Spigel, D.R.2
Kelly, K.3
-
71
-
-
84983248229
-
Safety, clinical activity, and PD-L1 expression of avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic urothelial carcinoma from the JAVELIN Solid Tumor phase Ib trial
-
Apolo AB, Infante JR, Hamid O, et al. Safety, clinical activity, and PD-L1 expression of avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with metastatic urothelial carcinoma from the JAVELIN Solid Tumor phase Ib trial. J Clin Oncol. 2015;33:suppl 2S; abstr 367.
-
(2015)
J Clin Oncol
, vol.33
-
-
Apolo, A.B.1
Infante, J.R.2
Hamid, O.3
|