The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion

Science

Volumn 358, Issue 6365, 2017, Pages 888-893

  Tenthorey, Jeannette L ^a   Haloupek, Nicole ^a   López Blanco, José Ramón ^b   Grob, Patricia ^a   Adamson, Elise ^a,c   Hartenian, Ella ^a   Lind, Nicholas A ^a   Bourgeois, Natasha M ^a   Chacón, Pablo ^b   Nogales, Eva ^a,d   Vance, Russell E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^c UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; INFLAMMASOME; LIGAND; MULTIPROTEIN COMPLEX; NLR FAMILY APOPTOSIS INHIBITORY PROTEIN 5; PROTEIN; TOLL LIKE RECEPTOR 5; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CALCIUM BINDING PROTEIN; FLAA PROTEIN, BACTERIA; IPAF PROTEIN, MOUSE; NAIP5 PROTEIN, MOUSE; NEURONAL APOPTOSIS INHIBITORY PROTEIN;

APOPTOSIS; BACTERIUM; DEFENSE MECHANISM; DETECTION METHOD; HOST; IMMUNE SYSTEM; LIGAND; PATHOGEN; PROTEIN;

AMINO TERMINAL SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; IMMUNE EVASION; INNATE IMMUNITY; LEGIONELLA PNEUMOPHILA; LIGAND BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; SURFACE PROPERTY; ANIMAL; CHEMISTRY; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; MOUSE; ULTRASTRUCTURE;

ANIMALIA; BACTERIA (MICROORGANISMS);

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CRYOELECTRON MICROSCOPY; FLAGELLIN; HEK293 CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; LEGIONELLA PNEUMOPHILA; MICE; MUTATION; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; PROTEIN DOMAINS;

EID: 85034056063     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aao1140     Document Type: Article

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