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Volumn 46, Issue 2, 2017, Pages 87-94

Serum tocilizumab trough concentration can be used to monitor systemic IL-6 receptor blockade in patients with rheumatoid arthritis: a prospective observational cohort study

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; DRUG ANTIBODY; INTERLEUKIN 6; TOCILIZUMAB; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY;

EID: 84978951824     PISSN: 03009742     EISSN: 15027732     Source Type: Journal    
DOI: 10.1080/03009742.2016.1183039     Document Type: Article
Times cited : (32)

References (45)
  • 1
    • 0024271851 scopus 로고
    • Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases
    • Swaak AJ, van Rooyen A, Nieuwenhuis E, Aarden L., Interleukin-6 (IL-6) in synovial fluid and serum of patients with rheumatic diseases. Scand J Rheumatol 1988;17:469–74.
    • (1988) Scand J Rheumatol , vol.17 , pp. 469-474
    • Swaak, A.J.1    van Rooyen, A.2    Nieuwenhuis, E.3    Aarden, L.4
  • 2
    • 0344534939 scopus 로고    scopus 로고
    • Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies
    • Usón J, Balsa A, Pascual-Salcedo D, Cabezas JA, Gonzalez-Tarrio JM, Martín-Mola E, et al. Soluble interleukin 6 (IL-6) receptor and IL-6 levels in serum and synovial fluid of patients with different arthropathies. J Rheumatol 1997;24:2069–75.
    • (1997) J Rheumatol , vol.24 , pp. 2069-2075
    • Usón, J.1    Balsa, A.2    Pascual-Salcedo, D.3    Cabezas, J.A.4    Gonzalez-Tarrio, J.M.5    Martín-Mola, E.6
  • 3
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation
    • Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 1996;11:88–95.
    • (1996) J Bone Miner Res , vol.11 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3    Takahashi, N.4    Udagawa, N.5    Nakamura, I.6
  • 4
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 2007;7:429–42.
    • (2007) Nat Rev Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 5
    • 33748092926 scopus 로고    scopus 로고
    • Interleukin-6 and rheumatic diseases
    • Lipsky PE. Interleukin-6 and rheumatic diseases. Arthritis Res Ther 2006;8(Suppl 2):S4.
    • (2006) Arthritis Res Ther , vol.8 , pp. S4
    • Lipsky, P.E.1
  • 6
    • 85047693039 scopus 로고
    • Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat
    • Castell JV, Geiger T, Gross V, Andus T, Walter E, Hirano T, et al. Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat. Eur J Biochem 1988;177:357–61.
    • (1988) Eur J Biochem , vol.177 , pp. 357-361
    • Castell, J.V.1    Geiger, T.2    Gross, V.3    Andus, T.4    Walter, E.5    Hirano, T.6
  • 8
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
    • Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor:importance for the pro-inflammatory activities of IL-6. Int J Biol Sci 2012;8:1237–47.
    • (2012) Int J Biol Sci , vol.8 , pp. 1237-1247
    • Rose-John, S.1
  • 9
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study):a double-blind, placebo-controlled, randomised trial. Lancet 2008;371:987–97.
    • (2008) Lancet , vol.371 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3    Ramos-Remus, C.4    Rovensky, J.5    Alecock, E.6
  • 10
    • 33749363027 scopus 로고    scopus 로고
    • Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Erratum in Arthritis Rheum 2008;3:887
    • Maini RN, Taylor PC, Szechinski J, Pavelka K, Bröll J, Balint G, et al. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 2006;54:2817–29. Erratum in Arthritis Rheum 2008;3:887.
    • (2006) Arthritis Rheum , vol.54 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3    Pavelka, K.4    Bröll, J.5    Balint, G.6
  • 11
    • 84896689880 scopus 로고    scopus 로고
    • Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis
    • Ogata A, Tanimura K, Sugimoto T, Inoue H, Urata Y, Matsubara T, et al. Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 2014;66:344–54.
    • (2014) Arthritis Care Res (Hoboken) , vol.66 , pp. 344-354
    • Ogata, A.1    Tanimura, K.2    Sugimoto, T.3    Inoue, H.4    Urata, Y.5    Matsubara, T.6
  • 12
    • 58149154996 scopus 로고    scopus 로고
    • Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
    • Nishimoto N, Terao K, Mima T, Nakahara H, Takagi N, Kakehi T. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood 2008;112:3959–64.
    • (2008) Blood , vol.112 , pp. 3959-3964
    • Nishimoto, N.1    Terao, K.2    Mima, T.3    Nakahara, H.4    Takagi, N.5    Kakehi, T.6
  • 13
    • 84877871136 scopus 로고    scopus 로고
    • Exposure-response relationship of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis
    • Levi M, Grange S, Frey N. Exposure-response relationship of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis. J Clin Pharmacol 2013;53:151–9.
    • (2013) J Clin Pharmacol , vol.53 , pp. 151-159
    • Levi, M.1    Grange, S.2    Frey, N.3
  • 14
    • 77953764543 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of tocilizumab in patients with rheumatoid arthritis
    • Frey N, Grange S, Woodworth T. Population pharmacokinetic analysis of tocilizumab in patients with rheumatoid arthritis. J Clin Pharmacol 2010;50:754–66.
    • (2010) J Clin Pharmacol , vol.50 , pp. 754-766
    • Frey, N.1    Grange, S.2    Woodworth, T.3
  • 15
    • 84888857505 scopus 로고    scopus 로고
    • Long-term drug survival of TNF inhibitor therapy in RA patients: a systematic review of European National Drug Registers
    • Arora A, Mahajan A, Spurden D, Boyd H, Porter D. Long-term drug survival of TNF inhibitor therapy in RA patients:a systematic review of European National Drug Registers. Int J Rheumatol 2013;2013:764518.
    • (2013) Int J Rheumatol , vol.2013 , pp. 764518
    • Arora, A.1    Mahajan, A.2    Spurden, D.3    Boyd, H.4    Porter, D.5
  • 16
    • 84882261762 scopus 로고    scopus 로고
    • Immunogenicity of monoclonal antibodies against tumor necrosis factor used in chronic immune-mediated inflammatory conditions: systematic review and meta-analysis
    • Maneiro JR, Salgado E, Gomez-Reino JJ. Immunogenicity of monoclonal antibodies against tumor necrosis factor used in chronic immune-mediated inflammatory conditions:systematic review and meta-analysis. JAMA Intern Med 2013;173:1416–28.
    • (2013) JAMA Intern Med , vol.173 , pp. 1416-1428
    • Maneiro, J.R.1    Salgado, E.2    Gomez-Reino, J.J.3
  • 17
    • 84898003691 scopus 로고    scopus 로고
    • Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy
    • Nishina N, Kikuchi J, Hashizume M, Yoshimoto K, Kameda H, Takeuchi T. Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab:implications for molecular targeted therapy. Ann Rheum Dis 2014;73:945–7.
    • (2014) Ann Rheum Dis , vol.73 , pp. 945-947
    • Nishina, N.1    Kikuchi, J.2    Hashizume, M.3    Yoshimoto, K.4    Kameda, H.5    Takeuchi, T.6
  • 18
    • 0023945481 scopus 로고
    • The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
    • Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–24.
    • (1988) Arthritis Rheum , vol.31 , pp. 315-324
    • Arnett, F.C.1    Edworthy, S.M.2    Bloch, D.A.3    McShane, D.J.4    Fries, J.F.5    Cooper, N.S.6
  • 19
    • 0028815803 scopus 로고
    • Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
    • Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:44–8.
    • (1995) Arthritis Rheum , vol.38 , pp. 44-48
    • Prevoo, M.L.1    van’t Hof, M.A.2    Kuper, H.H.3    van Leeuwen, M.A.4    van de Putte, L.B.5    van Riel, P.L.6
  • 20
    • 85015134932 scopus 로고    scopus 로고
    • Accessed, June, 2016
    • Food and Drug Administration. 2013 (http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/125276s064lbl.pdf). Accessed 22 June 2016.
    • (2013)
  • 21
    • 79952454134 scopus 로고    scopus 로고
    • Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody
    • Rispens T, Leeuwen Av, Vennegoor A, Killestein J, Aalberse RC, Wolbink GJ, et al. Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody. Anal Biochem 2011;411:271–6.
    • (2011) Anal Biochem , vol.411 , pp. 271-276
    • Rispens, T.1    Leeuwen, A.2    Vennegoor, A.3    Killestein, J.4    Aalberse, R.C.5    Wolbink, G.J.6
  • 22
    • 33644931095 scopus 로고    scopus 로고
    • Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis
    • Wolbink GJ, Vis M, Lems W, Voskuyl AE, de Groot E, Nurmohamed MT, et al. Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis. Arthritis Rheum 2006;54:711–15.
    • (2006) Arthritis Rheum , vol.54 , pp. 711-715
    • Wolbink, G.J.1    Vis, M.2    Lems, W.3    Voskuyl, A.E.4    de Groot, E.5    Nurmohamed, M.T.6
  • 23
    • 84855351064 scopus 로고    scopus 로고
    • Antibodies to constant domains of therapeutic monoclonal antibodies: anti-hinge antibodies in immunogenicity testing
    • Rispens T, de Vrieze H, de Groot E, Wouters D, Stapel S, Wolbink GJ, et al. Antibodies to constant domains of therapeutic monoclonal antibodies:anti-hinge antibodies in immunogenicity testing. J Immunol Methods 2012;375:93–9.
    • (2012) J Immunol Methods , vol.375 , pp. 93-99
    • Rispens, T.1    de Vrieze, H.2    de Groot, E.3    Wouters, D.4    Stapel, S.5    Wolbink, G.J.6
  • 24
    • 79953906254 scopus 로고    scopus 로고
    • Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up
    • Bartelds GM, Krieckaert CL, Nurmohamed MT, van Schouwenburg PA, Lems WF, Twisk JW, et al. Development of antidrug antibodies against adalimumab and association with disease activity and treatment failure during long-term follow-up. JAMA 2011;305:1460–8.
    • (2011) JAMA , vol.305 , pp. 1460-1468
    • Bartelds, G.M.1    Krieckaert, C.L.2    Nurmohamed, M.T.3    van Schouwenburg, P.A.4    Lems, W.F.5    Twisk, J.W.6
  • 26
    • 67650137185 scopus 로고    scopus 로고
    • Dealing with immunogenicity of biologicals: assessment and clinical relevance
    • Wolbink GJ, Aarden LA, Dijkmans BA. Dealing with immunogenicity of biologicals:assessment and clinical relevance. Curr Opin Rheumatol 2009;21:211–15.
    • (2009) Curr Opin Rheumatol , vol.21 , pp. 211-215
    • Wolbink, G.J.1    Aarden, L.A.2    Dijkmans, B.A.3
  • 27
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, Macfarlane JD, et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998;41:1552–63.
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3    Smolen, J.S.4    Davis, D.5    Macfarlane, J.D.6
  • 28
    • 84941183781 scopus 로고    scopus 로고
    • Monoclonal antibodies in excess: A simple way to avoid immunogenicity in patients?
    • Chaigne B, Watier H., Monoclonal antibodies in excess:A simple way to avoid immunogenicity in patients? J Allergy Clin Immunol 2015;136:814–16.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 814-816
    • Chaigne, B.1    Watier, H.2
  • 29
    • 77958507060 scopus 로고    scopus 로고
    • A novel method for the detection of antibodies to adalimumab in the presence of drug reveals “hidden” immunogenicity in rheumatoid arthritis patients
    • van Schouwenburg PA, Bartelds GM, Hart MH, Aarden L, Wolbink GJ, Wouters D. A novel method for the detection of antibodies to adalimumab in the presence of drug reveals “hidden” immunogenicity in rheumatoid arthritis patients. J Immunol Methods 2010;362:82–8.
    • (2010) J Immunol Methods , vol.362 , pp. 82-88
    • van Schouwenburg, P.A.1    Bartelds, G.M.2    Hart, M.H.3    Aarden, L.4    Wolbink, G.J.5    Wouters, D.6
  • 30
    • 84930341194 scopus 로고    scopus 로고
    • Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients
    • Bloem K, van Leeuwen A, Verbeek G, Nurmohamed MT, Wolbink GJ, van der Kleij D, et al. Systematic comparison of drug-tolerant assays for anti-drug antibodies in a cohort of adalimumab-treated rheumatoid arthritis patients. J Immunol Methods 2015;418:29–38.
    • (2015) J Immunol Methods , vol.418 , pp. 29-38
    • Bloem, K.1    van Leeuwen, A.2    Verbeek, G.3    Nurmohamed, M.T.4    Wolbink, G.J.5    van der Kleij, D.6
  • 31
    • 23644442893 scopus 로고    scopus 로고
    • Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family
    • Mihara M, Kasutani K, Okazaki M, Nakamura A, Kawai S, Sugimoto M, et al. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family. Int Immunopharmacol 2005;5:1731–40.
    • (2005) Int Immunopharmacol , vol.5 , pp. 1731-1740
    • Mihara, M.1    Kasutani, K.2    Okazaki, M.3    Nakamura, A.4    Kawai, S.5    Sugimoto, M.6
  • 32
    • 84885339903 scopus 로고    scopus 로고
    • IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis
    • Wang J, Platt A, Upmanyu R, Germer S, Lei G, Rabe C, et al. IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis. BMJ Open 2013;8:e003199.
    • (2013) BMJ Open , vol.8 , pp. e003199
    • Wang, J.1    Platt, A.2    Upmanyu, R.3    Germer, S.4    Lei, G.5    Rabe, C.6
  • 33
    • 84904256239 scopus 로고    scopus 로고
    • Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis
    • Enevold C, Baslund B, Linde L, Josephsen NL, Tarp U, Lindegaard H, et al. Interleukin-6-receptor polymorphisms rs12083537, rs2228145, and rs4329505 as predictors of response to tocilizumab in rheumatoid arthritis. Pharmacogenet Genomics 2014;24:401–5.
    • (2014) Pharmacogenet Genomics , vol.24 , pp. 401-405
    • Enevold, C.1    Baslund, B.2    Linde, L.3    Josephsen, N.L.4    Tarp, U.5    Lindegaard, H.6
  • 34
    • 23944478301 scopus 로고    scopus 로고
    • Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score
    • Aletaha D, Nell VPK, Stamm T, Uffmann M, Pflugbeil S, Machold K, et al. Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis:validation of a clinical activity score. Arthritis Res Ther 2005;7:R796–806.
    • (2005) Arthritis Res Ther , vol.7 , pp. R796-R806
    • Aletaha, D.1    Nell, V.P.K.2    Stamm, T.3    Uffmann, M.4    Pflugbeil, S.5    Machold, K.6
  • 36
    • 84888057974 scopus 로고    scopus 로고
    • Mechanism-based approach using a biomarker response to evaluate tocilizumab subcutaneous injection in patients with rheumatoid arthritis with an inadequate response to synthetic DMARDs (MATSURI study)
    • Ohta S, Tsuru T, Terao K, Mogi S, Suzaki M, Shono E, et al. Mechanism-based approach using a biomarker response to evaluate tocilizumab subcutaneous injection in patients with rheumatoid arthritis with an inadequate response to synthetic DMARDs (MATSURI study). J Clin Pharmacol 2014;54:109–19.
    • (2014) J Clin Pharmacol , vol.54 , pp. 109-119
    • Ohta, S.1    Tsuru, T.2    Terao, K.3    Mogi, S.4    Suzaki, M.5    Shono, E.6
  • 37
    • 84969959750 scopus 로고    scopus 로고
    • Relationship between baseline/early changes in c-reactive protein and interleukin-6 and clinical response to tocilizumab for rheumatoid arthritis
    • Wang J, Devenport J, Low J, Yu D, Hitraya E. Relationship between baseline/early changes in c-reactive protein and interleukin-6 and clinical response to tocilizumab for rheumatoid arthritis. Arthritis Care Res (Hoboken) 2016;68:882–5.
    • (2016) Arthritis Care Res (Hoboken) , vol.68 , pp. 882-885
    • Wang, J.1    Devenport, J.2    Low, J.3    Yu, D.4    Hitraya, E.5
  • 38
    • 84958840838 scopus 로고    scopus 로고
    • The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease: the ATLAS study
    • Yarur AJ, Jain A, Sussman DA, Barkin JS, Quintero MA, Princen F, et al. The association of tissue anti-TNF drug levels with serological and endoscopic disease activity in inflammatory bowel disease:the ATLAS study. Gut 2016;65:249–55.
    • (2016) Gut , vol.65 , pp. 249-255
    • Yarur, A.J.1    Jain, A.2    Sussman, D.A.3    Barkin, J.S.4    Quintero, M.A.5    Princen, F.6
  • 39
    • 84893898345 scopus 로고    scopus 로고
    • Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn’s disease
    • Colombel JF, Sandborn WJ, Allez M, Dupas JL, Dewit O, D’Haens G, et al. Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn’s disease. Clin Gastroenterol Hepatol 2014;12:423–31.e1.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 423
    • Colombel, J.F.1    Sandborn, W.J.2    Allez, M.3    Dupas, J.L.4    Dewit, O.5    D’Haens, G.6
  • 41
    • 84931062985 scopus 로고    scopus 로고
    • Developing a therapeutic range of adalimumab serum concentrations in management of psoriasis: a step toward personalized treatment
    • Menting SP, Coussens E, Pouw MF, van den Reek JMPA, Temmerman L, Boonen H, et al. Developing a therapeutic range of adalimumab serum concentrations in management of psoriasis:a step toward personalized treatment. JAMA Dermatol 2015;151:616–22.
    • (2015) JAMA Dermatol , vol.151 , pp. 616-622
    • Menting, S.P.1    Coussens, E.2    Pouw, M.F.3    van den Reek, J.M.P.A.4    Temmerman, L.5    Boonen, H.6
  • 42
    • 84872180107 scopus 로고    scopus 로고
    • Clinical results for tocilizumab over one year in the clinical setting as assessed by CDAI (clinical disease activity index): CRP at week 12 and MMP-3 at week 24 are predictive factors for CDAI
    • Kaneko A, Kida D, Saito K, Tsukamoto M, Sato T. Clinical results for tocilizumab over one year in the clinical setting as assessed by CDAI (clinical disease activity index):CRP at week 12 and MMP-3 at week 24 are predictive factors for CDAI. Rheumatol Int 2012;32:3631–7.
    • (2012) Rheumatol Int , vol.32 , pp. 3631-3637
    • Kaneko, A.1    Kida, D.2    Saito, K.3    Tsukamoto, M.4    Sato, T.5
  • 43
    • 84890957085 scopus 로고    scopus 로고
    • Predictors of response and remission in a large cohort of rheumatoid arthritis patients treated with tocilizumab in clinical practice
    • Pers YM, Fortunet C, Constant E, Lambert J, Godfrin-Valnet M, De Jong A, et al. Predictors of response and remission in a large cohort of rheumatoid arthritis patients treated with tocilizumab in clinical practice. Rheumatology (Oxford) 2014;53:76–84.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 76-84
    • Pers, Y.M.1    Fortunet, C.2    Constant, E.3    Lambert, J.4    Godfrin-Valnet, M.5    De Jong, A.6
  • 44
    • 84983189195 scopus 로고    scopus 로고
    • Calprotectin more accurately discriminates the disease status of rheumatoid arthritis patients receiving tocilizumab than acute phase reactants
    • Inciarte-Mundo J, Ruiz-Esquide V, Hernández MV, Cañete JD, Cabrera-Villalba SR, Ramirez J, et al. Calprotectin more accurately discriminates the disease status of rheumatoid arthritis patients receiving tocilizumab than acute phase reactants. Rheumatology (Oxford) 2015;54:2239–43.
    • (2015) Rheumatology (Oxford) , vol.54 , pp. 2239-2243
    • Inciarte-Mundo, J.1    Ruiz-Esquide, V.2    Hernández, M.V.3    Cañete, J.D.4    Cabrera-Villalba, S.R.5    Ramirez, J.6
  • 45
    • 85006669673 scopus 로고    scopus 로고
    • Tocilizumab in combination therapy and monotherapy versus methotrexate in methotrexate-naïve patients with early rheumatoid arthritis: clinical and radiographic outcomes from a randomized placebo-controlled trial
    • Suppl S1
    • Burmester GR, Rigby W, van Vollenhoven RF, Kay J, Rubbert-Roth A, Kelman A, et al. Tocilizumab in combination therapy and monotherapy versus methotrexate in methotrexate-naïve patients with early rheumatoid arthritis:clinical and radiographic outcomes from a randomized placebo-controlled trial. Arthritis Rheumatol 2013;65:(Suppl S1);182–3.
    • (2013) Arthritis Rheumatol , vol.65 , pp. 182-183
    • Burmester, G.R.1    Rigby, W.2    van Vollenhoven, R.F.3    Kay, J.4    Rubbert-Roth, A.5    Kelman, A.6


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