The effect of piceatannol from passion fruit (Passiflora edulis) seeds on metabolic health in humans

Nutrients

Volumn 9, Issue 10, 2017, Pages

  Kitada, Munehiro ^a   Ogura, Yoshio ^a   Maruki Uchida, Hiroko ^b   Sai, Masahiko ^b   Suzuki, Taeko ^a   Kanasaki, Keizo ^a   Hara, Yuna ^a   Seto, Hiromi ^a   Kuroshima, Yuka ^a   Monno, Itaru ^a   Koya, Daisuke ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b Morinaga and Company Limited   (Japan)

Author keywords

An analogue of resveratrol; Insulin sensitivity; Metabolic health; Piceatannol

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATININE; GAMMA CYCLODEXTRIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N(G),N(G) DIMETHYLARGININE; PASSION FRUIT EXTRACT; PICEATANNOL; PLACEBO; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID; 3,3',4,5'-TETRAHYDROXYSTILBENE; BIOLOGICAL MARKER; STILBENE DERIVATIVE;

ADULT; AGED; AGING; ARTICLE; BIOCHEMICAL ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ENDOTHELIUM CELL; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; FLOW-MEDIATED DILATION TEST; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN SENSITIVITY; MALE; METABOLIC DISORDER; OXIDATIVE STRESS; PASSION FRUIT; PROFILE OF MOOD STATES; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; WESTERN BLOTTING; BLOOD; BLOOD PRESSURE; CHEMISTRY; DRUG EFFECT; ENERGY METABOLISM; HEALTH STATUS; HEART RATE; INSULIN RESISTANCE; ISOLATION AND PURIFICATION; JAPAN; MEDICINAL PLANT; MICROCAPSULE; MIDDLE AGED; OBESITY; ORAL DRUG ADMINISTRATION; PASSIFLORA; PATHOPHYSIOLOGY; PHYTOTHERAPY; PLANT SEED; TIME FACTOR; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, ORAL; ADULT; AGED; BIOMARKERS; BLOOD PRESSURE; CAPSULES; DOUBLE-BLIND METHOD; ENERGY METABOLISM; FEMALE; HEALTH STATUS; HEART RATE; HUMANS; INSULIN RESISTANCE; JAPAN; MALE; MIDDLE AGED; OVERWEIGHT; PASSIFLORA; PHYTOTHERAPY; PLANTS, MEDICINAL; SEEDS; STILBENES; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85032880230     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9101142     Document Type: Article

References (39)

1. Matsuzawa, Y.; Funahashi, T.; Nakamura, T. The concept of metabolic syndrome: Contribution of visceral fat accumulation and its molecular mechanism. J. Atheroscler. Thromb. 2011, 18, 629–639.
2. Kirkland, J.L. Translating advances from the basic biology of aging into clinical application. Exp. Gerontol. 2013, 48, 1–5.
3. Tchkonia, T.; Morbeck, D.E.; Von Zglinicki, T.; Van Deursen, J.; Lustgarten, J.; Scrable, H.; Khosla, S.; Jensen, M.D.; Kirkland, J.L. Fat tissue, aging, and cellular senescence. Aging Cell 2010, 9, 667–684.
4. Garcia-Prieto, C.F.; Fernandez-Alfonso, M.S. Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders. Nutrients 2016, 8, doi:10.3390/nu8060370.
5. Larson-Meyer, D.E.; Heilbronn, L.K.; Redman, L.M.; Newcomer, B.R.; Frisard, M.I.; Anton, S.; Smith, S.R.; Alfonso, A.; Ravussin, E. Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006, 29, 1337–1344.
6. Baur, J.A.; Pearson, K.J.; Price, N.L.; Jamieson, H.A.; Lerin, C.; Kalra, A.; Prabhu, V.V.; Allard, J.S.; Lopez-Lluch, G.; Lewis, K.; et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444, 337–342.
7. Lagouge, M.; Argmann, C.; Gerhart-Hines, Z.; Meziane, H.; Lerin, C.; Daussin, F.; Messadeq, N.; Milne, J.; Lambert, P.; Elliott, P.; et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127, 1109–1122.
8. Pearson, K.J.; Baur, J.A.; Lewis, K.N.; Peshkin, L.; Price, N.L.; Labinskyy, N.; Swindell, W.R.; Kamara, D.; Minor, R.K.; Perez, E.; et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008, 8, 157–168.
9. Sun, C.; Zhang, F.; Ge, X.; Yan, T.; Chen, X.; Shi, X.; Zhai, Q. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab. 2007, 6, 307–319.
10. Szkudelski, T.; Szkudelska, K. Resveratrol and diabetes: From animal to human studies. Biochim. Biophys. Acta 2015, 1852, 1145–1154.
11. Timmers, S.; Konings, E.; Bilet, L.; Houtkooper, R.H.; van de Weijer, T.; Goossens, G.H.; Hoeks, J.; van der Krieken, S.; Ryu, D.; Kersten, S.; et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011, 14, 612– 622.
12. Kershaw, J.; Kim, K.H. The Therapeutic Potential of Piceatannol, a Natural Stilbene, in Metabolic Diseases: A Review. J. Med. Food 2017, 20, 427–438.
13. Rodríguez-Cabo, T.; Rodríguez, I.; López, P.; Ramil, M.; Cela, R. Investigation of liquid chromatography quadrupole time-of-flight mass spectrometry performance for identification and determination of hydroxylated stilbene antioxidants in wine. J. Chromatogr. A 2014, 1337, 162–170.
14. Matsui, Y.; Sugiyama, K.; Kamei, M.; Takahashi, T.; Suzuki, T.; Katagata, Y.; Ito, T. Extract of passion fruit (Passiflora edulis) seed containing high amounts of piceatannol inhibits melanogenesis and promotes collagen synthesis. J. Agric. Food Chem. 2010, 58, 11112–11118.
15. Kawakami, S.; Kinoshita, Y.; Maruki-Uchida, H.; Yanae, K.; Sai, M.; Ito, T. Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line. Nutrients 2014, 6, 4794– 4804.
16. Sano, S.; Sugiyama, K.; Ito, T.; Katano, Y.; Ishihata, A. Identification of the strong vasorelaxing substance scirpusin B, a dimer of piceatannol, from passion fruit (Passiflora edulis) seeds. J. Agric. Food Chem. 2011, 59, 6209–6213.
17. Kinoshita, Y.; Kawakami, S.; Yanae, K.; Sano, S.; Uchida, H.; Inagaki, H.; Ito, T. Effect of long-term piceatannol treatment on eNOS levels in cultured endothelial cells. Biochem. Biophys. Res. Commun. 2013, 430, 1164–1168.
18. Maruki-Uchida, H.; Kurita, I.; Sugiyama, K.; Sai, M.; Maeda, K.; Ito, T. The protective effects of piceatannol from passion fruit (Passiflora edulis) seeds in UVB-irradiated keratinocytes. Biol. Pharm. Bull. 2013, 36, 845– 849.
19. Matsuo, S.; Imai, E.; Horio, M.; Yasuda, Y.; Tomita, K.; Nitta, K.; Yamagata, K.; Tomino, Y.; Yokoyama, H.; Hishida, A.; et al. Revised equations for estimated GFR from serum creatinine in Japan. J. Natl. Kidney Found 2009, 53, 982–992.
20. Imatoh, T.; Kamimura, S.; Tanihara, S. Moderate oxidative stress and high antioxidative activity are associated with steatosis in Japanese males. Clin. Transl. Sci. 2013, 6, 45–49.
21. Corretti, M.C.; Anderson, T.J.; Benjamin, E.J.; Celermajer, D.; Charbonneau, F.; Creager, M.A.; Deanfield, J.; Drexler, H.; Gerhard-Herman, M.; Herrington, D.; et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force. J. Am. Coll. Cardiol. 2002, 39, 257–265.
22. Shigiyama, F.; Kumashiro, N.; Miyagi, M.; Ikehara, K.; Kanda, E.; Uchino, H.; Hirose, T. Effectiveness of dapagliflozin on vascular endothelial function and glycemic control in patients with early-stage type 2 diabetes mellitus: DEFENCE study. Cardiovasc. Diabetol. 2017, 16, 84.
23. Kitada, M.; Kume, S.; Takeda-Watanabe, A.; Tsuda, S.; Kanasaki, K.; Koya, D. Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. Biochim. Biophys. Acta 2013, 1830, 4820–4827.
24. Matsumoto, T.; Asakura, H.; Hayashi, T. Does lavender aromatherapy alleviate premenstrual emotional symptoms?: A randomized crossover trial. BioPsychoSoc. Med. 2013, 7, doi:10.1186/1751-0759-7-12.
25. Yokoyama, K. POMS Shortened Version; Kaneko Shobo, Tokyo, 2015. (In Japanese)
26. Price, D.D.; Bush, F.M.; Long, S.; Harkins, S.W. A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales. Pain 1994, 56, 217–226.
27. Uchida-Maruki, H.; Inagaki, H.; Ito, R.; Kurita, I.; Sai, M.; Ito, T. Piceatannol lowers the blood glucose level in diabetic mice. Biol. Pharm. Bull. 2015, 38, 629–633.
28. Minakawa, M.; Miura, Y.; Yagasaki, K. Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice. Biochem. Biophys. Res. Commun. 2012, 422, 469–475.
29. Zhang, A.J.; Rimando, A.M.; Mizuno, C.S.; Mathews, S.T. alpha-Glucosidase inhibitory effect of resveratrol and piceatannol. J. Nutr. Biochem. 2017, 47, 86–93.
30. Tang, Y.L.; Chan, S.W. A review of the pharmacological effects of piceatannol on cardiovascular diseases. Phytother. Res. 2014, 28, 1581–1588.
31. Yamamoto, T.; Li, Y.; Hanafusa, Y.; Yeh, Y.S.; Maruki-Uchida, H.; Kawakami, S.; Sai, M.; Goto, T.; Ito, T.; Kawada, T. Piceatannol exhibits anti-inflammatory effects on macrophages interacting with adipocytes. Food Sci. Nutr. 2017, 5, 76–85.
32. Gimbrone, M.A., Jr.; Garcia-Cardena, G. Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis. Circ. Res. 2016, 118, 620–636.
33. Frombaum, M.; Therond, P.; Djelidi, R.; Beaudeux, J.L.; Bonnefont-Rousselot, D.; Borderie, D. Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress. Free Radic. Res. 2011, 45, 293–302.
34. Nguyen, M.C.; Ryoo, S. Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice. Korean J. Physiol. Pharmacol. 2017, 21, 83–90.
35. Jeong, S.O.; Son, Y.; Lee, J.H.; Cheong, Y.K.; Park, S.H.; Chung, H.T.; Pae, H.O. Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells. Mol. Med. Rep. 2015, 12, 937–944.
36. Verberne, A.J.; Stornetta, R.L.; Guyenet, P.G. Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat. J. Physiol. 1999, 517 Pt 2, 477–494.
37. Ma, H.J.; Cao, Y.K.; Liu, Y.X.; Wang, R.; Wu, Y.M. Microinjection of resveratrol into rostral ventrolateral medulla decreases sympathetic vasomotor tone through nitric oxide and intracellular Ca2+ in anesthetized male rats. Acta Pharmacol. Sin. 2008, 29, 906–912.
38. Hijona, E.; Aguirre, L.; Pérez-Matute, P.; Villanueva-Millán, M.J.; Mosqueda-Solis, A.; Hasnaoui, M.; Nepveu, F.; Senard, J.M.; Bujanda, L.; Aldámiz-Echevarría, L.; et al. Limited beneficial effects of piceatannol supplementation on obesity complications in the obese Zucker rat: Gut microbiota, metabolic, endocrine, and cardiac aspects. J. Physiol. Biochem. 2016, 72, 567–582.
39. Tung, Y.C.; Lin, Y.H.; Chen, H.J.; Chou, S.C.; Cheng, A.C.; Kalyanam, N.; Ho, C.T.; Pan, M.H. Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota. Molecules 2016, 21, doi:10.3390/molecules21111419.