Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176—based on recent publications that measured specific-to-non-displaceable ratios

EJNMMI Research

Volumn 7, Issue , 2017, Pages

  Fujita, Masahiro ^a   Kobayashi, Masato ^a   Ikawa, Masamichi ^a   Gunn, Roger N ^b,c   Rabiner, Eugenii A ^b,d   Owen, David R ^c   Zoghbi, Sami S ^a   Haskali, Mohamad B ^a   Telu, Sanjay ^a   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b Imanova Ltd   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

BPND; Neuroinflammation; Radiometabolites; Single nucleotide polymorphism; Specific to non displaceable ratio

Indexed keywords

DPA 713; ER176; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PBR28; PROTEIN; TRANSLOCATOR PROTEIN; UNCLASSIFIED DRUG;

GENOTYPE; NOTE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN INTERACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 85032853734     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/s13550-017-0334-8     Document Type: Note

References (11)

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2. Owen DR, Gunn RN, Rabiner EA, Bennacef I, Fujita M, Kreisl WC, et al. Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med. 2011;52:24–32. doi:10.2967/jnumed.110.079459.
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10. 11C-(R)-PK11195. J Cereb Blood Flow Metab. In press
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