11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain

Journal of Nuclear Medicine

Volumn 58, Issue 2, 2017, Pages 320-325

  Ikawa, Masamichi ^a   Lohith, Talakad G ^a   Shrestha, Stal ^a   Telu, Sanjay ^a   Zoghbi, Sami S ^a   Castellano, Sabrina ^b   Taliani, Sabrina ^c   Da Settimo, Federico ^c   Fujita, Masahiro ^a   Pike, Victor W ^a   Innis, Robert B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF PISA   (Italy)

Author keywords

11C ER176; 18 kDa translocator protein (TSPO); Positron emission tomography; Rs6971 polymorphism; XBD173

Indexed keywords

ACETAMIDE DERIVATIVE; CARBON 11; CARBON N SEC BUTYL 4 (2 CHLOROPHENYL) N METHYLQUINAZOLINE 2 CARBOXAMIDE C 11; UNCLASSIFIED DRUG; [N BENZYL N ETHYL 2 (7 METHYL 8 OXO 2 PHENYLPURIN 9 YL)ACETAMIDE]; 4 AMINOBUTYRIC ACID RECEPTOR; CARBON; RADIOPHARMACEUTICAL AGENT; TSPO PROTEIN, HUMAN;

ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOSIMETRY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR STABILITY; NEUROIMAGING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOASSAY; RADIOCHEMISTRY; SENSITIVITY ANALYSIS; WHOLE BODY IMAGING; ADULT; BRAIN; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; FEMALE; MALE; METABOLISM; MOLECULAR IMAGING; OBSERVER VARIATION; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADULT; BRAIN; CARBON RADIOISOTOPES; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENOTYPE; HUMANS; MALE; MOLECULAR IMAGING; OBSERVER VARIATION; RADIOPHARMACEUTICALS; RECEPTORS, GABA; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 85012016369     PISSN: 01615505     EISSN: 2159662X     Source Type: Journal    
DOI: 10.2967/jnumed.116.178996     Document Type: Article

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