The effect of tranexamic acid to reduce blood loss and transfusion on off-pump coronary artery bypass surgery: A systematic review and cumulative meta-analysis

Journal of Clinical Anesthesia

Volumn 44, Issue , 2018, Pages 23-31

  Dai, Zhao ^a   Chu, Haichen ^a   Wang, Shiduan ^a   Liang, Yongxin ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Coronary artery bypass grafting (CABG); Fibrinolytic therapy; Off pump; Tranexamic acid

Indexed keywords

FRESH FROZEN PLASMA; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

BLOOD TRANSFUSION; DRUG EFFECT; HUMAN; META ANALYSIS; MORBIDITY; OFF PUMP CORONARY SURGERY; OUTCOME ASSESSMENT; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REOPERATION; REVIEW; SURGICAL MORTALITY; SYSTEMATIC REVIEW; THROMBOSIS; CHEMICALLY INDUCED; OPERATIVE BLOOD LOSS; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

ANTIFIBRINOLYTIC AGENTS; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; CORONARY ARTERY BYPASS, OFF-PUMP; HUMANS; POSTOPERATIVE HEMORRHAGE; THROMBOSIS; TRANEXAMIC ACID; TREATMENT OUTCOME;

EID: 85032831726     PISSN: 09528180     EISSN: 18734529     Source Type: Journal    
DOI: 10.1016/j.jclinane.2017.10.004     Document Type: Review

References (31)

1. Ozal, E., Kuralay, E., Bingöl, H., et al. Does tranexamic acid reduce desmopressin-induced hyperfibrinolysis?. J Thorac Cardiovasc Surg 123 (2002), 539–543.
2. Reeves, B.C., Murphy, G.J., Increased mortality, morbidity, and cost associated with red blood cell transfusion after cardiac surgery. Curr Opin Cardiol 23 (2008), 607–612.
3. Pinosky, M.L., Kennedy, D.J., Fishman, R.L., et al. Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo. J Card Surg 12 (1997), 330–338.
4. Murphy, G.J., Mango, E., Lucchetti, V., et al. A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting. J Thorac Cardiovasc Surg 132 (2006), 475–480.
5. Adler Ma, S.C., Brindle, W., Burton, G., et al. Tranexamic acid is associated with less blood transfusion in off-pump coronary artery bypass graft surgery: a systematic review and meta-analysis.[J]. J Cardiothorac Vasc Anesth 25 (2011), 26–35.
6. Lytle, B.W., On-pump and off-pump coronary bypass surgery. Circulation 116 (2007), 1108–1109.
7. Halkos, M.E., Puskas, J.D., Off-pump versus on-pump coronary artery bypass grafting. Surg Clin North Am 89 (2009), 913–922.
8. Casati, V., Gerli, C., Franco, A., et al. Activation of coagulation and fibrinolysis during coronary surgery: on-pump versus off-pump techniques. Anesthesiology 95 (2001), 1103–1109.
9. Myles, P.S., Smith, J.A., Forbes, A., et al. Tranexamic acid in patients undergoing coronary-artery surgery. N Engl J Med, 376, 2017, 136.
10. Mehr-Aein, A., Sadeghi, M., Madani-Civi, M., Does tranexamic acid reduce blood loss in off-pump coronary artery bypass?. Asian Cardiovasc Thorac Ann 15 (2007), 285–289.
11. Casati, V., Gerli, C., Franco, A., et al. Tranexamic acid in off-pump coronary surgery: a preliminary, randomized, double-blind, placebo-controlled study. Ann Thorac Surg 72 (2001), 470–475.
12. Vanek, T., Jares, M., Fajt, R., et al. Fibrinolytic inhibitors in off-pump coronary surgery: a prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo). Eur J Cardiothorac Surg 28:4 (2005), 563–568.
13. Taghaddomi, R.J., Mirzaee, A., Attar, A.S., et al. Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery. J Cardiothorac Vasc Anesth, 23, 2009, 312.
14. Casati, V., Della, V.P., Benussi, S., et al. Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: comparison between on-pump and off-pump techniques.[J]. J Thorac Cardiovasc Surg, 128, 2004, 83.
15. Chakravarthy, M., Muniraj, G., Patil, S., et al. A randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130/0.4) undergoing off pump coronary artery bypass surgery. Ann Card Anaesth, 15, 2012, 105.
16. Jares, M., Vanek, T., Straka, Z., et al. Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting. J Card Surg, 44, 2003, 205.
17. Aoki, M., Okawa, Y., Goto, Y., et al. Local administration of tranexamic acid in off-pump coronary artery bypass. Asian Cardiovasc Thorac Ann 20 (2012), 658–662.
18. Aoki, M., Goto, Y., Ogawa, S., et al. Can local administration of tranexamic acid reduce aspirin-induced bleeding in off-pump coronary artery bypass grafting (CABG). Kyobu Geka 66 (2013), 1119–1125.
19. Ahn, S.W., Shim, J.K., Youn, Y.N., et al. Effect of tranexamic acid on transfusion requirement in dual antiplatelet-treated anemic patients undergoing off-pump coronary artery bypass graft surgery. Circ J 76 (2012), 96–101.
20. Hosseini, H., Rahimianfar, A.A., Abdollahi, M.H., et al. Evaluations of topical application of tranexamic acid on post-operative blood loss in off-pump coronary artery bypass surgery. Saudi J Anaesth, 8, 2014, 224.
21. Wang, G., Xie, G., Jiang, T., et al. Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study. Anesth Anal 115 (2012), 239–243.
22. Wei, M., Jian, K., Guo, Z., et al. Tranexamic acid reduces postoperative bleeding in off-pump coronary artery bypass grafting. Scand Cardiovasc J 40 (2006), 105–109.
23. Higgins, J.P.T., Thompson, S.G., Quantifying heterogeneity in a meta-analysis[J]. Stat Med, 21, 2002, 1539.
24. Henry, Carless D.A., Moxey, P.A., et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. 2011.
25. Al-Ruzzeh, S., Ambler, G., Asimakopoulos, G., Off-pump coronary artery bypass (OPCAB) surgery reduces risk-stratified morbidity and mortality: a United Kingdom multicenter comparative analysis of early clinical outcome[J]. Circulation 13 (2004), II1–8.
26. Laupacis, A., Fergusson, D., Drugs to minimize perioperative blood loss in cardiac surgery: meta-analyses using perioperative blood transfusion as the outcome. The International Study of Peri-operative Transfusion (ISPOT) Investigators. Anesth Anal, 85, 1997, 1258.
27. Greiff, G., Stenseth, R., Wahba, A., et al. Tranexamic acid reduces blood transfusions in elderly patients undergoing combined aortic valve and coronary artery bypass graft surgery: a randomized controlled trial.[J]. J Cardiothorac Vasc Anesth 26 (2011), 232–238.
28. Shi, J., Wang, G., Lv, H., et al. Tranexamic acid in on-pump coronary artery bypass grafting without clopidogrel and aspirin cessation: randomized trial and 1-year follow-up. Ann Thorac Surg, 95, 2013, 795.
29. Ker, K., Edwards, P., Perel, P., et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ, 344, 2012, e3054.
30. Schulz, K.F., Grimes, D.A., Sample size calculations in randomised trials: mandatory and mystical. Lancet, 365, 2005, 1348.
31. Murkin, J.M., Falter, F., Granton, J., et al. High-dose tranexamic acid is associated with nonischemic clinical seizures in cardiac surgical patients. Anesth Anal, 110, 2010, 350.