A randomized prospective analysis of alteration of hemostatic function in patients receiving tranexamic acid and hydroxyethyl starch (130/0.4) undergoing off pump coronary artery bypass surgery

Annals of Cardiac Anaesthesia

Volumn 15, Issue 2, 2012, Pages 105-110

  Chakravarthy, Murali ^a   Muniraj, Geetha ^a   Patil, Swapnil ^a   Suryaprakash, Sharadaprasad ^a   Mitra, Sona ^a   Shivalingappa, Benak ^a  

^a Fortis Hospitals   (India)

Author keywords

Hydroxyl ethyl starch; off pump coronary bypass; thromboelastogram; tranexamic acid

Indexed keywords

HETASTARCH; RINGER LACTATE SOLUTION; TRANEXAMIC ACID; TROPONIN T;

ADULT; AGED; ARTICLE; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ELECTROCARDIOGRAM; FEMALE; FLUID THERAPY; HEART INFARCTION; HEMODILUTION; HEMOSTASIS; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; OFF PUMP CORONARY SURGERY; PERIOPERATIVE PERIOD; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; SURGICAL TECHNIQUE; THROMBOELASTOGRAPHY;

ADULT; AGED; ANALYSIS OF VARIANCE; ANTIFIBRINOLYTIC AGENTS; BLOOD COAGULATION; BLOOD LOSS, SURGICAL; CORONARY ARTERY BYPASS, OFF-PUMP; DRUG COMBINATIONS; FEMALE; HEMODILUTION; HEMOSTASIS; HETASTARCH; HUMANS; INTRAOPERATIVE COMPLICATIONS; LENGTH OF STAY; MALE; MIDDLE AGED; PLASMA SUBSTITUTES; PROSPECTIVE STUDIES; THROMBELASTOGRAPHY; THROMBOSIS; TRANEXAMIC ACID;

EID: 84860472267     PISSN: 09719784     EISSN: 09745181     Source Type: Journal    
DOI: 10.4103/0971-9784.95072     Document Type: Article

References (20)

1. Mehr-Aein A, Sadeghi M, Madani-civi M. Does tranexamic acid reduce blood loss in off-pump coronary artery bypass? Asian Cardiovasc Thorac Ann 2007;15:285-9 (Pubitemid 47377176)
2. Ascione R, Williams S, Lloyd CT, Sundaramoorthi T, Pitsis AA, Angelini GD. Reduced postoperative blood loss and transfusion requirement after beating-heart coronary operations: a prospective randomized study. J Thorac Cardiovasc Surg 2001;121:689-96.
3. Jares M, Vanek T, Bednar F, Maly M, Snircova J, Straka Z. Offpump versus on pump coronary artery surgery. identification of fibrinolysis using rotation thromboelastography; A Preliminary, prospective, randomized study. Int Heart J 2007;48:57-67. (Pubitemid 46522733)
4. Chassot PG, van der Linden P, Zaugg M, Mueller XM, Spahn DR. Offpump coronary artery bypass surgery: physiology and anesthetic management. Br J Anaesth 2004,92:400-13. (Pubitemid 38263511)
5. Kim JY, Lee JW, Kweon TD, Kwak YL, Kim JH, Bang SO. The effect of 6% HES 130/0.4 on hemostasis and hemodynamic efficacy in offpump coronary artery bypass surgery: a comparison with 6% HES 200/0.5 Korean J Anesthesiol 2007;53:S14-21.
6. Kasper SM, Meinert P, Kampe S, Görg C, Geisen C, Mehlhorn U, et al. Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses. Anesthesiology 2003;99:42-7. (Pubitemid 36799031)
7. Casati V, Della Valle P, Benussi S, Franco A, Gerli C, Baili P, et al. Effects of tranexamic acid on postoperative bleeding and related hematochemical variables in coronary surgery: Comparison between on-pump and offpump techniques. J Thorac Cardiovasc Surg 2004;128:83-91. (Pubitemid 38881200)
8. Vanek T, Jares M, Fajt R, Straka Z, Jirasek K, Kolesar M, et al. Fibrinolytic inhibitors in off-pump coronary surgery: a prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo). Eur J Cardiothorac Surg 2005;28:563-8. (Pubitemid 41345245)
9. Thai J, Reynolds EJ, Natalia N, Cornelissen C, Lemmens HJ, Hill CC, et al. Comparison between RapidTEG® and conventional thromboelastography in cardiac surgery patients. Br J Anaesth 2011;106:605-6.
10. Türkan H, Ural AU, Beyan C, Yalçin A. Effects of hydroxyethyl starch on blood coagulation profile. Eur J Anaesthesiol 1999;16:156-9.
11. Brown JR, Birkmeyer NJ, O'Connor GT. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation 2007;115:2801-13. (Pubitemid 46876483)
12. Schramko A, Suojaranta-Ylinen R, Kuitunen A, Raivio P, Kukkonen S, Niemi T. Hydroxyethylstarch and gelatin solutions impair blood coagulation after cardiac surgery: a prospective randomized trial. Br J Anaesth 2010;104:691-7.
13. Boldt J, Haisch G, Suttner S, Kumle B, Schellhaass A. Effects of a new modified, balanced hydroxyethyl starch preparation (Hextend) on measures of coagulation. Br J Anaesth 2002;89:722-8. (Pubitemid 35277221)
14. Ekseth K, Abildgaard L, Vegfors M, Berg-Johnsen J, Engdahl O. The in vitro effects of crystalloids and colloids on coagulation. Anaesthesia 2002;57:1102-8. (Pubitemid 35282559)
15. Engström M, Reinstrup P, Schött U. An in vitro evaluation of standard rotational thromboelastography in monitoring of effects of recombinant factor VIIa on coagulopathy induced by hydroxy ethyl starch. BMC Blood Disord 2005;5:3.
16. Schols SE, Lancé MD, Feijge MA, Damoiseaux J, Marcus MA, Hamulyák K, et al. Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery. Thromb Haemost 2010;103:318-28.
17. Mahdy AM, Webster NR. Perioperative systemic haemostatic agents. Br J Anaesth 2004;93:842-58. (Pubitemid 39585616)
18. Well PS. Safety and efficacy of methods for reducing perioperative allogeneic transfusion: a critical review of the literature. Am J Ther 2002;9:377-88.
19. Kasper SM, Meinert P, Kampe S, Görg C, Geisen C, Mehlhorn U, et al. Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses. Anesthesiology 2003;99:42-7. (Pubitemid 36799031)
20. Tempe DK, Hasija S. Are tranexamic acid and ?-aminocaproic acid adequate substitutes for aprotinin? Ann Card Anaesth 2012;15:4-5.