Tranexamic acid reduces blood transfusions in elderly patients undergoing combined aortic valve and coronary artery bypass graft surgery: A randomized controlled trial

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 26, Issue 2, 2012, Pages 232-238

  Greiff, Guri ^a,b   Stenseth, Roar ^a,b   Wahba, Alexander ^a,b   Videm, Vibeke ^a,b   Lydersen, Stian ^b   Irgens, Wenche ^a   Bjella, Lise ^a   Pleym, Hilde ^a,b  

^a TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

cardiac surgery; fibrinolysis; hemorrhage; tranexamic acid; transfusion

Indexed keywords

PLACEBO; TRANEXAMIC ACID;

AORTA VALVE REPLACEMENT; ARTICLE; BLOOD TRANSFUSION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOUBLE BLIND PROCEDURE; FEMALE; HEMOSTASIS; HOSPITALIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNIVERSITY HOSPITAL;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; AORTIC VALVE; BLOOD TRANSFUSION; CORONARY ARTERY BYPASS; DOUBLE-BLIND METHOD; FEMALE; HEART VALVE PROSTHESIS IMPLANTATION; HUMANS; MALE; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; TRANEXAMIC ACID;

EID: 84858155780     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2011.07.010     Document Type: Article

References (36)

1. D. Paparella, S.J. Brister, M.R. Buchanan Coagulation disorders of cardiopulmonary bypass: A review Intensive Care Med 30 2004 1873 1881 (Pubitemid 39468407)
2. L.J. Dacey, J.J. Munoz, Y.R. Baribeau Reexploration for hemorrhage following coronary artery bypass grafting: Incidence and risk factors Northern New England Cardiovascular Disease Study Group Arch Surg 133 1998 442 447 (Pubitemid 28193531)
3. M.J. Unsworth-White, A. Herriot, O. Valencia Resternotomy for bleeding after cardiac operation: A marker for increased morbidity and mortality Ann Thorac Surg 59 1995 664 667
4. M. Sellman, M.A. Intonti, T. Ivert Reoperations for bleeding after coronary artery bypass procedures during 25 years Eur J Cardiothorac Surg 11 1997 521 527 (Pubitemid 27146164)
5. M.J. Moulton, L.L. Creswell, M.E. Mackey Reexploration for bleeding is a risk factor for adverse outcomes after cardiac operations J Thorac Cardiovasc Surg 111 1996 1037 1046 (Pubitemid 26146058)
6. M. Kuduvalli, A.Y. Oo, N. Newall Effect of peri-operative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery Eur J Cardiothorac Surg 27 2005 592 598 (Pubitemid 40409729)
7. G.J. Murphy, B.C. Reeves, C.A. Rogers Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery Circulation 116 2007 2544 2552 (Pubitemid 350179219)
8. D.S. Holloway, L. Summaria, J. Sandesara Decreased platelet number and function and increased fibrinolysis contribute to postoperative bleeding in cardiopulmonary bypass patients Thromb Haemost 59 1988 62 67 (Pubitemid 18053651)
9. O. Kucuk, H.C. Kwaan, J. Frederickson Increased fibrinolytic activity in patients undergoing cardiopulmonary bypass operation Am J Hematol 23 1986 223 229 (Pubitemid 17201653)
10. H. Pleym, A. Wahba, V. Videm Increased fibrinolysis and platelet activation in elderly patients undergoing coronary bypass surgery Anesth Analg 102 2006 660 667
11. J.C. Horrow, J. Hlavacek, M.D. Strong Prophylactic tranexamic acid decreases bleeding after cardiac operations J Thorac Cardiovasc Surg 99 1990 70 74 (Pubitemid 20041516)
12. P.D. Mongan, R.S. Brown, B.K. Thwaites Tranexamic acid and aprotinin reduce postoperative bleeding and transfusions during primary coronary revascularization Anesth Analg 87 1998 258 265 (Pubitemid 28369074)
13. M.L. Pinosky, D.J. Kennedy, R.L. Fishman Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo J Cardiovasc Surg 12 1997 330 338 (Pubitemid 28292762)
14. R.S. Brown, B.K. Thwaites, P.D. Mongan Tranexamic acid is effective in decreasing postoperative bleeding and transfusions in primary coronary artery bypass operations: A double-blind, randomized, placebo-controlled trial Anesth Analg 85 1997 963 970 (Pubitemid 27471507)
15. R.J. Taghaddomi, A. Mirzaee, A.S. Attar Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery J Cardiothorac Vasc Anesth 23 2009 312 315
16. D.A. Fergusson, P.C. Hbert, C.D. Mazer A comparison of aprotinin and lysine analogues in high-risk cardiac surgery N Engl J Med 358 2008 2319 2331 (Pubitemid 351749156)
17. D.A. Henry, P.A. Carless, A.J. Moxey Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion Cochrane Database Syst Rev 2011 CD:001886
18. J.C. Horrow, D.F. Van Riper, M.D. Strong The dose-response relationship of tranexamic acid Anesthesiology 82 1995 383 392
19. D. Moher, S. Hopewell, K.F. Schulz CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials BMJ 340 2010 c869
20. C.G. Koch, L. Li, A.I. Duncan Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting Crit Care Med 34 2006 1608 1616 (Pubitemid 43810038)
21. J.M. Karski, S.J. Teasdale, P. Norman Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid Double-blind, randomized clinical trial J Thorac Cardiovasc Surg 110 1995 835 842
22. L. Shore-Lesserson, D.L. Reich, F. Vela-Cantos Tranexamic acid reduces transfusions and mediastinal drainage in repeat cardiac surgery Anesth Analg 83 1996 18 26 (Pubitemid 26225369)
23. D. Zabeeda, B. Medalion, M. Sverdlov Tranexamic acid reduces bleeding and the need for blood transfusion in primary myocardial revascularization Ann Thorac Surg 74 2002 733 738 (Pubitemid 35001800)
24. J.M. Karski, N.P. Dowd, R. Joiner The effect of three different doses of tranexamic acid on blood loss after cardiac surgery with mild systemic hypothermia (32 degrees C) J Cardiothorac Vasc Anesth 12 1998 642 646 (Pubitemid 29001680)
25. A. Laupacis, D. Fergusson Drugs to minimize perioperative blood loss in cardiac surgery: Meta-analyses using perioperative blood transfusion as the outcome The International Study of Peri-operative Transfusion (ISPOT) Investigators Anesth Analg 85 1997 1258 1267 (Pubitemid 28130521)
26. M. Levi, M.E. Cromheecke, E. de Jonge Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints Lancet 354 1999 1940 1947
27. M.A. Ruel, F. Wang, M.E. Bourke Is tranexamic acid safe in patients undergoing coronary endarterectomy? Ann Thorac Surg 71 2001 1508 1511
28. E. Ovrum, E. Am Holen, M. Abdelnoor Tranexamic acid (Cyklokapron) is not necessary to reduce blood loss after coronary artery bypass operations J Thorac Cardiovasc Surg 105 1993 78 83 (Pubitemid 23033763)
29. D. Henry, P. Carless, D. Fergusson The safety of aprotinin and lysine-derived antifibrinolytic drugs in cardiac surgery: A meta-analysis CMAJ 180 2009 183 193
30. C. Keyl, R. Uhl, F. Beyersdorf High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement Eur J Cardiothorac Surg 39 2011 e114 e121
31. K. Martin, J. Knorr, T. Breuer Seizures after open heart surgery: Comparison of epsilon-aminocaproic acid and tranexamic acid J Cardiothorac Vasc Anesth 25 2011 20 25
32. M. Sander, C.D. Spies, V. Martiny Mortality associated with administration of high-dose tranexamic acid and aprotinin in primary open-heart procedures: A retrospective analysis Crit Care 14 2010 R148
33. J.J. Jimenez, J.L. Iribarren, L. Lorente Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial Crit Care 11 2007 R117
34. T. Kojima, S. Gando, Y. Morimoto Systematic elucidation of effects of tranexamic acid on fibrinolysis and bleeding during and after cardiopulmonary bypass surgery Thromb Res 104 2001 301 307 (Pubitemid 33152950)
35. A. Laupacis, D. Fergusson Drugs to minimize perioperative blood loss in cardiac surgery: Meta-analyses using perioperative blood transfusion as the outcome The International Study of Peri-operative Transfusion (ISPOT) Investigators Anesth Analg 85 1997 1258 1267 (Pubitemid 28130521)
36. D.W. Kaufman, S. Shapiro Epidemiological assessment of drug-induced disease Lancet 356 2000 1339 1343