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Volumn 37, Issue , 2017, Pages 80-86

Modulating bile acid pathways and TGR5 receptors for treating liver and GI diseases

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BILE ACID; CHENODEOXYCHOLIC ACID; COLESEVELAM; COLESTYRAMINE; DIGESTIVE TRACT AGENT; FARNESOID X RECEPTOR; FEXARAMINE; G PROTEIN COUPLED BILE ACID RECEPTOR 1; GSK 2330672; HYDROXYPROPYLCELLULOSE; MARALIXIBAT; NGM 282; OBETICHOLIC ACID; PROTEIN INHIBITOR; RECEPTOR; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; G PROTEIN COUPLED RECEPTOR; GPBAR1 PROTEIN, HUMAN;

EID: 85032676174     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2017.09.008     Document Type: Review
Times cited : (38)

References (44)
  • 1
    • 84904358423 scopus 로고    scopus 로고
    • Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract
    • Bunnett, N.W., Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract. J Physiol 592 (2014), 2943–2950.
    • (2014) J Physiol , vol.592 , pp. 2943-2950
    • Bunnett, N.W.1
  • 2
    • 0015866738 scopus 로고
    • Relationships between ion and water movement in the human jejunum, ileum and colon during perfusion with bile acids
    • Wingate, D.L., Krag, E., Mekhjian, H.S., Phillips, S.F., Relationships between ion and water movement in the human jejunum, ileum and colon during perfusion with bile acids. Clin Sci Mol Med 45 (1973), 593–606.
    • (1973) Clin Sci Mol Med , vol.45 , pp. 593-606
    • Wingate, D.L.1    Krag, E.2    Mekhjian, H.S.3    Phillips, S.F.4
  • 3
    • 0016743726 scopus 로고
    • Bile acids and colonic motility in the rabbit and the human
    • Kirwan, W.O., Smith, A.N., Mitchell, W.D., et al. Bile acids and colonic motility in the rabbit and the human. Gut 16 (1975), 894–902.
    • (1975) Gut , vol.16 , pp. 894-902
    • Kirwan, W.O.1    Smith, A.N.2    Mitchell, W.D.3
  • 4
    • 0036083695 scopus 로고    scopus 로고
    • The proximal colonic motor response to rectal mechanical and chemical stimulation
    • Bampton, P.A., Dinning, P.G., Kennedy, M.L., et al. The proximal colonic motor response to rectal mechanical and chemical stimulation. Am J Physiol Gastrointest Liver Physiol 282 (2002), G443–G449.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282 , pp. G443-G449
    • Bampton, P.A.1    Dinning, P.G.2    Kennedy, M.L.3
  • 5
    • 84946071276 scopus 로고    scopus 로고
    • Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G protein-coupled bile acid receptors
    • Brighton, C.A., Rievaj, J., Kuhre, R.E., et al. Bile acids trigger GLP-1 release predominantly by accessing basolaterally located G protein-coupled bile acid receptors. Endocrinology 156 (2015), 3961–3970.
    • (2015) Endocrinology , vol.156 , pp. 3961-3970
    • Brighton, C.A.1    Rievaj, J.2    Kuhre, R.E.3
  • 7
    • 0018694645 scopus 로고
    • Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability, and morphology in the perfused rabbit colon
    • Chadwick, V.S., Gaginella, T.S., Carlson, G.L., Debongnie, J.C., Phillips, S.F., Hofmann, A.F., Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability, and morphology in the perfused rabbit colon. J Lab Clin Med 94 (1979), 661–674.
    • (1979) J Lab Clin Med , vol.94 , pp. 661-674
    • Chadwick, V.S.1    Gaginella, T.S.2    Carlson, G.L.3    Debongnie, J.C.4    Phillips, S.F.5    Hofmann, A.F.6
  • 10
    • 84881621285 scopus 로고    scopus 로고
    • − secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells
    • − secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol 305 (2013), C447–C456.
    • (2013) Am J Physiol Cell Physiol , vol.305 , pp. C447-C456
    • Ao, M.1    Sarathy, J.2    Domingue, J.3    Alrefai, W.A.4    Rao, M.C.5
  • 11
    • 0032982972 scopus 로고    scopus 로고
    • Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin
    • Peregrin, A.T., Ahlman, H., Jodal, M., Lundgren, O., Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br J Pharmacol 127 (1999), 887–894.
    • (1999) Br J Pharmacol , vol.127 , pp. 887-894
    • Peregrin, A.T.1    Ahlman, H.2    Jodal, M.3    Lundgren, O.4
  • 13
    • 84871304988 scopus 로고    scopus 로고
    • The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
    • Alemi, F., Poole, D.P., Chiu, J., Schoonjans, K., Cattaruzza, F., Grider, J.R., Bunnett, N.W., Corvera, C.U., The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144 (2013), 145–154.
    • (2013) Gastroenterology , vol.144 , pp. 145-154
    • Alemi, F.1    Poole, D.P.2    Chiu, J.3    Schoonjans, K.4    Cattaruzza, F.5    Grider, J.R.6    Bunnett, N.W.7    Corvera, C.U.8
  • 14
    • 85030753711 scopus 로고    scopus 로고
    • Bile acid deficiency in subgroup of irritable bowel syndrome with constipation based on serum and fecal biomarkers
    • pii: S1542-3565(17)30786-3 [Epub ahead of print]
    • Vijayvargiya, P., Busciglio, I., Burton, D., Donato, L., Lueke, A., Camilleri, M., Bile acid deficiency in subgroup of irritable bowel syndrome with constipation based on serum and fecal biomarkers. Clin Gastroenterol Hepatol, 2017, 10.1016/j.cgh.2017.06.039 pii: S1542-3565(17)30786-3 [Epub ahead of print].
    • (2017) Clin Gastroenterol Hepatol
    • Vijayvargiya, P.1    Busciglio, I.2    Burton, D.3    Donato, L.4    Lueke, A.5    Camilleri, M.6
  • 16
    • 82955195427 scopus 로고    scopus 로고
    • Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation
    • Wong, B.S., Camilleri, M., McKinzie, S., Burton, D., Graffner, H., Zinsmeister, A.R., Effects of A3309, an ileal bile acid transporter inhibitor, on colonic transit and symptoms in females with functional constipation. Am J Gastroenterol 106 (2011), 2154–2164.
    • (2011) Am J Gastroenterol , vol.106 , pp. 2154-2164
    • Wong, B.S.1    Camilleri, M.2    McKinzie, S.3    Burton, D.4    Graffner, H.5    Zinsmeister, A.R.6
  • 17
    • 80053912847 scopus 로고    scopus 로고
    • A randomized placebo-controlled phase IIb trial of A3309, a bile acid transporter inhibitor, for chronic idiopathic constipation
    • Chey, W.D., Camilleri, M., Chang, L., Rikner, L., Graffner, H., A randomized placebo-controlled phase IIb trial of A3309, a bile acid transporter inhibitor, for chronic idiopathic constipation. Am J Gastroenterol 106 (2011), 1803–1812.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1803-1812
    • Chey, W.D.1    Camilleri, M.2    Chang, L.3    Rikner, L.4    Graffner, H.5
  • 18
    • 85028296481 scopus 로고    scopus 로고
    • Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation: a phase II, multicenter, double-blind, placebo-controlled randomized clinical trial
    • [Epub ahead of print]
    • Nakajima, A., Seki, M., Taniguchi, S., Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation: a phase II, multicenter, double-blind, placebo-controlled randomized clinical trial. J Gastroenterol, 2017, 10.1007/s00535-017-1383-5 [Epub ahead of print].
    • (2017) J Gastroenterol
    • Nakajima, A.1    Seki, M.2    Taniguchi, S.3
  • 19
    • 85032689019 scopus 로고    scopus 로고
    • NGM282, variant of FGF19, is a gastric and colonic prokinetic and stimulates bowel function in patients with functional constipation: phase 1B, two-dose, placebo-controlled study
    • Oduyebo, I., Nelson, A.D., Khemani, D., et al. NGM282, variant of FGF19, is a gastric and colonic prokinetic and stimulates bowel function in patients with functional constipation: phase 1B, two-dose, placebo-controlled study. Gastroenterology, 152, 2017, S1315.
    • (2017) Gastroenterology , vol.152 , pp. S1315
    • Oduyebo, I.1    Nelson, A.D.2    Khemani, D.3
  • 20
    • 84941670697 scopus 로고    scopus 로고
    • Biomarkers for bile acid diarrhea in functional bowel disorder with diarrhea: a systematic review and meta-analysis
    • Valentin, N., Camilleri, M., Altayar, O., Vijayvargiya, P., Acosta, A., Nelson, A.D., Murad, M.H., Biomarkers for bile acid diarrhea in functional bowel disorder with diarrhea: a systematic review and meta-analysis. Gut 65 (2016), 1951–1959.
    • (2016) Gut , vol.65 , pp. 1951-1959
    • Valentin, N.1    Camilleri, M.2    Altayar, O.3    Vijayvargiya, P.4    Acosta, A.5    Nelson, A.D.6    Murad, M.H.7
  • 21
    • 84929130043 scopus 로고    scopus 로고
    • Randomised clinical trial: cholestyramine vs. hydroxypropyl cellulose in patients with functional chronic watery diarrhoea
    • Fernández-Bañares, F., Rosinach, M., Piqueras, M., et al. Randomised clinical trial: cholestyramine vs. hydroxypropyl cellulose in patients with functional chronic watery diarrhoea. Aliment Pharmacol Ther 41 (2015), 1132–1140.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 1132-1140
    • Fernández-Bañares, F.1    Rosinach, M.2    Piqueras, M.3
  • 22
    • 84898601884 scopus 로고    scopus 로고
    • Systematic review: the management of chronic diarrhoea due to bile acid malabsorption
    • Wilcox, C., Turner, J., Green, J., Systematic review: the management of chronic diarrhoea due to bile acid malabsorption. Aliment Pharmacol Ther 39 (2014), 923–939.
    • (2014) Aliment Pharmacol Ther , vol.39 , pp. 923-939
    • Wilcox, C.1    Turner, J.2    Green, J.3
  • 23
    • 84919714351 scopus 로고    scopus 로고
    • Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS
    • Bajor, A., Törnblom, H., Rudling, M., et al. Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS. Gut 64 (2015), 84–92.
    • (2015) Gut , vol.64 , pp. 84-92
    • Bajor, A.1    Törnblom, H.2    Rudling, M.3
  • 24
    • 84921842684 scopus 로고    scopus 로고
    • Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome
    • Camilleri, M., Acosta, A., Busciglio, I., et al. Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther 41 (2015), 438–448.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 438-448
    • Camilleri, M.1    Acosta, A.2    Busciglio, I.3
  • 25
    • 75349109261 scopus 로고    scopus 로고
    • Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function
    • Odunsi-Shiyanbade, S.T., Camilleri, M., McKinzie, S., et al. Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function. Clin Gastroenterol Hepatol 8 (2010), 159–165.
    • (2010) Clin Gastroenterol Hepatol , vol.8 , pp. 159-165
    • Odunsi-Shiyanbade, S.T.1    Camilleri, M.2    McKinzie, S.3
  • 26
    • 84952628204 scopus 로고    scopus 로고
    • Long-term outcomes in patients diagnosed with bile-acid diarrhoea
    • Lin, S., Sanders, D.S., Gleeson, J.T., et al. Long-term outcomes in patients diagnosed with bile-acid diarrhoea. Eur J Gastroenterol Hepatol 28 (2016), 240–245.
    • (2016) Eur J Gastroenterol Hepatol , vol.28 , pp. 240-245
    • Lin, S.1    Sanders, D.S.2    Gleeson, J.T.3
  • 27
    • 84915747794 scopus 로고    scopus 로고
    • The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid
    • Walters, J.R., Johnston, I.M., Nolan, J.D., et al. The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid. Aliment Pharmacol Ther 41 (2015), 54–64.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 54-64
    • Walters, J.R.1    Johnston, I.M.2    Nolan, J.D.3
  • 28
    • 84958576368 scopus 로고    scopus 로고
    • Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control Clostridium difficile germination and growth
    • Weingarden, A.R., Dosa, P.I., DeWinter, E., et al. Changes in colonic bile acid composition following fecal microbiota transplantation are sufficient to control Clostridium difficile germination and growth. PLOS ONE, 11, 2016, e0147210.
    • (2016) PLOS ONE , vol.11 , pp. e0147210
    • Weingarden, A.R.1    Dosa, P.I.2    DeWinter, E.3
  • 29
    • 84944754899 scopus 로고    scopus 로고
    • Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pouchitis associated with the infection
    • Weingarden, A.R., Chen, C., Zhang, N., et al. Ursodeoxycholic acid inhibits Clostridium difficile spore germination and vegetative growth, and prevents the recurrence of ileal pouchitis associated with the infection. J Clin Gastroenterol 50 (2016), 624–630.
    • (2016) J Clin Gastroenterol , vol.50 , pp. 624-630
    • Weingarden, A.R.1    Chen, C.2    Zhang, N.3
  • 30
    • 85007575443 scopus 로고    scopus 로고
    • Complete microbiota engraftment is not essential for recovery from recurrent Clostridium difficile infection following fecal microbiota transplantation
    • pii: e01965-16
    • Staley, C., Kelly, C.R., Brandt, L.J., et al. Complete microbiota engraftment is not essential for recovery from recurrent Clostridium difficile infection following fecal microbiota transplantation. MBio, 2016, 7 pii: e01965-16.
    • (2016) MBio , pp. 7
    • Staley, C.1    Kelly, C.R.2    Brandt, L.J.3
  • 31
    • 85018624661 scopus 로고    scopus 로고
    • Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease
    • e3
    • Chávez-Talavera, O., Tailleux, A., Lefebvre, P., et al. Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Gastroenterology 152 (2017), 1679–1694 e3.
    • (2017) Gastroenterology , vol.152 , pp. 1679-1694
    • Chávez-Talavera, O.1    Tailleux, A.2    Lefebvre, P.3
  • 32
    • 84982102773 scopus 로고    scopus 로고
    • A placebo-controlled trial of obeticholic acid in primary biliary dholangitis
    • Nevens, F., Andreone, P., Mazzella, G., et al. A placebo-controlled trial of obeticholic acid in primary biliary dholangitis. N Engl J Med 375 (2016), 631–643.
    • (2016) N Engl J Med , vol.375 , pp. 631-643
    • Nevens, F.1    Andreone, P.2    Mazzella, G.3
  • 33
    • 62949221007 scopus 로고    scopus 로고
    • Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid
    • Kuiper, E.M., Hansen, B.E., de Vries, R.A., et al. Improved prognosis of patients with primary biliary cirrhosis that have a biochemical response to ursodeoxycholic acid. Gastroenterology 136 (2009), 1281–1287.
    • (2009) Gastroenterology , vol.136 , pp. 1281-1287
    • Kuiper, E.M.1    Hansen, B.E.2    de Vries, R.A.3
  • 34
    • 85011850416 scopus 로고    scopus 로고
    • Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study
    • Hegade, V.S., Kendrick, S.F., Dobbins, R.L., et al. Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study. Lancet 389 (2017), 1114–1123.
    • (2017) Lancet , vol.389 , pp. 1114-1123
    • Hegade, V.S.1    Kendrick, S.F.2    Dobbins, R.L.3
  • 35
    • 84958163560 scopus 로고    scopus 로고
    • NGM282, a novel variant of FGF-19, demonstrates biologic activity in primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid: results of a phase 2 multicenter, randomized, double blinded, placebo controlled trial
    • Mayo, M.J., Wigg, A.J., Roberts, S.K., et al. NGM282, a novel variant of FGF-19, demonstrates biologic activity in primary biliary cirrhosis patients with an incomplete response to ursodeoxycholic acid: results of a phase 2 multicenter, randomized, double blinded, placebo controlled trial. Hepatology 62 (2015), 263A–264A.
    • (2015) Hepatology , vol.62 , pp. 263A-264A
    • Mayo, M.J.1    Wigg, A.J.2    Roberts, S.K.3
  • 37
  • 38
    • 85032679362 scopus 로고    scopus 로고
    • NGM282, a novel variant of FGF19, significantly reduces hepatic steatosis and key biomarkers of NASH: results of a phase 2, multicenter, randomized, double-blinded, placebo controlled trial in biopsy-confirmed NASH patients
    • Harrison, S.A., Abdelmalek, M.F., TroRer, J.F., et al. NGM282, a novel variant of FGF19, significantly reduces hepatic steatosis and key biomarkers of NASH: results of a phase 2, multicenter, randomized, double-blinded, placebo controlled trial in biopsy-confirmed NASH patients. Presented at The International Liver Congress™ Amsterdam, Netherlands, April 22, 2017.
    • (2017) Presented at The International Liver Congress™ Amsterdam, Netherlands, April 22
    • Harrison, S.A.1    Abdelmalek, M.F.2    TroRer, J.F.3
  • 39
    • 84920401295 scopus 로고    scopus 로고
    • Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
    • Jiang, C., Xie, C., Li, F., et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest 125 (2015), 386–402.
    • (2015) J Clin Invest , vol.125 , pp. 386-402
    • Jiang, C.1    Xie, C.2    Li, F.3
  • 40
    • 84988892012 scopus 로고    scopus 로고
    • Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice
    • Rao, A., Kosters, A., Mells, J.E., et al. Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice. Sci Transl Med, 8, 2016, 357ra122.
    • (2016) Sci Transl Med , vol.8 , pp. 357ra122
    • Rao, A.1    Kosters, A.2    Mells, J.E.3
  • 41
    • 84925507991 scopus 로고    scopus 로고
    • Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
    • Fang, S., Suh, J.M., Reilly, S.M., et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 21 (2015), 159–165.
    • (2015) Nat Med , vol.21 , pp. 159-165
    • Fang, S.1    Suh, J.M.2    Reilly, S.M.3
  • 42
    • 84875848761 scopus 로고    scopus 로고
    • The TGR5 receptor mediates bile acid-induced itch and analgesia
    • Alemi, F., Kwon, E., Poole, D.P., et al. The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest 123 (2013), 1513–1530.
    • (2013) J Clin Invest , vol.123 , pp. 1513-1530
    • Alemi, F.1    Kwon, E.2    Poole, D.P.3
  • 43
    • 84903313532 scopus 로고    scopus 로고
    • Pruritus in cholestasis: facts and fiction
    • Beuers, U., Kremer, A.E., Bolier, R., et al. Pruritus in cholestasis: facts and fiction. Hepatology 60 (2014), 399–407.
    • (2014) Hepatology , vol.60 , pp. 399-407
    • Beuers, U.1    Kremer, A.E.2    Bolier, R.3
  • 44
    • 84925362562 scopus 로고    scopus 로고
    • Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
    • Hirschfield, G.M., Mason, A., Luketic, V., et al. Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid. Gastroenterology 148 (2015), 751–761.
    • (2015) Gastroenterology , vol.148 , pp. 751-761
    • Hirschfield, G.M.1    Mason, A.2    Luketic, V.3


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