-
1
-
-
84875848761
-
The TGR5 receptor mediates bile acid-induced itch and analgesia
-
Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW & Corvera CU (2013a). The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest 123, 1513-1530.
-
(2013)
J Clin Invest
, vol.123
, pp. 1513-1530
-
-
Alemi, F.1
Kwon, E.2
Poole, D.P.3
Lieu, T.4
Lyo, V.5
Cattaruzza, F.6
Cevikbas, F.7
Steinhoff, M.8
Nassini, R.9
Materazzi, S.10
Guerrero-Alba, R.11
Valdez-Morales, E.12
Cottrell, G.S.13
Schoonjans, K.14
Geppetti, P.15
Vanner, S.J.16
Bunnett, N.W.17
Corvera, C.U.18
-
2
-
-
84871304988
-
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
-
Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW & Corvera CU (2013b). The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144, 145-154.
-
(2013)
Gastroenterology
, vol.144
, pp. 145-154
-
-
Alemi, F.1
Poole, D.P.2
Chiu, J.3
Schoonjans, K.4
Cattaruzza, F.5
Grider, J.R.6
Bunnett, N.W.7
Corvera, C.U.8
-
3
-
-
0019984161
-
Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum
-
Angelin B, Björkhem I, Einarsson K & Ewerth S (1982). Hepatic uptake of bile acids in man. Fasting and postprandial concentrations of individual bile acids in portal venous and systemic blood serum. J Clin Invest 70, 724-731.
-
(1982)
J Clin Invest
, vol.70
, pp. 724-731
-
-
Angelin, B.1
Björkhem, I.2
Einarsson, K.3
Ewerth, S.4
-
4
-
-
84055169868
-
Pharmacology of the new treatments for lower gastrointestinal motility disorders and irritable bowel syndrome
-
Camilleri M (2012). Pharmacology of the new treatments for lower gastrointestinal motility disorders and irritable bowel syndrome. Clin Pharmacol Ther 91, 44-59.
-
(2012)
Clin Pharmacol Ther
, vol.91
, pp. 44-59
-
-
Camilleri, M.1
-
5
-
-
80053909415
-
Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders
-
e458.
-
Camilleri M, Vazquez-Roque MI, Carlson P, Burton D, Wong BS & Zinsmeister AR (2011). Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders. Neurogastroenterol Motil 23, 995-999, e458.
-
(2011)
Neurogastroenterol Motil
, vol.23
, pp. 995-999
-
-
Camilleri, M.1
Vazquez-Roque, M.I.2
Carlson, P.3
Burton, D.4
Wong, B.S.5
Zinsmeister, A.R.6
-
6
-
-
84874082742
-
Expression of bile acid receptor TGR5 in gastric adenocarcinoma
-
Cao W, Tian W, Hong J, Li D, Tavares R, Noble L, Moss SF & Resnick MB (2013). Expression of bile acid receptor TGR5 in gastric adenocarcinoma. Am J Physiol Gastrointest Liver Physiol 304, G322-G327.
-
(2013)
Am J Physiol Gastrointest Liver Physiol
, vol.304
-
-
Cao, W.1
Tian, W.2
Hong, J.3
Li, D.4
Tavares, R.5
Noble, L.6
Moss, S.F.7
Resnick, M.B.8
-
7
-
-
84861682490
-
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
-
Harach T, Pols TW, Nomura M, Maida A, Watanabe M, Auwerx J & Schoonjans K (2012). TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci Rep 2, 430.
-
(2012)
Sci Rep
, vol.2
, pp. 430
-
-
Harach, T.1
Pols, T.W.2
Nomura, M.3
Maida, A.4
Watanabe, M.5
Auwerx, J.6
Schoonjans, K.7
-
8
-
-
50249180215
-
Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics
-
Hofmann AF & Hagey LR (2008). Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci 65, 2461-2483.
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 2461-2483
-
-
Hofmann, A.F.1
Hagey, L.R.2
-
9
-
-
79959497278
-
TGR5 sequence variation in primary sclerosing cholangitis
-
Hov JR, Keitel V, Schrumpf E, Haussinger D & Karlsen TH (2011). TGR5 sequence variation in primary sclerosing cholangitis. Dig Dis 29, 78-84.
-
(2011)
Dig Dis
, vol.29
, pp. 78-84
-
-
Hov, J.R.1
Keitel, V.2
Schrumpf, E.3
Haussinger, D.4
Karlsen, T.H.5
-
10
-
-
84881464516
-
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts
-
Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW & Corvera CU (2013). The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J Biol Chem 288, 22942-22960.
-
(2013)
J Biol Chem
, vol.288
, pp. 22942-22960
-
-
Jensen, D.D.1
Godfrey, C.B.2
Niklas, C.3
Canals, M.4
Kocan, M.5
Poole, D.P.6
Murphy, J.E.7
Alemi, F.8
Cottrell, G.S.9
Korbmacher, C.10
Lambert, N.A.11
Bunnett, N.W.12
Corvera, C.U.13
-
11
-
-
0022648261
-
Involvement of the enteric nervous system in the intestinal secretion induced by sodium deoxycholate and sodium ricinoleate
-
Karlström L, Cassuto J, Jodal M & Lundgren O (1986). Involvement of the enteric nervous system in the intestinal secretion induced by sodium deoxycholate and sodium ricinoleate. Scand J Gastroenterol 21, 331-340.
-
(1986)
Scand J Gastroenterol
, vol.21
, pp. 331-340
-
-
Karlström, L.1
Cassuto, J.2
Jodal, M.3
Lundgren, O.4
-
12
-
-
13844299425
-
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
-
Katsuma S, Hirasawa A & Tsujimoto G (2005). Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem Biophys Res Commun 329, 386-390.
-
(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 386-390
-
-
Katsuma, S.1
Hirasawa, A.2
Tsujimoto, G.3
-
13
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
Kawamata Y, Fujii R, Hosoya M, Harada M, Yoshida H, Miwa M, Fukusumi S, Habata Y, Itoh T, Shintani Y, Hinuma S, Fujisawa Y & Fujino M (2003). A G protein-coupled receptor responsive to bile acids. J Biol Chem 278, 9435-9440.
-
(2003)
J Biol Chem
, vol.278
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
Harada, M.4
Yoshida, H.5
Miwa, M.6
Fukusumi, S.7
Habata, Y.8
Itoh, T.9
Shintani, Y.10
Hinuma, S.11
Fujisawa, Y.12
Fujino, M.13
-
14
-
-
70449726007
-
Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells
-
Keating N, Mroz MS, Scharl MM, Marsh C, Ferguson G, Hofmann AF & Keely SJ (2009). Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells. J Cell Mol Med 13, 2293-2303.
-
(2009)
J Cell Mol Med
, vol.13
, pp. 2293-2303
-
-
Keating, N.1
Mroz, M.S.2
Scharl, M.M.3
Marsh, C.4
Ferguson, G.5
Hofmann, A.F.6
Keely, S.J.7
-
15
-
-
70349255713
-
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
-
Keitel V, Cupisti K, Ullmer C, Knoefel WT, Kubitz R & Haussinger D (2009). The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 50, 861-870.
-
(2009)
Hepatology
, vol.50
, pp. 861-870
-
-
Keitel, V.1
Cupisti, K.2
Ullmer, C.3
Knoefel, W.T.4
Kubitz, R.5
Haussinger, D.6
-
16
-
-
78649386642
-
The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
-
Keitel V, Görg B, Bidmon HJ, Zemtsova I, Spomer L, Zilles K & Häussinger D (2010). The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia 58, 1794-1805.
-
(2010)
Glia
, vol.58
, pp. 1794-1805
-
-
Keitel, V.1
Görg, B.2
Bidmon, H.J.3
Zemtsova, I.4
Spomer, L.5
Zilles, K.6
Häussinger, D.7
-
17
-
-
84867886430
-
Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells
-
Kumar DP, Rajagopal S, Mahavadi S, Mirshahi F, Grider JR, Murthy KS & Sanyal AJ (2012). Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Biochem Biophys Res Commun 427, 600-605.
-
(2012)
Biochem Biophys Res Commun
, vol.427
, pp. 600-605
-
-
Kumar, D.P.1
Rajagopal, S.2
Mahavadi, S.3
Mirshahi, F.4
Grider, J.R.5
Murthy, K.S.6
Sanyal, A.J.7
-
18
-
-
77956276608
-
ATP channels
-
ATP channels. J Physiol 588, 3295-3305.
-
(2010)
J Physiol
, vol.588
, pp. 3295-3305
-
-
Lavoie, B.1
Balemba, O.B.2
Godfrey, C.3
Watson, C.A.4
Vassileva, G.5
Corvera, C.U.6
Nelson, M.T.7
Mawe, G.M.8
-
19
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
Lefebvre P, Cariou B, Lien F, Kuipers F & Staels B (2009). Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 89, 147-191.
-
(2009)
Physiol Rev
, vol.89
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
20
-
-
79957663467
-
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
-
Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA & Mangelsdorf DJ (2011). The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol Endocrinol 25, 1066-1071.
-
(2011)
Mol Endocrinol
, vol.25
, pp. 1066-1071
-
-
Li, T.1
Holmstrom, S.R.2
Kir, S.3
Umetani, M.4
Schmidt, D.R.5
Kliewer, S.A.6
Mangelsdorf, D.J.7
-
21
-
-
84895164072
-
Gpba: A G protein-coupled receptor for bile acids and an emerging therapeutic target for disorders of digestion and sensation
-
Lieu T, Jayaweera G & Bunnett NW (2014). Gpba: A G protein-coupled receptor for bile acids and an emerging therapeutic target for disorders of digestion and sensation. Br J Pharmacol 171, 1156-1166.
-
(2014)
Br J Pharmacol
, vol.171
, pp. 1156-1166
-
-
Lieu, T.1
Jayaweera, G.2
Bunnett, N.W.3
-
22
-
-
0036432845
-
Identification of membrane-type receptor for bile acids (M-BAR)
-
Maruyama T, Miyamoto Y, Nakamura T, Tamai Y, Okada H, Sugiyama E, Nakamura T, Itadani H & Tanaka K (2002). Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun 298, 714-719.
-
(2002)
Biochem Biophys Res Commun
, vol.298
, pp. 714-719
-
-
Maruyama, T.1
Miyamoto, Y.2
Nakamura, T.3
Tamai, Y.4
Okada, H.5
Sugiyama, E.6
Nakamura, T.7
Itadani, H.8
Tanaka, K.9
-
23
-
-
75149187435
-
Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1
-
Perides G, Laukkarinen JM, Vassileva G & Steer ML (2010). Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1. Gastroenterology 138, 715-725.
-
(2010)
Gastroenterology
, vol.138
, pp. 715-725
-
-
Perides, G.1
Laukkarinen, J.M.2
Vassileva, G.3
Steer, M.L.4
-
24
-
-
82955168360
-
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
-
Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J & Schoonjans K (2011). TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab 14, 747-757.
-
(2011)
Cell Metab
, vol.14
, pp. 747-757
-
-
Pols, T.W.1
Nomura, M.2
Harach, T.3
Lo Sasso, G.4
Oosterveer, M.H.5
Thomas, C.6
Rizzo, G.7
Gioiello, A.8
Adorini, L.9
Pellicciari, R.10
Auwerx, J.11
Schoonjans, K.12
-
25
-
-
77953352917
-
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
-
e227-818.
-
Poole DP, Godfrey C, Cattaruzza F, Cottrell GS, Kirkland JG, Pelayo JC, Bunnett NW & Corvera CU (2010). Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil 22, 814-825, e227-818.
-
(2010)
Neurogastroenterol Motil
, vol.22
, pp. 814-825
-
-
Poole, D.P.1
Godfrey, C.2
Cattaruzza, F.3
Cottrell, G.S.4
Kirkland, J.G.5
Pelayo, J.C.6
Bunnett, N.W.7
Corvera, C.U.8
-
26
-
-
84874031840
-
Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
-
Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA & Burgess SC (2013). Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol 304, G371-G380.
-
(2013)
Am J Physiol Gastrointest Liver Physiol
, vol.304
-
-
Potthoff, M.J.1
Potts, A.2
He, T.3
Duarte, J.A.4
Taussig, R.5
Mangelsdorf, D.J.6
Kliewer, S.A.7
Burgess, S.C.8
-
27
-
-
84874630085
-
Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway
-
Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR & Murthy KS (2013). Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Am J Physiol Gastrointest Liver Physiol 304, G527-G535.
-
(2013)
Am J Physiol Gastrointest Liver Physiol
, vol.304
-
-
Rajagopal, S.1
Kumar, D.P.2
Mahavadi, S.3
Bhattacharya, S.4
Zhou, R.5
Corvera, C.U.6
Bunnett, N.W.7
Grider, J.R.8
Murthy, K.S.9
-
28
-
-
84893696729
-
A membrane-proximal, C-terminal α-helix is required for plasma membrane localization and function of the G protein-coupled receptor (GPCR) TGR5
-
Spomer L, Gertzen CG, Schmitz B, Häussinger D, Gohlke H & Keitel V (2014). A membrane-proximal, C-terminal α-helix is required for plasma membrane localization and function of the G protein-coupled receptor (GPCR) TGR5. J Biol Chem 289, 3689-3702.
-
(2014)
J Biol Chem
, vol.289
, pp. 3689-3702
-
-
Spomer, L.1
Gertzen, C.G.2
Schmitz, B.3
Häussinger, D.4
Gohlke, H.5
Keitel, V.6
-
29
-
-
39449124119
-
Bile acids and the membrane bile acid receptor TGR5-connecting nutrition and metabolism
-
Thomas C, Auwerx J & Schoonjans K (2008). Bile acids and the membrane bile acid receptor TGR5-connecting nutrition and metabolism. Thyroid 18, 167-174.
-
(2008)
Thyroid
, vol.18
, pp. 167-174
-
-
Thomas, C.1
Auwerx, J.2
Schoonjans, K.3
-
30
-
-
69149083245
-
TGR5-mediated bile acid sensing controls glucose homeostasis
-
Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J & Schoonjans K (2009). TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab 10, 167-177.
-
(2009)
Cell Metab
, vol.10
, pp. 167-177
-
-
Thomas, C.1
Gioiello, A.2
Noriega, L.3
Strehle, A.4
Oury, J.5
Rizzo, G.6
Macchiarulo, A.7
Yamamoto, H.8
Mataki, C.9
Pruzanski, M.10
Pellicciari, R.11
Auwerx, J.12
Schoonjans, K.13
-
31
-
-
77049235724
-
The effect of exclusion of the bile upon gastrointestinal motility
-
Thorner RS (1955). The effect of exclusion of the bile upon gastrointestinal motility. Am J Roentgenol Radium Ther Nucl Med 74, 1096-1122.
-
(1955)
Am J Roentgenol Radium Ther Nucl Med
, vol.74
, pp. 1096-1122
-
-
Thorner, R.S.1
-
32
-
-
80053308007
-
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice
-
Wang YD, Chen WD, Yu D, Forman BM & Huang W (2011). The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology 54, 1421-1432.
-
(2011)
Hepatology
, vol.54
, pp. 1421-1432
-
-
Wang, Y.D.1
Chen, W.D.2
Yu, D.3
Forman, B.M.4
Huang, W.5
-
33
-
-
84880136128
-
The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon
-
Ward JB, Mroz MS & Keely SJ (2013). The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon. Neurogastroenterol Motil 25, 708-711.
-
(2013)
Neurogastroenterol Motil
, vol.25
, pp. 708-711
-
-
Ward, J.B.1
Mroz, M.S.2
Keely, S.J.3
-
34
-
-
33846345695
-
Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells
-
Yasuda H, Hirata S, Inoue K, Mashima H, Ohnishi H & Yoshiba M (2007). Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. Biochem Biophys Res Commun 354, 154-159.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 154-159
-
-
Yasuda, H.1
Hirata, S.2
Inoue, K.3
Mashima, H.4
Ohnishi, H.5
Yoshiba, M.6
-
35
-
-
84876041065
-
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
-
Yoneno K, Hisamatsu T, Shimamura K, Kamada N, Ichikawa R, Kitazume MT, Mori M, Uo M, Namikawa Y, Matsuoka K, Sato T, Koganei K, Sugita A, Kanai T & Hibi T (2013). TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology 139, 19-29.
-
(2013)
Immunology
, vol.139
, pp. 19-29
-
-
Yoneno, K.1
Hisamatsu, T.2
Shimamura, K.3
Kamada, N.4
Ichikawa, R.5
Kitazume, M.T.6
Mori, M.7
Uo, M.8
Namikawa, Y.9
Matsuoka, K.10
Sato, T.11
Koganei, K.12
Sugita, A.13
Kanai, T.14
Hibi, T.15
|