Effect of monthly, high-dose, long-term vitamin D supplementation on central blood pressure parameters: A randomized controlled trial substudy

Journal of the American Heart Association

Volumn 6, Issue 10, 2017, Pages

  Sluyter, John D ^a   Camargo, Carlos A ^b   Stewart, Alistair W ^a   Waayer, Debbie ^a   Lawes, Carlene M M ^a   Toop, Les ^c   Khaw, Kay Tee ^d   Thom, Simon A McG ^e   Hametner, Bernhard ^f   Wassertheurer, Siegfried ^f   Parker, Kim H ^e   Hughes, Alun D ^g   Scragg, Robert ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

^f AIT AUSTRIAN INSTITUTE OF TECHNOLOGY   (Austria)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Arterial stiffness; Blood pressure; Randomized controlled trial; Vitamin D; Wave reflection

Indexed keywords

25 HYDROXYVITAMIN D; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; COLECALCIFEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; PLACEBO; 25-HYDROXYVITAMIN D; ANTIHYPERTENSIVE AGENT; BIOLOGICAL MARKER; VITAMIN D;

ADULT; AGED; AORTIC PRESSURE; ARTICLE; AUGMENTATION INDEX; BLOOD PRESSURE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MEGADOSE; FEMALE; HEMODYNAMIC PARAMETERS; HUMAN; HYPERTENSION; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OSCILLOMETRY; PRIORITY JOURNAL; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; BLOOD; BRACHIAL ARTERY; DIETARY SUPPLEMENT; DRUG ADMINISTRATION; INTENTION TO TREAT ANALYSIS; MIDDLE AGED; NEW ZEALAND; PATHOPHYSIOLOGY; TIME FACTOR; TREATMENT OUTCOME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; BIOMARKERS; BLOOD PRESSURE; BRACHIAL ARTERY; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPERTENSION; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; NEW ZEALAND; PULSE WAVE ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 85032196018     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.117.006802     Document Type: Article

References (49)

1. Burgaz A, Orsini N, Larsson SC, Wolk A. Blood 25-hydroxyvitamin D concentration and hypertension: a meta-analysis. J Hypertens. 2011;29:636-645.
2. Wang L, Song Y, Manson JE, Pilz S, März W, Michaëlsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, Eaton CB, May HT, Anderson JL, Sesso HD. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a metaanalysis of prospective studies. Circ Cardiovasc Qual Outcomes. 2012;5:819-829.
3. Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, Alvarez JA, Boxer RS, Dalbeni A, Gepner AD, Isbel NM, Larsen T, Nagpal J, Petchey WG, Stricker H, Strobel F, Tangpricha V, Toxqui L, Vaquero MP, Wamberg L, Zittermann A, Witham MD. Effect of vitamin D supplementation on blood pressure a systematic review and meta-analysis incorporating individual patient data. JAMA Intern Med. 2015;175:745-754.
4. Arora P, Song Y, Dusek J, PlotnikoffG, Sabatine MS, Cheng S, Valcour A, Swales H, Taylor B, Carney E, Guanaga D, Young JR, Karol C, Torre M, Azzahir A, Strachan SM, O-Neill DC, Wolf M, Harrell F, Newton-Cheh C, Wang TJ. Vitamin D therapy in individuals with prehypertension or hypertension the DAYLIGHT trial. Circulation. 2015;131:254-262.
5. Rodríguez AJ, Scott D, Srikanth V, Ebeling P. Effect of vitamin D supplementation on measures of arterial stiffness: a systematic review and meta-analysis of randomized controlled trials. Clin Endocrinol (Oxf). 2016;84:645-657.
6. Vlachopoulos C, Aznaouridis K, O'Rourke MF, Safar ME, Baou K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis. Eur Heart J. 2010;31:1865-1871.
7. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness. A systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318-1327.
8. Davies JE, Lacy P, Tillin T, Collier D, Cruickshank JK, Francis DP, Malaweera A, Mayet J, Stanton A, Williams B, Parker KH, Thom SAM, Hughes AD. Excess pressure integral predicts cardiovascular events independent of other risk factors in the Conduit Artery Functional Evaluation (CAFE) sub-study of Anglo-Scandanavian Cardiac Outcomes Trial (ASCOT). Hypertension. 2014;4:60-68.
9. Weber T, Wassertheurer S, Rammer M, Haiden A, Hametner B, Eber B. Wave reflections, assessed with a novel method for pulse wave separation, are associated with end-organ damage and clinical outcomes. Hypertension. 2012;60:534-541.
10. Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, Hughes AD, Thurston H, O'Rourke M. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006;113:1213-1225.
11. Manisty CH, Zambanini A, Parker KH, Davies JE, Francis DP, Mayet J, Thom SAMCG, Hughes AD. Differences in the magnitude of wave reflection account for differential effects of amlodipine-versus atenolol-based regimens on central blood pressure: an Anglo-Scandinavian Cardiac Outcome Trial substudy. Hypertension. 2009;54:724-730.
12. Boutouyrie P, Achouba A, Trunet P, Laurent S. Amlodipine-valsartan combination decreases central systolic blood pressure more effectively than the amlodipine-atenolol combination: the EXPLOR study. Hypertension. 2010;55:1314-1322.
13. Witham MD, Price RJG, Struthers AD, Donnan PT, Messow CM, Ford I, McMurdo MET. Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension the VitDISH randomized controlled trial. JAMA Intern Med. 2013;173:1672-1679.
14. Veloudi P, Blizzard CL, Ding CH, Cicuttini FM, Jin X, Wluka AE, Winzenberg T, Jones G, Sharman JE. Effect of vitamin D supplementation on aortic stiffness and arterial hemodynamics in people with osteoarthritis and vitamin D deficiency. J Am Coll Cardiol. 2015;66:2679-2681.
15. Witham MD, Price RJG, Struthers AD, Donnan PT, Messow M, McConnachie A, Ford I, McMurdo MET. Effect of vitamin D supplementation on orthostatic hypotension: data from the vitamin D in isolated systolic hypertension randomized controlled trial. J Hypertens. 2014;32:1693-1699.
16. Breslavsky A, Frand J, Matas Z, Boaz M, Barnea Z, Shargorodsky M. Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clin Nutr. 2013;32:970-975.
17. Martins D, Meng Y, Tareen N, Artaza J, Lee J, Farodolu C, Gibbons G, Norris K. The effect of short term vitamin D supplementation on the inflammatory and oxidative mediators of arterial stiffness. Health (Irvine Calif). 2014;6:1503-1511.
18. Chitalia N, Ismail T, Tooth L, Boa F, Hampson G, Goldsmith D, Kaski JC, Banerjee D. Impact of vitamin D supplementation on arterial vasomotion, stiffness and endothelial biomarkers in chronic kidney disease patients. PLoS One. 2014;9:e91363.
19. Gepner AD, Ramamurthy R, Krueger DC, Korcarz CE, Binkley N, Stein JH. A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One. 2012;7:e36617.
20. Larsen T, Mose FH, Bech JN, Hansen AB, Pedersen EB. Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial. Am J Hypertens. 2012;25:1215-1222.
21. Stricker H, Tosi Bianda F, Guidicelli-Nicolosi S, Limoni C, Colucci G. Effect of a single, oral, high-dose vitamin D supplementation on endothelial function in patients with peripheral arterial disease: a randomised controlled pilot study. Eur J Vasc Endovasc Surg. 2012;44:307-312.
22. Scragg R, Waayer D, Stewart AW, Lawes CMM, Toop L, Murphy J, Khaw KT, Camargo CA Jr. The vitamin D assessment (ViDA) study: design of a randomised controlled trial of vitamin D supplementation to prevent cardiovascular disease, respiratory infection, falls and fractures. J Steroid Biochem Mol Biol. 2016;164:318-325.
23. Lin ACW, Lowe A, Sidhu K, Harrison W, Ruygrok P, Stewart R. Evaluation of a novel sphygmomanometer, which estimates central aortic blood pressure from analysis of brachial artery suprasystolic pressure waves. J Hypertens. 2012;30:1743-1750.
24. Climie RED, Schultz MG, Nikolic SB, Ahuja KDK, Fell JW, Sharman JE. Validity and reliability of central blood pressure estimated by upper arm oscillometric cuffpressure. Am J Hypertens. 2012;25:414-420.
25. Hametner B, Wassertheurer S, Kropf J, Mayer C, Eber B, Weber T. Oscillometric estimation of aortic pulse wave velocity: comparison with intra-aortic catheter measurements. Blood Press Monit. 2013;18:173-176.
26. Weber T, Wassertheurer S, Hametner B, Rammer M, Lassnig E, Eber B, Wels-Grieskirchen K. Aortic stiffness, measured invasively, or estimated from radial waveforms, predicts severe cardiovascular events. Eur Heart J. 2013;34:515.
27. Hametner B, Wassertheurer S, Hughes AD, Parker KH, Weber T, Eber B. Reservoir and excess pressures predict cardiovascular events in high-risk patients. Int J Cardiol. 2014;171:31-36.
28. Manisty C, Mayet J, Tapp RJ, Parker KH, Sever P, Poulter NH, Thom SAM, Hughes AD. Wave reflection predicts cardiovascular events in hypertensive individuals independent of blood pressure and other cardiovascular risk factors. An ASCOT (Anglo-Scandinavian Cardiac Outcome Trial) substudy. J Am Coll Cardiol. 2010;56:24-30.
29. Wang KL, Cheng HM, Sung SH, Chuang SY, Li CH, Spurgeon HA, Ting CT, Najjar SS, Lakatta EG, Yin FCP, Chou P, Chen CH. Wave reflection and arterial stiffness in the prediction of 15-year all-cause and cardiovascular mortalities: a community-based study. Hypertension. 2010;55:799-805.
30. Davies JE, Baksi J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Foale RA, Malik IS, Tyberg JV, Parker KH, Mayet J, Hughes AD. The arterial reservoir pressure increases with aging and is the major determinant of the aortic augmentation index. Am J Physiol Heart Circ Physiol. 2010;298:H580-H586.
31. Hametner B, Wassertheurer S, Kropf J, Mayer C, Holzinger A, Eber B, Weber T. Wave reflection quantification based on pressure waveforms alone-methods, comparison, and clinical covariates. Comput Methods Programs Biomed. 2013;109:250-259.
32. Woolston A, Tu YK, Baxter PD, Gilthorpe MS. A comparison of different approaches to unravel the latent structure within metabolic syndrome. PLoS One. 2012;7:e34410.
33. Sachs MC, Shoben A, Levin GP, Robinson-Cohen C, Hoofnagle AN, Swords-Jenny N, Ix JH, BudoffM, Lutsey PL, Siscovick DS, Kestenbaum B, De Boer IH. Estimating mean annual 25-hydroxyvitamin D concentrations from single measurements: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr. 2013;97:1243-1251.
34. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 2012;95:91-100.
35. Gaksch M, Jorde R, Grimnes G, Joakimsen R, Schirmer H, Wilsgaard T, Mathiesen EB, Njølstad I, Løchen ML, Maürz W, Kleber ME, Tomaschitz A, Gruübler M, Eiriksdottir G, Gudmundsson EF, Harris TB, Cotch MF, Aspelund T, Gudnason V, Rutters F, Beulens JWJ, Van't Riet E, Nijpels G, Dekker JM, Grove-Laugesen D, Rejnmark L, Busch MA, Mensink GBM, Scheidt-Nave C, Thamm M, Swart KMA, Brouwer IA, Lips P, Van Schoor NM, Sempos CT, Durazo-Arvizu RA, Škrabaókovaó Z, Dowling KG, Cashman KD, Kiely M, Pilz S. Vitamin D and mortality: individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS One. 2017;12:e0170791.
36. Kramer CK, Ye C, Hanley AJ, Connelly PW, Sermer M, Zinman B, Retnakaran R. The relationship between parathyroid hormone and 25-hydroxyvitamin D during and after pregnancy. J Clin Endocrinol Metab. 2016;101:1729-1736.
37. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990;1:43-46.
38. Garg G, Kachhawa G, Ramot R, Khadgawat R, Tandon N, Sreenivas V, Kriplani A, Gupta N. Effect of vitamin D supplementation on insulin kinetics and cardiovascular risk factors in polycystic ovarian syndrome: a pilot study. Endocr Connect. 2015;4:108-116.
39. Zaleski A, Panza G, Swales H, Arora P, Newton-Cheh C, Wang T, Thompson PD, Taylor B. High-dose versus low-dose vitamin D supplementation and arterial stiffness among individuals with prehypertension and vitamin D deficiency. Dis Markers. 2015;2015:918968.
40. McGreevy C, Barry M, Davenport C, Byrne B, Donaghy C, Collier G, Tormey W, Smith D, Bennett K, Williams D. The effect of vitamin D supplementation on arterial stiffness in an elderly community-based population. J Am Soc Hypertens. 2015;9:176-183.
41. Dreyer G, Tucker AT, Harwood SM, Pearse RM, Raftery MJ, Yaqoob MM. Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin D deficiency: an exploratory, double blind, randomised controlled trial. PLoS One. 2014;9:e99461.
42. Ryu OH, Chung W, Lee S, Hong KS, Choi MG, Yoo HJ. The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes. Korean J Intern Med. 2014;29:620-629.
43. BressendorffI, Brandi L, Schou M, Nygaard B, Frandsen NE, Rasmussen K, Ødum L, Østergaard OV, Hansen D. The effect of high dose cholecalciferol on arterial stiffness and peripheral and central blood pressure in healthy humans: a randomized controlled trial. PLoS One. 2016;11:e0160905.
44. Tamez H, Kalim S, Thadhani RI. Does vitamin D modulate blood pressure? Curr Opin Nephrol Hypertens. 2013;22:204-209.
45. Matsui Y, Eguchi K, O'Rourke MF, Ishikawa J, Miyashita H, Shimada K, Kario K. Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients. Hypertension. 2009;54:716-723.
46. Scragg R, Stewart AW, Waayer D, Lawes CMM, Toop L, Sluyter J, Murphy J, Khaw KT, Camargo CA Jr. Effect of monthly high-dose vitamin D supplementation on cardiovascular disease: the vitamin D assessment study (a randomized controlled trial). JAMA Cardiol. 2017;2:608-616.
47. Dijkman B, Kooistra B, Bhandari M, Archibald S, Baillie F, Cadeddu M, Cinà C, Farrokhyar F, Goldsmith CH, Haines T, Hansebout R, Jaeschke R, Levis C, Simunovic M, Tandan V, Thoma A, Cornacchi S, Garnett A. How to work with a subgroup analysis. Can J Surg. 2009;52:515-522.
48. Kaiser LD. Stratification of randomization is not required for a pre-specified subgroup analysis. Pharm Stat. 2013;12:43-47.
49. Nessvi S, Johansson L, Jopson J, Stewart A, Reeder A, McKenzie R, Scragg RK. Association of 25-hydroxyvitamin D3 levels in adult New Zealanders with ethnicity, skin color and self-reported skin sensitivity to sun exposure. Photochem Photobiol. 2011;87:1173-1178.