Effect of a single, oral, high-dose vitamin D supplementation on endothelial function in patients with peripheral arterial disease: A randomised controlled pilot study

European Journal of Vascular and Endovascular Surgery

Volumn 44, Issue 3, 2012, Pages 307-312

  Stricker, H ^a   Tosi Bianda, F ^a   Guidicelli Nicolosi, S ^a   Limoni, C ^b   Colucci, G ^c  

^a Kantonsspital Frauenfeld   (Switzerland)

^b Biometrics ^*  (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

25 Hydroxyvitamin D; Arterial stiffness; Coagulation; Endothelial function; Peripheral arterial disease

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL; PARATHYROID HORMONE; PLACEBO; VITAMIN D;

AGED; ARTERIAL STIFFNESS; ARTICLE; BLOOD CLOTTING; CAUCASIAN; CELL FUNCTION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SUMMER; VASCULAR ENDOTHELIUM; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WINTER;

ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD COAGULATION; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; HEMODYNAMICS; HUMANS; INFLAMMATION MEDIATORS; LINEAR MODELS; MALE; MIDDLE AGED; PARATHYROID HORMONE; PERIPHERAL ARTERIAL DISEASE; PILOT PROJECTS; SEASONS; SWITZERLAND; TIME FACTORS; TREATMENT OUTCOME; VASCULAR STIFFNESS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84865452289     PISSN: 10785884     EISSN: 15322165     Source Type: Journal    
DOI: 10.1016/j.ejvs.2012.06.023     Document Type: Article

References (28)

1. M.H. Criqui, R.D. Langer, A. Fronek, H.S. Feigelson, M.R. Klauber, and T.J. McCann Mortality over a period of 10 years in patients with peripheral arterial disease N Engl J Med 326 1992 381 386
2. P.C. Bennett, S.H. Silverman, P.S. Gill, and G.Y. Lip Peripheral arterial disease and Virchow's triad Thromb Haemost 101 2009 1032 1040
3. E. Selvin, and T.P. Erlinger Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000 Circulation 110 2004 738 743 (Pubitemid 39056275)
4. R. Ross Atherosclerosis-an inflammatory disease N Engl J Med 340 1999 115 126
5. M.A. Allison, M.H. Criqui, R.L. McClelland, J.M. Scott, M.M. McDermott, and K. Liu The effect of novel cardiovascular risk factors on the ethnic-specific odds for peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis (MESA) J Am Coll Cardiol 48 2006 1190 1197 (Pubitemid 44345134)
6. J.L. Anderson, H.T. May, B.D. Horne, T.L. Bair, N.L. Hall, and J.F. Carlquist Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population Am J Cardiol 106 2010 963 968
7. D. Martins, M. Wolf, D. Pan, A. Zadshir, N. Tareen, and R. Thadhani Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey Arch Intern Med 167 2007 1159 1165 (Pubitemid 46919818)
8. M.L. Melamed, P. Muntner, E.D. Michos, J. Uribarri, C. Weber, and J. Sharma Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004 Arterioscler Thromb Vasc Biol 28 2008 1179 1185
9. B. Dawson-Hughes, A. Mithal, J.P. Bonjour, S. Boonen, P. Burckhardt, and G.E. Fuleihan IOF position statement: vitamin D recommendations for older adults Osteoporos Int 21 2010 1151 1154
10. T.J. Wang, M.J. Pencina, S.L. Booth, P.F. Jacques, E. Ingelsson, and K. Lanier Vitamin D deficiency and risk of cardiovascular disease Circulation 117 2008 503 511
11. A.G. Pittas, M. Chung, T. Trikalinos, J. Mitri, M. Brendel, and K. Patel Systematic review: vitamin D and cardiometabolic outcomes Ann Intern Med 152 2010 307 314
12. S.K. Jassal, M. Chonchol, D. von Muhlen, G. Smits, and E. Barrett-Connor Vitamin d, parathyroid hormone, and cardiovascular mortality in older adults: the Rancho Bernardo study Am J Med 123 2010 1114 1120
13. A.C. Ross, J.E. Manson, S.A. Abrams, J.F. Aloia, P.M. Brannon, and S.K. Clinton The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know J Clin Endocrinol Metab 96 2011 53 58
14. I. Al Mheid, R. Patel, J. Murrow, A. Morris, A. Rahman, and L. Fike Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans J Am Coll Cardiol 58 2011 186 192
15. C. Binggeli, L.E. Spieker, R. Corti, I. Sudano, V. Stojanovic, and D. Hayoz Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice? J Am Coll Cardiol 42 2003 71 77 (Pubitemid 36760763)
16. P. Autier, and S. Gandini Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials Arch Intern Med 167 2007 1730 1737 (Pubitemid 47403059)
17. P.G. Lindqvist, E. Epstein, and H. Olsson Does an active sun exposure habit lower the risk of venous thrombotic events? A D-lightful hypothesis J Thromb Haemost 7 2009 605 610
18. M. Zagura, M. Serg, P. Kampus, M. Zilmer, J. Eha, and E. Unt Aortic stiffness and vitamin D are independent markers of aortic calcification in patients with peripheral arterial disease and in healthy subjects Eur J Vasc Endovasc Surg 42 2011 689 695
19. H. Dobnig, S. Pilz, H. Scharnagl, W. Renner, U. Seelhorst, and B. Wellnitz Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality Arch Intern Med 168 2008 1340 1349 (Pubitemid 351930842)
20. E. Guallar, E.R. Miller 3rd, J.M. Ordovas, and S. Stranges Vitamin D supplementation in the age of lost innocence Ann Intern Med 152 2010 327 329
21. J.A. Sugden, J.I. Davies, M.D. Witham, A.D. Morris, and A.D. Struthers Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels Diabet Med 25 2008 320 325 (Pubitemid 351322698)
22. R. Jorde, M. Sneve, P. Torjesen, Y. Figenschau, and J.B. Hansen Parameters of the thrombogram are associated with serum 25-hydroxyvitamin D levels at baseline, but not affected during supplementation with vitamin D Thromb Res 125 2010 e210 213
23. M. Pfeifer, B. Begerow, H.W. Minne, D. Nachtigall, and C. Hansen Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women J Clin Endocrinol Metab 86 2001 1633 1637 (Pubitemid 32377290)
24. D.P. Trivedi, R. Doll, and K.T. Khaw Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial BMJ 326 2003 469
25. A. Avenell, G.S. MacLennan, D.J. Jenkinson, G.C. McPherson, A.M. McDonald, and P.R. Pant Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial) J Clin Endocrinol Metab 97 2011 614 622
26. M.B. Elamin, N.O. Abu Elnour, K.B. Elamin, M.M. Fatourechi, A.A. Alkatib, and J.P. Almandoz Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis J Clin Endocrinol Metab 96 2011 1931 1942
27. T.D. Thacher, and B.L. Clarke Vitamin D insufficiency Mayo Clin Proc 86 2011 50 60
28. T.J. Wang, F. Zhang, J.B. Richards, B. Kestenbaum, J.B. van Meurs, and D. Berry Common genetic determinants of vitamin D insufficiency: a genome-wide association study Lancet 376 2010 180 188