Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients

Clinical Nutrition

Volumn 32, Issue 6, 2013, Pages 970-975

  Breslavsky, A ^a   Frand, J ^a   Matas, Z ^a   Boaz, M ^a,b   Barnea, Z ^a   Shargorodsky, M ^a,b  

^a Wolfson Medical Center   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Arterial stiffness; Circulating adiponectin; Glucose homeostasis parameters; Vitamin D

Indexed keywords

ADIPONECTIN; CALCIFEDIOL; GLUCOSE; HEMOGLOBIN A1C; LEPTIN; PLACEBO; VITAMIN D;

ADOLESCENT; ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; AUGMENTATION INDEX; BLOOD SAMPLING; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG MEGADOSE; FEMALE; GLUCOSE HOMEOSTASIS; HEMODYNAMIC PARAMETERS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; TREATMENT DURATION; VITAMIN SUPPLEMENTATION;

ARTERIAL STIFFNESS; CIRCULATING ADIPONECTIN; GLUCOSE HOMEOSTASIS PARAMETERS; VITAMIN D;

ADIPONECTIN; ADMINISTRATION, ORAL; AGED; ARTERIES; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HOMEOSTASIS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LEPTIN; LINEAR MODELS; MALE; MIDDLE AGED; VITAMIN D;

EID: 84887623941     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.01.020     Document Type: Article

References (33)

1. Scragg R., Sowers M., Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004, 27:2813-2818.
2. Need A.G., O'Loughlin P.D., Horowitz M., Nordin B. Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women. Clin Endocrinol (Oxf) 2005, 62:738-741.
3. Palomer X., González-Clemente J.M., Blanco-Vaca F., Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab 2008, 10(3):185-197.
4. 3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract 2003, 57:258-261.
5. Chiu K.C., Chu A., Go V.L., Saad M.F. Hypovitaminosis D is associated with insulin resistance and ß-cell dysfunction. Am J Clin Nutr 2004, 79:820-825.
6. 3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J 2000, 47:383-391.
7. Forman J.P., Giovannucci E., Holmes M.D., Bischoff-Ferrari H.A., Tworoger S.S., Willett W.C., et al. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007, 49:1063-1069.
8. Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 2006, 92:39-48.
9. Wang T.J., Pencina M.J., Booth S.L., Jacques P.F., Ingelsson E., Lanier K., et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008, 117:503-511.
10. Giovannucci E., Liu Y., Hollis B.W., Rimm E.B. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 2008, 168:1174-1180.
11. Al Mheid I., Patel R., Murrow J., Morris A., Rahman A., Fike L., et al. Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. JAm Coll Cardiol 2011, 58(2):186-192.
12. 3 supplementation for 16 weeks improves flow-mediated dilation in overweight African-American adults. Am J Hypertens 2011, 24(5):557-562.
13. Sugden J.A., Davies J.I., Witham M.D., Morris A.D., Struthers A.D. Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels. Diabet Med 2008, 25(3):320-325.
14. van Popele N.M., Grobbee D.E., Bots M.L., Asmar R., Topouchian J., Reneman R.S., et al. Association between arterial stiffness and atherosclerosis: the Rotterdam study. Stroke 2001, 32:454-460.
15. Cruickshank K., Riste L., Anderson S.G., Wright J.S., Dunn G., Gosling R.G. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance. An integrated index of vascular function?. Circulation 2002, 106:2085-2090.
16. Zieman S.J., Melenovsky V., Kass D.A. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol 2005, 25:932-943.
17. Schiffrin E.L. Vascular stiffening and arterial compliance. Am J Hypertens 2004, 17:39-48.
18. Wan Y., Heneghan C., Stevens R., McManus R.J., Ward A., Perera R., et al. Determining which automatic digital blood pressure device performs adequately: asystematic review. JHum Hypertens 2010, 24(7):431-438.
19. O'Rourke M., Staessen J.A. Clinical application of arterial stiffness definitions and reference values. Am J Hypertens 2002, 15:426-444.
20. Giovannucci Edward, Liu Yan, Hollis Bruce W., Rimm Eric B. ScD 25-hydroxyvitamin D and risk of myocardial infarction in men. A prospective study. Arch Intern Med 2008, 168(11):1174-1180.
21. 3. Diabetologia 1994, 37:552-558.
22. Gregori S., Giarratana N., Smiroldo S., Uskokovic M., Adorini L.A. 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002, 51:1367-1374.
23. Pilz S., van den Hurk K., Nijpels G., Stehouwer C.D., Van't Riet E., Kienreich K., et al. Vitamin D status, incident diabetes and prospective changes in glucose metabolism in older subjects: the Hoorn study. Nutr Metab Cardiovasc Dis 2012, 22(10):883-889.
24. Pittas A.G., Harris S.S., Stark P.C., Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in non-diabetic adults. Diabetes Care 2007, 30:980-986.
25. Gepner A.D., Ramamurthy R., Krueger D.C., Korcarz C.E., Binkley N., Stein J.H. Aprospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One 2012, 7(5):e36617.
26. Larsen T., Mose F.H., Bech J.N., Hansen A.B., Pedersen E.B. Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial. Am J Hypertens 2012, 25(11):1215-1222.
27. Orwoll E., Riddle M., Prince M. Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr 1994, 59:1083-1087.
28. Ljunghall S., Lind L., Lithell H., Skarfors E., Selinus I., Sorensen O.H., et al. Treatment with one-hydroxycholecalciferol in middle-aged men with impaired glucose tolerance - a prospective randomized double-blind study. Acta Med Scand 1987, 222:361-367.
29. Stefan N., Vozarova B., Funahashi T., Matsuzawa Y., Weyer C., Lindsay R.S., et al. Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes 2002, 51:1884-1888.
30. Tan K.C.B., Xu A., Chow W.S., Lam M.C.W., Ai V.H.G., Tam S.C.F., et al. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. JClin Endocrinol Metab 2004, 89:765-769.
31. Störk S., Bots M.L., Angerer P., Schacky C., Grobbee D.E., Angermann C.E., et al. Low levels of adiponectin predict worsening of arterial morphology and function. Atherosclerosis 2007, 194:e147-e153.
32. Ukkola O., Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities?. JMol Med 2002, 80:696-702.
33. Shargorodsky M., Boaz M., Goldberg Y., Matas Z., Gavish D., Fux A., et al. Adiponectin and vascular properties in obese patients: is it a novel biomarker of early atherosclerosis?. Int J Obes (Lond) 2009, 33(5):553-558.