The expression of APE1 in triple-negative breast cancer and its effect on drug sensitivity of olaparib

Tumor Biology

Volumn 39, Issue 10, 2017, Pages 1-9

  Chen, Tianran ^a   Liu, Chuan ^b   Lu, Heng ^a   Yin, Mingzhen ^a   Shao, Changjuan ^c   Hu, Xiaoding ^c   Wu, Jiaxue ^c   Wang, Yajie ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

apurinic apyrimidyl endonuclease 1; BER; olaparib; Poly (ADP ribose) polymerase 1 inhibitor; triple negative breast cancer

Indexed keywords

APURINIC APYRIMIDINIC ENDONUCLEASE1; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OLAPARIB; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APEX1 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

ADULT; APOPTOSIS; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CANCER TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DRUG SENSITIVITY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; GROWTH CURVE; HCC1937 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IC50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MIDDLE AGED; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME; AGED; DRUG EFFECTS; DRUG RESISTANCE; FLOW CYTOMETRY; GENE INACTIVATION; KAPLAN MEIER METHOD; METABOLISM; MORTALITY; PHYSIOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TISSUE MICROARRAY; TRIPLE NEGATIVE BREAST NEOPLASMS; TUMOR CELL LINE;

ADULT; AGED; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG RESISTANCE, NEOPLASM; FEMALE; FLOW CYTOMETRY; GENE KNOCKOUT TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; POLY(ADP-RIBOSE) POLYMERASES; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TISSUE ARRAY ANALYSIS; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 85032152870     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1177/1010428317713390     Document Type: Article

References (11)

1. Rummel S, Varner E, Shriver CD. Evaluation of BRCA1 mutations in an unselected patient population with triple-negative breast cancer. Breast Cancer Res Treat 2013; 137: 119–125.
2. O’Shaughnessy J, Osborne C, Pippen JE. Iniparib plus chemotherapy in metastatic triple-negative breast cancer. N Engl J Med 2011; 364: 205–214.
3. McLornan DP, List A, Mufti GJ., Applying synthetic lethality for the selective targeting of cancer. N Engl J Med 2014; 371: 1725–1735.
4. Kaufman B, Shapira-Frommer R, Schmutzler RK. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol 2015; 33: 244–250.
5. Zander SA, Kersbergen A, van der Burg E. Sensitivity and acquired resistance of BRCA1;p53-deficient mouse mammary tumors to the topoisomerase I inhibitor topotecan. Cancer Res 2010; 70: 1700–1710.
6. Puglisi F, Aprile G, Minisini AM. Prognostic significance of Ape1/ref-1 subcellular localization in non-small cell lung carcinomas. Anticancer Res 2001; 21: 4041–4049.
7. Di Maso V, Avellini C, Croce LS. Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance. Mol Med 2007; 13: 89–96.
8. Stoppa-Lyonnet D, Ansquer Y, Dreyfus H. Familial invasive breast cancers: worse outcome related to BRCA1 mutations. J Clin Oncol 2000; 18: 4053–4059.
9. Harris JL, Jakob B, Taucher-Scholz G. Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage. Hum Mol Genet 2009; 18: 4102–4117.
10. Khodyreva SN, Prasad R, Ilina ES. Apurinic/apyrimidinic (AP) site recognition by the 5′-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proc Natl Acad Sci U S A 2010; 107: 22090–22095.
11. Peddi SR, Chattopadhyay R, Naidu CV. The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks. Toxicology 2006; 224: 44–55.