Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 4, 2012, Pages 1007-1008.e1

  Mansbach, Jonathan M ^a   Piedra, Pedro A ^b   Borregaard, Niels ^c   Martineau, Adrian R ^d   Neuman, Mark I ^a   Espinola, Janice A ^e   Camargo Jr , Carlos A ^e  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Rigshospitalet   (Denmark)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CATHELICIDIN;

BLOOD SAMPLING; BRONCHIOLITIS; COMMUNITY ACQUIRED PNEUMONIA; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; EMERGENCY WARD; HEMODIALYSIS; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; HUMAN RHINOVIRUS; LETTER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; THROAT CULTURE; VIRUS ETIOLOGY; VIRUS IDENTIFICATION; VITAMIN BLOOD LEVEL;

EID: 84869098336     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.07.044     Document Type: Article

References (9)

1. Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics 2006;118:1774-93.
2. Mansbach JM, Piedra PA, Teach SJ, Sullivan AF, Forgey T, Clark S, et al. Prospective, multicenter study of viral etiology and hospital length-of-stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med 2012;166:700-6.
3. Bartley J. Vitamin D, innate immunity and upper respiratory tract infection. J Laryngol Otol 2010;124:465-9.
4. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006; 311:1770-3.
5. Adams JS, Hewison M. Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab 2008; 4:80-90.
6. Bhan I, Camargo CA Jr, Wenger J, Ricciardi C, Ye J, Borregaard N, et al. Circulating levels of 25-hydroxyvitamin D and human cathelicidin in healthy adults. J Allergy Clin Immunol 2011;127:1302-4, e1301.
7. Leow L, Simpson T, Cursons R, Karalus N, Hancox RJ. Vitamin D, innate immunity and outcomes in community acquired pneumonia. Respirology 2011;16:611-6.
8. Mansbach JM, Camargo CA Jr. Acute respiratory infections. In: Litonjua A, ed. Vitamin D and lung: Mechanism and disease associations. New York, NY: Humana; 2012: Pp. 181-200.
9. Gombart AF, Bhan I, Borregaard N, Tamez H, Camargo CA Jr, Koeffler HP, et al. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. Clin Infect Dis 2009;48:418-24.