CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells

Cardiovascular Research

Volumn 113, Issue 10, 2017, Pages 1198-1207

  Shu, Ya Nan ^a   Dong, Li Hua ^a   Li, Han ^a   Pei, Qian Qian ^a   Miao, Sui Bing ^a   Zhang, Fan ^a   Zhang, Dan Dan ^a   Chen, Rong ^a   Yin, Ya Juan ^a   Lin, Yan Ling ^a   Xue, Zhen Ying ^a   Lv, Pin ^a   Xie, Xiao Li ^a   Zhao, Li Li ^a   Nie, Xi ^a   Chen, Peng ^a   Han, Mei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

CKII; Inflammation; SIRT1; SM22 ; VSMCs

Indexed keywords

CASEIN KINASE II; SIRTUIN 1; TRANSCRIPTION FACTOR EZH2; TRANSGELIN; TUMOR NECROSIS FACTOR; ACTIN BINDING PROTEIN; EZH2 PROTEIN, RAT; HISTONE; MUSCLE PROTEIN; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAROTID ARTERY INJURY; CAROTID ARTERY LIGATION; CONTROLLED STUDY; DEACETYLATION; HYPERPLASIA; IN VITRO STUDY; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; VASCULAR SMOOTH MUSCLE CELL; VASCULITIS; ACETYLATION; ANIMAL; CELL CULTURE; DISEASE MODEL; DNA METHYLATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; GENOTYPE; HUMAN; INFLAMMATION; KNOCKOUT MOUSE; MALE; METABOLISM; PATHOLOGY; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ACETYLATION; ANIMALS; CAROTID ARTERY INJURIES; CASEIN KINASE II; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA METHYLATION; ENHANCER OF ZESTE HOMOLOG 2 PROTEIN; ENZYME ACTIVATION; GENOTYPE; HISTONES; HUMANS; HYPERPLASIA; INFLAMMATION; MALE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; PHENOTYPE; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85031820866     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvx048     Document Type: Article

References (30)

1. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002;105:1135-1143.
2. Li Q, Verma IM. NF-kappaB regulation in the immune system. Nat Rev Immunol 2002;2:725-734.
3. Kutuk O, Basaga H. Inflammation meets oxidation: NF-kappaB as a mediator of initial lesion development in atherosclerosis. Trends Mol Med 2003;9:549-557.
4. Gillum MP, Kotas ME, Erion DM, Kursawe R, Chatterjee P, Nead KT, Muise ES, Hsiao JJ, Frederick DW, Yonemitsu S, Banks AS, Qiang L, Bhanot S, Olefsky JM, Sears DD, Caprio S, Shulman GI. Sirt1 regulates adipose tissue inflammation. Diabetes 2011;60:3235-3245.
5. Jia Y, Zheng Z, Wang Y, Zhou Q, Cai W, Jia W, Yang L, Dong M, Zhu X, Su L, Hu D. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One 2015;10:e0120849.
6. Chen HZ, Wang F, Gao P, Pei JF, Liu Y, Xu TT, Tang X, Fu WY, Lu J, Yan YF, Wang XM, Han L, Zhang ZQ, Zhang R, Zou MH, Liu DP. Age-associated Sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm. Circ Res 2016;119:1076-1088.
7. Chen Z, Peng IC, Cui X, Li YS, Chien S, Shyy JY. Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci USA 2010;107:10268-10273.
8. Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. The EMBO J 2004;23:2369-2380.
9. Gao P, Xu TT, Lu J, Li L, Xu J, Hao DL, Chen HZ, Liu DP. Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice. J Mol Med 2014;92:347-357.
10. Zhang JC, Kim S, Helmke BP, Yu WW, Du KL, Lu MM, Strobeck M, Yu Q, Parmacek MS. Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol 2001;21:1336-1344.
11. Dong LH, Wen JK, Liu G, McNutt MA, Miao SB, Gao R, Zheng B, Zhang H, Han M. Blockade of the Ras-extracellular signal-regulated kinase 1/2 pathway is involved in smooth muscle 22 alpha-mediated suppression of vascular smooth muscle cell proliferation and neointima hyperplasia. Arterioscler Thromb Vasc Biol 2010;30: 683-691.
12. Lv P, Miao SB, Shu YN, Dong LH, Liu G, Xie XL, Gao M, Wang YC, Yin YJ, Wang XJ, Han M. Phosphorylation of smooth muscle 22a facilitates angiotensin II-induced ROS production via activation of the PKCd-P47phox axis through release of PKCd and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo. Circ Res 2012;111:697-707.
13. Dong LH, Lv P, Han M. Roles of SM22alpha in cellular plasticity and vascular diseases. Cardiovasc Hematol Disord Drug Targets 2012;12:119-125.
14. Shen J, Yang M, Ju D, Jiang H, Zheng JP, Xu Z, Li L. Disruption of SM22 promotes inflammation after artery injury via nuclear factor kappaB activation. Circ Res 2010;106:1351-1362.
15. Shu YN, Zhang F, Bi W, Dong LH, Zhang DD, Chen R, Lv P, Xie XL, Lin YL, Xue ZY, Li H, Miao SB, Zhao LL, Wang H, Han M. SM22a inhibits vascular inflammation via stabilization of IkBa in vascular smooth muscle cells. J Mol Cell Cardiol 2015;84:191-199.
16. Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y. Role of histone H3 lysine 27 methylation in X inactiva-tion. Science 2003;300:131-135.
17. Wan J, Zhan J, Li S, Ma J, Xu W, Liu C, Xue X, Xie Y, Fang W, Chin YE, Zhang H. PCAF-primed EZH2 acetylation regulates its stability and promotes lung adenocar-cinoma progression. Nucleic Acids Res 2015;43:3591-3604.
18. Li L, Zhang HN, Chen HZ, Gao P, Zhu LH, Li HL, Lv X, Zhang QJ, Zhang R, Wang Z, She ZG, Zhang R, Wei YS, Du GH, Liu DP, Liang CC. SIRT1 acts as a modulator of neointima formation following vascular injury in mice. Circ Res 2011;108:1180-1189.
19. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest 2010;120:545-558.
20. Hirasawa Y, Arai M, Imazeki F, Tada M, Mikata R, Fukai K, Miyazaki M, Ochiai T, Saisho H, Yokosuka O. Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma. Oncology 2006;71:77-85.
21. Zhao L, Wang H, Deng YJ, Wang S, Liu C, Jin H, Ding YQ. Transgelin as a suppressor is associated with poor prognosis in colorectal carcinoma patients. Modern Pathol 2009;22:786-796.
22. Starke RM, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez F, Hasan DM, Rosenwasser RH, Owens GK, Koch WJ, Dumont AS. Cigarette smoke modulates vascular smooth muscle phenotype: implications for carotid and cerebrovascular disease. PLoS One 2013;8:e71954.
23. Lockman K, Taylor JM, Mack CP. The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression. Circ Res 2007;101:e115-123.
24. Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein. Genes Dev 2002;16:2893-2905.
25. Kang H, Jung JW, Kim MK, Chung JH. CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PLoS One 2009;4:e6611.
26. Xie XL, Liu YB, Liu YP, Du BL, Li Y, Han M, Li BH. Reduced expression of SM22 is correlated with low autophagy activity in human colorectal cancer. Pathol Res Pract 2013;209:237-243.
27. Dixit D, Sharma V, Ghosh S, Mehta VS, Sen E. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFa)-induced apoptosis through SIRT1 inhibition. Cell Death Dis 2012;3:e271.
28. Maleszewska M, Gjaltema RA, Krenning G, Harmsen MC. Enhancer of zeste homolog-2 (EZH2) methyltransferase regulates transgelin/smooth muscle-22a expression in endothelial cells in response to interleukin-1b and transforming growth factor-b2. Cell Signal 2015;27:1589-1596.
29. Wong GS, Rustgi AK. Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis. Brit J Cancer 2013;108:755-761.
30. Radisky DC, Stallings-Mann M, Hirai Y, Bissell MJ. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol 2009;10:228-234.