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Volumn 11, Issue , 2017, Pages

Schizophrenia: What’s arc got to do with it?

Author keywords

Arg3.1; Behavior; Dopamine; Glutamate; Immediate early gene; Mice; RDoC

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; DOPAMINE; GLUTAMIC ACID; NEUROLEPTIC AGENT;

EID: 85031816860     PISSN: 16625153     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnbeh.2017.00181     Document Type: Review
Times cited : (11)

References (123)
  • 1
    • 79551663694 scopus 로고    scopus 로고
    • Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks
    • Alberi, L., Liu, S., Wang, Y., Badie, R., Smith-Hicks, C., Wu, J., et al. (2011). Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron 69, 437-444. doi: 10.1016/j.neuron.2011.01.004
    • (2011) Neuron , vol.69 , pp. 437-444
    • Alberi, L.1    Liu, S.2    Wang, Y.3    Badie, R.4    Smith-Hicks, C.5    Wu, J.6
  • 2
    • 0032832346 scopus 로고    scopus 로고
    • Memory impairment in schizophrenia: A meta-analysis
    • Aleman, A., Hijman, R., de Haan, E. H., and Kahn, R. S. (1999). Memory impairment in schizophrenia: a meta-analysis. Am. J. Psychiatry 156, 1358-1366. doi: 10.1176/ajp.156.9.1358
    • (1999) Am. J. Psychiatry , vol.156 , pp. 1358-1366
    • Aleman, A.1    Hijman, R.2    De Haan, E.H.3    Kahn, R.S.4
  • 3
    • 0003472502 scopus 로고    scopus 로고
    • American Psychiatric Association, Washington, DC: American Psychiatric Association
    • American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association.
    • (2013) Diagnostic and Statistical Manual of Mental Disorders
  • 5
    • 33749063363 scopus 로고    scopus 로고
    • Modeling madness in mice: One piece at a time
    • Arguello, P. A., and Gogos, J. A. (2006). Modeling madness in mice: one piece at a time. Neuron 52, 179-196. doi: 10.1016/j.neuron.2006. 09.023
    • (2006) Neuron , vol.52 , pp. 179-196
    • Arguello, P.A.1    Gogos, J.A.2
  • 6
    • 59149105577 scopus 로고    scopus 로고
    • Differential regulation of psychostimulant-induced gene expression of brain derived neurotrophic factor and the immediate-early gene Arc in the juvenile and adult brain
    • Banerjee, P. S., Aston, J., Khundakar, A. A., and Zetterstrom, T. S. (2009). Differential regulation of psychostimulant-induced gene expression of brain derived neurotrophic factor and the immediate-early gene Arc in the juvenile and adult brain. Eur. J. Neurosci. 29, 465-476. doi: 10.1111/j.1460-9568.2008. 06601.x
    • (2009) Eur. J. Neurosci , vol.29 , pp. 465-476
    • Banerjee, P.S.1    Aston, J.2    Khundakar, A.A.3    Zetterstrom, T.S.4
  • 7
    • 33947302270 scopus 로고    scopus 로고
    • Recognition memory for objects, place, and temporal order: A disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex
    • Barker, G. R. I., Bird, F., Alexander, V., and Warburton, E. C. (2007). Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex. J. Neurosci. 27, 2948-2957. doi: 10.1523/jneurosci.5289-06.2007
    • (2007) J. Neurosci , vol.27 , pp. 2948-2957
    • Barker, G.R.I.1    Bird, F.2    Alexander, V.3    Warburton, E.C.4
  • 8
    • 0018709829 scopus 로고
    • Efferent connections of the substantia nigra and ventral tegmental area in the rat
    • Beckstead, R. M., Domesick, V. B., and Nauta, W. J. (1979). Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res. 175, 191-217. doi: 10.1016/0006-8993(79)91001-1
    • (1979) Brain Res , vol.175 , pp. 191-217
    • Beckstead, R.M.1    Domesick, V.B.2    Nauta, W.J.3
  • 9
    • 85009881965 scopus 로고    scopus 로고
    • The arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese
    • Alzheimer’s Disease Neuroimaging Initiative, et al
    • Bi, R., Kong, L. L., Xu, M., Li, G. D., Zhang, D. F., Alzheimer’s Disease Neuroimaging Initiative, et al. (2017). The arc gene confers genetic susceptibility to Alzheimer’s disease in Han Chinese. Mol. Neurobiol. doi: 10.1007/s12035-017-0397-6
    • (2017) Mol. Neurobiol
    • Bi, R.1    Kong, L.L.2    Xu, M.3    Li, G.D.4    Zhang, D.F.5
  • 10
    • 85010966329 scopus 로고    scopus 로고
    • Repeated exposure to D-Amphetamine decreases global protein synthesis and regulates the translation of a subset of mRNAs in the striatum
    • Biever, A., Boubaker-Vitre, J., Cutando, L., Gracia-Rubio, I., Costa-Mattioli, M., Puighermanal, E., et al. (2017). Repeated exposure to D-Amphetamine decreases global protein synthesis and regulates the translation of a subset of mRNAs in the striatum. Front. Mol. Neurosci. 9:165. doi: 10.3389/fnmol.2016. 00165
    • (2017) Front. Mol. Neurosci , vol.9 , pp. 165
    • Biever, A.1    Boubaker-Vitre, J.2    Cutando, L.3    Gracia-Rubio, I.4    Costa-Mattioli, M.5    Puighermanal, E.6
  • 11
    • 84877709987 scopus 로고    scopus 로고
    • Social cognition in schizophrenia: From social stimuli processing to social engagement
    • Billeke, P., and Aboitiz, F. (2013). Social cognition in schizophrenia: from social stimuli processing to social engagement. Front. Psychiatry 4:4. doi: 10.3389/fpsyt.2013.00004
    • (2013) Front. Psychiatry , vol.4 , pp. 4
    • Billeke, P.1    Aboitiz, F.2
  • 12
    • 38049107884 scopus 로고    scopus 로고
    • Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways
    • Bloomer, W. A., VanDongen, H. M., and VanDongen, A. M. (2008). Arc/Arg3.1 translation is controlled by convergent N-methyl-D-aspartate and Gs-coupled receptor signaling pathways. J. Biol. Chem. 283, 582-592. doi: 10.1074/jbc.m702451200
    • (2008) J. Biol. Chem , vol.283 , pp. 582-592
    • Bloomer, W.A.1    Vandongen, H.M.2    Vandongen, A.M.3
  • 13
    • 84939793826 scopus 로고    scopus 로고
    • From the genetic architecture to synaptic plasticity in autism spectrum disorder
    • Bourgeron, T. (2015). From the genetic architecture to synaptic plasticity in autism spectrum disorder. Nat. Rev. Neurosci. 16, 551-563. doi: 10.1038/ nrn3992
    • (2015) Nat. Rev. Neurosci , vol.16 , pp. 551-563
    • Bourgeron, T.1
  • 14
    • 0025190458 scopus 로고
    • Sensorimotor gating and schizophrenia. Human and animal model studies
    • Braff, D. L., and Geyer, M. A. (1990). Sensorimotor gating and schizophrenia. Human and animal model studies. Arch. Gen. Psychiatry 47, 181-188. doi: 10.1001/archpsyc.1990.01810140081011
    • (1990) Arch. Gen. Psychiatry , vol.47 , pp. 181-188
    • Braff, D.L.1    Geyer, M.A.2
  • 16
    • 84997109194 scopus 로고    scopus 로고
    • Efficacy and safety of adjunctive bitopertin versus placebo in patients with suboptimally controlled symptoms of schizophrenia treated with antipsychotics: Results from three phase 3, randomised, double-blind, parallel-group, placebo-controlled, multicentre studies in the SearchLyte clinical trial programme
    • Bugarski-Kirola, D., Iwata, N., Sameljak, S., Reid, C., Blaettler, T., Millar, L., et al. (2016). Efficacy and safety of adjunctive bitopertin versus placebo in patients with suboptimally controlled symptoms of schizophrenia treated with antipsychotics: results from three phase 3, randomised, double-blind, parallel-group, placebo-controlled, multicentre studies in the SearchLyte clinical trial programme. Lancet Psychiatry 3, 1115-1128. doi: 10.1016/s2215-0366(16)30344-3
    • (2016) Lancet Psychiatry , vol.3 , pp. 1115-1128
    • Bugarski-Kirola, D.1    Iwata, N.2    Sameljak, S.3    Reid, C.4    Blaettler, T.5    Millar, L.6
  • 17
    • 0027490265 scopus 로고
    • Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder
    • Cadenhead, K. S., Geyer, M. A., and Braff, D. L. (1993). Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am. J. Psychiatry 150, 1862-1867. doi: 10.1176/ajp.150. 12.1862
    • (1993) Am. J. Psychiatry , vol.150 , pp. 1862-1867
    • Cadenhead, K.S.1    Geyer, M.A.2    Braff, D.L.3
  • 18
    • 0033806859 scopus 로고    scopus 로고
    • Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: Evidence of inhibitory deficits
    • Cadenhead, K. S., Swerdlow, N. R., Shafer, K. M., Diaz, M., and Braff, D. L. (2000). Modulation of the startle response and startle laterality in relatives of schizophrenic patients and in subjects with schizotypal personality disorder: evidence of inhibitory deficits. Am. J. Psychiatry 157, 1660-1668. doi: 10.1176/appi.ajp.157.10.1660
    • (2000) Am. J. Psychiatry , vol.157 , pp. 1660-1668
    • Cadenhead, K.S.1    Swerdlow, N.R.2    Shafer, K.M.3    Diaz, M.4    Braff, D.L.5
  • 19
    • 84874747160 scopus 로고    scopus 로고
    • Impairment of TrkB-PSD-95 signaling in Angelman syndrome
    • Cao, C., Rioult-Pedotti, M. S., Migani, P., Yu, C. J., Tiwari, R., Parang, K., et al. (2013). Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biol. 11:e1001478. doi: 10.1371/journal.pbio.1001478
    • (2013) Plos Biol , vol.11
    • Cao, C.1    Rioult-Pedotti, M.S.2    Migani, P.3    Yu, C.J.4    Tiwari, R.5    Parang, K.6
  • 20
    • 0034060459 scopus 로고    scopus 로고
    • Twin studies of schizophrenia: From bow-and-arrow concordances to star wars Mx and functional genomics
    • Cardno, A. G., and Gottesman, I. I. (2000). Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. Am. J. Med. Genet. 97, 12-17. doi: 10.1002/(sici)1096-8628(200021) 97:1<12::aid-ajmg3>3.3.co;2-l
    • (2000) Am. J. Med. Genet , vol.97 , pp. 12-17
    • Cardno, A.G.1    Gottesman, I.I.2
  • 21
    • 84957961024 scopus 로고    scopus 로고
    • Neuronal activity-induced sterol regulatory element binding protein-1 (SREBP1) is disrupted in dysbindin-null mice-potential link to cognitive impairment in schizophrenia
    • Chen, Y., Bang, S., McMullen, M. F., Kazi, H., Talbot, K., Ho, M. X., et al. (2017). Neuronal activity-induced sterol regulatory element binding protein-1 (SREBP1) is disrupted in dysbindin-null mice-potential link to cognitive impairment in schizophrenia. Mol. Neurobiol. 54, 1699-1709. doi: 10.1007/s12035-016-9773-x
    • (2017) Mol. Neurobiol , vol.54 , pp. 1699-1709
    • Chen, Y.1    Bang, S.2    McMullen, M.F.3    Kazi, H.4    Talbot, K.5    Ho, M.X.6
  • 22
    • 84881097682 scopus 로고    scopus 로고
    • Hippocampal Arc (Arg3.1) expression is induced by memory recall and required for memory reconsolidation in trace fear conditioning
    • Chia, C., and Otto, T. (2013). Hippocampal Arc (Arg3.1) expression is induced by memory recall and required for memory reconsolidation in trace fear conditioning. Neurobiol. Learn. Mem. 106, 48-55. doi: 10.1016/j.nlm. 2013.06.021
    • (2013) Neurobiol. Learn. Mem , vol.106 , pp. 48-55
    • Chia, C.1    Otto, T.2
  • 23
    • 33750506086 scopus 로고    scopus 로고
    • Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
    • Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., et al. (2006). Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52, 445-459. doi: 10.1016/j.neuron.2006. 08.033
    • (2006) Neuron , vol.52 , pp. 445-459
    • Chowdhury, S.1    Shepherd, J.D.2    Okuno, H.3    Lyford, G.4    Petralia, R.S.5    Plath, N.6
  • 25
    • 33749074397 scopus 로고    scopus 로고
    • Glutamate and schizophrenia: Beyond the dopamine hypothesis
    • Coyle, J. T. (2006). Glutamate and schizophrenia: beyond the dopamine hypothesis. Cell. Mol. Neurobiol. 26, 363-382. doi: 10.1007/s10571-006-9062-8
    • (2006) Cell. Mol. Neurobiol , vol.26 , pp. 363-382
    • Coyle, J.T.1
  • 26
    • 79961214161 scopus 로고    scopus 로고
    • The importance of having Arc: Expression of the immediate-early gene Arc is required for hippocampus-dependent fear conditioning and blocked by NMDA receptor antagonism
    • Czerniawski, J., Ree, F., Chia, C., Ramamoorthi, K., Kumata, Y., and Otto, T. A. (2011). The importance of having Arc: expression of the immediate-early gene Arc is required for hippocampus-dependent fear conditioning and blocked by NMDA receptor antagonism. J. Neurosci. 31, 11200-11207. doi: 10.1523/jneurosci.2211-11.2011
    • (2011) J. Neurosci , vol.31 , pp. 11200-11207
    • Czerniawski, J.1    Ree, F.2    Chia, C.3    Ramamoorthi, K.4    Kumata, Y.5    Otto, T.A.6
  • 28
    • 84872593582 scopus 로고    scopus 로고
    • Activity-dependent neuronal signalling and autism spectrum disorder
    • Ebert, D. H., and Greenberg, M. E. (2013). Activity-dependent neuronal signalling and autism spectrum disorder. Nature 493, 327-337. doi: 10.1038/nature11860
    • (2013) Nature , vol.493 , pp. 327-337
    • Ebert, D.H.1    Greenberg, M.E.2
  • 29
    • 78649908087 scopus 로고    scopus 로고
    • The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: A meta-analysis
    • Fett, A. K., Viechtbauer, W., Dominguez, M. D., Penn, D. L., van Os, J., and Krabbendam, L. (2011). The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci. Biobehav. Rev. 35, 573-588. doi: 10.1016/j.neubiorev.2010.07.001
    • (2011) Neurosci. Biobehav. Rev , vol.35 , pp. 573-588
    • Fett, A.K.1    Viechtbauer, W.2    Dominguez, M.D.3    Penn, D.L.4    Van Os, J.5    Krabbendam, L.6
  • 30
    • 73749086389 scopus 로고    scopus 로고
    • Anomalous neural circuit function in schizophrenia during a virtual Morris water task
    • Folley, B. S., Astur, R., Jagannathan, K., Calhoun, V. D., and Pearlson, G. D. (2010). Anomalous neural circuit function in schizophrenia during a virtual Morris water task. Neuroimage 49, 3373-3384. doi: 10.1016/j.neuroimage.2009.11.034
    • (2010) Neuroimage , vol.49 , pp. 3373-3384
    • Folley, B.S.1    Astur, R.2    Jagannathan, K.3    Calhoun, V.D.4    Pearlson, G.D.5
  • 31
    • 84896743886 scopus 로고    scopus 로고
    • Reviewing the ketamine model for schizophrenia
    • Frohlich, J., and Van Horn, J. D. (2014). Reviewing the ketamine model for schizophrenia. J. Psychopharmacol. 28, 287-302. doi: 10.1177/0269881113512909
    • (2014) J. Psychopharmacol , vol.28 , pp. 287-302
    • Frohlich, J.1    Van Horn, J.D.2
  • 32
    • 84893919352 scopus 로고    scopus 로고
    • De novo mutations in schizophrenia implicate synaptic networks
    • Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., et al. (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature 506, 179-184. doi: 10.1038/nature12929
    • (2014) Nature , vol.506 , pp. 179-184
    • Fromer, M.1    Pocklington, A.J.2    Kavanagh, D.H.3    Williams, H.J.4    Dwyer, S.5    Gormley, P.6
  • 33
    • 66449116639 scopus 로고    scopus 로고
    • Single session of cocaine intravenous self-administration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex
    • Fumagalli, F., Franchi, C., Caffino, L., Racagni, G., Riva, M. A., and Cervo, L. (2009). Single session of cocaine intravenous self-administration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex. Int. J. Neuropsychopharmacol. 12, 423-429. doi: 10.1017/s1461145708009681
    • (2009) Int. J. Neuropsychopharmacol , vol.12 , pp. 423-429
    • Fumagalli, F.1    Franchi, C.2    Caffino, L.3    Racagni, G.4    Riva, M.A.5    Cervo, L.6
  • 34
    • 77953077681 scopus 로고    scopus 로고
    • A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex
    • Gao, M., Sossa, K., Song, L., Errington, L., Cummings, L., Hwang, H., et al. (2010). A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex. J. Neurosci. 30, 7168-7178. doi: 10.1523/jneurosci.1067-10.2010
    • (2010) J. Neurosci , vol.30 , pp. 7168-7178
    • Gao, M.1    Sossa, K.2    Song, L.3    Errington, L.4    Cummings, L.5    Hwang, H.6
  • 36
    • 70349433522 scopus 로고    scopus 로고
    • Motivation and its relationship to neurocognition, social cognition, and functional outcome in schizophrenia
    • Gard, D. E., Fisher, M., Garrett, C., Genevsky, A., and Vinogradov, S. (2009). Motivation and its relationship to neurocognition, social cognition, and functional outcome in schizophrenia. Schizophr. Res. 115, 74-81. doi: 10.1016/j. schres.2009.08.015
    • (2009) Schizophr. Res , vol.115 , pp. 74-81
    • Gard, D.E.1    Fisher, M.2    Garrett, C.3    Genevsky, A.4    Vinogradov, S.5
  • 38
    • 0024405950 scopus 로고
    • Recall memory deficit in schizophrenia. A possible manifestation of prefrontal dysfunction
    • Goldberg, T. E., Weinberger, D. R., Pliskin, N. H., Berman, K. F., and Podd, M. H. (1989). Recall memory deficit in schizophrenia. A possible manifestation of prefrontal dysfunction. Schizophr. Res. 2, 251-257. doi: 10.1016/0920-9964(89)90001-7
    • (1989) Schizophr. Res , vol.2 , pp. 251-257
    • Goldberg, T.E.1    Weinberger, D.R.2    Pliskin, N.H.3    Berman, K.F.4    Podd, M.H.5
  • 39
    • 0029918481 scopus 로고    scopus 로고
    • What are the functional consequences of neurocognitive deficits in schizophrenia
    • Green, M. F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? Am. J. Psychiatry 153, 321-330. doi: 10.1176/ajp. 153.3.321
    • (1996) Am. J. Psychiatry , vol.153 , pp. 321-330
    • Green, M.F.1
  • 40
    • 84941875650 scopus 로고    scopus 로고
    • Social cognition in schizophrenia
    • Green, M. F., Horan, W. P., and Lee, J. (2015). Social cognition in schizophrenia. Nat. Rev. Neurosci. 16, 620-631. doi: 10.1038/nrn4005
    • (2015) Nat. Rev. Neurosci , vol.16 , pp. 620-631
    • Green, M.F.1    Horan, W.P.2    Lee, J.3
  • 41
    • 0033018320 scopus 로고    scopus 로고
    • Should schizophrenia be treated as a neurocognitive disorder?
    • Green, M. F., and Nuechterlein, K. H. (1999). Should schizophrenia be treated as a neurocognitive disorder? Schizophr. Bull. 25, 309-319. doi: 10.1093/oxfordjournals.schbul.a033380
    • (1999) Schizophr. Bull , vol.25 , pp. 309-319
    • Green, M.F.1    Nuechterlein, K.H.2
  • 42
    • 77649083119 scopus 로고    scopus 로고
    • The angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc
    • Greer, P. L., Hanayama, R., Bloodgood, B. L., Mardinly, A. R., Lipton, D. M., Flavell, S. W., et al. (2010). The angelman syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell 140, 704-716. doi: 10.1016/j. cell.2010.01.026
    • (2010) Cell , vol.140 , pp. 704-716
    • Greer, P.L.1    Hanayama, R.2    Bloodgood, B.L.3    Mardinly, A.R.4    Lipton, D.M.5    Flavell, S.W.6
  • 43
    • 84897115867 scopus 로고    scopus 로고
    • Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia
    • Guillozet-Bongaarts, A. L., Hyde, T. M., Dalley, R. A., Hawrylycz, M. J., Henry, A., Hof, P. R., et al. (2014). Altered gene expression in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol. Psychiatry 19, 478-485. doi: 10.1038/mp.2013.30
    • (2014) Mol. Psychiatry , vol.19 , pp. 478-485
    • Guillozet-Bongaarts, A.L.1    Hyde, T.M.2    Dalley, R.A.3    Hawrylycz, M.J.4    Henry, A.5    Hof, P.R.6
  • 44
    • 0034213297 scopus 로고    scopus 로고
    • Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory
    • Guzowski, J. F., Lyford, G. L., Stevenson, G. D., Houston, F. P., McGaugh, J. L., Worley, P. F., et al. (2000). Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J. Neurosci. 20, 3993-4001.
    • (2000) J. Neurosci , vol.20 , pp. 3993-4001
    • Guzowski, J.F.1    Lyford, G.L.2    Stevenson, G.D.3    Houston, F.P.4    McGaugh, J.L.5    Worley, P.F.6
  • 45
    • 0029051676 scopus 로고
    • The phencyclidine-glutamate model of schizophrenia
    • Halberstadt, A. L. (1995). The phencyclidine-glutamate model of schizophrenia. Clin. Neuropharmacol. 18, 237-249. doi: 10.1097/00002826-199506000-00004
    • (1995) Clin. Neuropharmacol , vol.18 , pp. 237-249
    • Halberstadt, A.L.1
  • 46
    • 33645230162 scopus 로고    scopus 로고
    • Negative symptoms and cognitive deficits: What is the nature of their relationship?
    • Harvey, P. D., Koren, D., Reichenberg, A., and Bowie, C. R. (2006). Negative symptoms and cognitive deficits: what is the nature of their relationship? Schizophr. Bull. 32, 250-258. doi: 10.1093/schbul/sbj011
    • (2006) Schizophr. Bull , vol.32 , pp. 250-258
    • Harvey, P.D.1    Koren, D.2    Reichenberg, A.3    Bowie, C.R.4
  • 47
    • 84872356828 scopus 로고    scopus 로고
    • World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: Update 2012 on the long-term treatment of schizophrenia and management of antipsychoticinduced side effects
    • Hasan, A., Falkai, P., Wobrock, T., Lieberman, J., Glenthoj, B., Gattaz, W. F., et al. (2013). World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychoticinduced side effects. World J. Biol. Psychiatry 14, 2-44. doi: 10.3109/15622975. 2012.739708
    • (2013) World J. Biol. Psychiatry , vol.14 , pp. 2-44
    • Hasan, A.1    Falkai, P.2    Wobrock, T.3    Lieberman, J.4    Glenthoj, B.5    Gattaz, W.F.6
  • 48
    • 84937966462 scopus 로고    scopus 로고
    • A novel maternally inherited 8q24.3 and a rare paternally inherited 14q23.3 CNVs in a family with neurodevelopmental disorders
    • Hu, J., Sathanoori, M., Kochmar, S., Azage, M., Mann, S., Madan-Khetarpal, S., et al. (2015). A novel maternally inherited 8q24.3 and a rare paternally inherited 14q23.3 CNVs in a family with neurodevelopmental disorders. Am. J. Med. Genet. A 167A, 1921-1926. doi: 10.1002/ajmg. a.37110
    • (2015) Am. J. Med. Genet. A , vol.167A , pp. 1921-1926
    • Hu, J.1    Sathanoori, M.2    Kochmar, S.3    Azage, M.4    Mann, S.5    Madan-Khetarpal, S.6
  • 49
    • 84949238528 scopus 로고    scopus 로고
    • Association of SNPs in EGR3 and ARC with schizophrenia supports a biological pathway for schizophrenia risk
    • Huentelman, M. J., Muppana, L., Corneveaux, J. J., Dinu, V., Pruzin, J. J., Reiman, R., et al. (2015). Association of SNPs in EGR3 and ARC with schizophrenia supports a biological pathway for schizophrenia risk. PLoS One 10:e0135076. doi: 10.1371/journal.pone.0135076
    • (2015) Plos One , vol.10
    • Huentelman, M.J.1    Muppana, L.2    Corneveaux, J.J.3    Dinu, V.4    Pruzin, J.J.5    Reiman, R.6
  • 50
    • 84942550270 scopus 로고    scopus 로고
    • Effects of glutamate positive modulators on cognitive deficits in schizophrenia: A systematic review and meta-analysis of double-blind randomized controlled trials
    • Iwata, Y., Nakajima, S., Suzuki, T., Keefe, R. S., Plitman, E., Chung, J. K., et al. (2015). Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials. Mol. Psychiatry 20, 1151-1160. doi: 10.1038/mp. 2015.68
    • (2015) Mol. Psychiatry , vol.20 , pp. 1151-1160
    • Iwata, Y.1    Nakajima, S.2    Suzuki, T.3    Keefe, R.S.4    Plitman, E.5    Chung, J.K.6
  • 51
    • 84884756183 scopus 로고    scopus 로고
    • Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression
    • Jakkamsetti, V., Tsai, N. P., Gross, C., Molinaro, G., Collins, K. A., Nicoletti, F., et al. (2013). Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression. Neuron 80, 72-79. doi: 10.1016/j.neuron.2013.07.020
    • (2013) Neuron , vol.80 , pp. 72-79
    • Jakkamsetti, V.1    Tsai, N.P.2    Gross, C.3    Molinaro, G.4    Collins, K.A.5    Nicoletti, F.6
  • 52
    • 0023870096 scopus 로고
    • Development of the dopaminergic innervation in the prefrontal cortex of the rat
    • Kalsbeek, A., Voorn, P., Buijs, R. M., Pool, C. W., and Uylings, H. B. (1988). Development of the dopaminergic innervation in the prefrontal cortex of the rat. J. Comp. Neurol. 269, 58-72. doi: 10.1002/cne. 902690105
    • (1988) J. Comp. Neurol , vol.269 , pp. 58-72
    • Kalsbeek, A.1    Voorn, P.2    Buijs, R.M.3    Pool, C.W.4    Uylings, H.B.5
  • 53
    • 77956648156 scopus 로고    scopus 로고
    • N-methyl-D-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?
    • Kantrowitz, J. T., and Javitt, D. C. (2010). N-methyl-D-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?. Brain Res. Bull. 83, 108-121. doi: 10.1016/j.brainresbull.2010. 04.006
    • (2010) Brain Res. Bull , vol.83 , pp. 108-121
    • Kantrowitz, J.T.1    Javitt, D.C.2
  • 54
    • 84863744270 scopus 로고    scopus 로고
    • Recurrent network activity drives striatal synaptogenesis
    • Kozorovitskiy, Y., Saunders, A., Johnson, C. A., Lowell, B. B., and Sabatini, B. L. (2012). Recurrent network activity drives striatal synaptogenesis. Nature 485, 646-650. doi: 10.1038/nature11052
    • (2012) Nature , vol.485 , pp. 646-650
    • Kozorovitskiy, Y.1    Saunders, A.2    Johnson, C.A.3    Lowell, B.B.4    Sabatini, B.L.5
  • 55
    • 84857348229 scopus 로고    scopus 로고
    • Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    • Kumar, V., Fahey, P. G., Jong, Y. J., Ramanan, N., and O’Malley, K. L. (2012). Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J. Biol. Chem. 287, 5412-5425. doi: 10.1074/jbc.M111.301366
    • (2012) J. Biol. Chem , vol.287 , pp. 5412-5425
    • Kumar, V.1    Fahey, P.G.2    Jong, Y.J.3    Ramanan, N.4    O’Malley, K.L.5
  • 56
    • 84888317489 scopus 로고    scopus 로고
    • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
    • Lambert, J. C., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013). Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat. Genet. 45, 1452-1458. doi: 10.1038/ng.2802
    • (2013) Nat. Genet , vol.45 , pp. 1452-1458
    • Lambert, J.C.1    Ibrahim-Verbaas, C.A.2    Harold, D.3    Naj, A.C.4    Sims, R.5    Bellenguez, C.6
  • 57
    • 0032987267 scopus 로고    scopus 로고
    • Increased dopamine transmission in schizophrenia: Relationship to illness phases
    • Laruelle, M., Abi-Dargham, A., Gil, R., Kegeles, L., and Innis, R. (1999). Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol. Psychiatry 46, 56-72. doi: 10.1016/s0006-3223(99)00067-0
    • (1999) Biol. Psychiatry , vol.46 , pp. 56-72
    • Laruelle, M.1    Abi-Dargham, A.2    Gil, R.3    Kegeles, L.4    Innis, R.5
  • 58
    • 33748474553 scopus 로고    scopus 로고
    • Pathophysiologically based treatment interventions in schizophrenia
    • Lewis, D. A., and Gonzalez-Burgos, G. (2006). Pathophysiologically based treatment interventions in schizophrenia. Nat. Med. 12, 1016-1022. doi: 10.1038/nm1478
    • (2006) Nat. Med , vol.12 , pp. 1016-1022
    • Lewis, D.A.1    Gonzalez-Burgos, G.2
  • 59
    • 0036308284 scopus 로고    scopus 로고
    • Schizophrenia as a disorder of neurodevelopment
    • Lewis, D. A., and Levitt, P. (2002). Schizophrenia as a disorder of neurodevelopment. Annu. Rev. Neurosci. 25, 409-432. doi: 10.1146/annurev. neuro.25.112701.142754
    • (2002) Annu. Rev. Neurosci , vol.25 , pp. 409-432
    • Lewis, D.A.1    Levitt, P.2
  • 60
    • 0033693190 scopus 로고    scopus 로고
    • Ventral tegmental area afferents to the prefrontal cortex maintain membrane potential ‘up’ states in pyramidal neurons via D(1) dopamine receptors
    • Lewis, B. L., and O’Donnell, P. (2000). Ventral tegmental area afferents to the prefrontal cortex maintain membrane potential ‘up’ states in pyramidal neurons via D(1) dopamine receptors. Cereb. Cortex 10, 1168-1175. doi: 10.1093/cercor/10.12.1168
    • (2000) Cereb. Cortex , vol.10 , pp. 1168-1175
    • Lewis, B.L.1    O’Donnell, P.2
  • 61
    • 84938320876 scopus 로고    scopus 로고
    • A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)’s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression
    • Li, Y., Pehrson, A. L., Waller, J. A., Dale, E., Sanchez, C., and Gulinello, M. (2015). A critical evaluation of the activity-regulated cytoskeleton-associated protein (Arc/Arg3.1)’s putative role in regulating dendritic plasticity, cognitive processes, and mood in animal models of depression. Front. Neurosci. 9:279. doi: 10.3389/fnins.2015.00279
    • (2015) Front. Neurosci , vol.9 , pp. 279
    • Li, Y.1    Pehrson, A.L.2    Waller, J.A.3    Dale, E.4    Sanchez, C.5    Gulinello, M.6
  • 62
    • 0029046978 scopus 로고
    • Somatodendritic expression of an immediate early gene is regulated by synaptic activity
    • Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., et al. (1995). Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc. Natl. Acad. Sci. U S A 92, 5734-5738. doi: 10.1073/pnas. 92.12.5734
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , pp. 5734-5738
    • Link, W.1    Konietzko, U.2    Kauselmann, G.3    Krug, M.4    Schwanke, B.5    Frey, U.6
  • 63
    • 0028853459 scopus 로고
    • Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
    • Lyford, G. L., Yamagata, K., Kaufmann, W. E., Barnes, C. A., Sanders, L. K., Copeland, N. G., et al. (1995). Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14, 433-445. doi: 10.1016/0896-6273(95) 90299-6
    • (1995) Neuron , vol.14 , pp. 433-445
    • Lyford, G.L.1    Yamagata, K.2    Kaufmann, W.E.3    Barnes, C.A.4    Sanders, L.K.5    Copeland, N.G.6
  • 64
    • 84962651842 scopus 로고    scopus 로고
    • Effects of Arc/Arg3.1 gene deletion on rhythmic synchronization of hippocampal CA1 neurons during locomotor activity and sleep
    • Malkki, H. A., Mertens, P. E., Lankelma, J. V., Vinck, M., van Schalkwijk, F. J., van Mourik-Donga, L. B., et al. (2016). Effects of Arc/Arg3.1 gene deletion on rhythmic synchronization of hippocampal CA1 neurons during locomotor activity and sleep. Neurobiol. Learn. Mem. 131, 155-165. doi: 10.1016/j.nlm. 2016.03.021
    • (2016) Neurobiol. Learn. Mem , vol.131 , pp. 155-165
    • Malkki, H.A.1    Mertens, P.E.2    Lankelma, J.V.3    Vinck, M.4    Van Schalkwijk, F.J.5    Van Mourik-Donga, L.B.6
  • 65
    • 84981738094 scopus 로고    scopus 로고
    • Genetic disruption of Arc/Arg3.1 in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia
    • Managò, F., Mereu, M., Mastwal, S., Mastrogiacomo, R., Scheggia, D., Emanuele, M., et al. (2016). Genetic disruption of Arc/Arg3.1 in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia. Cell Rep. 16, 2116-2128. doi: 10.1016/j.celrep.2016.07.044
    • (2016) Cell Rep , vol.16 , pp. 2116-2128
    • Managò, F.1    Mereu, M.2    Mastwal, S.3    Mastrogiacomo, R.4    Scheggia, D.5    Emanuele, M.6
  • 66
    • 79958246447 scopus 로고    scopus 로고
    • The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry
    • Manitt, C., Mimee, A., Eng, C., Pokinko, M., Stroh, T., Cooper, H. M., et al. (2011). The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. J. Neurosci. 31, 8381-8394. doi: 10.1523/JNEUROSCI.0606-11.2011
    • (2011) J. Neurosci , vol.31 , pp. 8381-8394
    • Manitt, C.1    Mimee, A.2    Eng, C.3    Pokinko, M.4    Stroh, T.5    Cooper, H.M.6
  • 67
    • 84997770295 scopus 로고    scopus 로고
    • Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects
    • Marshall, C. R., Howrigan, D. P., Merico, D., Thiruvahindrapuram, B., Wu, W., and Greer, D. S. (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat. Genet. 49, 27-35. doi: 10.1038/ng.3725
    • (2017) Nat. Genet , vol.49 , pp. 27-35
    • Marshall, C.R.1    Howrigan, D.P.2    Merico, D.3    Thiruvahindrapuram, B.4    Wu, W.5    Greer, D.S.6
  • 68
    • 84904282102 scopus 로고    scopus 로고
    • Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence
    • Mastwal, S., Ye, Y., Ren, M., Jimenez, D. V., Martinowich, K., Gerfen, C. R., et al. (2014). Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence. J. Neurosci. 34, 9484-9496. doi: 10.1523/JNEUROSCI. 1114-14.2014
    • (2014) J. Neurosci , vol.34 , pp. 9484-9496
    • Mastwal, S.1    Ye, Y.2    Ren, M.3    Jimenez, D.V.4    Martinowich, K.5    Gerfen, C.R.6
  • 69
    • 77953394141 scopus 로고    scopus 로고
    • Neural activity changes underlying the working memory deficit in a-CaMKII heterozygous knockout mice
    • Matsuo, N., Yamasaki, N., Ohira, K., Takao, K., Toyama, K., Eguchi, M., et al. (2009). Neural activity changes underlying the working memory deficit in a-CaMKII heterozygous knockout mice. Front. Behav. Neurosci. 3:20. doi: 10.3389/neuro.08.020.2009
    • (2009) Front. Behav. Neurosci , vol.3 , pp. 20
    • Matsuo, N.1    Yamasaki, N.2    Ohira, K.3    Takao, K.4    Toyama, K.5    Eguchi, M.6
  • 70
    • 84901246368 scopus 로고    scopus 로고
    • De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
    • McCarthy, S. E., Gillis, J., Kramer, M., Lihm, J., Yoon, S., Berstein, Y., et al. (2014). De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol. Psychiatry 19, 652-658. doi: 10.1038/mp.2014.29
    • (2014) Mol. Psychiatry , vol.19 , pp. 652-658
    • McCarthy, S.E.1    Gillis, J.2    Kramer, M.3    Lihm, J.4    Yoon, S.5    Berstein, Y.6
  • 71
    • 23044452836 scopus 로고    scopus 로고
    • Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus
    • McIntyre, C. K., Miyashita, T., Setlow, B., Marjon, K. D., Steward, O., Guzowski, J. F., et al. (2005). Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proc. Natl. Acad. Sci. U S A 102, 10718-10723. doi: 10.1073/pnas. 0504436102
    • (2005) Proc. Natl. Acad. Sci. U S A , vol.102 , pp. 10718-10723
    • McIntyre, C.K.1    Miyashita, T.2    Setlow, B.3    Marjon, K.D.4    Steward, O.5    Guzowski, J.F.6
  • 72
    • 85019152151 scopus 로고    scopus 로고
    • Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder
    • Mereu, M., Contarini, G., Buonaguro, E. F., Latte, G., Managò, F., Iasevoli, F., et al. (2017). Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder. Neuropharmacology 121, 179-194. doi: 10.1016/j.neuropharm.2017.04.037
    • (2017) Neuropharmacology , vol.121 , pp. 179-194
    • Mereu, M.1    Contarini, G.2    Buonaguro, E.F.3    Latte, G.4    Managò, F.5    Iasevoli, F.6
  • 73
    • 34848919232 scopus 로고    scopus 로고
    • Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo
    • Messaoudi, E., Kanhema, T., Soulé, J., Tiron, A., Dagyte, G., da Silva, B., et al. (2007). Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo. J. Neurosci. 27, 10445-10455. doi: 10.1523/JNEUROSCI. 2883-07.2007
    • (2007) J. Neurosci , vol.27 , pp. 10445-10455
    • Messaoudi, E.1    Kanhema, T.2    Soulé, J.3    Tiron, A.4    Dagyte, G.5    Da Silva, B.6
  • 74
    • 33748924655 scopus 로고    scopus 로고
    • Intermediate phenotypes and genetic mechanisms of psychiatric disorders
    • Meyer-Lindenberg, A., and Weinberger, D. R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat. Rev. Neurosci. 7, 818-827. doi: 10.1038/nrn1993
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 818-827
    • Meyer-Lindenberg, A.1    Weinberger, D.R.2
  • 75
    • 84899858579 scopus 로고    scopus 로고
    • Negative symptoms of schizophrenia: Clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment
    • Millan, M. J., Fone, K., Steckler, T., and Horan, W. P. (2014). Negative symptoms of schizophrenia: clinical characteristics, pathophysiological substrates, experimental models and prospects for improved treatment. Eur. Neuropsychopharmacol. 24, 645-692. doi: 10.1016/j.euroneuro.2014.03.008
    • (2014) Eur. Neuropsychopharmacol , vol.24 , pp. 645-692
    • Millan, M.J.1    Fone, K.2    Steckler, T.3    Horan, W.P.4
  • 76
    • 12344326514 scopus 로고    scopus 로고
    • Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs
    • Miyamoto, S., Duncan, G. E., Marx, C. E., and Lieberman, J. A. (2005). Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol. Psychiatry 10, 79-104. doi: 10.1038/sj.mp. 4001556
    • (2005) Mol. Psychiatry , vol.10 , pp. 79-104
    • Miyamoto, S.1    Duncan, G.E.2    Marx, C.E.3    Lieberman, J.A.4
  • 77
    • 39849094023 scopus 로고    scopus 로고
    • Networks of neurons, networks of genes: An integrated view of memory consolidation
    • Miyashita, T., Kubik, S., Lewandowski, G., and Guzowski, J. F. (2008). Networks of neurons, networks of genes: an integrated view of memory consolidation. Neurobiol. Learn. Mem. 89, 269-284. doi: 10.1016/j.nlm.2007.08.012
    • (2008) Neurobiol. Learn. Mem , vol.89 , pp. 269-284
    • Miyashita, T.1    Kubik, S.2    Lewandowski, G.3    Guzowski, J.F.4
  • 78
    • 34249785082 scopus 로고    scopus 로고
    • Effects of SKF-38393, a dopamine D1 receptor agonist on expression of amphetamineinduced behavioral sensitization and expression of immediate early gene arc in prefrontal cortex of rats
    • Moro, H., Sato, H., Ida, I., Oshima, A., Sakurai, N., Shihara, N., et al. (2007). Effects of SKF-38393, a dopamine D1 receptor agonist on expression of amphetamineinduced behavioral sensitization and expression of immediate early gene arc in prefrontal cortex of rats. Pharmacol. Biochem. Behav. 87, 56-64. doi: 10.1016/j. pbb.2007.03.020
    • (2007) Pharmacol. Biochem. Behav , vol.87 , pp. 56-64
    • Moro, H.1    Sato, H.2    Ida, I.3    Oshima, A.4    Sakurai, N.5    Shihara, N.6
  • 79
    • 4644373224 scopus 로고    scopus 로고
    • Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice
    • Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., et al. (2004). Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav. 3, 287-302. doi: 10.1111/j.1601-1848.2004.00076.x
    • (2004) Genes Brain Behav , vol.3 , pp. 287-302
    • Moy, S.S.1    Nadler, J.J.2    Perez, A.3    Barbaro, R.P.4    Johns, J.M.5    Magnuson, T.R.6
  • 80
    • 43449085499 scopus 로고    scopus 로고
    • Social approach and repetitive behavior in eleven inbred mouse strains
    • Moy, S. S., Nadler, J. J., Young, N. B., Nonneman, R. J., Segall, S. K., Andrade, G. M., et al. (2008). Social approach and repetitive behavior in eleven inbred mouse strains. Behav. Brain Res. 191, 118-129. doi: 10.1016/j.bbr.2008. 03.015
    • (2008) Behav. Brain Res , vol.191 , pp. 118-129
    • Moy, S.S.1    Nadler, J.J.2    Young, N.B.3    Nonneman, R.J.4    Segall, S.K.5    Rade, G.M.6
  • 81
    • 2942648152 scopus 로고    scopus 로고
    • Schizophrenia
    • Mueser, K. T., and McGurk, S. R. (2004). Schizophrenia. Lancet 363, 2063-2072. doi: 10.1016/S0140-6736(04)16458-1
    • (2004) Lancet , vol.363 , pp. 2063-2072
    • Mueser, K.T.1    McGurk, S.R.2
  • 82
    • 84935027067 scopus 로고    scopus 로고
    • Arc is a flexible modular protein capable of reversible selfoligomerization
    • Myrum, C., Baumann, A., Bustad, H. J., Flydal, M. I., Mariaule, V., Alvira, S., et al. (2015a). Arc is a flexible modular protein capable of reversible selfoligomerization. Biochem. J. 468, 145-158. doi: 10.1042/BJ20141446
    • (2015) Biochem. J , vol.468 , pp. 145-158
    • Myrum, C.1    Baumann, A.2    Bustad, H.J.3    Flydal, M.I.4    Mariaule, V.5    Alvira, S.6
  • 83
  • 84
    • 84920996955 scopus 로고    scopus 로고
    • Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory
    • Nakayama, D., Iwata, H., Teshirogi, C., Ikegaya, Y., Matsuki, N., and Nomura, H. (2015). Long-delayed expression of the immediate early gene Arc/Arg3.1 refines neuronal circuits to perpetuate fear memory. J. Neurosci. 35, 819-830. doi: 10.1523/JNEUROSCI.2525-14.2015
    • (2015) J. Neurosci , vol.35 , pp. 819-830
    • Nakayama, D.1    Iwata, H.2    Teshirogi, C.3    Ikegaya, Y.4    Matsuki, N.5    Nomura, H.6
  • 85
    • 84860112662 scopus 로고    scopus 로고
    • Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression
    • Niere, F., Wilkerson, J. R., and Huber, K. M. (2012). Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. J. Neurosci. 32, 5924-5936. doi: 10.1523/JNEUROSCI.4650-11.2012
    • (2012) J. Neurosci , vol.32 , pp. 5924-5936
    • Niere, F.1    Wilkerson, J.R.2    Huber, K.M.3
  • 86
    • 85031801327 scopus 로고    scopus 로고
    • NIH/NIMH, Research Domain Criteria (RDoC)
    • NIH/NIMH. (2017). Research Domain Criteria (RDoC). Available online at: https://www.nimh.nih.gov/research-priorities/rdoc/index.shtml
    • (2017)
  • 87
    • 84992337495 scopus 로고    scopus 로고
    • The implications of the shared genetics of psychiatric disorders
    • O’Donovan, M. C., and Owen, M. J. (2016). The implications of the shared genetics of psychiatric disorders. Nat. Med. 22, 1214-1219. doi: 10.1038/nm.4196
    • (2016) Nat. Med , vol.22 , pp. 1214-1219
    • O’Donovan, M.C.1    Owen, M.J.2
  • 88
    • 84860871082 scopus 로고    scopus 로고
    • Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIb
    • Okuno, H., Akashi, K., Ishii, Y., Yagishita-Kyo, N., Suzuki, K., Nonaka, M., et al. (2012). Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIb. Cell 149, 886-898. doi: 10.1016/j.cell.2012.02.062
    • (2012) Cell , vol.149 , pp. 886-898
    • Okuno, H.1    Akashi, K.2    Ishii, Y.3    Yagishita-Kyo, N.4    Suzuki, K.5    Nonaka, M.6
  • 89
    • 84856100262 scopus 로고    scopus 로고
    • Mouse models of genetic effects on cognition: Relevance to schizophrenia
    • Papaleo, F., Lipska, B. K., and Weinberger, D. R. (2012). Mouse models of genetic effects on cognition: relevance to schizophrenia. Neuropharmacology 62, 1204-1220. doi: 10.1016/j.neuropharm.2011.04.025
    • (2012) Neuropharmacology , vol.62 , pp. 1204-1220
    • Papaleo, F.1    Lipska, B.K.2    Weinberger, D.R.3
  • 90
    • 46149087988 scopus 로고    scopus 로고
    • Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD
    • Park, S., Park, J. M., Kim, S., Kim, J. A., Shepherd, J. D., Smith-Hicks, C. L., et al. (2008). Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59, 70-83. doi: 10.1016/j.neuron.2008.05.023
    • (2008) Neuron , vol.59 , pp. 70-83
    • Park, S.1    Park, J.M.2    Kim, S.3    Kim, J.A.4    Shepherd, J.D.5    Smith-Hicks, C.L.6
  • 91
    • 33750496896 scopus 로고    scopus 로고
    • Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
    • Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., et al. (2006). Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron 52, 437-444. doi: 10.1016/j.neuron.2006.08.024
    • (2006) Neuron , vol.52 , pp. 437-444
    • Plath, N.1    Ohana, O.2    Dammermann, B.3    Errington, M.L.4    Schmitz, D.5    Gross, C.6
  • 92
    • 58149379023 scopus 로고    scopus 로고
    • The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala
    • Ploski, J. E., Pierre, V. J., Smucny, J., Park, K., Monsey, M. S., Overeem, K. A., et al. (2008). The activity-regulated cytoskeletal-associated protein (Arc/Arg3.1) is required for memory consolidation of pavlovian fear conditioning in the lateral amygdala. J. Neurosci. 28, 12383-12395. doi: 10.1523/JNEUROSCI.1662-08.2008
    • (2008) J. Neurosci , vol.28 , pp. 12383-12395
    • Ploski, J.E.1    Pierre, V.J.2    Smucny, J.3    Park, K.4    Monsey, M.S.5    Overeem, K.A.6
  • 93
    • 84893904007 scopus 로고    scopus 로고
    • A polygenic burden of rare disruptive mutations in schizophrenia
    • Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., et al. (2014). A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185-190. doi: 10.1038/nature12975
    • (2014) Nature , vol.506 , pp. 185-190
    • Purcell, S.M.1    Moran, J.L.2    Fromer, M.3    Ruderfer, D.4    Solovieff, N.5    Roussos, P.6
  • 94
    • 44749094779 scopus 로고    scopus 로고
    • The cognitive neuroscience of memory function and dysfunction in schizophrenia
    • Ranganath, C., Minzenberg, M. J., and Ragland, J. D. (2008). The cognitive neuroscience of memory function and dysfunction in schizophrenia. Biol. Psychiatry 64, 18-25. doi: 10.1016/j.biopsych.2008.04.011
    • (2008) Biol. Psychiatry , vol.64 , pp. 18-25
    • Ranganath, C.1    Minzenberg, M.J.2    Ragland, J.D.3
  • 95
    • 84899845231 scopus 로고    scopus 로고
    • Arc regulates experience-dependent persistent firing patterns in frontal cortex
    • Ren, M., Cao, V., Ye, Y., Manji, H. K., and Wang, K. H. (2014). Arc regulates experience-dependent persistent firing patterns in frontal cortex. J. Neurosci. 34, 6583-6595. doi: 10.1523/JNEUROSCI.0167-14.2014
    • (2014) J. Neurosci , vol.34 , pp. 6583-6595
    • Ren, M.1    Cao, V.2    Ye, Y.3    Manji, H.K.4    Wang, K.H.5
  • 96
    • 33750513623 scopus 로고    scopus 로고
    • Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission
    • Rial Verde, E. M., Lee-Osbourne, J., Worley, P. F., Malinow, R., and Cline, H. T. (2006). Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron 52, 461-474. doi: 10.1016/j.neuron.2006.09.031
    • (2006) Neuron , vol.52 , pp. 461-474
    • Rial Verde, E.M.1    Lee-Osbourne, J.2    Worley, P.F.3    Malinow, R.4    Cline, H.T.5
  • 97
    • 0029899023 scopus 로고    scopus 로고
    • Patients with schizophrenia remember that an event has occurred, but not when
    • Rizzo, L., Danion, J. M., van der Linden, M., and Grange, D. (1996). Patients with schizophrenia remember that an event has occurred, but not when. Br. J. Psychiatry 168, 427-431. doi: 10.1192/bjp.168.4.427
    • (1996) Br. J. Psychiatry , vol.168 , pp. 427-431
    • Rizzo, L.1    Danion, J.M.2    Van Der Linden, M.3    Grange, D.4
  • 98
    • 84994588935 scopus 로고    scopus 로고
    • Activity-regulated cytoskeleton-associated protein accumulates in the nucleus in response to cocaine and acts as a brake on chromatin remodeling and long-term behavioral alterations
    • Salery, M., Dos Santos, M., Saint-Jour, E., Moumné, L., Pagès, C., Kappès, V., et al. (2017). Activity-regulated cytoskeleton-associated protein accumulates in the nucleus in response to cocaine and acts as a brake on chromatin remodeling and long-term behavioral alterations. Biol. Psychiatry 81, 573-584. doi: 10.1016/j. biopsych.2016.05.025
    • (2017) Biol. Psychiatry , vol.81 , pp. 573-584
    • Salery, M.1    Dos Santos, M.2    Saint-Jour, E.3    Moumné, L.4    Pagès, C.5    Kappès, V.6
  • 99
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427. doi: 10.1038/nature13595
    • (2014) Nature , vol.511 , pp. 421-427
  • 101
    • 79952006979 scopus 로고    scopus 로고
    • New views of Arc, a master regulator of synaptic plasticity
    • Shepherd, J. D., and Bear, M. F. (2011). New views of Arc, a master regulator of synaptic plasticity. Nat. Neurosci. 14, 279-284. doi: 10.1038/nn.2708
    • (2011) Nat. Neurosci , vol.14 , pp. 279-284
    • Shepherd, J.D.1    Bear, M.F.2
  • 102
    • 33750503402 scopus 로고    scopus 로고
    • Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors
    • Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., et al. (2006). Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron 52, 475-484. doi: 10.1016/j.neuron.2006.08.034
    • (2006) Neuron , vol.52 , pp. 475-484
    • Shepherd, J.D.1    Rumbaugh, G.2    Wu, J.3    Chowdhury, S.4    Plath, N.5    Kuhl, D.6
  • 103
    • 77649092400 scopus 로고    scopus 로고
    • A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia
    • Simpson, E. H., Kellendonk, C., and Kandel, E. (2010). A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia. Neuron 65, 585-596. doi: 10.1016/j.neuron.2010.02.014
    • (2010) Neuron , vol.65 , pp. 585-596
    • Simpson, E.H.1    Kellendonk, C.2    Kandel, E.3
  • 104
    • 84925401870 scopus 로고    scopus 로고
    • Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: A positron emission tomographic functional magnetic resonance imaging study
    • Slifstein, M., van de Giessen, E., Van Snellenberg, J., Thompson, J. L., Narendran, R., Gil, R., et al. (2015). Deficits in prefrontal cortical and extrastriatal dopamine release in schizophrenia: a positron emission tomographic functional magnetic resonance imaging study. JAMA Psychiatry 72, 316-324. doi: 10.1001/jamapsychiatry.2014.2414
    • (2015) JAMA Psychiatry , vol.72 , pp. 316-324
    • Slifstein, M.1    Van De Giessen, E.2    Van Snellenberg, J.3    Thompson, J.L.4    Narendran, R.5    Gil, R.6
  • 105
    • 80053626726 scopus 로고    scopus 로고
    • Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice
    • 103ra197
    • Smith, S. E., Zhou, Y. D., Zhang, G., Jin, Z., Stoppel, D. C., and Anderson, M. P. (2011). Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice. Sci. Transl. Med. 3:103ra197. doi: 10.1126/scitranslmed.3002627
    • (2011) Sci. Transl. Med , vol.3
    • Smith, S.E.1    Zhou, Y.D.2    Zhang, G.3    Jin, Z.4    Stoppel, D.C.5    Anderson, M.P.6
  • 106
    • 0035036344 scopus 로고    scopus 로고
    • Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation
    • Steward, O., and Worley, P. F. (2001). Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30, 227-240. doi: 10.1016/s0896-6273(01)00275-6
    • (2001) Neuron , vol.30 , pp. 227-240
    • Steward, O.1    Worley, P.F.2
  • 107
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • Sullivan, P. F., Kendler, K. S., and Neale, M. C. (2003). Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 60, 1187-1192. doi: 10.1001/archpsyc.60.12.1187
    • (2003) Arch. Gen. Psychiatry , vol.60 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 108
    • 46649110318 scopus 로고    scopus 로고
    • Realistic expectations of prepulse inhibition in translational models for schizophrenia research
    • Swerdlow, N. R., Weber, M., Qu, Y., Light, G. A., and Braff, D. L. (2008). Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology (Berl) 199, 331-388. doi: 10.1007/s00213-008-1072-4
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 331-388
    • Swerdlow, N.R.1    Weber, M.2    Qu, Y.3    Light, G.A.4    Braff, D.L.5
  • 109
    • 84923254821 scopus 로고    scopus 로고
    • Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice
    • Takagi, S., Balu, D. T., and Coyle, J. T. (2015). Subchronic pharmacological and chronic genetic NMDA receptor hypofunction differentially regulate the Akt signaling pathway and Arc expression in juvenile and adult mice. Schizophr. Res. 162, 216-221. doi: 10.1016/j.schres.2014. 12.034
    • (2015) Schizophr. Res , vol.162 , pp. 216-221
    • Takagi, S.1    Balu, D.T.2    Coyle, J.T.3
  • 110
    • 84879417053 scopus 로고    scopus 로고
    • Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia
    • Takao, K., Kobayashi, K., Hagihara, H., Ohira, K., Shoji, H., Hattori, S., et al. (2013). Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38, 1409-1425. doi: 10.1038/npp.2013.38
    • (2013) Neuropsychopharmacology , vol.38 , pp. 1409-1425
    • Takao, K.1    Kobayashi, K.2    Hagihara, H.3    Ohira, K.4    Shoji, H.5    Hattori, S.6
  • 111
    • 33750512959 scopus 로고    scopus 로고
    • Arc/Arg3.1: Linking gene expression to synaptic plasticity and memory
    • Tzingounis, A. V., and Nicoll, R. A. (2006). Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. Neuron 52, 403-407. doi: 10.1016/j.neuron. 2006.10.016
    • (2006) Neuron , vol.52 , pp. 403-407
    • Tzingounis, A.V.1    Nicoll, R.A.2
  • 112
    • 77749279516 scopus 로고    scopus 로고
    • Modeling the positive symptoms of schizophrenia in genetically modified mice: Pharmacology and methodology aspects
    • van den Buuse, M. (2010). Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects. Schizophr. Bull. 36, 246-270. doi: 10.1093/schbul/sbp132
    • (2010) Schizophr. Bull , vol.36 , pp. 246-270
    • Van Den Buuse, M.1
  • 113
    • 33746955145 scopus 로고    scopus 로고
    • Spatial exploration induces ARC, a plasticityrelated immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain
    • Vazdarjanova, A., Ramirez-Amaya, V., Insel, N., Plummer, T. K., Rosi, S., Chowdhury, S., et al. (2006). Spatial exploration induces ARC, a plasticityrelated immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J. Comp. Neurol. 498, 317-329. doi: 10.1002/cne. 21003
    • (2006) J. Comp. Neurol , vol.498 , pp. 317-329
    • Vazdarjanova, A.1    Ramirez-Amaya, V.2    Insel, N.3    Plummer, T.K.4    Rosi, S.5    Chowdhury, S.6
  • 114
    • 84957831300 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors induce a form of LTP controlled by translation and Arc signaling in the hippocampus
    • Wang, H., Ardiles, A. O., Yang, S., Tran, T., Posada-Duque, R., Valdivia, G., et al. (2016). Metabotropic glutamate receptors induce a form of LTP controlled by translation and Arc signaling in the hippocampus. J. Neurosci. 36, 1723-1729. doi: 10.1523/JNEUROSCI.0878-15.2016
    • (2016) J. Neurosci , vol.36 , pp. 1723-1729
    • Wang, H.1    Ardiles, A.O.2    Yang, S.3    Tran, T.4    Posada-Duque, R.5    Valdivia, G.6
  • 115
    • 46149123205 scopus 로고    scopus 로고
    • Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate
    • Waung, M. W., Pfeiffer, B. E., Nosyreva, E. D., Ronesi, J. A., and Huber, K. M. (2008). Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron 59, 84-97. doi: 10.1016/j.neuron.2008.05.014
    • (2008) Neuron , vol.59 , pp. 84-97
    • Waung, M.W.1    Pfeiffer, B.E.2    Nosyreva, E.D.3    Ronesi, J.A.4    Huber, K.M.5
  • 117
    • 43949112985 scopus 로고    scopus 로고
    • Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and ‘schizophrenia-related’ behaviors
    • Wiedholz, L. M., Owens, W. A., Horton, R. E., Feyder, M., Karlsson, R. M., Hefner, K., et al. (2008). Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and ‘schizophrenia-related’ behaviors. Mol. Psychiatry 13, 631-640. doi: 10.1038/sj.mp.4002056
    • (2008) Mol. Psychiatry , vol.13 , pp. 631-640
    • Wiedholz, L.M.1    Owens, W.A.2    Horton, R.E.3    Feyder, M.4    Karlsson, R.M.5    Hefner, K.6
  • 118
    • 77955173454 scopus 로고    scopus 로고
    • Clinical and genetic aspects of Angelman syndrome
    • Williams, C. A., Driscoll, D. J., and Dagli, A. I. (2010). Clinical and genetic aspects of Angelman syndrome. Genet. Med. 12, 385-395. doi: 10.1097/GIM. 0b013e3181def138
    • (2010) Genet. Med , vol.12 , pp. 385-395
    • Williams, C.A.1    Driscoll, D.J.2    Dagli, A.I.3
  • 119
    • 5044225291 scopus 로고    scopus 로고
    • Genes, dopamine and cortical signalto-noise ratio in schizophrenia
    • Winterer, G., and Weinberger, D. R. (2004). Genes, dopamine and cortical signalto-noise ratio in schizophrenia. Trends Neurosci. 27, 683-690. doi: 10.1016/j. tins.2004.08.002
    • (2004) Trends Neurosci , vol.27 , pp. 683-690
    • Winterer, G.1    Weinberger, D.R.2
  • 120
    • 80155123814 scopus 로고    scopus 로고
    • Arc/Arg3.1 regulates an endosomal pathway essential for activitydependent b-amyloid generation
    • Wu, J., Petralia, R. S., Kurushima, H., Patel, H., Jung, M. Y., Volk, L., et al. (2011). Arc/Arg3.1 regulates an endosomal pathway essential for activitydependent b-amyloid generation. Cell 147, 615-628. doi: 10.1016/j.cell. 2011.09.036
    • (2011) Cell , vol.147 , pp. 615-628
    • Wu, J.1    Petralia, R.S.2    Kurushima, H.3    Patel, H.4    Jung, M.Y.5    Volk, L.6
  • 121
    • 85024384475 scopus 로고    scopus 로고
    • Dopamine is required for activity-dependent amplification of Arc mRNA in developing postnatal frontal cortex
    • Ye, Y., Mastwal, S., Cao, V. Y., Ren, M., Liu, Q., Zhang, W., et al. (2016). Dopamine is required for activity-dependent amplification of Arc mRNA in developing postnatal frontal cortex. Cereb. Cortex doi: 10.1093/cercor/bhw181
    • (2016) Cereb. Cortex
    • Ye, Y.1    Mastwal, S.2    Cao, V.Y.3    Ren, M.4    Liu, Q.5    Zhang, W.6
  • 122
    • 84929163928 scopus 로고    scopus 로고
    • Structural basis of arc binding to synaptic proteins: Implications for cognitive disease
    • Zhang, W., Wu, J., Ward, M. D., Yang, S., Chuang, Y. A., Xiao, M., et al. (2015). Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron 86, 490-500. doi: 10.1016/j.neuron. 2015.03.030
    • (2015) Neuron , vol.86 , pp. 490-500
    • Zhang, W.1    Wu, J.2    Ward, M.D.3    Yang, S.4    Chuang, Y.A.5    Xiao, M.6
  • 123
    • 85007480353 scopus 로고    scopus 로고
    • Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders
    • Zhao, H., and Nyholt, D. R. (2017). Gene-based analyses reveal novel genetic overlap and allelic heterogeneity across five major psychiatric disorders. Hum. Genet. 136, 263-274. doi: 10.1007/s00439-016-1755-6
    • (2017) Hum. Genet , vol.136 , pp. 263-274
    • Zhao, H.1    Nyholt, D.R.2


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