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Volumn 25, Issue 1, 2018, Pages 39-53

Stimulation of anxiety-like behavior via ERK pathway by competitive serotonin receptors 2A and 1A in post-Traumatic stress disordered mice

Author keywords

5HT1AR; 5HT2AR; Anxiety like behavior; ERK pathway; Post Traumatic stress disorder

Indexed keywords

CRE RECOMBINASE; GENOMIC DNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR;

EID: 85031401532     PISSN: 1424862X     EISSN: 14248638     Source Type: Journal    
DOI: 10.1159/000481791     Document Type: Article
Times cited : (17)

References (49)
  • 3
    • 84893439165 scopus 로고    scopus 로고
    • Making memories of stressful events: A journey along epigenetic, gene transcription, and signaling, pathways
    • Reul JM: Making memories of stressful events: A journey along epigenetic, gene transcription, and signaling pathways. Front Psychiatry 2014;5:5.
    • (2014) Front Psychiatry , vol.5 , pp. 5
    • Reul, J.M.1
  • 4
    • 84870558067 scopus 로고    scopus 로고
    • Neurogenesis and generalization: A new approach to stratify and treat anxiety disorders
    • Kheirbek MA, Klemenhagen KC, Sahay A, Hen R: Neurogenesis and generalization: A new approach to stratify and treat anxiety disorders. Nat Neurosci 2012;15:1613-1620.
    • (2012) Nat Neurosci , vol.15 , pp. 1613-1620
    • Kheirbek, M.A.1    Klemenhagen, K.C.2    Sahay, A.3    Hen, R.4
  • 6
    • 3943103488 scopus 로고    scopus 로고
    • The amygdala modulates the consolidation of memories of emotionally arousing experiences
    • McGaugh JL: The amygdala modulates the consolidation of memories of emotionally arousing experiences. Annu Rev Neurosci 2004;27:1-28.
    • (2004) Annu Rev Neurosci , vol.27 , pp. 1-28
    • McGaugh, J.L.1
  • 7
    • 79551714028 scopus 로고    scopus 로고
    • Activity of 5-HT1A receptor is involved in neuronal apoptosis of the amygdala in a rat model of post-Traumatic stress disorder
    • Liu H, Wang HT, Han F, Shi YX: Activity of 5-HT1A receptor is involved in neuronal apoptosis of the amygdala in a rat model of post-Traumatic stress disorder. Mol Med Rep 2011;4:291-295.
    • (2011) Mol Med Rep , vol.4 , pp. 291-295
    • Liu, H.1    Wang, H.T.2    Han, F.3    Shi, Y.X.4
  • 9
    • 70449553410 scopus 로고    scopus 로고
    • Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: A rat model of post-stroke depression
    • Wang SH, Zhang ZJ, Guo YJ, Teng GJ, Chen BA: Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: A rat model of post-stroke depression. Psychiatry Res 2009;170:245-251.
    • (2009) Psychiatry Res , vol.170 , pp. 245-251
    • Wang, S.H.1    Zhang, Z.J.2    Guo, Y.J.3    Teng, G.J.4    Chen, B.A.5
  • 10
    • 0032145210 scopus 로고    scopus 로고
    • The spectrum of behaviors influenced by serotonin
    • Lucki I: The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998;44:151-162.
    • (1998) Biol Psychiatry , vol.44 , pp. 151-162
    • Lucki, I.1
  • 11
    • 0031799621 scopus 로고    scopus 로고
    • Mood and neuropsychological function in depression: The role of corticosteroids and serotonin
    • McAllister-Williams RH, Ferrier IN, Young AH: Mood and neuropsychological function in depression: The role of corticosteroids and serotonin. Psychol Med 1998;28:573-584.
    • (1998) Psychol Med , vol.28 , pp. 573-584
    • McAllister-Williams, R.H.1    Ferrier, I.N.2    Young, A.H.3
  • 12
    • 84862871694 scopus 로고    scopus 로고
    • Single-prolonged stress induce changes of CaM/CaMKIIalpha in the rats of dorsal raphe nucleus
    • Xie H, Han F, Shi X: Single-prolonged stress induce changes of CaM/CaMKIIalpha in the rats of dorsal raphe nucleus. Neurochem Res 2012;37:1043-1049.
    • (2012) Neurochem Res , vol.37 , pp. 1043-1049
    • Xie, H.1    Han, F.2    Shi, X.3
  • 13
    • 79952621309 scopus 로고    scopus 로고
    • Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle
    • Spannuth BM, Hale MW, Evans AK, Lukkes JL, Campeau S, Lowry CA: Investigation of a central nucleus of the amygdala/dorsal raphe nucleus serotonergic circuit implicated in fear-potentiated startle. Neuroscience 2011;179:104-119.
    • (2011) Neuroscience , vol.179 , pp. 104-119
    • Spannuth, B.M.1    Hale, M.W.2    Evans, A.K.3    Lukkes, J.L.4    Campeau, S.5    Lowry, C.A.6
  • 14
    • 84871190306 scopus 로고    scopus 로고
    • Serotonin circuits and anxiety: What can invertebrates teach us?
    • Curran KP, Chalasani SH: Serotonin circuits and anxiety: What can invertebrates teach us? Invert Neurosci 2012;12:81-92.
    • (2012) Invert Neurosci , vol.12 , pp. 81-92
    • Curran, K.P.1    Chalasani, S.H.2
  • 16
    • 27144536263 scopus 로고    scopus 로고
    • Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation
    • Vienna
    • Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP: Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm (Vienna) 2005;112:1479-1485.
    • (2005) J Neural Transm , vol.112 , pp. 1479-1485
    • Canli, T.1    Congdon, E.2    Gutknecht, L.3    Constable, R.T.4    Lesch, K.P.5
  • 17
    • 84856332025 scopus 로고    scopus 로고
    • Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, beta-catenin and antidepressant-like effects
    • Pilar-Cuellar F, Vidal R, Pazos A: Subchronic treatment with fluoxetine and ketanserin increases hippocampal brain-derived neurotrophic factor, beta-catenin and antidepressant-like effects. Br J Pharmacol 2012;165:1046-1057.
    • (2012) Br J Pharmacol , vol.165 , pp. 1046-1057
    • Pilar-Cuellar, F.1    Vidal, R.2    Pazos, A.3
  • 18
    • 0034687815 scopus 로고    scopus 로고
    • Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors
    • Sarnyai Z, Sibille EL, Pavlides C, Fenster RJ, McEwen BS, Toth M: Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors. Proc Natl Acad Sci U S A 2000;97:14731-14736.
    • (2000) Proc Natl Acad Sci, U S A , vol.97 , pp. 14731-14736
    • Sarnyai, Z.1    Sibille, E.L.2    Pavlides, C.3    Fenster, R.J.4    McEwen, B.S.5    Toth, M.6
  • 19
    • 84864660730 scopus 로고    scopus 로고
    • Effects of swim stress and fluoxetine on 5-HT1A receptor gene expression and monoamine metabolism in the rat brain regions
    • Shishkina GT, Kalinina TS, Dygalo NN: Effects of swim stress and fluoxetine on 5-HT1A receptor gene expression and monoamine metabolism in the rat brain regions. Cell Mol Neurobiol 2012;32:787-794.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 787-794
    • Shishkina, G.T.1    Kalinina, T.S.2    Dygalo, N.N.3
  • 21
    • 84884510184 scopus 로고    scopus 로고
    • The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway
    • Liu C, Zhang X, Zhou JX, Wei W, Liu DH, Ke P, Zhang GF, Cai GJ, Su DF: The protective action of ketanserin against lipopolysaccharide-induced shock in mice is mediated by inhibiting inducible NO synthase expression via the MEK/ERK pathway. Free Radic Biol Med 2013;65:658-666.
    • (2013) Free Radic Biol Med , vol.65 , pp. 658-666
    • Liu, C.1    Zhang, X.2    Zhou, J.X.3    Wei, W.4    Liu, D.H.5    Ke, P.6    Zhang, G.F.7    Cai, G.J.8    Su, D.F.9
  • 22
    • 84860343504 scopus 로고    scopus 로고
    • Conditioned fear stress combined with single-prolonged stress: A new PTSD mouse model
    • Wang H, Zuo D, He B, Qiao F, Zhao M, Wu Y: Conditioned fear stress combined with single-prolonged stress: A new PTSD mouse model. Neurosci Res 2012;73:142-152.
    • (2012) Neurosci Res , vol.73 , pp. 142-152
    • Wang, H.1    Zuo, D.2    He, B.3    Qiao, F.4    Zhao, M.5    Wu, Y.6
  • 23
    • 79251643772 scopus 로고    scopus 로고
    • Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD
    • Cohen H, Kaplan Z, Koresh O, Matar MA, Geva AB, Zohar J: Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD. Eur Neuropsychopharmacol 2011;21:230-240.
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 230-240
    • Cohen, H.1    Kaplan, Z.2    Koresh, O.3    Matar, M.A.4    Geva, A.B.5    Zohar, J.6
  • 24
    • 84902880986 scopus 로고    scopus 로고
    • Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in, aged mice
    • Li XM, Su F, Ji MH, Zhang GF, Qiu LL, Jia M, Gao J, Xie Z, Yang JJ: Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice. Anesthesiology 2014;121:79-88.
    • (2014) Anesthesiology , vol.121 , pp. 79-88
    • Li, X.M.1    Su, F.2    Ji, M.H.3    Zhang, G.F.4    Qiu, L.L.5    Jia, M.6    Gao, J.7    Xie, Z.8    Yang, J.J.9
  • 26
    • 84924086597 scopus 로고    scopus 로고
    • Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia
    • Yang Y, Gao K, Hu Z, Li W, Davies H, Ling S, Rudd JA, Fang M: Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia. Mediators Inflamm 2015;2015:120198.
    • (2015) Mediators Inflamm , vol.2015 , pp. 120198
    • Yang, Y.1    Gao, K.2    Hu, Z.3    Li, W.4    Davies, H.5    Ling, S.6    Rudd, J.A.7    Fang, M.8
  • 27
    • 84885002447 scopus 로고    scopus 로고
    • 5-HT1A receptor antagonists reduce food intake and body weight by reducing total meals with no conditioned taste aversion
    • Dill MJ, Shaw J, Cramer J, Sindelar DK: 5-HT1A receptor antagonists reduce food intake and body weight by reducing total meals with no conditioned taste aversion. Pharmacol Biochem Behav 2013;112:1-8.
    • (2013) Pharmacol Biochem Behav , vol.112 , pp. 1-8
    • Dill, M.J.1    Shaw, J.2    Cramer, J.3    Sindelar, D.K.4
  • 29
    • 84874358720 scopus 로고    scopus 로고
    • Ziprasidone ameliorates anxiety-like behaviors in a rat model of PTSD and up-regulates neurogenesis in the hippocampus and hippocampus-derived neural stem cells
    • Peng Z, Zhang R, Wang H, Chen Y, Xue F, Wang L, Yang F, Liu L, Kuang F, Tan Q: Ziprasidone ameliorates anxiety-like behaviors in a rat model of PTSD and up-regulates neurogenesis in the hippocampus and hippocampus-derived neural stem cells. Behav Brain Res 2013;244:1-8.
    • (2013) Behav Brain Res , vol.244 , pp. 1-8
    • Peng, Z.1    Zhang, R.2    Wang, H.3    Chen, Y.4    Xue, F.5    Wang, L.6    Yang, F.7    Liu, L.8    Kuang, F.9    Tan, Q.10
  • 31
    • 84867539538 scopus 로고    scopus 로고
    • Sex differences in fear memory and extinction of mice with forebrain-specific disruption of the mineralocorticoid receptor
    • Ter Horst JP, Carobrez AP, van Der Mark MH, de Kloet ER, Oitzl MS: Sex differences in fear memory and extinction of mice with forebrain-specific disruption of the mineralocorticoid receptor. Eur J Neurosci 2012;36:3096-3102.
    • (2012) Eur J Neurosci , vol.36 , pp. 3096-3102
    • Ter Horst, J.P.1    Carobrez, A.P.2    Van Der Mark, M.H.3    De Kloet, E.R.4    Oitzl, M.S.5
  • 32
    • 84959495496 scopus 로고    scopus 로고
    • Investigating the role of nisoldipine in foot-shock-induced post-Traumatic stress disorder in mice
    • Verma M, Bali A, Singh N, Jaggi AS: Investigating the role of nisoldipine in foot-shock-induced post-Traumatic stress disorder in mice. Fundam Clin Pharmacol 2016;30:128-136.
    • (2016) Fundam Clin Pharmacol , vol.30 , pp. 128-136
    • Verma, M.1    Bali, A.2    Singh, N.3    Jaggi, A.S.4
  • 33
    • 84863011717 scopus 로고    scopus 로고
    • Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus, following focal cerebral infarction
    • Xing S, Zhang Y, Li J, Zhang J, Li Y, Dang C, Li C, Fan Y, Yu J, Pei Z, Zeng J: Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction. Autophagy 2012;8:63-76.
    • (2012) Autophagy , vol.8 , pp. 63-76
    • Xing, S.1    Zhang, Y.2    Li, J.3    Zhang, J.4    Li, Y.5    Dang, C.6    Li, C.7    Fan, Y.8    Yu, J.9    Pei, Z.10    Zeng, J.11
  • 34
  • 37
    • 84871690753 scopus 로고    scopus 로고
    • Inhibitor of apoptosis protein-like protein-2 as a novel serological biomarker for breast cancer
    • Xiang M, Zhou W, Gao D, Fang X, Liu Q: Inhibitor of apoptosis protein-like protein-2 as a novel serological biomarker for breast cancer. Int J Mol Sci 2012;13:16737-16750.
    • (2012) Int J Mol Sci , vol.13 , pp. 16737-16750
    • Xiang, M.1    Zhou, W.2    Gao, D.3    Fang, X.4    Liu, Q.5
  • 38
    • 70349319632 scopus 로고    scopus 로고
    • Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats
    • Shi: Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats. Int J Mol Med 2009;24:.
    • (2009) Int J Mol Med , pp. 24
    • Shi1
  • 39
    • 84875712359 scopus 로고    scopus 로고
    • Changes in 5-HT1A receptor expression in the oculomotor nucleus in a rat model of post-Traumatic stress disorder
    • Liu D, Xiao B, Han F, Luo F, Wang E, Shi Y: Changes in 5-HT1A receptor expression in the oculomotor nucleus in a rat model of post-Traumatic stress disorder. J Mol Neurosci 2013;49:360-368.
    • (2013) J Mol Neurosci , vol.49 , pp. 360-368
    • Liu, D.1    Xiao, B.2    Han, F.3    Luo, F.4    Wang, E.5    Shi, Y.6
  • 40
    • 31844432926 scopus 로고    scopus 로고
    • The HPA and immune axes in stress: The involvement of the serotonergic system
    • Leonard BE: The HPA and immune axes in stress: The involvement of the serotonergic system. Eur Psychiatry 2005;20: 302-306.
    • (2005) Eur Psychiatry , vol.20 , pp. 302-306
    • Leonard, B.E.1
  • 41
    • 77953915171 scopus 로고    scopus 로고
    • 5HT-1A receptors and anxiety-like behaviours: Studies in rats with constitutionally upregulated/downregulated serotonin transporter
    • Bordukalo-Niksic T, Mokrovic G, Stefulj J, Zivin M, Jernej B, Cicin-Sain L: 5HT-1A receptors and anxiety-like behaviours: studies in rats with constitutionally upregulated/downregulated serotonin transporter. Behav Brain Res 2010;213:238-245.
    • (2010) Behav Brain Res , vol.213 , pp. 238-245
    • Bordukalo-Niksic, T.1    Mokrovic, G.2    Stefulj, J.3    Zivin, M.4    Jernej, B.5    Cicin-Sain, L.6
  • 42
    • 84857486022 scopus 로고    scopus 로고
    • Anxiety-like behavior and cognitive flexibility in adult rats perinatally exposed to increased serotonin concentrations
    • Blazevic S, Colic L, Culig L, Hranilovic D: Anxiety-like behavior and cognitive flexibility in adult rats perinatally exposed to increased serotonin concentrations. Behav Brain Res 2012;230:175-181.
    • (2012) Behav Brain Res , vol.230 , pp. 175-181
    • Blazevic, S.1    Colic, L.2    Culig, L.3    Hranilovic, D.4
  • 43
    • 0031925702 scopus 로고    scopus 로고
    • The role of serotonin in depression and anxiety
    • Deakin J: The role of serotonin in depression and anxiety. Eur Psychiatry 1998;13:S57s-63s.
    • (1998) Eur Psychiatry , vol.13
    • Deakin, J.1
  • 44
    • 77955769870 scopus 로고    scopus 로고
    • The serotonin 5-HT(2A) receptor agonist TCB-2: A behavioral and neurophysiological analysis
    • Berl
    • Fox MA, French HT, LaPorte JL, Blackler AR, Murphy DL: The serotonin 5-HT(2A) receptor agonist TCB-2: A behavioral and neurophysiological analysis. Psychopharmacology (Berl) 2010;212:13-23.
    • (2010) Psychopharmacology , vol.212 , pp. 13-23
    • Fox, M.A.1    French, H.T.2    LaPorte, J.L.3    Blackler, A.R.4    Murphy, D.L.5
  • 45
    • 84914678507 scopus 로고    scopus 로고
    • Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats
    • Chen L, Chen G, Guo Y, Liu L, Xiao L, Fan W, Shi B, Qian Y: Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. Liver Transpl 2014;20:1317-1326.
    • (2014) Liver Transpl , vol.20 , pp. 1317-1326
    • Chen, L.1    Chen, G.2    Guo, Y.3    Liu, L.4    Xiao, L.5    Fan, W.6    Shi, B.7    Qian, Y.8
  • 46
    • 0242600079 scopus 로고    scopus 로고
    • Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior
    • Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL: Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 2003;28:2077-2088.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 2077-2088
    • Holmes, A.1    Yang, R.J.2    Lesch, K.P.3    Crawley, J.N.4    Murphy, D.L.5
  • 47
    • 84930847687 scopus 로고    scopus 로고
    • Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety
    • Garcia-Garcia AL, Meng Q, Richardson-Jones J, Dranovsky A, Leonardo ED: Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience 2016;321:210- 221.
    • (2016) Neuroscience , vol.321 , pp. 210-221
    • Garcia-Garcia, A.L.1    Meng, Q.2    Richardson-Jones, J.3    Dranovsky, A.4    Leonardo, E.D.5
  • 48
    • 0042731683 scopus 로고    scopus 로고
    • A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: The involvement of MAP kinases
    • Kurrasch-Orbaugh DM, Parrish JC, Watts VJ, Nichols DE: A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: The involvement of MAP kinases. J Neurochem 2003;86:980-991.
    • (2003) J Neurochem , vol.86 , pp. 980-991
    • Kurrasch-Orbaugh, D.M.1    Parrish, J.C.2    Watts, V.J.3    Nichols, D.E.4
  • 49
    • 84872537290 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling
    • Franklin JM, Carrasco GA: Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling. Synapse 2013;67:145-159.
    • (2013) Synapse , vol.67 , pp. 145-159
    • Franklin, J.M.1    Carrasco, G.A.2


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