Coronary flow reserve is predictive of the risk of cardiovascular death regardless of chronic kidney disease stage

Kidney International

Volumn 93, Issue 2, 2018, Pages 501-509

  Charytan, David M ^a   Skali, Hicham ^a   Shah, Nishant R ^a   Veeranna, Vikas ^a   Cheezum, Michael K ^a   Taqueti, Viviany R ^a   Kato, Takashi ^a,b   Bibbo, Courtney R ^a   Hainer, Jon ^a   Dorbala, Sharmila ^a   Blankstein, Ron ^a   Di Carli, Marcelo F ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b GIFU PREFECTURAL GIFU HOSPITAL   (Japan)

Author keywords

cardiovascular disease; chronic kidney disease; end stage renal disease

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHRONIC KIDNEY FAILURE; COMORBIDITY; CORONARY FLOW RESERVE; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; HEART FAILURE; HEART INFARCTION; HEART MUSCLE BLOOD FLOW; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MYOCARDIAL PERFUSION IMAGING; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; COMPARATIVE STUDY; COMPLICATION; DIAGNOSTIC IMAGING; FRACTIONAL FLOW RESERVE; GLOMERULUS FILTRATION RATE; KIDNEY; MIDDLE AGED; MORTALITY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROCEDURES; PROGNOSIS; RISK FACTOR; SEVERITY OF ILLNESS INDEX; TIME FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; FEMALE; FRACTIONAL FLOW RESERVE, MYOCARDIAL; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; MALE; MIDDLE AGED; MYOCARDIAL PERFUSION IMAGING; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RENAL INSUFFICIENCY, CHRONIC; RISK ASSESSMENT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 85031319908     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2017.07.025     Document Type: Article

References (46)

1. Go, A.S., Chertow, G.M., Fan, D., et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351 (2004), 1296–1305.
2. Anavekar, N.S., McMurray, J.J., Velazquez, E.J., et al. Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. N Engl J Med 351 (2004), 1285–1295.
3. Foley, R.N., Parfrey, P.S., Sarnak, M.J., Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32:Suppl 3 (1998), S112–S119.
4. Pun, P.H., Smarz, T.R., Honeycutt, E.F., et al. Chronic kidney disease is associated with increased risk of sudden cardiac death among patients with coronary artery disease. Kidney Int 76 (2009), 652–658.
5. Amann, K., Wiest, G., Zimmer, G., et al. Reduced capillary density in the myocardium of uremic rats—a stereological study. Kidney Int 42 (1992), 1079–1085.
6. Jacobi, J., Porst, M., Cordasic, N., et al. Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats. Kidney Int 69 (2006), 2013–2021.
7. Charytan, D.M., Padera, R., Helfand, A.M., et al. Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease. Int J Cardiol 176 (2014), 99–109.
8. Amann, K., Breitbach, M., Ritz, E., Mall, G., Myocyte/capillary mismatch in the heart of uremic patients. J Am Soc Nephrol 9 (1998), 1018–1022.
9. Taqueti, V.R., Hachamovitch, R., Murthy, V.L., et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation 131 (2015), 19–27.
10. Taqueti, V.R., Everett, B.M., Murthy, V.L., et al. Interaction of impaired coronary flow reserve and cardiomyocyte injury on adverse cardiovascular outcomes in patients without overt coronary artery disease. Circulation 131 (2015), 528–535.
11. Farhad, H., Dunet, V., Bachelard, K., et al. Added prognostic value of myocardial blood flow quantitation in rubidium-82 positron emission tomography imaging. Eur Heart J Cardiovasc Imaging 14 (2013), 1203–1210.
12. Murthy, V.L., Naya, M., Foster, C.R., et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging 5 (2012), 1025–1034.
13. Shah, N.R., Charytan, D.M., Murthy, V.L., et al. Prognostic value of coronary flow reserve in patients with dialysis-dependent ESRD. J Am Soc Nephrol 27 (2016), 1823–1829.
14. Charytan, D.M., Shelbert, H.R., Di Carli, M.F., Coronary microvascular function in early chronic kidney disease. Circ Cardiovasc Imaging 3 (2010), 663–671.
15. Mohandas, R., Segal, M.S., Huo, T., et al. Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia. PloS One, 10, 2015, e0125374.
16. Chade, A.R., Brosh, D., Higano, S.T., et al. Mild renal insufficiency is associated with reduced coronary flow in patients with non-obstructive coronary artery disease. Kidney Int 69 (2006), 266–271.
17. Koivuviita, N., Tertti, R., Jarvisalo, M., et al. Increased basal myocardial perfusion in patients with chronic kidney disease without symptomatic coronary artery disease. Nephrol Dial Transplant 24 (2009), 2773–2779.
18. Tok, D., Gullu, H., Erdogan, D., et al. Impaired coronary flow reserve in hemodialysis patients: a transthoracic Doppler echocardiographic study. Nephron Clin Pract 101 (2005), c200–c206.
19. Foley, R.N., Parfrey, P.S., Harnett, J.D., et al. The impact of anemia on cardiomyopathy, morbidity, and mortality in end-stage renal disease. Am J Kidney Dis 28 (1996), 53–61.
20. Levin, A., Thompson, C.R., Ethier, J., et al. Left ventricular mass index increase in early renal disease: impact of decline in hemoglobin. Am J Kidney Dis 34 (1999), 125–134.
21. Kanbay, M., Goldsmith, D., Akcay, A., Covic, A., Phosphate—the silent stealthy cardiorenal culprit in all stages of chronic kidney disease: a systematic review. Blood Purif 27 (2009), 220–230.
22. Nakanishi, K., Fukuda, S., Shimada, K., et al. Prognostic value of coronary flow reserve on long-term cardiovascular outcomes in patients with chronic kidney disease. Am J Cardiol 112 (2013), 928–932.
23. Zhang, J., Bottiglieri, B., McCulough, P.A., The central role of endothelial dysfunction in cardiorenal syndrome. Cardiorenal Med 7 (2017), 104–117.
24. Dikow, R., Kihm, L.P., Zeier, M., et al. Increased infarct size in uremic rats: reduced ischemia tolerance?. J Am Soc Nephrol 15 (2004), 1530–1536.
25. Schellinger, I.N., Cordasic, N., Panesar, J., et al. Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease. Kidney Int 91 (2017), 616–627.
26. Matsumoto, Y., Ueda, S., Yamagishi, S., et al. Dimethylarginine dimethylaminohydrolase prevents progression of renal dysfunction by inhibiting loss of peritubular capillaries and tubulointerstitial fibrosis in a rat model of chronic kidney disease. J Am Soc Nephrol 18 (2007), 1525–1533.
27. Wu, M., Tang, R.N., Liu, H., et al. Cinacalcet ameliorates aortic calcification in uremic rats via suppression of endothelial-to-mesenchymal transition. Acta Pharmacol Sin 37 (2016), 1423–1431.
28. Thang, O.H., Serne, E.H., Grooteman, M.P., et al. Capillary rarefaction in advanced chronic kidney disease is associated with high phosphorus and bicarbonate levels. Nephrol Dial Transplant 26 (2011), 3529–3536.
29. Edwards-Richards, A., DeFreitas, M., Katsoufis, C.P., et al. Capillary rarefaction: an early marker of microvascular disease in young hemodialysis patients. Clin Kidney J 7 (2014), 569–574.
30. Koleganova, N., Piecha, G., Ritz, E., et al. Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic. Lab Invest 89 (2009), 520–530.
31. Kaul, S., The role of capillaries in determining coronary blood flow reserve: implications for stress-induced reversible perfusion defects. J Nucl Cardiol 8 (2001), 694–700.
32. Jayaweera, A.R., Wei, K., Coggins, M., et al. Role of capillaries in determining CBF reserve: new insights using myocardial contrast echocardiography. Am J Physiol 277 (1999), H2363–H2372.
33. Tsagalou, E.P., Anastasiou-Nana, M., Agapitos, E., et al. Depressed coronary flow reserve is associated with decreased myocardial capillary density in patients with heart failure due to idiopathic dilated cardiomyopathy. J Am Coll Cardiol 52 (2008), 1391–1398.
34. Schubert, S., Abdul-Khaliq, H., Wellnhofer, E., et al. Coronary flow reserve measurement detects transplant coronary artery disease in pediatric heart transplant patients. J Heart Lung Transplant 27 (2008), 514–521.
35. Kuhle, W.G., Porenta, G., Huang, S.C., et al. Quantification of regional myocardial blood flow using 13N-ammonia and reoriented dynamic positron emission tomographic imaging. Circulation 86 (1992), 1004–1017.
36. Nitzsche, E.U., Choi, Y., Czernin, J., et al. Noninvasive quantification of myocardial blood flow in humans. A direct comparison of the [13N]ammonia and the [15O]water techniques. Circulation 93 (1996), 2000–2006.
37. Camici, P.G., Crea, F., Coronary microvascular dysfunction. N Engl J Med 356 (2007), 830–840.
38. Buus, N.H., Bottcher, M., Hermansen, F., et al. Influence of nitric oxide synthase and adrenergic inhibition on adenosine-induced myocardial hyperemia. Circulation 104 (2001), 2305–2310.
39. Murthy, V.L., Naya, M., Foster, C.R., et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation 124 (2011), 2215–2224.
40. Cerqueira, M.D., Weissman, N.J., Dilsizian, V., et al., American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105 (2002), 539–542.
41. Levey, A.S., Stevens, L.A., Schmid, C.H., et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 150 (2009), 604–612.
42. Levey, A.S., Coresh, J., Balk, E., et al. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139 (2003), 137–147.
43. Nakamori, S., Onishi, K., Ishida, M., et al. Myocardial perfusion reserve is impaired in patients with chronic obstructive pulmonary disease: a comparison to current smokers. Eur Heart J Cardiovasc Imaging 15 (2014), 180–188.
44. Niiranen, T.J., Vasan, R.S., Epidemiology of cardiovascular disease: recent novel outlooks on risk factors and clinical approaches. Expert Rev Cardiovasc Ther 14 (2016), 855–869.
45. Labazi, H., Trask, A.J., Coronary microvascular disease as an early culprit in the pathophysiology of diabetes and metabolic syndrome. Pharmacol Res 123 (2017), 114–121.
46. Graham, G., Racial and ethnic differences in acute coronary syndrome and myocardial infarction within the United States: from demographics to outcomes. Clin Cardiol 39 (2016), 299–306.