Anti-hyperglycemic effect of aqueous extract of Juglans regia L. leaf (walnut leaf) on type 2 diabetic patients: A randomized controlled trial

Advances in Integrative Medicine

Volumn 4, Issue 3, 2017, Pages 98-102

  Abdoli, Mahsima ^a,b   Dabaghian, Fataneh Hashem ^a   Goushegir, Ashrafeddin ^a   Shirazi, Maryam Taghavi ^a   Nakhjavani, Manuchehr ^c   Shojaii, Asie ^a   Rezvani, Shirin ^c   Mahlooji, Kamran ^c  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b BABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diabetes mellitus; Herbal medicine; Juglans regia; Persian medicine; Randomized controlled trial

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CREATININE; FLAVONOID; HEMOGLOBIN A1C; JUGLANS REGIA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIDIABETIC ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; JUGLANS REGIA; KIDNEY FUNCTION; LIVER FUNCTION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PLANT LEAF; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UREA NITROGEN BLOOD LEVEL;

EID: 85030844172     PISSN: 22129588     EISSN: 22129596     Source Type: Journal    
DOI: 10.1016/j.aimed.2017.10.001     Document Type: Article

References (37)

1. Shaw, J.E., Sicree, R.A., Zimmet, P.Z., Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 87:1 (2010), 4–14.
2. Esteghamati, A., Gouya, M.M., Abbasi, M., Delavari, A., Alikhani, S., Alaedini, F., et al. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran. Diabetes Care 31:1 (2008), 96–98.
3. Philippe, J., Raccah, D., Treating type 2 diabetes: how safe are current therapeutic agents?. Int. J. Clin. Pract. 63:2 (2009), 321–332.
4. Gilbert, M.P., Pratley, R.E., Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus. Eur. J. Intern. Med. 20:Suppl. 2 (2009), S309–S318.
5. Zarshenas, M.M., Khademian, S., Moein, M., Diabetes and related remedies in medieval Persian medicine. Indian J. Endocrinol. Metab. 18:2 (2014), 142–149.
6. Zarshenas, M.M., Jamshidi, S., Zargaran, A., Cardiovascular aspects of geriatric medicines in traditional Persian medicine; a review of phytochemistry and pharmacology. Phytomedicine 23:11 (2016), 1182–1189.
7. Sadighi, J., Maftoon, F., Moshrefi, M., Knowledge, attitude and use of complementary medicine in Tehran. Payesh 3:4 (2004), 279–289.
8. Tehrani Banihashemi, S.A., Asghrifard, H., Haghdoost, A.A., Barghmadi, M., Mohammadhosseini, N., The use of complementary/alternative medicine among the general population in Tehran. Payesh 5:4 (2008), 355–362.
9. Chang, H.Y., Wallis, M., Tiralongo, E., Use of complementary and alternative medicine among people living with diabetes: literature review. J. Adv. Nurs. 58:4 (2007), 307–319.
10. Panth, N., Paudel, K.R., Karki, R., Phytochemical profile and biological activity of Juglans regia. J. Integr. Med. 14:5 (2016), 359–373.
11. Almonte-Flores, D.C., Paniagua-Castro, N., Escalona-Cardoso, G., Rosales-Castro, M., Pharmacological and genotoxic properties of polyphenolic extracts of Cedrela odorata L. and Juglans regia L. Barks in rodents. Evid. Based Complement. Alternat. Med., 2015, 187346, 10.1155/2015/187346.
12. Asgary, S., Parkhideh, S., Solhpour, A., Madani, H., Mahzouni, P., Rahimi, P., Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced rats. J. Med. Food 11:3 (2008), 533–538.
13. Javidanpour, S., Fatemi Tabtabaei, S., Siahpoosh, A., Morovati, H., Shahriari, A., Comparison of the effects of fresh leaf and peel extracts of walnut (Juglans regia L.) on blood glucose and β-cells of streptozotocin-induced diabetic rats. Vet. Res. Forum 3:4 (2012), 251–255.
14. Noureddini, M., Rezaee-Joshogani, F., The comparative effects of aqueous extract of walnut (Juglans regia) leaf and glibenclamide on serum glucose levels of alloxan-induced diabetic rats. Zahedan J. Res. Med. Sci. 5:11 (2012), 9–14.
15. Komeili, G.H., Bagheri, H., Effects of walnut leaf aqueous extract on blood sugar and lipids in male diabetic rats. Saudi Med. J. 29:9 (2008), 447–448.
16. Said, S., Fulder, K.H., Khalil, H., Azaizeh, E., Kassis, B., Maintaining a physiological blood glucose level with ‘Glucolevel’, a combination of four anti-diabetes plants used in the traditional arab herbal medicine. Evid. Based Complement. Alternat. Med. 5:4 (2008), 421–428.
17. S, Hosseini, L., Jamshidi, S., Mehrzadi, K., Mohammad, A.R., Najmizadeh, Alimoradi, H., et al. Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial. J. Ethnopharmacol. 152:3 (2014), 451–456.
18. Hosseinzadeh, H., Zarei, H., Taghiabadi, E., Antinociceptive, anti-inflammatory and acute toxicity effects of juglans regia L. Leaves in mice. Iran. Red Crescent Med. J. 13:1 (2011), 27–33.
19. Nickavar, B., Kamalinejad, M., Haj-Yahya, M., Shafaghi, B., Comparison of the free radical scavenging activity of six Iranian achillea species. Pharm. Biol. 44:3 (2006), 208–212.
20. Jelodar, G., Mohsen, M., Shahram, S., Effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. Afr. J. Tradit. Complement. Altern. Med. 4:3 (2007), 299–305.
21. Ortiz-Andrade, R.R., Garcia-Jimenez, S., Castillo-Espana, P., Ramirez-Avila, G., Villalobos-Molina, R., Estrada-Soto, S., alpha-Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: an anti-hyperglycemic agent. J. Ethnopharmacol. 109:1 (2007), 48–53.
22. Del Rio, D., Rodriguez-Mateos, A., Spencer, J.P., Tognolini, M., Borges, G., Crozier, A., Dietary(poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid. Redox Signal. 18:14 (2013), 1818–1892.
23. Pickup, J.C., Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27:3 (2004), 813–823.
24. Banerji, M.A., Buckley, M.C., Chaiken, R.L., Gordon, D., Lebovitz, H.E., Kral, J.G., Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM. Int. J. Obes. Relat. Metab. Disord. 19:12 (1995), 846–850.
25. Madani, H., Rahimi, P., Mahzouni, P., Effects of hydroalcoholic extract of Juglans regia leaves on activity of ast and alt enzymes in alloxan- induced diabetic rats. Pharm. Sci. 15:2 (2009), 213–218.
26. Tsasi, G., Milošević-Ifantis, T., Skaltsa, H., Phytochemical study of Juglans regia L. pericarps from Greece with a chemotaxonomic approach. Chem. Biodivers. 13:12 (2016), 1636–1640.
27. Amaral, J.S., Seabra, R.M., Andrade, P.B., Valent, A.O.P., Pereira, J.A., Ferreres, F., Phenolic profile in the quality control of walnut (Juglans regia L.) leaves. J. Food Chem. 88 (2004), 373–379.
28. Pereira, I., Oliveira, A., Sousa, P., Valentao, P.B., Andrade, I.C., et al. Walnut (Juglans regia L.) leaves: phenolic compounds, antibacterial activity and antioxidant potential of different cultivars. Food Chem. Toxicol. 45:11 (2007), 2287–2295.
29. Jalili, A., Sadeghzade, A., Comparative phenolic profile of Persian walnut (Juglans regia L.) leaves cultivars grown in Iran. Afr. J. Biochem. Res. 6 (2012), 33–38.
30. Narita, Y., Inouye, K., Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas α-amylase isozymes I and II. J. Agric. Food. Chem. 57:19 (2009), 9218–9225.
31. Kim, C.S., Kim, J., Lee, Y.M., Sohn, E., Jo, K., Kim, J.S., Inhibitory effects of chlorogenic acid on aldose reductase activity in vitro and cataractogenesis in galactose-fed rats. Arch. Pharm. Res. 4:5 (2011), 847–852.
32. Pereira, J.A., Oliveira, I., Sousa, A., Ferreira, I.C., Bento, A., Estevinho, L., Bioactive properties and chemical composition of six walnut (Juglans regia L.) cultivars. Food Chem. Toxicol. 6:6 (2008), 2103–2111.
33. Sun, J., Chu, Y.F., Wu, X., Liu, R.H., Antioxidant and antiproliferative activities of common fruits. J. Agric. Food. Chem. 50:25 (2002), 7449–7454.
34. Carvalho, M., Ferreira, P.J., Mendes, V.S., Silva, R., Pereira, J.A., Jeronimo, C., et al. Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food Chem. Toxicol. 48:1 (2010), 441–447.
35. Rahimi, R., Nikfar, S., Larijani, B., Abdollahi, M., A review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother. 9:7 (2005), 365–373.
36. Xiao, J., Kai, G., Yamamoto, K., Chen, X., Advance in dietary polyphenols as alpha-glucosidases inhibitors: a review on structure-activity relationship aspect. Crit. Rev. Food Sci. Nutr. 3:8 (2013), 818–836.
37. Hosseini, S., Huseini, H.F., Larijani, B., Mohammad, K., Najmizadeh, A., Nourijelyani, K., et al. The hypoglycemic effect of Juglans regia leaves aqueous extract in diabetic patients: a first human trial. Daru, 22(1), 2014, 19.