Deciphering the molecular mechanism underlying anticancer activity of coumestrol in triple-negative breast cancer cells

Toxicology in Vitro

Volumn 46, Issue , 2018, Pages 19-28

  Zafar, Atif ^a   Singh, Swarnendra ^b   Satija, Yatendra Kumar ^c   Saluja, Daman ^c   Naseem, Imrana ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c UNIVERSITY OF DELHI   (India)

Author keywords

Apoptosis; Coumestrol; DNA damage; ROS; Triple negative breast cancer

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; ACETYLCYSTEINE; COPPER; COUMESTROL; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; BAX PROTEIN, HUMAN; PHYTOESTROGEN; PROTEIN BINDING;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MDA-MB-231 CELL LINE; MITOCHONDRIAL MEMBRANE; MOLECULAR DOCKING; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN SECRETION; PROTEIN STRUCTURE; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION; DRUG EFFECT; FEMALE; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR MODEL; PROTEIN CONFORMATION; SCANNING ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASTRUCTURE;

BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; COUMESTROL; DNA DAMAGE; FEMALE; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, SCANNING; MODELS, MOLECULAR; PHYTOESTROGENS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 85030830547     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2017.10.007     Document Type: Article

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