Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

Nature Medicine

Volumn 23, Issue 10, 2017, Pages 1234-1240

  Kuntz, Elodie M ^a   Baquero, Pablo ^b   Michie, Alison M ^c   Dunn, Karen ^c   Tardito, Saverio ^d   Holyoake, Tessa L ^c   Helgason, G Vignir ^b   Gottlieb, Eyal ^a,d  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; GLUCOSE C 13; GLUTAMINE C 13; IMATINIB; PALMITIC ACID C 13; PHENFORMIN; STABLE ISOTOPE; TIGECYCLINE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; MINOCYCLINE; PROTEIN KINASE INHIBITOR;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RESISTANCE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL FUNCTION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLOMICS; MINIMAL RESIDUAL DISEASE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION; XENOTRANSPLANTATION; ANALOGS AND DERIVATIVES; ANIMAL; CELL SURVIVAL; COMBINATION DRUG THERAPY; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; NONOBESE DIABETIC MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; TUMOR STEM CELL ASSAY; WESTERN BLOTTING;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOTTING, WESTERN; CELL SURVIVAL; CHROMATOGRAPHY, LIQUID; DRUG RESISTANCE, NEOPLASM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; IMATINIB MESYLATE; IN VITRO TECHNIQUES; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MASS SPECTROMETRY; METABOLOMICS; MICE; MICE, INBRED NOD; MINOCYCLINE; MITOCHONDRIA; NEOPLASTIC STEM CELLS; OXIDATIVE PHOSPHORYLATION; PHENFORMIN; PROTEIN KINASE INHIBITORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85030765321     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4399     Document Type: Article

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