Simultaneous quantitative analysis of uremic toxins by LC–MS/MS with a reversed-phase/cation-exchange/anion-exchange tri-modal mixed-mode column

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 1068-1069, Issue , 2017, Pages 1-8

  Kanemitsu, Yoshitomi ^a   Asaji, Kei ^a   Matsumoto, Yotaro ^a   Tsukamoto, Hiroki ^a   Saigusa, Daisuke ^a   Mukawa, Chikahisa ^a   Tachikawa, Tatsuki ^a   Abe, Takaaki ^a,b   Tomioka, Yoshihisa ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Chronic kidney disease (CKD); liquid chromatography tandem mass spectrometry (LC MS MS); Mixed mode chromatography (MMC); Scherzo SS C18; Uremic toxins (UTx)

Indexed keywords

CHEMICAL ANALYSIS; CHROMATOGRAPHY; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; SPECTROMETRY; SULFUR COMPOUNDS; TOXIC MATERIALS;

CHRONIC KIDNEY DISEASE; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MIXEDMODE CHROMATOGRAPHIES (MMC); SCHERZO SS-C18; UREMIC TOXINS;

COLUMN CHROMATOGRAPHY;

1 METHYLADENOSINE; 4 CRESYL SULFATE; 4 ETHYLPHENYL SULFATE; CREATININE; INDICAN; PHENYL SULFATE; STABLE ISOTOPE; TRIMETHYLAMINE OXIDE; UNCLASSIFIED DRUG; UREMIC TOXIN; TOXIN;

ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; BLOOD ANALYSIS; CHROMATOGRAPHY BY MOBILE PHASE; CHRONIC KIDNEY FAILURE; HUMAN; ION EXCHANGE CHROMATOGRAPHY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PKA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; BLOOD; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, ION EXCHANGE; CHROMATOGRAPHY, REVERSE-PHASE; HUMANS; LINEAR MODELS; RENAL INSUFFICIENCY, CHRONIC; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TOXINS, BIOLOGICAL;

EID: 85030754031     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2017.10.009     Document Type: Article

References (33)

1. Wang, L., Wei, W., Xia, Z., et al. Recent advances in materials for stationary phases of mixed-mode high-performance liquid chromatography. TrAC –Trends Anal. Chem. 80 (2016), 495–506.
2. Qiu, H., Mallik, A.K., Takafuji, M., et al. New poly(ionic liquid)-grafted silica multi-mode stationary phase for anion-exchange/reversed-phase/hydrophilic interaction liquid chromatography. Analyst 137 (2012), 2553–2555.
3. Cai, X., Guo, Z., Xue, X., et al. Two-dimensional liquid chromatography separation of peptides using reversed-phase/weak cation-exchange mixed-mode column in first dimension. J. Chromatogr. A 1228 (2012), 242–249.
4. Wolters, D.A., Washburn, M.P., Yates, J.R., Biotechnol IIIN an automated multidimensional protein identification technology for shotgun proteomics. Anal. Chem. 73 (2001), 5683–5690.
5. Wei, F., Ji, S.-X., Hu, N., et al. Online profiling of triacylglycerols in plant oils by two-dimensional liquid chromatography using a single column coupled with atmospheric pressure chemical ionization mass spectrometry. J. Chromatogr. A 1312 (2013), 69–79.
6. Hu, N., Wei, F., Lv, X., et al. Profiling of triacylglycerols in plant oils by high-performance liquid chromatography-atmosphere pressure chemical ionization mass spectrometry using a novel mixed-mode column. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 972 (2014), 65–72.
7. Peng, X.T., Shi, Z.G., Feng, Y.Q., Rapid and high-throughput determination of melamine in milk products and eggs by full automatic on-line polymer monolith microextraction coupled to high-performance liquid chromatography. Food Anal. Methods 4 (2011), 381–388.
8. Wei, F., Hu, N., Lv, X., et al. Quantitation of triacylglycerols in edible oils by off-line comprehensive two-dimensional liquid chromatography ?atmospheric pressure chemical ionization mass spectrometry using a single column. J. Chromatogr. A 1404 (2015), 60–71.
9. Kwon, W., Kim, J.Y., Suh, S., In, M.K., Simultaneous determination of creatinine and uric acid in urine by liquid chromatography-tandem mass spectrometry with polarity switching electrospray ionization. Forensic Sci. Int. 221 (2012), 57–64.
10. Wei, J., Guo, Z., Zhang, P., et al. A new reversed-phase/strong anion-exchange mixed-mode stationary phase based on polar-copolymerized approach and its application in the enrichment of aristolochic acids. J. Chromatogr. A 1246 (2012), 129–136.
11. Liu, X., Pohl, C., Woodruff, A., Chen, J., Chromatographic evaluation of reversed-phase/anion-exchange/cation-exchange trimodal stationary phases prepared by electrostatically driven self-assembly process. J. Chromatogr. A 1218 (2011), 3407–3412.
12. Choi, H., Kim, S., Ahn, S., et al. Development of an analytical method for simultaneous detection of psychotropic phenylalkylamines in hair by LC-MS/MS with a multi-mode reversed-phase column using pH gradient elution. Forensic Sci. Int. 259 (2016), 69–76.
13. Yanes, O., Tautenhahn, R., Patti, G.J., Siuzdak, G., Expanding coverage of the metabolome for global metabolite profiling. Anal. Chem. 83 (2011), 2152–2161.
14. Liu, X., Pohl, C.A., Comparison of reversed-phase/cation-exchange/anion-exchange trimodal stationary phases and their use in active pharmaceutical ingredient and counterion determinations. J. Chromatogr. A 1232 (2012), 190–195.
15. Lisowska, B., Role of uremic compounds in organ injury. J. Nephrol. Ther. 5 (2014), 3–6.
16. Neirynck, N., Vanholder, R., Schepers, E., et al. An update on uremic toxins. Int. Urol. Nephrol. 45 (2013), 139–150.
17. Depner, T.A., Uremic toxicity: urea and beyond. Semin. Dial. 14 (2008), 246–251.
18. Vanholder, R., De Smet, R., Glorieux, G., et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 63 (2003), 1934–1943.
19. Vanholder, R., Laecke, S., Glorieux, G., What is new in uremic toxicity?. Pediatr. Nephrol. 23 (2008), 1211–1221.
20. Ramezani, A., Massy, Z.A., Meijers, B., et al. Role of the gut microbiome in uremia: a potential therapeutic target. Am. J. Kidney Dis., 2015, 1–16.
21. Mishima, E., Inoue, C., Saigusa, D., et al. Conformational change in transfer RNA is an early indicator of acute cellular damage. J. Am. Soc. Nephrol. 25 (2014), 2316–2326.
22. Cuoghi, A., Caiazzo, M., Bellei, E., et al. Quantification of p-cresol sulphate in human plasma by selected reaction monitoring. Anal. Bioanal. Chem. 404 (2012), 2097–2104.
23. Itoh, Y., Ezawa, A., Kikuchi, K., et al. Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production. Anal. Bioanal. Chem. 403 (2012), 1841–1850.
24. Shu, C., Chen, X., Xia, T., et al. LC-MS/MS method for simultaneous determination of serum p- cresyl sulfate and indoxyl sulfate in patients undergoing peritoneal dialysis. Biomed. Chromatogr., 2016, 1782–1788.
25. de Loor, H., Poesen, R., De Leger, W., et al. A liquid chromatography ?tandem mass spectrometry method to measure a selected panel of uremic retention solutes derived from endogenous and colonic microbial metabolism. Anal. Chim. Acta 936 (2016), 149–156.
26. Boelaert, J., Lynen, F., Glorieux, G., et al. A novel UPLC-MS–MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients. Anal. Bioanal. Chem. 405 (2013), 1937–1947.
27. Shah, V.O., Townsend, R.R., Feldman, H.I., et al. Plasma metabolomic profiles in different stages of CKD. Clin. J. Am. Soc. Nephrol. 8 (2013), 363–370.
28. Boelaert, J., Lynen, F., Glorieux, G., et al. Metabolic profiling of human plasma and urine in chronic kidney disease by hydrophilic interaction liquid chromatography coupled with time-of-flight mass spectrometry: a pilot study. Anal. Bioanal. Chem. 409 (2017), 2201–2211.
29. Ocque, A.J., Stubbs, J.R., Nolin, T.D., Development and validation of a simple UHPLC-MS/MS method for the simultaneous determination of trimethylamine N-oxide, choline, and betaine in human plasma and urine. J. Pharm. Biomed. Anal. 109 (2015), 128–135.
30. Fraselle, S.K., Cremer, De, Coucke, W., et al. Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method to measure creatinine in human urine. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 988 (2015), 88–97.
31. Hou, W., Zhong, D., Zhang, P., et al. A strategy for the targeted metabolomics analysis of 11 gut microbiota-host co-metabolites in rat serum, urine and feces by ultra high performance liquid chromatography?tandem mass spectrometry. J. Chromatogr. A 1429 (2016), 207–217.
32. Stubbs, J.R., House, J.A., Ocque, A.J., et al. Serum trimethylamine-N-Oxide is elevated in CKD and correlates with Coronary atherosclerosis burden. J. Am. Soc. Nephrol. 27 (2015), 305–313.
33. Mishima, E., Fukuda, S., Mukawa, C., et al. Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE -TOFMS?based metabolomics approach. Kidney Int., 2017, 1–12.