Parenteral Plant Sterols Accumulate in the Liver Reflecting Their Increased Serum Levels and Portal Inflammation in Children with Intestinal Failure

Journal of Parenteral and Enteral Nutrition

Volumn 41, Issue 6, 2017, Pages 1014-1022

  Hukkinen, Maria ^a   Mutanen, Annika ^a   Nissinen, Markku ^b   Merras Salmio, Laura ^a   Gylling, Helena ^b   Pakarinen, Mikko P ^a  

^a UNIVERSITY OF HELSINKI AND HELSINKI UNIVERSITY HOSPITAL   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

intestinal failure associated liver disease; lipid emulsions; parenteral nutrition; phytosterols; short bowel syndrome

Indexed keywords

AVENASTEROL; BIOCHEMICAL MARKER; CAMPESTEROL; CHOLESTEROL; CLINOLEIC; OMEGAVEN; PHYTOSTEROL; SITOSTEROL; SMOFLIPID; STEROL DERIVATIVE; STIGMASTEROL; UNCLASSIFIED DRUG; VEGETABLE OIL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE; GAMMA-SITOSTEROL; SITOSTEROL DERIVATIVE; TRIACYLGLYCEROL;

ADULT; ANUS ATRESIA; ARTICLE; BLOOD BIOCHEMISTRY; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG LIVER LEVEL; HEPATIC PORTAL VEIN; HIRSCHSPRUNG DISEASE; HISTOPATHOLOGY; HUMAN; INFLAMMATION; INTESTINAL FAILURE; INTESTINE PSEUDOOBSTRUCTION; INTESTINE RESECTION; INTESTINE VOLVULUS; LIVER; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER FUNCTION; LIVER INJURY; NECROTIZING ENTEROCOLITIS; PARENTERAL NUTRITION; PORTAL INFLAMMATION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SERUM; SHORT BOWEL SYNDROME; WEANING; YOUNG ADULT; ANALOGS AND DERIVATIVES; BLOOD; COMPLICATION; DRUG EFFECT; ENTEROPATHY; FEMALE; INFANT; MALE; PATHOLOGY; PATHOPHYSIOLOGY; TOXIC HEPATITIS;

ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHILD; CHILD, PRESCHOOL; CHOLESTEROL; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; INFANT; INFLAMMATION; INTESTINAL DISEASES; LIVER; MALE; PARENTERAL NUTRITION; PHYTOSTEROLS; PLANT OILS; PORTAL VEIN; SITOSTEROLS; STIGMASTEROL; TRIGLYCERIDES;

EID: 85030702773     PISSN: 01486071     EISSN: 19412444     Source Type: Journal    
DOI: 10.1177/0148607116637855     Document Type: Article

References (35)

1. Lauriti G, Zani A, Aufieri R, et al. Incidence, prevention, and treatment of parenteral nutrition-associated cholestasis and intestinal failure-associated liver disease in infants and children: a systematic review. JPEN J Parenter Enteral Nutr. 2014; 38: 70-85.
2. Kelly DA,. Preventing parenteral nutrition liver disease. Early Hum Dev. 2010; 86: 683-687.
3. D'Antiga L, Goulet O,. Intestinal failure in children: the European view. J Pediatr Gastroenterol Nutr. 2013; 56: 118-126.
4. El Kasmi KC, Anderson AL, Devereaux MW, et al. Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease. Sci Transl Med. 2013; 5: 206ra137.
5. Mutanen A, Lohi J, Heikkila P, Koivusalo AI, Rintala RJ, Pakarinen MP,. Persistent abnormal liver fibrosis after weaning off parenteral nutrition in pediatric intestinal failure. Hepatology. 2013; 58: 729-738.
6. Llop JM, Virgili N, Moreno-Villares JM, et al. Phytosterolemia in parenteral nutrition patients: implications for liver disease development. Nutrition. 2008; 24: 1145-1152.
7. Clayton PT, Whitfield P, Iyer K,. The role of phytosterols in the pathogenesis of liver complications of pediatric parenteral nutrition. Nutrition. 1998; 14: 158-164.
8. Kurvinen A, Nissinen MJ, Andersson S, et al. Parenteral plant sterols and intestinal failure-associated liver disease in neonates. J Pediatr Gastroenterol Nutr. 2012; 54: 803-811.
9. Zaloga GP,. Phytosterols, lipid administration, and liver disease during parenteral nutrition. JPEN J Parenter Enteral Nutr. 2015; 39: 39S-60S.
10. Vlaardingerbroek H, Ng K, Stoll B, et al. New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs. J Lipid Res. 2014; 55: 466-477.
11. Sudhop T, Sahin Y, Lindenthal B, et al. Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion. Gut. 2002; 51: 860-863.
12. Mutanen A, Nissinen MJ, Lohi J, Heikkila P, Gylling H, Pakarinen MP,. Serum plant sterols, cholestanol, and cholesterol precursors associate with histological liver injury in pediatric onset intestinal failure. Am J Clin Nutr. 2014; 100: 1085-1094.
13. Savini S, D'Ascenzo R, Biagetti C, et al. The effect of 5 intravenous lipid emulsions on plasma phytosterols in preterm infants receiving parenteral nutrition: a randomized clinical trial. Am J Clin Nutr. 2013; 98: 312-318.
14. Hallikainen M, Huikko L, Kontra K, et al. Effect of parenteral serum plant sterols on liver enzymes and cholesterol metabolism in a patient with short bowel syndrome. Nutr Clin Pract. 2008; 23: 429-435.
15. Kurvinen A, Nissinen MJ, Gylling H, et al. Effects of long-term parenteral nutrition on serum lipids, plant sterols, cholesterol metabolism, and liver histology in pediatric intestinal failure. J Pediatr Gastroenterol Nutr. 2011; 53: 440-446.
16. Park HW, Lee NM, Kim JH, Kim KS, Kim SN,. Parenteral fish oil-containing lipid emulsions may reverse parenteral nutrition-associated cholestasis in neonates: a systematic review and meta-analysis. J Nutr. 2015; 145: 277-283.
17. Iyer KR, Spitz L, Clayton P,. BAPS prize lecture: new insight into mechanisms of parenteral nutrition-associated cholestasis. Role of plant sterols. British Association of Paediatric Surgeons. J Pediatr Surg. 1998; 33: 1-6.
18. Merras-Salmio L, Pakarinen MP,. Refined multidisciplinary protocol based approach to short bowel syndrome improves outcomes. J Pediatr Gastroenterol Nutr. 2015; 61 (1): 24-29.
19. Struijs MC, Diamond IR, de Silva N, Wales PW,. Establishing norms for intestinal length in children. J Pediatr Surg. 2009; 44: 933-938.
20. Hukkinen M, Kivisaari R, Lohi J, et al. Transient elastography and aspartate aminotransferase to platelet ratio predict liver injury in pediatric intestinal failure. Liver Int. 2016; 36 (3): 361-369.
21. Xu Z, Harvey KA, Pavlina T, et al. Steroidal compounds in commercial parenteral lipid emulsions. Nutrients. 2012; 4: 904-921.
22. Bedossa P, Dargere D, Paradis V,. Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology. 2003; 38: 1449-1457.
23. Miettinen TA,. Cholesterol metabolism during ketokonazole treatment in man. J Lipis Res. 1988; 29: 43-51.
24. Forchielli ML, Bersani G, Tala S, Grossi G, Puggioli C, Masi M,. The spectrum of plant and animal sterols in different oil-derived intravenous emulsions. Lipids. 2010; 45: 63-71.
25. Reimund JM, Arondel Y, Joly F, Messing B, Duclos B, Baumann R,. Potential usefulness of olive oil-based lipid emulsions in selected situations of home parenteral nutrition-associated liver disease. Clin Nutr. 2004; 23: 1418-1425.
26. Burrin DG, Ng K, Stoll B, Saenz De Pipaon M,. Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease. Adv Nutr. 2014; 5: 82-91.
27. Skouroliakou M, Konstantinou D, Agakidis C, et al. Cholestasis, bronchopulmonary dysplasia, and lipid profile in preterm infants receiving MCT/omega-3-PUFA-containing or soybean-based lipid emulsions. Nutr Clin Pract. 2012; 27: 817-824.
28. Pakarinen MP, Kurvinen A, Gylling H, et al. Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition. Dig Liver Dis. 2010; 42: 554-559.
29. Pianese P, Salvia G, Campanozzi A, et al. Sterol profiling in red blood cell membranes and plasma of newborns receiving total parenteral nutrition. J Pediatr Gastroenterol Nutr. 2008; 47: 645-651.
30. Naini BV, Lassman CR,. Total parenteral nutrition therapy and liver injury: a histopathologic study with clinical correlation. Hum Pathol. 2012; 43: 826-833.
31. Carter BA, Taylor OA, Prendergast DR, et al. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res. 2007; 62: 301-306.
32. Mandal S, Miraglia R, Maruzzelli L, et al. US-guided percutaneous liver biopsy in pediatric liver transplant recipients. J Pediatr Gastroenterol Nutr. 2014; 58: 756-761.
33. Buchman AL, Iyer K, Fryer J,. Parenteral nutrition-associated liver disease and the role for isolated intestine and intestine/liver transplantation. Hepatology. 2006; 43: 9-19.
34. El Kasmi KC, Anderson AL, Devereaux MW, et al. Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury. Hepatology. 2012; 55: 1518-1528.
35. Pakarinen MP, Koivusalo AI, Rintala RJ,. Outcomes of intestinal failure: a comparison between children with short bowel and dysmotile intestine. J Pediatr Surg. 2009; 44: 2139-2144.