New generation lipid emulsions prevent PNALD in chronic parenterally fed preterm pigs

Journal of Lipid Research

Volumn 55, Issue 3, 2014, Pages 466-477

  Vlaardingerbroek, Hester ^a   Ng, Kenneth ^b   Stoll, Barbara ^b   Benight, Nancy ^b   Chacko, Shaji ^b   Kluijtmans, Leo A J ^c   Kulik, Wim ^d   Squires, E James ^e   Olutoye, Oluyinka ^b   Schady, Deborah ^b   Finegold, Milton L ^b   Van Goudoever, Johannes B ^a,d,f   Burrin, Douglas G ^b  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY OF GUELPH   (Canada)

^f VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cholestasis; FGF19; Fish oil; Parenteral nutrition associated liver disease; Soybean oil

Indexed keywords

7ALPHA HYDROXYCHOLEST 4 EN 3 ONE; BILE ACID; BILE SALT EXPORT PUMP; BILIRUBIN GLUCURONIDE; CHOLEST 4 EN 3 ONE; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; FISH OIL; GAMMA GLUTAMYLTRANSFERASE; LIPID EMULSION; MEDIUM CHAIN TRIACYLGLYCEROL; OLIVE OIL; PHYTOSTEROL; SOYBEAN OIL EMULSION; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHOLESTASIS; CONTROLLED STUDY; ENTERIC FEEDING; GENE; GENE EXPRESSION; HISTOLOGY; LIVER CELL; LIVER DISEASE; LIVER INJURY; NONHUMAN; NUCLEOTIDE SEQUENCE; NUTRITIONAL SUPPORT; ORGANIC SOLUTE TRANSPORTER ALPHA GENE; PARENTERAL NUTRITION ASSOCIATED LIVER DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STEATOSIS; SWINE; TOTAL PARENTERAL NUTRITION; WESTERN BLOTTING;

CHOLESTASIS; FGF19; FISH OIL; PARENTERAL NUTRITION-ASSOCIATED LIVER DISEASE; SOYBEAN OIL;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELLS, CULTURED; CHOLESTENONES; CHOLESTEROL 7-ALPHA-HYDROXYLASE; FAT EMULSIONS, INTRAVENOUS; FEMALE; FISH OILS; GAMMA-GLUTAMYLTRANSFERASE; GENE EXPRESSION; HUMANS; LIPIDS; LIVER DISEASES; PARENTERAL NUTRITION; PLANT OILS; PREGNANCY; PREMATURE BIRTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SOYBEAN OIL; SWINE; SWINE DISEASES; TRIGLYCERIDES;

EID: 84894838012     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M044545     Document Type: Article

References (33)

1. Christensen, R. D., E. Henry, S. E. Wiedmeier, J. Burnett, and D. K. Lambert. 2007. Identifying patients, on the first day of life, at high-risk of developing parenteral nutrition-associated liver disease. J. Perinatol. 27: 284-290. (Pubitemid 46647905)
2. Carter, B. A., and R. J. Shulman. 2007. Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Nat. Clin. Pract. Gastroenterol. Hepatol. 4: 277-287. (Pubitemid 46711465)
3. Waitzberg, D. L., R. S. Torrinhas, and T. M. Jacintho. 2006. New parenteral lipid emulsions for clinical use. JPEN J. Parenter. Enteral Nutr. 30: 351-367.
4. Clayton, P. T., A. Bowron, K. A. Mills, A. Massoud, M. Casteels, and P. J. Milla. 1993. Phytosterolemia in children with parenteral nutrition-associated cholestatic liver disease. Gastroenterology. 105: 1806-1813. (Pubitemid 24002799)
5. Carter, B. A., O. A. Taylor, D. R. Prendergast, T. L. Zimmerman, R. Von Furstenberg, D. D. Moore, and S. J. Karpen. 2007. Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr. Res. 62: 301-306. (Pubitemid 47301479)
6. Colomb, V., A. Jobert-Giraud, F. Lacaille, O. Goulet, J. C. Fournet, and C. Ricour. 2000. Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition in children. JPEN J. Parenter. Enteral Nutr. 24: 345-350.
7. Cober, M. P., G. Killu, A. Brattain, K. B. Welch, S. M. Kunisaki, and D. H. Teitelbaum. 2012. Intravenous fat emulsions reduction for patients with parenteral nutrition-associated liver disease. J. Pediatr. 160: 421-427.
8. de Meijer, V. E., K. M. Gura, H. D. Le, J. A. Meisel, and M. Puder. 2009. Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience. JPEN J. Parenter. Enteral Nutr. 33: 541-547.
9. Gura, K. M., S. Lee, C. Valim, J. Zhou, S. Kim, B. P. Modi, D. A. Arsenault, R. A. Strijbosch, S. Lopes, C. Dugan, et al. 2008. Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics. 121: e678-e686.
10. Diamond, I. R., A. Sterescu, P. B. Pencharz, J. H. Kim, and P. W. Wales. 2009. Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. J. Pediatr. Gastroenterol. Nutr. 48: 209-215.
11. Sangild, P. T., Y. M. Petersen, M. Schmidt, J. Elnif, T. K. Petersen, R. K. Buddington, G. Greisen, K. F. Michaelsen, and D. G. Burrin. 2002. Preterm birth affects the intestinal response to parenteral and enteral nutrition in newborn pigs. J. Nutr. 132: 3786-3794.
12. Stoll, B., D. A. Horst, L. Cui, X. Chang, K. J. Ellis, D. L. Hadsell, A. Suryawan, A. Kurundkar, A. Maheshwari, T. A. Davis, et al. 2010. Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs. J. Nutr. 140: 2193-2200.
13. Stoll, B., P. J. Puiman, L. Cui, X. Chang, N. M. Benight, C. Bauchart-Thevret, B. Hartmann, J. J. Holst, and D. G. Burrin. 2012. Continuous parenteral and enteral nutrition induces metabolic dysfunction in neonatal pigs. JPEN J. Parenter. Enteral Nutr. 36: 538-550.
14. Puiman, P., and B. Stoll. 2008. Animal models to study neonatal nutrition in humans. Curr. Opin. Clin. Nutr. Metab. Care. 11: 601-606.
15. Koopman, B. J., B. G. Wolthers, J. C. van der Molen, G. T. Nagel, R. J. Waterreus, and H. J. Oosterhuis. 1984. Capillary gas chromatographic determinations of urinary bile acids and bile alcohols in CTX patients proving the ineffectivity of ursodeoxycholic acid treatment. Clin. Chim. Acta. 142: 103-111. (Pubitemid 14068955)
16. Bootsma, A. H., H. Overmars, A. van Rooij, A. E. van Lint, R. J. Wanders, A. H. van Gennip, and P. Vreken. 1999. Rapid analysis of conjugated bile acids in plasma using electrospray tandem mass spectrometry: application for selective screening of peroxisomal disorders. J. Inherit. Metab. Dis. 22: 307-310. (Pubitemid 29259501)
17. Ferdinandusse, S., S. Denis, H. Overmars, E. L. Van, P. P. Van Veldhoven, M. Duran, R. J. Wanders, and M. Baes. 2005. Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice. J. Biol. Chem. 280: 18658-18666. (Pubitemid 41379566)
18. Denk, G. U., S. Maitz, R. Wimmer, C. Rust, P. Invernizzi, S. Ferdinandusse, W. Kulik, A. Fuchsbichler, P. Fickert, M. Trauner, et al. 2010. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology. 52: 1758-1768.
19. Steiner, C., A. von Eckardstein, K. M. Rentsch. 2010. Quantification of the 15 major human bile acids and their precursor 7alpha-hydroxy-4-cholesten-3- one in serum by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878: 2870-2880.
20. Gray, M. A., C. B. Pollock, L. B. Schook, and E. J. Squires. 2010. Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants. Exp. Biol. Med. (Maywood). 235: 718-736.
21. Lefebvre, P., B. Cariou, F. Lien, F. Kuipers, and B. Staels. 2009. Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89: 147-191.
22. Kidambi, S., and S. B. Patel. 2008. Cholesterol and non-cholesterol sterol transporters: ABCG5, ABCG8 and NPC1L1: a review. Xenobiotica. 38: 1119-1139.
23. Jain, A. K., B. Stoll, D. G. Burrin, J. J. Holst, and D. D. Moore. 2012. Enteral bile acid treatment improves parenteral nutrition-related liver disease and intestinal mucosal atrophy in neonatal pigs. Am. J. Physiol. Gastrointest. Liver Physiol. 302: G218-G224.
24. Pellicciari, R., G. Costantino, E. Camaioni, B. M. Sadeghpour, A. Entrena, T. M. Willson, S. Fiorucci, C. Clerici, and A. Gioiello. 2004. Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid. J. Med. Chem. 47: 4559-4569. (Pubitemid 39096842)
25. Diamond, I. R., P. B. Pencharz, and P. W. Wales. 2009. Omega-3 lipids for intestinal failure associated liver disease. Semin. Pediatr. Surg. 18: 239-245.
26. Kurvinen, A., M. J. Nissinen, H. Gylling, T. A. Miettinen, H. Lampela, A. I. Koivusalo, R. J. Rintala, and M. P. Pakarinen. 2011. Effects of long-term parenteral nutrition on serum lipids, plant sterols, cholesterol metabolism, and liver histology in pediatric intestinal failure. J. Pediatr. Gastroenterol. Nutr. 53: 440-446.
27. Puder, M., C. Valim, J. A. Meisel, H. D. Le, V. E. de Meijer, E. M. Robinson, J. Zhou, C. Duggan, and K. M. Gura. 2009. Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann. Surg. 250: 395-402.
28. Kurvinen, A., M. J. Nissinen, S. Andersson, P. Korhonen, T. Ruuska, M. Taimisto, M. Kalliomäki, L. Lehtonen, U. Sankilampi, P. Arikoski, et al. 2012. Parenteral plant sterols and intestinal failure-associated liver disease in neonates. J. Pediatr. Gastroenterol. Nutr. 54: 803-811.
29. Shang, Q., G. L. Guo, A. Honda, M. Saumoy, G. Salen, and G. Xu. 2013. FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels. J. Lipid Res. 54: 2606-2614.
30. El Kasmi, K. C., A. L. Anderson, M. W. Devereaux, P. M. Vue, W. Zhang, K. D. R. Setchell, S. J. Karpen, and R. J. Sokol. 2013. Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease. Sci. Transl. Med. 5: 206ra137.
31. Lee, J. Y., A. Plakidas, W. H. Lee, A. Heikkinen, P. Chanmugam, G. Bray, and D. H. Hwang. 2003. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. J. Lipid Res. 44: 479-486. (Pubitemid 37279695)
32. Sanyal, A. J., N. Chalasani, K. V. Kowdley, A. McCullough, A. M. Diehl, N. M. Bass, B. A. Neuschwander-Tetri, J. E. Lavine, J. Tonascia, A. Unalp, et al. 2010. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N. Engl. J. Med. 362: 1675-1685.
33. Alwayn, I. P., K. Gura, V. Nosé, B. Zausche, P. Javid, J. Garza, J. Verbesey, S. Voss, M. Ollero, A. Andersson, et al. 2005. Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease. Pediatr. Res. 57: 445-452. (Pubitemid 40293615)