Indications for and adverse effects of red-cell transfusion

New England Journal of Medicine

Volumn 377, Issue 13, 2017, Pages 1261-1272

  Carson, Jeffrey L ^a   Triulzi, Darrell J ^b   Ness, Paul M ^c  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CITRIC ACID; HEMOGLOBIN;

ACUTE CORONARY SYNDROME; ANEMIA; BLOOD CONSERVATION; BLOOD SAFETY; BLOOD TRANSFUSION REACTION; CARDIOVASCULAR DISEASE; CRITICAL ILLNESS; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; GASTROINTESTINAL HEMORRHAGE; HEART SURGERY; HEMORRHAGIC SHOCK; HUMAN; HYPERKALEMIA; HYPOTHERMIA; IMMUNOMODULATION; INFECTION RISK; IRON OVERLOAD; MORTALITY RATE; ORTHOPEDIC SURGERY; PREGNANT WOMAN; PREMATURITY; PRIORITY JOURNAL; REVIEW; TRANSFUSION ASSOCIATED GRAFT VERSUS HOST DISEASE; TRANSFUSION RELATED ACUTE LUNG INJURY; ADULT; ADVERSE EFFECTS; CARDIOVASCULAR DISEASES; CHILD; PRACTICE GUIDELINE; STANDARDS; STATISTICS AND NUMERICAL DATA;

ADULT; CARDIOVASCULAR DISEASES; CHILD; ERYTHROCYTE TRANSFUSION; GASTROINTESTINAL HEMORRHAGE; HEMOGLOBINS; HUMANS; PRACTICE GUIDELINES AS TOPIC; TRANSFUSION REACTION;

EID: 85030649324     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMra1612789     Document Type: Review

References (80)

1. Carson JL, Stanworth SJ, Roubinian N, et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2016;10:CD002042.
2. Hébert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. N Engl J Med 1999;340: 409-17.
3. Lacroix J, Hébert PC, Hutchison JS, et al. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med 2007;356:1609-19.
4. Carson JL, Terrin ML, Noveck H, et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 2011;365:2453-62.
5. Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med 2013; 368:11-21.
6. Holst LB, Haase N, Wetterslev J, et al. Lower versus higher hemoglobin threshold for transfusion in septic shock. N Engl J Med 2014;371:1381-91.
7. Murphy GJ, Pike K, Rogers CA, et al. Liberal or restrictive transfusion after cardiac surgery. N Engl J Med 2015;372:997-1008.
8. Carson JL, Sieber F, Cook DR, et al. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial. Lancet 2015;385:1183-9.
9. Carson JL, Guyatt G, Heddle NM, et al. Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage. JAMA 2016;316:2025-35.
10. Carson JL, Duff A, Poses RM, et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996;348:1055-60.
11. Shander A, Javidroozi M, Naqvi S, et al. An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME). Transfusion 2014;54:2688-95.
12. Carson JL, Brooks MM, Abbott JD, et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 2013; 165(6):964-971.e1.
13. Jairath V, Kahan BC, Gray A, et al. Restrictive versus liberal blood transfusion for acute upper gastrointestinal bleeding (TRIGGER): a pragmatic, open-label, cluster randomised feasibility trial. Lancet 2015;386:137-44.
14. Docherty AB, O’Donnell R, Brunskill S, et al. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ 2016;352:i1351.
15. Blair SD, Janvrin SB, McCollum CN, Greenhalgh RM. Effect of early blood transfusion on gastrointestinal haemorrhage. Br J Surg 1986;73:783-5.
16. Blood transfusion. London: NICE (National Institute for Health and Care Excellence), 2015 (https://www.nice.org.uk/guidance/ng24).
17. American Society of Anesthesiologists Task Force on Perioperative Blood Management. Practice guidelines for periop-erative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management. Anesthesiology 2015; 122:241-75.
18. Killick SB, Carter C, Culligan D, et al. Guidelines for the diagnosis and management of adult myelodysplastic syndromes. Br J Haematol 2014;164:503-25.
19. NCCN clinical practice guidelines in oncology: cancer- and chemotherapy-induced anemia. Fort Washington, PA: National Comprehensive Cancer Network, 2013.
20. Qaseem A, Humphrey LL, Fitterman N, Starkey M, Shekelle P. Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians. Ann Intern Med 2013;159:770-9.
21. Dellinger RP, Levy MM, Rhodes A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013;39:165-228.
22. Retter A, Wyncoll D, Pearse R, et al. Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients. Br J Haematol 2013;160: 445-64.
23. Patient blood management guidelines. Lyneham, ACT: National Blood Authority Australia, 2012 (http://www.blood.gov.au/pbm-guidelines).
24. Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney Int Suppl 2012;2:279-335.
25. Van Remoortel H, De Buck E, Dieltjens T, Pauwels NS, Compernolle V, Vandekerck-hove P. Methodologic quality assessment of red blood cell transfusion guidelines and the evidence base of more restrictive transfusion thresholds. Transfusion 2016; 56:472-80.
26. Alexander J, Cifu AS. Transfusion of red blood cells. JAMA 2016;316:2038-9.
27. Cooper HA, Rao SV, Greenberg MD, et al. Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). Am J Cardiol 2011;108:1108-11.
28. Whitaker B, Rajbhandary S, Kleinman S, Harris A, Kamani N. Trends in United States blood collection and transfusion: results from the 2013 AABB Blood Collection, Utilization, and Patient Blood Management Survey. Transfusion 2016;56: 2173-83.
29. Chung KW, Basavaraju SV, Mu Y, et al. Declining blood collection and utilization in the United States. Transfusion 2016;56: 2184-92.
30. Ellingson KD, Sapiano MRP, Haass KA, et al. Continued decline in blood collection and transfusion in the United States-2015. Transfusion 2017;57:Suppl 2: 1588-98.
31. Leahy MF, Hofmann A, Towler S, et al. Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals. Transfusion 2017;57:1347-58.
32. Goodnough LT, Shander A. Patient blood management. Anesthesiology 2012; 116:1367-76.
33. The collection, testing and use of blood and blood components in Europe. 2013 report. Strasbourg, France: Council of Europe, European Directorate for the Quality of Medicines & Healthcare, 2016 (https://www.edqm.eu/sites/default/files/ the_collection_testing_and_use_of_blood _and_blood_components_in_europe_2013.pdf).
34. PlaneCrashInfo.com. Causes of fatal accidents by decade. 2017 (http://www.planecrashinfo.com/cause.htm).
35. National Weather Service. How dangerous is lightning? 2017 (http://www.lightningsafety.noaa.gov/odds.shtml).
36. Miniño AM, Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2008. Natl Vital Stat Rep 2011;59:1-126.
37. Kohn L. To err is human: an interview with the Institute of Medicine’s Linda Kohn. Jt Comm J Qual Improv 2000;26: 227-34.
38. Zou S, Dorsey KA, Notari EP, et al. Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing. Transfusion 2010; 50:1495-504.
39. Aberle-Grasse J, Orton SL, Notari E IV, et al. Predictive value of past and current screening tests for syphilis in blood donors: changing from a rapid plasma reagin test to an automated specific trepo-nemal test for screening. Transfusion 1999;39:206-11.
40. Stramer SL, Wend U, Candotti D, et al. Nucleic acid testing to detect HBV infection in blood donors. N Engl J Med 2011; 364:236-47.
41. Stramer SL, Glynn SA, Kleinman SH, et al. Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid–amplification testing. N Engl J Med 2004;351:760-8.
42. Ness PM, Nass CC. Blood donor testing for HIV-I/II and HTLV-I/II. Arch Pathol Lab Med 1994;118:337-41.
43. Busch MP, Caglioti S, Robertson EF, et al. Screening the blood supply for West Nile virus RNA by nucleic acid amplification testing. N Engl J Med 2005;353:460-7.
44. Cantey PT, Stramer SL, Townsend RL, et al. The United States Trypanosoma cruzi Infection Study: evidence for vector-borne transmission of the parasite that causes Chagas disease among United States blood donors. Transfusion 2012; 52:1922-30.
45. Katz LM, Rossmann SN. Zika and the blood supply: a work in progress. Arch Pathol Lab Med 2017;141:85-92.
46. Blajchman MA, Goldman M, Freedman JJ, Sher GD. Proceedings of a consensus conference: prevention of post-transfusion CMV in the era of universal leukoreduction. Transfus Med Rev 2001; 15:1-20.
47. Brecher ME, Hay SN. Bacterial contamination of blood components. Clin Micro-biol Rev 2005;18:195-204.
48. Mungai M, Tegtmeier G, Chamberland M, Parise M. Transfusion-transmitted malaria in the United States from 1963 through 1999. N Engl J Med 2001; 344:1973-8.
49. Bloch EM, Levin AE, Williamson PC, et al. A prospective evaluation of chronic Babesia microti infection in seroreactive blood donors. Transfusion 2016;56:1875-82.
50. Moritz ED, Winton CS, Tonnetti L, et al. Screening for Babesia microti in the U.S. blood supply. N Engl J Med 2016;375: 2236-45.
51. Fang DC, McCullough J. Transfusion-transmitted Babesia microti. Transfus Med Rev 2016;30:132-8.
52. Stramer SL, Linnen JM, Carrick JM, et al. Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico. Transfusion 2012;52:1657-66.
53. Petersen LR, Stramer SL, Powers AM. Chikungunya virus: possible impact on transfusion medicine. Transfus Med Rev 2010;24:15-21.
54. Hoofnagle JH, Nelson KE, Purcell RH. Hepatitis E. N Engl J Med 2012;367:1237-44.
55. McCullough J, Vesole DH, Benjamin RJ, et al. Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial. Blood 2004;104:1534-41.
56. Prowse CV. Component pathogen inactivation: a critical review. Vox Sang 2013; 104:183-99.
57. Allain JP, Owusu-Ofori AK, Assennato SM, Marschner S, Goodrich RP, Owusu-Ofori S. Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial. Lancet 2016;387:1753-61.
58. Roubinian NH, Hendrickson JE, Triulzi DJ, et al. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang 2017;112:56-63.
59. Narick C, Triulzi DJ, Yazer MH. Transfusion-associated circulatory overload after plasma transfusion. Transfusion 2012; 52:160-5.
60. Blood safety surveillance. Atlanta: Centers for Disease Control and Prevention, 2009 (https://www.cdc.gov/nhsn/acute-care-hospital/bio-hemo/).
61. Transfusion-associated circulatory overload (TACO) 2014 revision. London: International Society of Blood Transfusion Working Party on Haemovigilance, International Haemovigilance Network, December 2014 (http://www.isbtweb.org/fileadmin/user_upload/files-2015/haemovigilance/TACO_definition_validation_form _jan2015_haemovigilance.pdf).
62. Roubinian NH, Murphy EL. Transfusion-associated circulatory overload (TACO): prevention, management, and patient outcomes. Int J Clin Transfus Med 2015;3:17-28.
63. Kleinman S, Caulfield T, Chan P, et al. Toward an understanding of transfusion-related acute lung injury: statement of a consensus panel. Transfusion 2004;44: 1774-89.
64. Toy P, Gajic O, Bacchetti P, et al. Transfusion-related acute lung injury: incidence and risk factors. Blood 2012;119: 1757-67.
65. Toy P, Popovsky MA, Abraham E, et al. Transfusion-related acute lung injury: definition and review. Crit Care Med 2005;33: 721-6.
66. Müller MC, van Stein D, Binnekade JM, van Rhenen DJ, Vlaar AP. Low-risk transfusion-related acute lung injury donor strategies and the impact on the onset of transfusion-related acute lung injury: a meta-analysis. Transfusion 2015;55:164-75.
67. Fatalities reported to FDA following blood collection and transfusion: annual summary for FY2015. Silver Spring, MD: Food and Drug Administration (https://www.fda.gov/downloads/BiologicsBloodVaccines/SafetyAvailability/Reporta Problem/TransfusionDonationFatalities/ UCM518148.pdf).
68. Davenport RD, Bluth MH. Hemolytic transfusion reactions. In: Simon TL, McCullough J, Snyder EL, Solheim BG, Strauss RG, eds. Rossi’s principles of transfusion medicine. 5th ed. West Sussex, United Kingdom: Wiley-Blackwell, 2016: 642-51.
69. Transfusion/donation fatalities: notification process for transfusion related fatalities and donation related deaths. Silver Spring, MD: Food and Drug Administration (http://www.fda.gov/BiologicsBloodVaccines/SafetyAvailability/ReportaProblem/ TransfusionDonationFatalities/).
70. Hoffbrand AV, Taher A, Cappellini MD. How I treat transfusional iron overload. Blood 2012;120:3657-69.
71. Vamvakas EC, Bordin JO, Blajchman MA. Immunomodulatory and pro-inflammatory effects of allogeneic blood transfusion. In: Simon TL, McCullough JM, Snyder E, Solheim BG, Strauss RG, eds. Rossi’s principles of transfusion medicine. 5th ed. West Sussex, United Kingdom: Wiley-Blackwell, 2016:695-710.
72. Elmer J, Wilcox SR, Raja AS. Massive transfusion in traumatic shock. J Emerg Med 2013;44:829-38.
73. Cohn SM, Nathens AB, Moore FA, et al. Tissue oxygen saturation predicts the development of organ dysfunction during traumatic shock resuscitation. J Trauma 2007;62:44-55.
74. Murkin JM, Arango M. Near-infrared spectroscopy as an index of brain and tissue oxygenation. Br J Anaesth 2009;103: Suppl 1:i3-i13.
75. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, et al. Effect of transfusion of red blood cells with longer vs shorter storage duration on elevated blood lactate levels in children with severe anemia: the TOTAL randomized clinical trial. JAMA 2015;314:2514-23.
76. Dhabangi A, Ainomugisha B, Cserti-Gazdewich C, et al. Cerebral oximetry in Ugandan children with severe anemia: clinical categories and response to transfusion. JAMA Pediatr 2016;170:995-1002.
77. Alayash AI. Blood substitutes: why haven’t we been more successful? Trends Biotechnol 2014;32:177-85.
78. Abuchowski A. PEGylated bovine car-boxyhemoglobin (SANGUINATE): results of clinical safety testing and use in patients. Adv Exp Med Biol 2016;876:461-7.
79. Migliaccio AR, Masselli E, Varricchio L, Whitsett C. Ex-vivo expansion of red blood cells: how real for transfusion in humans? Blood Rev 2012;26:81-95.
80. Giarratana MC, Rouard H, Dumont A, et al. Proof of principle for transfusion of in vitro-generated red blood cells. Blood 2011;118:5071-9.