Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial

The Lancet

Volumn 385, Issue 9974, 2015, Pages 1183-1189

  Carson, Jeffrey L ^a   Sieber, Frederick ^b   Cook, Donald Richard ^c   Hoover, Donald R ^d   Noveck, Helaine ^a   Chaitman, Bernard R ^e   Fleisher, Lee ^f   Beaupre, Lauren ^g   Macaulay, William ^h   Rhoads, George G ⁱ   Paris, Barbara ^j   Zagorin, Aleksandra ^j   Sanders, David W ^k   Zakriya, Khwaja J ^l   Magaziner, Jay ^m  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d RUTGERS UNIVERSITY   (United States)

^e SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g UNIVERSITY OF ALBERTA   (Canada)

^h Och Spine at New York Presbyterian Hospitals   (United States)

ⁱ RUTGERS SCHOOL OF PUBLIC HEALTH   (United States)

^j MAIMONIDES MEDICAL CENTER   (United States)

^k UNIVERSITY OF WESTERN ONTARIO   (Canada)

^l Department of Anesthesia Surgeons Surgery Center   (United States)

^m UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CANADA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CEREBROVASCULAR ACCIDENT; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEMENTIA; FEMALE; FOLLOW UP; HEMOGLOBIN BLOOD LEVEL; HIGH RISK POPULATION; HIP FRACTURE; HUMAN; INFECTION; INTENTION TO TREAT ANALYSIS; INTERMETHOD COMPARISON; LIBERAL BLOOD TRANSFUSION; LONG TERM SURVIVAL; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MORTALITY; POSTOPERATIVE CARE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTRICTIVE BLOOD TRANSFUSION; SURVIVAL TIME; UNITED STATES; VERY ELDERLY; ADVERSE EFFECTS; ANEMIA; BLOOD; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; COMPARATIVE STUDY; HIP FRACTURES; MIDDLE AGED; MULTICENTER STUDY; PROCEDURES; RISK FACTOR; SINGLE BLIND PROCEDURE; SURVIVAL; UTILIZATION;

AGED; AGED, 80 AND OVER; ANEMIA; BLOOD TRANSFUSION; CANADA; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; FEMALE; HEMOGLOBINS; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE CARE; RISK FACTORS; SINGLE-BLIND METHOD; SURVIVAL ANALYSIS; UNITED STATES;

EID: 84926086663     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(14)62286-8     Document Type: Article

References (25)

1. JL Carson, PA Carless, PC Hebert Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion Cochrane Database Syst Rev 4 2012 CD002042.
2. JL Carson, MM Brooks, JD Abbott et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease Am Heart J 165 2013 964 971
3. C Villanueva, A Colomo, A Bosch et al. Transfusion strategies for acute upper gastrointestinal bleeding N Engl J Med 368 2013 11 21
4. JP Cata, H Wang, V Gottumukkala, J Reuben, DI Sessler Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions Br J Anaesth 110 2013 690 701
5. MA Refaai, N Blumberg Transfusion immunomodulation from a clinical perspective: an update Expert Rev Hematol 6 2013 653 663
6. HA Cooper, SV Rao, MD Greenberg et al. Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study) Am J Cardiol 108 2011 1108 1111
7. JL Carson, ML Terrin, H Noveck et al. Liberal or restrictive transfusion in high-risk patients after hip surgery N Engl J Med 365 2011 2453 2462
8. JL Carson, ML Terrin, J Magaziner et al. Transfusion trigger trial for functional outcomes in cardiovascular patients undergoing surgical hip fracture repair (FOCUS) Transfusion 46 2006 2192 2206
9. Centers for Disease Control and Prevention National Death Index http://www.cdc.gov/nchs/ndi.htm 2014 (accessed July 20, 2014).
10. WHO Manual of the international statistical classification of diseases, injuries, and causes of death: based on the recommendations of the ninth Revision Conference, 1975, and adopted by the twenty-ninth World Health Assembly. 1975 revision 1977 World Health Organization Geneva
11. DA Clark, RM Gorczynski, MA Blajchman Transfusion-related immunomodulation due to peripheral blood dendritic cells expressing the CD200 tolerance signaling molecule and alloantigen Transfusion 48 2008 814 821
12. EA Hod, SL Spitalnik Stored red blood cell transfusions: Iron, inflammation, immunity, and infection Transfus Clin Biol 19 2012 84 89
13. MM Heiss, W Mempel, KW Jauch et al. Beneficial effect of autologous blood transfusion on infectious complications after colorectal cancer surgery Lancet 342 1993 1328 1333
14. OR Busch, WC Hop, MA Hoynck van Papendrecht, RL Marquet, J Jeekel Blood transfusions and prognosis in colorectal cancer N Engl J Med 328 1993 1372 1376
15. AG Acheson, MJ Brookes, DR Spahn Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis Ann Surg 256 2012 235 244
16. HJ Chalfin, SM Frank, Z Feng et al. Allogeneic versus autologous blood transfusion and survival after radical prostatectomy Transfusion 54 2014 2168 2174
17. TY Yeoh, F Scavonetto, TN Weingarten et al. Perioperative allogeneic nonleukoreduced blood transfusion and prostate cancer outcomes after radical prostatectomy Transfusion 54 2014 2175 2181
18. JM Rohde, DE Dimcheff, N Blumberg et al. Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis JAMA 311 2014 1317 1326
19. MH Shishehbor, S Madhwal, V Rajagopal et al. Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction JACC Cardiovasc Interv 2 2009 46 53
20. AH van Straten, MW Bekker, MA Soliman Hamad et al. Transfusion of red blood cells: the impact on short-term and long-term survival after coronary artery bypass grafting, a ten-year follow-up Interact Cardiovasc Thorac Surg 10 2010 37 42
21. B Bhaskar, J Dulhunty, DV Mullany, JF Fraser Impact of blood product transfusion on short and long-term survival after cardiac surgery: more evidence Ann Thorac Surg 94 2012 460 467
22. M Engoren The effect of red blood cell transfusion on 90-day mortality in patients with acute lung injury J Intensive Care Med 27 2012 112 118
23. RE Shaw, CK Johnson, G Ferrari et al. Blood transfusion in cardiac surgery does increase the risk of 5-year mortality: results from a contemporary series of 1714 propensity-matched patients Transfusion 54 2014 1106 1113
24. MJ Stampfer, WC Willett, FE Speizer et al. Test of the National Death Index Am J Epidemiol 119 1984 837 839
25. Statistics Canada Vital statistics - death database http://www23.statcan.gc.ca/imdb/p2SV.pl?Function=getSurvey&SDDS=3233 Sept, 24, 2013 (accessed Nov 16, 2014).