Association of sex with risk of kidney graft failure differs by age

Journal of the American Society of Nephrology

Volumn 28, Issue 10, 2017, Pages 3014-3023

  Lepeytre, Fanny ^a   Dahhou, Mourad ^b   Zhang, Xun ^b   Boucquemont, Julie ^b,c   Sapir Pichhadze, Ruth ^b,c   Cardinal, Heloise ^a   Foster, Bethany J ^b,c,d  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MINOR HISTOCOMPATIBILITY ANTIGEN; PANEL REACTIVE ANTIBODY; SEX HORMONE;

ADULT; AGE; ARTICLE; BODY SIZE; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; ADOLESCENT; CHILD; INFANT; KIDNEY TRANSPLANTATION; MIDDLE AGED; PRESCHOOL CHILD; REGISTER; SEXUAL DEVELOPMENT; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; FEMALE; GRAFT SURVIVAL; HUMANS; INFANT; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; REGISTRIES; SEX CHARACTERISTICS; SEX FACTORS; YOUNG ADULT;

EID: 85030459724     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2016121380     Document Type: Article

References (49)

1. Foster BJ, Dahhou M, Zhang X, Platt RW, Samuel SM, Hanley JA: Association between age and graft failure rates in young kidney transplant recipients. Transplantation 92: 1237-1243, 2011
2. Keith DS, Cantarovich M, Paraskevas S, Tchervenkov J: Recipient age and risk of chronic allograft nephropathy in primary deceased donor kidney transplant. Transpl Int 19: 649-656, 2006
3. Kaboré R, CouchoudC, Macher M-A, Salomon R, Ranchin B, LahocheA, Roussey-Kesler G, Garaix F, Decramer S, Piètrement C, Lassalle M, Baudouin V, Cochat P, Niaudet P, Joly P, Leffondré K, Harambat J: Age dependent risk of graft failure in young kidney transplant recipients [published online ahead of print August 1, 2016]. Transplantation 10.1097/TP.0000000000001372
4. Kim SJ, Gill JS: H-Y incompatibility predicts short-term outcomes for kidney transplant recipients. J AmSoc Nephrol 20: 2025-2033, 2009
5. Meier-Kriesche HU, Ojo AO, Leavey SF, Hanson JA, Leichtman AB, Magee JC, Cibrik DM, Kaplan B: Gender differences in the risk for chronic renal allograft failure. Transplantation 71: 429-432, 2001
6. Gratwohl A, Döhler B, Stern M, Opelz G: H-Y as a minor histocompatibility antigen in kidney transplantation: A retrospective cohort study. Lancet 372: 49-53, 2008
7. Giefing-Kröll C, Berger P, Lepperdinger G, Grubeck-Loebenstein B: How sex and age affect immune responses, susceptibility to infections, and response to vaccination. Aging Cell 14: 309-321, 2015
8. Klein SL, Marriott I, Fish EN: Sex-based differences in immune function and responses to vaccination. Trans R Soc Trop Med Hyg 109: 9-15, 2015
9. Bouman A, Heineman MJ, Faas MM: Sex hormones and the immune response in humans. Hum Reprod Update 11: 411-423, 2005
10. Trigunaite A, Dimo J, Jørgensen TN: Suppressive effects of androgens on the immune system. Cell Immunol 294: 87-94, 2015
11. Denhaerynck K, Steiger J, Bock A, Schäfer-Keller P, Köfer S, Thannberger N, De Geest S: Prevalence and risk factors of non-adherence with immunosuppressive medication in kidney transplant patients. Am J Transplant 7: 108-116, 2007
12. Kiley DJ, Lam CS, Pollak R: A study of treatment compliance following kidney transplantation. Transplantation 55: 51-56, 1993
13. Frazier PA, Davis-Ali SH, Dahl KE: Correlates of noncompliance among renal transplant recipients. Clin Transplant 8: 550-557, 1994
14. OhC-K, Lee BM, Jeon KO, KimHJ, Pelletier SJ, KimSI, KimYS: Genderrelated differences of renal mass supply and metabolic demand after living donor kidney transplantation. Clin Transplant 20: 163-170, 2006
15. Feldman HI, Fazio I, Roth D, Berlin JA, Brayman K, Burns JE, Grossman RA: Recipient body size and cadaveric renal allograft survival. J AmSoc Nephrol 7: 151-157, 1996
16. Tan JC, Wadia PP, CoramM, Grumet FC, KambhamN, Miller K, Pereira S, Vayntrub T, Miklos DB: H-Y antibody development associates with acute rejection in female patients withmale kidney transplants. Transplantation 86: 75-81, 2008
17. Pfeffer PF, Thorsby E:HLA-restricted cytotoxicity against male-specific (H-Y) antigen after acute rejection of an HLA-identical sibling kidney: Clonal distribution of the cytotoxic cells. Transplantation 33: 52-56, 1982
18. Yuge J, Cecka JM: Sex and age effects in renal transplantation. In: Clinical Transplants, edited by Terasaki P, Los Angeles, UCLA Tissue Typing Laboratory, 1991, pp 257-267
19. Chen P-D, Tsai M-K, Lee C-Y, Yang C-Y, Hu R-H, Lee P-H, Lai H-S: Gender differences in renal transplant graft survival. J Formos Med Assoc 112: 783-788, 2013
20. Zeier M, Döhler B, Opelz G, Ritz E: The effect of donor gender on graft survival. J Am Soc Nephrol 13: 2570-2576, 2002
21. Fish EN: The X-files in immunity: Sex-based differences predispose immune responses. Nat Rev Immunol 8: 737-744, 2008
22. Tan JC, Paik J, Chertow GM, Grumet FC, Busque S, Lapasia J, DesaiM: Validity of surrogate measures for functional nephron mass. Transplantation 92: 1335-1341, 2011
23. Hoy WE, Douglas-Denton RN, Hughson MD, Cass A, Johnson K, Bertram JF: A stereological study of glomerular number and volume: Preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int 63 [Suppl 83]: S31-S37, 2003
24. Chisholm-BurnsMA, Spivey CA, Rehfeld R, Zawaideh M, RoeDJ, Gruessner R: Immunosuppressant therapy adherence and graft failureamongpediatric renal transplant recipients. Am J Transplant 9: 2497-2504, 2009
25. DewMA, Dabbs AD, Myaskovsky L, Shyu S, Shellmer DA, DiMartini AF, Steel J, Unruh M, Switzer GE, Shapiro R, Greenhouse JB:Meta-analysis of medical regimen adherence outcomes in pediatric solid organ transplantation. Transplantation 88: 736-746, 2009
26. Dobbels F, Ruppar T, De Geest S, Decorte A, Van Damme-Lombaerts R, Fine RN: Adherence to the immunosuppressive regimen in pediatric kidney transplant recipients: A systematic review. Pediatr Transplant 14: 603-613, 2010
27. Spivey CA, Chisholm-Burns MA, Damadzadeh B, Billheimer D: Determining the effect of immunosuppressant adherence on graft failure risk among renal transplant recipients. Clin Transplant 28: 96-104, 2014
28. Chisholm-Burns MA, Spivey CA, Tolley EA, Kaplan EK: Medication therapy management and adherence among US renal transplant recipients. Patient Prefer Adherence 10: 703-709, 2016
29. Boucquemont J, Foster BJ; The TAKE-IT investigators: Sex and Age Differences in Medication Adherence in Adolescent and Young Adult Kidney Transplant Recipients [Abstract]. J Am Soc Nephrol 27: 721A, 2016
30. Sapir-Pichhadze R, Young A, Joseph Kim S: Living donor age and kidney transplant outcomes: An assessment of risk across the age continuum. Transpl Int 26: 493-501, 2013
31. Simon AK, Hollander GA, McMichael A: Evolution of the immune system in humans from infancy to old age. Proc Biol Sci 282: 20143085, 2015
32. PrabhuDas M, Adkins B, Gans H, King C, LevyO, RamiloO, Siegrist CA: Challenges in infant immunity: Implications for responses to infection and vaccines. Nat Immunol 12: 189-194, 2011
33. Wikby A, Månsson IA, Johansson B, Strindhall J, Nilsson SE: The immune risk profile is associated with age and gender: Findings from three Swedish population studies of individuals 20-100 years of age. Biogerontology 9: 299-308, 2008
34. Weng NP: Aging of the immune system: How much can the adaptive immune system adapt?. Immunity 24: 495-499, 2006
35. Nie J, Li YY, Zheng SG, Tsun A, Li B: FOXP3(+) treg cells and gender bias in autoimmune diseases. Front Immunol 6: 493, 2015
36. Oertelt-Prigione S: The influence of sex and gender on the immune response. Autoimmun Rev 11: A479-A485, 2012
37. Uekert SJ, Akan G, Evans MD, Li Z, Roberg K, Tisler C, Dasilva D, Anderson E, Gangnon R, Allen DB, Gern JE, Lemanske RF Jr.: Sexrelated differences in immune development and the expression of atopy in early childhood. J Allergy Clin Immunol 118: 1375-1381, 2006
38. Kolonko A, Chudek J, Wiecek A: Nephron underdosing as a risk factor for impaired early kidney graft function and increased graft loss during the long-term follow-up period. Transplant Proc 45: 1639-1643, 2013
39. Shaheen MF, Shaheen FAM, Attar B, Elamin K, Al Hayyan H, Al Sayyari A: Impact of recipient and donor nonimmunologic factors on the outcome of deceased donor kidney transplantation. Transplant Proc 42: 273-276, 2010
40. Santiago EV, Silveira MR, Araújo VE, Farah Kde P, Acurcio Fde A, Ceccato Md: Gender in the allocation of organs in kidney transplants: Meta-analysis. Rev. Saude Publica 49: 68, 2015
41. Zhou J-Y, Cheng J, Huang H-F, Shen Y, Jiang Y, Chen J-H: The effect of donor-recipient gendermismatch on short- and long-termgraft survival in kidney transplantation: A systematic review and meta-analysis. Clin Transplant 27: 764-771, 2013
42. Wagner S:H-Y antigen in kidney transplant: Does gendermatter?. Gend Med 9: 387-388, 2012
43. Tan JC, Kim JP, Chertow GM, Grumet FC, Desai M: Donor-recipient sex mismatch in kidney transplantation. Gend Med 9: 335-347.e2, 2012
44. Potluri VS, Parikh CR, Hall IE, Ficek J, Doshi MD, Butrymowicz I, Weng FL, Schröppel B, Thiessen-Philbrook H, Reese PP: Validating early posttransplant outcomes reported for recipients of deceased donor kidney transplants. Clin J Am Soc Nephrol 11: 324-331, 2016
45. Foster BJ, Dahhou M, Zhang X, Dharnidharka VR, Conway J, Ng VL: High risk of liver allograft failure during late adolescence and young adulthood. Transplantation 100: 577-584, 2016
46. Foster BJ, Dahhou M, Zhang X, Dharnidharka V, Ng V, Conway J: High risk of graft failure in emerging adult heart transplant recipients. Am J Transplant 15: 3185-3193, 2015
47. Rothman KJ, Greenland S: Introduction to stratified analysis. In: Modern Epidemiology, 2nd Ed., edited by Rothman KJ, Greenland S, Philadelphia, Lippincott-Raven, 1998, p 256
48. Allison PD: Survival Analysis Using SAS: A Practical Guide, 2nd ed., edited by Press SAS, North Carolina, SAS Institute, 2010
49. Schafer JL:Multiple imputation: A primer. Stat MethodsMed Res 8: 3-15, 1999