Immunosuppressant therapy adherence and graft failure among pediatric renal transplant recipients

American Journal of Transplantation

Volumn 9, Issue 11, 2009, Pages 2497-2504

  Chisholm Burns, M A ^a,b   Spivey, C A ^a   Rehfeld, R ^a   Zawaideh, M ^b   Roe, D J ^a   Gruessner, R ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Graft failure; Medication adherence; Pediatric renal transplant recipients; Renal transplant

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN; TACROLIMUS;

ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; DEATH; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HAZARD ASSESSMENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KAPLAN MEIER METHOD; KIDNEY GRAFT; MAJOR CLINICAL STUDY; MALE; MEDICARE; PATIENT COMPLIANCE; PEDIATRICS; PRIORITY JOURNAL; SCHOOL CHILD; UNITED STATES;

ADOLESCENT; CHILD; CYCLOSPORINE; DRUG PRESCRIPTIONS; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KAPLAN-MEIERS ESTIMATE; KIDNEY TRANSPLANTATION; MALE; MEDICARE; MEDICATION ADHERENCE; PROPORTIONAL HAZARDS MODELS; TACROLIMUS; UNITED STATES;

EID: 70350126190     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02793.x     Document Type: Article

References (53)

1. Dobbels F, Van Damme-Lombaert R, Vanhaecke J, De Geest S. Growing pains: Non-adherence with the immunosuppressive regimen in adolescent transplant recipients. Pediatr Transplant 2005 9 : 381 390.
2. Foulkes L-M, Boggs SR, Fennell RS, Skibinski K. Social support, family variables, and compliance in renal transplant children. Pediatr Nephrol 1993 7 : 185 188.
3. Ettenger RB, Rosenthal JT, Marik JL et al. Improved cadaveric renal transplant outcome in children. Pediatr Nephrol 1991 5 : 137 142.
4. Beck DE, Fennell RS, Yost RL, Robinson JD, Geary D, Richards GA. Evaluation of an educational program on compliance with medication regimens in pediatric patients after renal transplants. J Pediatr 1980 96 : 1094 1097.
5. Shaw RJ, Plamer L, Blasey C, Sarwal M. A typology of non-adherence in pediatric renal transplant recipients. Pediatr Transplant 2003 7 : 489 493.
6. Delucchi A, Ferrario M, Varela M et al. Pediatric renal transplantation: A single center experience over 14 years. Pediatr Transplant 2006 10 : 193 197.
7. Feinstein S, Keich R, Becker-Cohen R, Rinat C, Schwartz SB, Frishberg Y. Is noncompliance among adolescent renal transplant recipients inevitable? Pediatrics 2005 115 : 969 973.
8. Gagnadoux M-F, Niaudet P, Broyer M. Non-immunological risk factors in paediatric renal transplantation. Pediatr Nephrol 1993 7 : 89 95.
9. Jarzembowski T, John E, Panaro F et al. Impact of non-compliance on outcome after pediatric kidney transplantation: An analysis in racial sub-groups. Pediatr Transplant 2004 8 : 367 371.
10. Korsch BM, Fine RN, Negrete VF. Noncompliance in children with renal transplants. Pediatrics 1978 61 : 872 876.
11. Meyers KEC, Weiland H, Thomson PD. Paediatric renal transplantation non-compliance. Pediatr Nephrol 1995 9 : 189 192.
12. Cecka JM, Gjertson DW, Tersaki PI. Pediatric renal transplantation: A review of the UNOS data. Pediatr Transplant 1997 1 : 55 64.
13. Smith JM, Fine RN, McDonald RA. Current state of pediatric renal transplantation. Front Biosci 2008 13 : 197 203.
14. Byerly MJ, Thompson A, Carmody T et al. Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. Psychiatr Serv 2007 58 : 844 847.
15. Butler JA, Peveler RC, Roderick P, Horne R, Mason JC. Measuring compliance with drug regimens after renal transplantation: Comparison of self-report and clinician rating with electronic monitoring. Transplantation 2004 77 : 786 789.
16. Rand CS, Wise RA. Measuring adherence to asthma medication regimens. Am J Resp Crit Care Med 1994 149 : 569 576.
17. Mushlin AI, Appel FA. Diagnosing potential non-compliance: Physician's ability in a behavioral dimension of medical care. Arch Intern Med 1977 137 : 318 321.
18. Steele DJ, Jackson TC, Guttmann MC. Have you been taking your pill? The adherence-monitoring sequence in the medical interview. J Fam Pract 1990 30 : 294 299.
19. Bennett Johnson S. Methodological issues in diabetes research. Diabetes Care 1992 15 : 1658 1667.
20. Schlenk EA, Dunbar-Jacob J, Engberg S. Medication non-adherence among older adults. J Gerontol Nurs 2004 30 : 33 43.
21. Modi AC, Lim CS, Yu N et al. A multi-method assessment of treatment adherence for children with cystic fibrosis. J Cyst Fibros 2006 5 : 177 185.
22. Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: Methods, validity, and applications. J Clin Epidemiol 1997 50 : 105 116.
23. Grymonpre R, Cheang M, Fraser M, Metge C, Sitar DS. Validity of a prescription claims database to estimate medication adherence in older persons. Med Care 206 44 : 471 477.
24. Partridge AH, Avorn J, Wang PS et al. Adherence to therapy with oral antineoplastic agents. J Natl Cancer Inst 2002 94 : 652 661.
25. United Network for Organ Sharing [UNOS]. Types of data collected. Available from : http://www.unos.org/data/about/collection.asp, Accessed April 2, 2008.
26. Smith JM, Nemeth TL, McDonald RA. Current immunosuppressive agents: Efficacy, side effects, and utilization. Pediatr Clin North Am 2003 50 : 1283 1300.
27. Filler G. Calcineurin inhibitors in pediatric renal transplant recipients. Pediatr Drugs 2007 9 : 165 174. (Pubitemid 46849136)
28. Takemoto SK, Pinsky B, Woodward RS. Outcomes and costs associated with immunosuppression compliance. Value Health 2007 10 : A102.
29. Nevins TE, Kruse L, Skeans MA, Thomas W. The natural history of azathioprine compliance after renal transplantation. Kidney Int 2001 60 : 1565 1570.
30. Matz K, Stablein DM. For the North American Pediatric Renal Trials and Cooperative Studies (NAPRTCS). NAPRTCS 2008 Annual Report. Available from : http://spitfire.emmes.com/study/ped/annlrept/Annual%20Report%20-2008.pdf, Accessed February 3, 2009.
31. Weng FL, Isnrani AK, Joffe MM et al. Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation. J Am Soc Nephrol 2005 16 : 1839 1848.
32. Dunbar J. Adherence measures and their utility. Control Clin Trials 1984 5 : 515 521.
33. Rudd P. In search of the gold standard for compliance measurement. Arch Intern Med 1979 139 : 627 628.
34. Penkower L, Dew MA, Ellis D, Sereika SM, Kitutu JMM, Shapiro R. Psychological distress and adherence to the medical regimen among adolescent renal transplant recipients. Am J Transplant 2003 3 : 1418 1425.
35. Blowey DL, Hébert D, Arbus GS, Pool R, Korus M, Koren G. Compliance with cyclosporine in adolescent renal transplant recipients. Pediatr Nephrol 1997 11 : 547 551.
36. Wu ZX, Yang SL, Wu WZ et al. The long-term outcomes of pediatric kidney transplantation: A single-centre experience in China. Pediatr Transplant 2008 12 : 215 218.
37. Chisholm MA, Lance CE, Mulloy LL. Patient factors associated with immunosuppressant therapy adherence in renal transplant recipients. Am J Health-Syst Pharm 2005 62 : 1775 1781.
38. Chisholm MA, Mulloy LL, DiPiro JT. Comparing renal transplant patients' adherence to free cyclosporine and free tacrolimus immunosuppressant therapy. Clin Transplant 2005 19 : 77 82.
39. Rx Watch: Generics in 2008. Available from : http://www.calendarlive.com/ media/acrobat/2008-03/36768569.pdf, Accessed January 13, 2009.
40. Stone VE, Jordan J, Tolson J, Miller R, Pilon T. Perspectives on adherence and simplicity for HIV-infected patients on antiretroviral therapy: Self-report of the relative importance of multiple attributes of highly active antiretroviral therapy (HAART) regimens in predicting adherence. J Acquir Immune Defic Syndr 2004 36 : 808 816.
41. Mateo JF, Gil-Guillén VF, Mateo E, Orozco D, Carbayo JA, Merino J. Multifactorial approach and adherence to prescribed oral medications in patients with type 2 diabetes. Int J Clin Pract 2006 60 : 422 428.
42. Maggiolo F, Ripamonti D, Arici C et al. Simpler regimens may enhance adherence to antiretrovirals in HIV-infected patients. HIV Clin Trials 2002 3 : 371 378.
43. Smith BA, Shuchman M. Problem of nonadherence in chronically ill adolescents: Strategies for assessment and intervention. Curr Opin Pediatr 2005 17 : 613 618.
44. Zelikovsky N, Schast AP, Palmer JA, Meyers KEC. Perceived barriers to adherence among adolescent renal transplant candidates. Pediatr Transplant 2008 12 : 300 308.
45. Nevins TE. Non-compliance and its management in teenagers. Pediatr Transplant 2002 6 : 475 479.
46. Rapoff MA. Adherence to Pediatric Medical Regimens. New York : Kluwer Academic/Plenum Publishers, 1999.
47. Rianthavorn P, Ettenger RB. Medication non-adherence in the adolescent renal transplant recipient: A clinician's viewpoint. Pediatr Transplant 2005 9 : 398 407.
48. Delucchi A, Gutierrez H, Arrellano P, Slater C, Meneses M, López I. Factors that influence nonadherence in immunosuppressant treatment in pediatric transplant recipients: A proposal for an educational strategy. Transplant Proc 2008 40 : 3241 3243.
49. Yin HS, Dreyer BP, van Schaik L, Foltin GL, Dinglas C, Mendelsohn AL. Randomized controlled trial of a pictogram-based intervention to reduce liquid medication dosing errors and improve adherence among caregivers of young children. Arch Pediatr Adolesc Med 2008 162 : 814 822.
50. Bartlett SJ, Lukk P, Butz A, Lampros-Klein F, Rand CS. Enhancing medication adherence among inner-city children with asthma: Results from pilot studies. J Asthma 2002 39 : 47 54.
51. Matsui D. Current issues in pediatric medication adherence. Paediatr Drugs 2007 9 : 283 288.
52. Garvia PA, Lensing S, Rai SN. Efficacy of a pill-swallowing training intervention to improve antiretroviral medication adherence in pediatric patients with HIV/AIDS. Pediatrics 2007 119 : e893 e899.
53. United Network for Organ Sharing [UNOS]. Transplants in the U.S. by Recipient Age. Available from : http://www.optn.org/latestData/rptData.asp, Accessed October 14, 2008.