Adherence to the immunosuppressive regimen in pediatric kidney transplant recipients: A systematic review

Pediatric Transplantation

Volumn 14, Issue 5, 2010, Pages 603-613

  Dobbels, F ^a,e   Ruppar, T ^a   De Geest, S ^a,b   Decorte, A ^c   Van Damme Lombaerts, R ^c   Fine, R N ^d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d STONY BROOK UNIVERSITY MEDICAL CENTER   (United States)

^e RESEARCH FOUNDATION FLANDERS FWO   (Belgium)

Author keywords

kidney transplantation; medication nonadherence; pediatric patients; systematic review

Indexed keywords

CYCLOSPORIN; DACLIZUMAB; IMMUNOSUPPRESSIVE AGENT; TACROLIMUS;

ACUTE GRAFT REJECTION; ARTICLE; DRUG BLOOD LEVEL; EVIDENCE BASED MEDICINE; GRAFT RECIPIENT; GROUPS BY AGE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; PATIENT COMPLIANCE; PATIENT EDUCATION; RISK FACTOR; SYSTEMATIC REVIEW; TREATMENT REFUSAL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; PATIENT COMPLIANCE; YOUNG ADULT;

EID: 77954499977     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2010.01299.x     Document Type: Article

References (67)

1. Neu AM. Special issues in pediatric kidney transplantation. Adv Chronic Kidney Dis 2006 : 13 : 62 69.
2. Dobbels F, Van Damme-Lombaert R, Vanhaecke J, et al. Growing pains: Non-adherence with the immunosuppressive regimen in adolescent transplant recipients. Pediatr Transplant 2005 : 9 : 381 390.
3. Sabaté E. Adherence to Long-term Therapies: Evidence for Action.
4. Nankivell BJ, Chapman JR. Chronic allograft nephropathy: Current concepts and future directions. Transplantation 2006 : 81 : 643 654.
5. Fine RN, Becker Y, De Geest S. Nonadherence Consensus Summary Conference Report. Am J Transplant 2009 : 9 : 35 41.
6. Bartosh SM, Ryckman FC, Shaddy R, et al. A national conference to determine research priorities in pediatric solid organ transplantation. Pediatr Transplant 2008 : 12 : 153 166.
7. Hesse UJ, Roth B, Knuppertz G, et al. Control of patient compliance in outpatient steroid treatment of nephrologic disease and renal transplant recipients. Transplant Proc 1990 : 22 : 1405 1406.
8. Ettenger RB, Rosenthal JT, Marik JL, et al. Improved cadaveric renal transplant outcome in children. Pediatr Nephrol 1991 : 5 : 137 142.
9. Foulkes LM, Boggs SR, Fennell RS, et al. Social support, family variables, and compliance in renal transplant children. Pediatr Nephrol 1993 : 7 : 185 188.
10. Morgenstern BZ, Murphy M, Dayton J, et al. Noncompliance in a pediatric renal transplant population. Transplant Proc 1994 : 26 : 129.
11. Meyers KE, Weiland H, Thomson PD. Paediatric renal transplantation non-compliance. Pediatr Nephrol 1995 : 9 : 189 192.
12. Meyers KE, Thomson PD, Weiland H. Noncompliance in children and adolescents after renal transplantation. Transplantation 1996 : 62 : 186 189.
13. Blowey DL, Hebert D, Arbus GS, et al. Compliance with cyclosporine in adolescent renal transplant recipients. Pediatr Nephrol 1997 : 11 : 547 551.
14. Wolff G, Strecker K, Vester U, et al. Non-compliance following renal transplantation in children and adolescents. Pediatr Nephrol 1998 : 12 : 703 708. (Pubitemid 28556789)
15. Penkower L, Dew MA, Ellis D, et al. Psychological distress and adherence to the medical regimen among adolescent renal transplant recipients. Am J Transplant 2003 : 3 : 1418 1425.
16. Shaw RJ, Palmer L, Blasey C, Sarwal M. A typology of non-adherence in pediatric renal transplant recipients. Pediatr Transplant 2003 : 7 : 489 493.
17. Gerson AC, Furth SL, Neu AM, Fivush BA. Assessing associations between medication adherence and potentially modifiable psychosocial variables in pediatric kidney transplant recipients and their families. Pediatr Transplant 2004 : 8 : 543 550.
18. Feinstein S, Keich R, Becker-Cohen R, et al. Is noncompliance among adolescent renal transplant recipients inevitable? Pediatrics 2005 : 115 : 969 973.
19. Takemoto SK, Pinsky BW, Schnitzler MA, et al. A retrospective analysis of immunosuppression compliance, dose reduction and discontinuation in kidney transplant recipients. Am J Transplant 2007 : 7 : 2704 2711.
20. Delucchi A, Gutierrez H, Arrellano P, et al. Factors that influence nonadherence in immunosuppressant treatment in pediatric transplant recipients: A proposal for an educational strategy. Transplant Proc 2008 : 40 : 3241 3243.
21. Simons LE, Gilleland J, Blount RL, et al. Multidimensional Adherence Classification System: Initial development with adolescent transplant recipients. Pediatr Transplant 2009 13 : 590 598 e-pub ahead of printing Oct 7, 2008)
22. Wu Z, Yang S, Wu W, et al. The long-term outcomes of pediatric kidney transplantation: A single-centre experience in China. Pediatr Transplant 2008 : 12 : 215 218.
23. Brodehl J, Bokenkamp A, Hoyer PF, et al. Long-term results of cyclosporin A therapy in children. J Am Soc Nephrol 1992 : 2 (Suppl. 12 S246 S254.
24. Garcia V, Bittar A, Keitel E, et al. Patient noncompliance as a major cause of kidney graft failure. Transplant Proc 1997 : 29 : 252 254.
25. Cecka JM, Gjertson DW, Terasaki PI. Pediatric renal transplantation; a review of the UNOS data. Pediatr Transplant 1997 : 1 : 55 64.
26. Jarzembowski T, John E, Panaro F, et al. Impact of non-compliance on outcome after pediatric kidney transplantation: An analysis in racial subgroups. Pediatr Transplant 2004 : 8 : 367 371.
27. Gulati S, Kumar A, Sharma RK, et al. Outcome of pediatric renal transplants in a developing country. Pediatr Nephrol 2004 : 19 : 96 100.
28. Berber I, Tellioglu G, Yigit B, et al. Pediatric renal transplantation: Clinical analysis of 28 cases. Transplant Proc 2006 : 38 : 430 431.
29. Delucchi A, Ferrario M, Varela M, et al. Pediatric renal transplantation: A single center experience over 14 years. Pediatr Transplant 2006 : 10 : 193 197.
30. Vlaminck H, Maes B, Evers G, et al. Prospective study on late consequences of subclinical non-compliance with immunosuppressive therapy in renal transplant patients. Am J Transplant 2004 : 4 : 1509 1513.
31. Remorino R, Taylor J. Smoothing things over: The transition from pediatric to adult care for kidney transplant recipients. Prog Transplant 2006 : 16 : 303 308.
32. Watson AR. Non-compliance and transfer from paediatric to adult transplant units. Pediatr Nephrol 2000 : 14 : 469 472.
33. Tucker CM, Petersen S, Herman KC, et al. Self-regulation predictors of medication adherence among ethnically different pediatric patients with renal transplants. J Pediatr Psychol 2001 : 26 : 455 464.
34. Tucker CM, Fennell RS, Pedersen T, et al. Associations with medication adherence among ethnically different pediatric patients with renal transplants. Pediatr Nephrol 2002 : 17 : 251 256.
35. Maikranz JM, Steele RG, Dreyer ML, et al. The relationship of hope and illness-related uncertainty to emotional adjustment and adherence among pediatric renal and liver transplant recipients. J Pediatr Psychol 2007 : 32 : 571 581.
36. Bullington P, Pawola L, Walker R, et al. Identification of medication non-adherence factors in adolescent transplant patients: The patient's viewpoint. Pediatr Transplant 2007 : 11 : 914 921.
37. Fennell RS, Tucker C, Pedersen T. Demographic and medical predictors of medication compliance among ethnically different pediatric renal transplant patients. Pediatr Transplant 2001 : 5 : 343 348. (Pubitemid 32834801)
38. Simons LE, Mccormick ML, Mee LL, et al. Parent and patient perspective on barriers to medication adherence in adolescent transplant recipients. Pediatr Transplant 2009 13 : 338 347 e-pub ahead of printing April 22, 2008)
39. Denhaerynck K, Dobbels F, Cleemput I, et al. Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: A literature review. Transpl Int 2005 : 18 : 1121 1133.
40. Butler JA, Roderick P, Mullee M, et al. Frequency and impact of nonadherence to immunosuppressants after renal transplantation: A systematic review. Transplantation 2004 : 77 : 769 776.
41. Laederach-Hofmann K, Bunzel B. Noncompliance in organ transplant recipients: A literature review. Gen Hosp Psychiatry 2000 : 22 : 412 424.
42. Chisholm MA. Issues of adherence to immunosuppressant therapy after solid organ transplantation. Drugs 2002 : 62 : 567 575.
43. Bunzel B, Laederach-Hofmann K. Solid organ transplantation: are there predictors for posttransplant noncompliance? A literature overview Transplantation 2000 : 70 : 711 716.
44. Fennell RS, Foulkes LM, Boggs SR. Family-based program to promote medication compliance in renal transplant children. Transplant Proc 1994 : 26 : 102 103.
45. Chaudhuri A, Salvatierra O Jr., Sarwal MM Extended daclizumab monotherapy for rejection-free survival in non-adherent adolescent recipients of renal allografts. Pediatr Transplant 2009 : 13 : 927 932.
46. Dhanireddy KK, Maniscalco J, Kirk AD. Is tolerance induction the answer to adolescent non-adherence? Pediatr Transplant 2005 : 9 : 357 363.
47. Dew MA, Dimartini AF, De Vito Dabbs A, et al. Rate and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 2007 : 83 : 858 873.
48. Chisholm MA, Lance CE, Williamson GM, et al. Development and validation of the immunosuppressant therapy adherence instrument (ITAS). Patient Educ Couns 2005 : 59 : 13 20.
49. Zelikovsky N, Schast AP. Eliciting accuracy reports of adherence in a clinical interview: Development of the Medical Adherence Measure. Pediatr Nurs 2008 : 34 : 141 146.
50. Russell CL, Conn VS, Ashbaugh C, et al. Intrasubject medication adherence patterns. Clin Nurs Res 2007 : 16 : 153 163.
51. Denhaerynck K, Schäfer-Keller P, Young J, et al. Examining the assumptions regarding valid electronic monitoring of medication therapy: Development of a validation framework and its application on a European sample of kidney transplant patients. BMC Med Res Methodol 2008 8 : e-pub ahead of printing.
52. Schellmer DA, Zelikovsky N. The challenges of using medication event monitoring technology with pediatric transplant patients. Pediatr Transplant 2007 : 11 : 422 428.
53. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005 : 353 : 487 497.
54. Schäfer-Keller P, Steiger J, Bock A, et al. Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients. Am J Transplant 2008 : 8 : 616 626.
55. Nevins TE, Kruse L, Skeans MA, et al. The natural history of azathioprine compliance after renal transplantation. Kidney Int 2001 : 60 : 1565 1570.
56. Nevins T, Thomas W. Quantitative patterns of azathioprine adherence after renal transplantation. Transplantation 2009 : 87 : 711 718.
57. De Geest S, Abraham I, Moons P, et al. Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients. J Heart Lung Transplant 1998 : 17 : 854 863.
58. Cleemput I, Kesteloot K, Vanrenterghem Y, et al. The economic implications of non-adherence after renal transplantation. Pharmacoeconomics 2004 : 22 : 1217 1234.
59. Hansen R, Seifeldin R, Noe L. Medication adherence in chronic disease: Issues in posttransplant immunosuppression. Transplant Proc 2007 : 39 : 1287 1300.
60. Tielen M, Van Staa AL, Jedeloo S, et al. Q-methodology to identify young adult renal transplant recipients at risk for nonadherence. Transplantation 2008 : 85 : 700 706.
61. Gordon EJ, Prohaska TR, Gallant MP, et al. Adherence to immunosuppression: A prospective diary study. Transplant Proc 2007 : 39 : 3081 3085.
62. Weng FL, Israni AK, Joffe MM, et al. Race and electronically measured adherence to immunosuppressive medications after deceased donor renal transplantation. J Am Soc Nephrol 2005 : 16 : 1839 1848.
63. Denhaerynck K, Desmyttere A, Dobbels F, et al. Prevalence of noncompliance with the immunosuppressive regimen in North American and European renal transplant recipients. Progress Transplant 2006 : 16 : 206 214.
64. De Bleser L, Matteson M, Dobbels F, et al. Interventions to improve medication adherence after transplantation: A systematic review. Transpl Int 2009 : 22 : 780 797.
65. De Geest S, Schafer-Keller P, Denhaerynck K, et al. Supporting medication adherence in renal transplantation (SMART): A pilot RCT to improve adherence to immunosuppressive regimens. Clin Transplant 2006 : 20 : 359 368.
66. Haynes RB, Ackloo E, Sahota N, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008 16 : CD 000011.
67. Abecassis MM, Seifeldin R, Riordan ME. Patient outcomes and economics of once-daily tacrolimus in renal transplant patients: Results of a modeling analysis. Transplant Proc 2008 : 40 : 1443 1445.