Transformation of prednisolone to a 20β-hydroxy prednisolone compound by Streptomyces roseochromogenes TS79

Applied Microbiology and Biotechnology

Volumn 92, Issue 4, 2011, Pages 727-735

  Zhang, Wenquan ^a   Cui, Li ^b   Wu, Mengyao ^b   Zhang, Rongqing ^a   Xie, Liping ^a   Wang, Hongzhong ^a  

^a TSINGHUA UNIVERSITY   (China)

^b DALIAN POLYTECHNIC UNIVERSITY   (China)

Author keywords

C20 hydroxy prednisolone; Hydroxylation; Microbial transformation; Streptomyces roseochromogenes TS79

Indexed keywords

FERMENTATION CULTURE; INDUSTRIAL PRODUCTION; MICROBIAL TRANSFORMATION; OPTIMUM VALUE; PHARMACEUTICAL PREPARATIONS; PREDNISOLONE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION PARAMETERS; SPECTRAL DATA; STREPTOMYCES ROSEOCHROMOGENES TS79;

BACTERIA; HYDROXYLATION; MASS SPECTROMETRY; OLEFINS;

NUCLEAR MAGNETIC RESONANCE;

20 DIHYDROPREDNISOLONE; DIMETHYL SULFOXIDE; MAGNESIUM SULFATE; PREDNISOLONE; PREDNISOLONE DERIVATIVE; UNCLASSIFIED DRUG;

BACTERIUM; BIOACTIVITY; BIOTECHNOLOGY; BIOTRANSFORMATION; DRUG; FERMENTATION; INDUSTRIAL PRODUCTION; KETONE; MASS SPECTROMETRY; MICROBIAL ACTIVITY; NUCLEAR MAGNETIC RESONANCE; STEROID;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; FERMENTATION MEDIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INCUBATION TIME; MASS FRAGMENTOGRAPHY; NONHUMAN; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES; STREPTOMYCES ROSEOCHROMOGENES;

BIOTRANSFORMATION; CULTURE MEDIA; FERMENTATION; MAGNETIC RESONANCE SPECTROSCOPY; PREDNISOLONE; STREPTOMYCES;

STREPTOMYCES ROSEOCHROMOGENES;

EID: 82355182128     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3382-4     Document Type: Article

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