Biotechnological transformation of hydrocortisone to 16α-hydroxy hydrocortisone by Streptomyces roseochromogenes

Applied Microbiology and Biotechnology

Volumn 98, Issue 3, 2014, Pages 1291-1299

  Restaino, Odile Francesca ^a   Marseglia, Mariacarmela ^a   De Castro, Cristina ^b   Diana, Paola ^a   Forni, Pasquale ^a   Parrilli, Michelangelo ^b   De Rosa, Mario ^a   Schiraldi, Chiara ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

16 hydroxylation; Hydrocortisone; Microbial transformation; Steroids; Streptomyces roseochromogenes

Indexed keywords

BACTERIA; BOTTLES; CORTISOL; ENZYMES; FERMENTATION; HYDROXYLATION;

BACTERIAL TRANSFORMATION; BY-PRODUCT FORMATION; FERMENTATION CONDITIONS; MICROBIAL TRANSFORMATION; STEROIDS; STREPTOMYCES ROSEOCHROMOGENES; SUBSTRATE CONCENTRATIONS; TRANSFORMATION REACTIONS;

CAPILLARY FLOW;

16ALPHA HYDROXY HYDROCORTISONE; HYDROCORTISONE; UNCLASSIFIED DRUG; CULTURE MEDIUM;

BACTERIUM; BIOTECHNOLOGY; BIOTRANSFORMATION; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; FERMENTATION; GROWTH RATE; HYDROXYL RADICAL; PROTEIN; STEROID; YEAST;

ARTICLE; BACTERIAL CELL; BACTERIAL KINETICS; BACTERIUM TRANSFORMATION; BATCH FERMENTATION; BIOREACTOR; BIOTRANSFORMATION; CELL GROWTH; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEROID HYDROXYLATION; STREPTOMYCES; STREPTOMYCES ROSEOCHROMOGENES; WHOLE CELL; YEAST; ANALOGS AND DERIVATIVES; CHEMISTRY; CULTURE MEDIUM; GROWTH, DEVELOPMENT AND AGING; HYDROXYLATION; METABOLISM; REPRODUCIBILITY;

BACTERIA (MICROORGANISMS); STREPTOMYCES ROSEOCHROMOGENES;

BIOTRANSFORMATION; CULTURE MEDIA; HYDROCORTISONE; HYDROXYLATION; REPRODUCIBILITY OF RESULTS; STREPTOMYCES;

EID: 84898869107     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5384-x     Document Type: Article

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