Studies of a pelleted growth form of Rhizopus nigricans as a biocatalyst for progesterone 11α-hydroxylation

Journal of Biotechnology

Volumn 60, Issue 3, 1998, Pages 207-216

  Žnidaršič, Polona ^a   Komel, Radovan ^b   Pavko, Aleksander ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

11 Hydroxylation; Pellet formation; Progesterone; Rhizopus nigricans

Indexed keywords

BATCH CELL CULTURE; BIOCATALYSTS; BIOCONVERSION; FUNGI; GROWTH KINETICS; HORMONES; HYDROXYLATION; MORPHOLOGY; PH EFFECTS; PHYSIOLOGY; REACTION KINETICS;

PROGESTERONE;

PLANT CELL CULTURE;

PROGESTERONE;

ARTICLE; BIOMASS; BIOTRANSFORMATION; DRUG HYDROXYLATION; FUNGUS CULTURE; FUNGUS GROWTH; MYCELIUM; NONHUMAN; PRIORITY JOURNAL; RHIZOPUS;

RHIZOPUS NIGRICANS;

EID: 0345403566     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1656(98)00010-8     Document Type: Article

References (25)

1. Bailey, J.E., Ollis, D.F., 1986. Biochemical Engineering Fundamentals. McGraw-Hill, New York.
2. Braun S., Vecht-Lifshitz S.E. Mycelial morphology and metabolite production. TIBTECH. 9:1991;63-68.
3. Byrne G.S., Ward O.P. Growth of Rhizopus arrhizus in fermentation media. J. Ind. Microbiol. 4:1989;155-161.
4. Carlsen M., Spohr A.B., Nielsen J., Villadsen J. Morphology and physiology of an α-amylase producing strain of Aspergillus oryzae during batch cuiltivations. Biotechnol. Bioeng. 49:1996;266-276.
5. Hanisch W.H., Dunnill P., Lilly M.D. Optimization of the production of progesterone 11α-hydroxylase by Rhizopus nigricans. Biotechnol. Bioeng. 22:1980;555-570.
6. Hudnik-Plevnik T., Črešnar B. Factors affecting the induction of 11α-hydroxylase of progesterone in the filamentous fungus Rhizopus nigricans. J. Steroid Biochem. 35(6):1990;749-751.
7. Maddox I.S., Dunnill P., Lilly M.D. Use of immobilized cells of Rhizopus nigricans for the 11α-hydroxylation of progesterone. Biotechnol. Bioeng. 23:1981;345-354.
8. Metz B., Kossen N.W.F. The growth of molds in the form of pellets - a literature review. Biotechnol. Bioeng. 19:1977;781-799.
9. Michel F.C. Jr., Grulke E.A., Reddy C.A. A kinetic model for the fungal pellet lifecycle. Am. Inst. Chem. Eng. J. 38(9):1992;1449-1460.
10. Morrin M., Ward O.P. Biotransformation of progesterone to 11-α-hydroxyprogesterone by different morphological forms of Rhizopus arrhizus. Biotechnol. Lett. 11(5):1989;319-324.
11. Nielsen, J., Carlsen, M., 1996. Fungal pellets. In: Willaert, R.G., Baron, G.V., De Backer, L. (Eds.), Immobilised Living Cell Systems. Wiley, Chichester, pp. 273-293.
12. Nielsen J., Krabben P. Hyphal growth and fragmentation of Penicillium chrysogenum in submerged cultures. Biotechnol. Bioeng. 46:1995;588-598.
13. Pirt S.J. A theory of the mode of growth of fungi in the form of pellets in submerged culture. Proc. R. Soc. B 166:1966;369-373.
14. van Suijdam J.C., Hols H., Kossen N.W.F. Unstructured model for growth of mycelial pellets in submerged cultures. Biotechnol. Bioeng. 24:1982;177-191.
15. Takahashi, Yamada, 1959. Studies on the effect on some physical conditions on the submerged mold culture. Part II. On the two types of pellet formation in the shaking culture. J. Agric. Chem. Soc. 38, 707-710.
16. Talboys B.L., Dunnill P. Effect of shear on membrane-associated enzymes: studies of isolated progesterone 11α-hydroxylase complex from Rhizopus nigricans. Biotechnol. Bioeng. 26:1985;1726-1729.
17. Trinci A.P.J. Kinetics of the growth of mycelial pellets of Aspergillus nidulans. Arch. Microbiol. 73:1970;353-367.
18. Trdič, F., Žnidaršič, P., Pavko, A., 1996. Use of image analysis for growth kinetics studies of Rhizopus nigricans in pelleted morphological form. Proc. 3rd Int. Conf. Life Sciences 1996, Gozd Martuljek, Slovenia, pp. 19-20.
19. Vecht-Lifshitz S.E., Magdassi S., Braun S. Pellet formation and cellular aggregation in Streptomyces tendae. Biotechnol. Bioeng. 35:1990;890-896.
20. Vitas M., Smith K., Rozman D., Komel R. Progesterone metabolism by the filamentous fungus Cochliobolus lunatus. J. Steroid Biochem. Mol. Biol. 49(1):1994;87-92.
21. Vitas M., Rozman D., Komel R., Kelly S.L. P450-mediated progesterone hydroxylation in Cochliobolus lunatus. J. Biotechnol. 42:1995;145-150.
22. Whitaker A., Long P.A. Fungal pelleting. Proc. Biochem. 66:1973;27-31.
23. Žnidaršič P., Pavko A., Komel R. Laboratory-scale biosynthesis of Trichoderma mycolytic enzymes for protoplast release from Cochliobolus lunatus. J. Ind. Microbiol. 9:1992;115-119.
24. Žnidaršič P., Pavko A., Komel R. The growth form of the inducing microorganism and chitin addition affect mycolytic enzyme production by Trichoderma harzianum. J. Ind. Microbiol. 15:1995;397-400.
25. Yang H., King R., Reichl U., Gilles E.D. Mathematical model for apical growth, septation and branching of mycelial microorganisms. Biotechnol. Bioeng. 39:1992;49-58.