Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis

Metabolic Engineering

Volumn 44, Issue , 2017, Pages 60-69

  Liang, Huichao ^a   Hu, Zongfeng ^a   Zhang, Tingting ^a   Gong, Ting ^a   Chen, Jingjing ^a   Zhu, Ping ^a   Li, Yan ^a   Yang, Jinling ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Bacillus subtilis; Ginsenoside biosynthesis; Metabolic engineering; Saccharomyces cerevisiae; UDP glycosyltransferase

Indexed keywords

BACTERIOLOGY; BIOCHEMISTRY; BIOLOGICAL ORGANS; DISEASES; METABOLIC ENGINEERING; YEAST;

ALTERNATIVE ROUTES; ANTICANCER ACTIVITIES; ARABIDOPSIS THALIANA; BACILLUS SUBTILIS; GINSENOSIDE BIOSYNTHESIS; GLYCOSYL TRANSFERASE; NADPH-CYTOCHROME P450 REDUCTASE; SYNTHETIC BIOLOGY;

PHARMACODYNAMICS;

ANTINEOPLASTIC AGENT; GINSENOSIDE; GLYCOSYLTRANSFERASE; PACLITAXEL; UDP GLYCOSYLTRANSFERASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BIOTECHNOLOGICAL PRODUCTION; CANCER CELL; CANCER CHEMOTHERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; HETEROLOGOUS EXPRESSION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; KINETIC PARAMETERS; LUNG CANCER; MALE; METABOLIC ENGINEERING; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; YEAST; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; METABOLISM; SACCHAROMYCES CEREVISIAE;

ANIMALS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; GINSENOSIDES; GLYCOSYLTRANSFERASES; MICE; SACCHAROMYCES CEREVISIAE;

EID: 85030129319     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.07.008     Document Type: Article

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