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1
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84940574400
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Pathways forward in cardiovascular disease prevention one and a half years after publication of the 2013 ACC/AHA cardiovascular disease prevention guidelines
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PID: 26269108
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Cainzos-Achirica M, Desai CS, Wang L, Blaha MJ, Lopez-Jimenez F, Kopecky SL, et al. Pathways forward in cardiovascular disease prevention one and a half years after publication of the 2013 ACC/AHA cardiovascular disease prevention guidelines. Mayo Clin Proc. 2015;90(9):1262–71.
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(2015)
Mayo Clin Proc
, vol.90
, Issue.9
, pp. 1262-1271
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Cainzos-Achirica, M.1
Desai, C.S.2
Wang, L.3
Blaha, M.J.4
Lopez-Jimenez, F.5
Kopecky, S.L.6
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2
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84923292052
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An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort
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DeFilippis AP, Young R, Carrubba CJ, McEvoy JW, Budoff MJ, Blumenthal RS, et al. An analysis of calibration and discrimination among multiple cardiovascular risk scores in a modern multiethnic cohort. Ann Intern Med [Internet]. 2015;162:266–75. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25686167
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(2015)
Ann Intern Med [Internet]
, vol.162
, pp. 266-275
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DeFilippis, A.P.1
Young, R.2
Carrubba, C.J.3
McEvoy, J.W.4
Budoff, M.J.5
Blumenthal, R.S.6
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3
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85016293425
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Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern mult
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Available from
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DeFilippis AP, Young R, McEvoy JW, Michos ED, Sandfort V, Kronmal RA, et al. Risk score overestimation: the impact of individual cardiovascular risk factors and preventive therapies on the performance of the American Heart Association-American College of Cardiology-Atherosclerotic Cardiovascular Disease risk score in a modern mult. Eur Heart J [Internet]. 2017;38:598–608. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27436865
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(2017)
Eur Heart J [Internet]
, vol.38
, pp. 598-608
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DeFilippis, A.P.1
Young, R.2
McEvoy, J.W.3
Michos, E.D.4
Sandfort, V.5
Kronmal, R.A.6
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4
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78650023399
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ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary
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Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, et al. ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary. J Am Coll Cardiol. 2010;2010:2182–99.
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(2010)
J Am Coll Cardiol
, vol.2010
, pp. 2182-2199
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Greenland, P.1
Alpert, J.S.2
Beller, G.A.3
Benjamin, E.J.4
Budoff, M.J.5
Fayad, Z.A.6
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5
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84895794526
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Treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: synopsis of the 2013 American College of Cardiology/American Heart Association cholesterol guideline
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Available from
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Stone NJ, Robinson JG, Lichtenstein AH, Goff DC, Lloyd-Jones DM, Smith SC, et al. Treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: synopsis of the 2013 American College of Cardiology/American Heart Association cholesterol guideline. Ann Intern Med [Internet]. 2014;160:339–43. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24474185
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(2014)
Ann Intern Med [Internet]
, vol.160
, pp. 339-343
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Stone, N.J.1
Robinson, J.G.2
Lichtenstein, A.H.3
Goff, D.C.4
Lloyd-Jones, D.M.5
Smith, S.C.6
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6
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84903165096
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2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
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Available from
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Goff DC, Lloyd-Jones DM, Bennett G, Coady S, D’Agostino RB, Gibbons R, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol [Internet]. 2014;63:2935–59. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24239921
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(2014)
J Am Coll Cardiol [Internet]
, vol.63
, pp. 2935-2959
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Goff, D.C.1
Lloyd-Jones, D.M.2
Bennett, G.3
Coady, S.4
D’Agostino, R.B.5
Gibbons, R.6
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7
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84907731035
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The new “intermediate risk” group: a comparative analysis of the new 2013 ACC/AHA risk assessment guidelines versus prior guidelines in men
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COI: 1:CAS:528:DC%2BC2cXhsVaktLnJ, Available from
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Blaha MJ, Dardari ZA, Blumenthal RS, Martin SS, Nasir K, Al-Mallah MH. The new “intermediate risk” group: a comparative analysis of the new 2013 ACC/AHA risk assessment guidelines versus prior guidelines in men. Atherosclerosis [Internet]. 2014;237:1–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25173946
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(2014)
Atherosclerosis [Internet]
, vol.237
, pp. 1-4
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Blaha, M.J.1
Dardari, Z.A.2
Blumenthal, R.S.3
Martin, S.S.4
Nasir, K.5
Al-Mallah, M.H.6
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8
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84959262587
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Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment
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PID: 26791059, This MESA study showed that non-traditional markers, such as CAC, ankle-brachial index, and family history, can predict ASCVD risk. However, CAC was the best marker, as it better-improved discrimination ability of PCE
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• Yeboah J, Young R, McClelland RL, Delaney JC, Polonsky TS, Dawood FZ, et al. Utility of nontraditional risk markers in atherosclerotic cardiovascular disease risk assessment. J Am Coll Cardiol. 2016;67:139–47. This MESA study showed that non-traditional markers, such as CAC, ankle-brachial index, and family history, can predict ASCVD risk. However, CAC was the best marker, as it better-improved discrimination ability of PCE.
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(2016)
J Am Coll Cardiol
, vol.67
, pp. 139-147
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Yeboah, J.1
Young, R.2
McClelland, R.L.3
Delaney, J.C.4
Polonsky, T.S.5
Dawood, F.Z.6
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9
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84992111579
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Providing evidence for subclinical CVD in risk assessment
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PID: 27741975, This review article describes CAC as the single best marker for cardiovascular disease risk prediction based on a series of landmark publications from MESA. MESA CHD Risk Estimator is now available based on these findings
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•• Blaha MJ, Yeboah J, Al Rifai M, Liu K, Kronmal R, Greenland P. Providing evidence for subclinical CVD in risk assessment. Glob Heart. 2016;11(3):275–85. This review article describes CAC as the single best marker for cardiovascular disease risk prediction based on a series of landmark publications from MESA. MESA CHD Risk Estimator is now available based on these findings.
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(2016)
Glob Heart
, vol.11
, Issue.3
, pp. 275-285
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Blaha, M.J.1
Yeboah, J.2
Al Rifai, M.3
Liu, K.4
Kronmal, R.5
Greenland, P.6
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10
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79952975082
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Quantification of coronary atherosclerosis and inflammation to predict coronary events and all-cause mortality
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Available from
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Möhlenkamp S, Lehmann N, Moebus S, Schmermund A, Dragano N, Stang A, et al. Quantification of coronary atherosclerosis and inflammation to predict coronary events and all-cause mortality. J Am Coll Cardiol [Internet]. 2011;57:1455–64. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21435514
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(2011)
J Am Coll Cardiol [Internet]
, vol.57
, pp. 1455-1464
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Möhlenkamp, S.1
Lehmann, N.2
Moebus, S.3
Schmermund, A.4
Dragano, N.5
Stang, A.6
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11
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84970004980
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Beyond coronary calcification, family history, and C-reactive protein: cholesterol efflux capacity and cardiovascular risk prediction
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COI: 1:CAS:528:DC%2BC28XosFaquro%3D, Available from
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Mody P, Joshi PH, Khera A, Ayers CR, Rohatgi A. Beyond coronary calcification, family history, and C-reactive protein: cholesterol efflux capacity and cardiovascular risk prediction. J Am Coll Cardiol [Internet]. 2016;67:2480–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27230043
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(2016)
J Am Coll Cardiol [Internet]
, vol.67
, pp. 2480-2487
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Mody, P.1
Joshi, P.H.2
Khera, A.3
Ayers, C.R.4
Rohatgi, A.5
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12
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84943311828
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10-Year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors: derivation in the MESA (multi-ethnic study of atherosclerosis) with validation in the HNR (Heinz Nixdorf Recall) study and the DHS (Dallas Heart Stu)
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COI: 1:CAS:528:DC%2BC2MXhs1Wjtr7L, Available from: This landmark study resulted in the inclusion of CAC along with other nontraditional risk factors to predict 10-year CHD risk in MESA population. This MESA CHD Risk Calculator (validated in two external cohorts) is valuable for guiding risk-based treatment strategies
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•• McClelland RL, Jorgensen NW, Budoff M, Blaha MJ, Post WS, Kronmal RA, et al. 10-Year coronary heart disease risk prediction using coronary artery calcium and traditional risk factors: derivation in the MESA (multi-ethnic study of atherosclerosis) with validation in the HNR (Heinz Nixdorf Recall) study and the DHS (Dallas Heart Stu). J Am Coll Cardiol [Internet]. 2015;66:1643–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26449133. This landmark study resulted in the inclusion of CAC along with other nontraditional risk factors to predict 10-year CHD risk in MESA population. This MESA CHD Risk Calculator (validated in two external cohorts) is valuable for guiding risk-based treatment strategies.
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(2015)
J Am Coll Cardiol [Internet]
, vol.66
, pp. 1643-1653
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McClelland, R.L.1
Jorgensen, N.W.2
Budoff, M.3
Blaha, M.J.4
Post, W.S.5
Kronmal, R.A.6
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13
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84943327960
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Coronary artery calcium scoring: are we there yet?
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Lloyd-Jones DM. Coronary artery calcium scoring: are we there yet? J Am Coll Cardiol [Internet]. 2015;66:1654–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26449134
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(2015)
J Am Coll Cardiol [Internet]
, vol.66
, pp. 1654-1656
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Lloyd-Jones, D.M.1
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14
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84902576469
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2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
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Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol [Internet]. 2014;63:2889–934. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24239923
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(2014)
J Am Coll Cardiol [Internet]
, vol.63
, pp. 2889-2934
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Stone, N.J.1
Robinson, J.G.2
Lichtenstein, A.H.3
Bairey Merz, C.N.4
Blum, C.B.5
Eckel, R.H.6
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15
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85026876917
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The identification of calcified coronary plaque is associated with initiation and continuation of pharmacological and lifestyle preventive therapies
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Gupta A, Lau E, Varshney R, Hulten EA, Cheezum M, Bittencourt MS, et al.;10:833–42. Available from: This study provides evidence that knowledge of CAC might improve dietary and exercise habits and help the patient to initiate and adhere to drug therapy
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•• Gupta A, Lau E, Varshney R, Hulten EA, Cheezum M, Bittencourt MS, et al. The identification of calcified coronary plaque is associated with initiation and continuation of pharmacological and lifestyle preventive therapies. JACC Cardiovasc Imaging [Internet]. 2017;10:833–42. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1936878X17305193 This study provides evidence that knowledge of CAC might improve dietary and exercise habits and help the patient to initiate and adhere to drug therapy.
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(2017)
JACC Cardiovasc Imaging [Internet].
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16
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84933073547
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Clinician-patient risk discussion for atherosclerotic cardiovascular disease prevention: importance to implementation of the 2013 ACC/AHA Guidelines
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Available from:This paper reviews guideline recommendations for clinician-patient risk discussion and general concepts of shared decision-making and decision aids
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Martin SS, Sperling LS, Blaha MJ, Wilson PWF, Gluckman TJ, Blumenthal RS, et al. Clinician-patient risk discussion for atherosclerotic cardiovascular disease prevention: importance to implementation of the 2013 ACC/AHA Guidelines. J Am Coll Cardiol [Internet]. 2015;65:1361–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25835448. This paper reviews guideline recommendations for clinician-patient risk discussion and general concepts of shared decision-making and decision aids.
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(2015)
J Am Coll Cardiol [Internet]
, vol.65
, pp. 1361-1368
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Martin, S.S.1
Sperling, L.S.2
Blaha, M.J.3
Wilson, P.W.F.4
Gluckman, T.J.5
Blumenthal, R.S.6
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17
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85014541435
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Clinical indications for coronary artery calcium scoring in asymptomatic patients: expert consensus statement from the Society of Cardiovascular Computed Tomography
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An important paper on shared decision-making. This statement from Society of Cardiovascular Computed Tomography (SCCT) discusses harms and benefits of statin treatment or CAC scoring versus no treatment or no testing
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•• Hecht H, Blaha MJ, Berman DS, Nasir K, Budoff M, Leipsic J, et al. Clinical indications for coronary artery calcium scoring in asymptomatic patients: expert consensus statement from the Society of Cardiovascular Computed Tomography. J Cardiovasc Comput Tomogr [Internet] Elsevier Ltd. 2017;11:157–68. https://doi.org/10.1016/j.jcct.2017.02.010. An important paper on shared decision-making. This statement from Society of Cardiovascular Computed Tomography (SCCT) discusses harms and benefits of statin treatment or CAC scoring versus no treatment or no testing.
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(2017)
J Cardiovasc Comput Tomogr [Internet] Elsevier Ltd
, vol.11
, pp. 157-168
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Hecht, H.1
Blaha, M.J.2
Berman, D.S.3
Nasir, K.4
Budoff, M.5
Leipsic, J.6
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18
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84943303318
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Implications of coronary artery calcium testing among statin candidates according to American College of Cardiology/American Heart Association cholesterol management guidelines: MESA (multi-ethnic study of atherosclerosis)
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COI: 1:CAS:528:DC%2BC2MXhs1Wjtr7E, Available from
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Nasir K, Bittencourt MS, Blaha MJ, Blankstein R, Agatson AS, Rivera JJ, et al. Implications of coronary artery calcium testing among statin candidates according to American College of Cardiology/American Heart Association cholesterol management guidelines: MESA (multi-ethnic study of atherosclerosis). J Am Coll Cardiol [Internet]. 2015;66:1657–68. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26449135
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(2015)
J Am Coll Cardiol [Internet]
, vol.66
, pp. 1657-1668
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Nasir, K.1
Bittencourt, M.S.2
Blaha, M.J.3
Blankstein, R.4
Agatson, A.S.5
Rivera, J.J.6
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19
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84995961562
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A simple disease-guided approach to personalize ACC/AHA-recommended statin allocation in elderly people: the BioImage study
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Available from: Showed that most old individuals were eligible for statin treatment according to the recent guidelines only because of their age. The absence of CAC could spare a considerable portion of elderly individuals from statin treatment
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• Mortensen MB, Fuster V, Muntendam P, Mehran R, Baber U, Sartori S, et al. A simple disease-guided approach to personalize ACC/AHA-recommended statin allocation in elderly people: the BioImage study. J Am Coll Cardiol [Internet]. 2016;68:881–91. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27561760. Showed that most old individuals were eligible for statin treatment according to the recent guidelines only because of their age. The absence of CAC could spare a considerable portion of elderly individuals from statin treatment.
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(2016)
J Am Coll Cardiol [Internet]
, vol.68
, pp. 881-891
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Mortensen, M.B.1
Fuster, V.2
Muntendam, P.3
Mehran, R.4
Baber, U.5
Sartori, S.6
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20
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84937460144
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Guideline-based statin eligibility, coronary artery calcification, and cardiovascular events
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COI: 1:CAS:528:DC%2BC2MXhtleqt7bE, Available from
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Pursnani A, Massaro JM, D’Agostino RB, O’Donnell CJ, Hoffmann U. Guideline-based statin eligibility, coronary artery calcification, and cardiovascular events. Jama [Internet]. 2015;314:134. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26172893
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(2015)
Jama [Internet]
, vol.314
, pp. 134
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Pursnani, A.1
Massaro, J.M.2
D’Agostino, R.B.3
O’Donnell, C.J.4
Hoffmann, U.5
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21
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84959502403
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Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the multi-ethnic study of atherosclerosis (MESA)
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COI: 1:CAS:528:DC%2BC28XjslClt7g%3D, PID: 26801055, This MESA study assessed the role of 13 negative risk markers for predicting the absence of events among asymptomatic individuals to see how they can add to previous risk models for a more accurate risk prediction. The absence of CAC resulted in the greatest downward shift in estimated CVD risk compared with negative results related to other tested risk markers
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•• Blaha MJ, Cainzos-Achirica M, Greenland P, McEvoy JW, Blankstein R, Budoff MJ, et al. Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the multi-ethnic study of atherosclerosis (MESA). Circulation. 2016;133:849–58. This MESA study assessed the role of 13 negative risk markers for predicting the absence of events among asymptomatic individuals to see how they can add to previous risk models for a more accurate risk prediction. The absence of CAC resulted in the greatest downward shift in estimated CVD risk compared with negative results related to other tested risk markers.
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(2016)
Circulation
, vol.133
, pp. 849-858
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Blaha, M.J.1
Cainzos-Achirica, M.2
Greenland, P.3
McEvoy, J.W.4
Blankstein, R.5
Budoff, M.J.6
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22
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85021308515
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Personalizing treatment: between primary and secondary prevention
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Available from: This article explains that a subgroup of patients with advanced atherosclerosis can be considered between primary and secondary prevention and may benefit from a more intensive preventive treatment strategy
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•• Blaha MJ. Personalizing treatment: between primary and secondary prevention. Am J Cardiol [Internet] Elsevier Inc. 2016;118:4A–12A. Available from: http://linkinghub.elsevier.com/retrieve/pii/S0002914916308803. This article explains that a subgroup of patients with advanced atherosclerosis can be considered between primary and secondary prevention and may benefit from a more intensive preventive treatment strategy.
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(2016)
Am J Cardiol [Internet] Elsevier Inc
, vol.118
, pp. 4A-12A
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Blaha, M.J.1
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23
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84903612169
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Use of coronary artery calcium testing to guide aspirin utilization for primary prevention: estimates from the multi-ethnic study of atherosclerosis
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Available from: A MESA study that showed subgroup of patients with CA≥100 had a net benefit from aspirin treatment with regard to CHD prevention. On the contrary, those with CAC=0 received net harm from aspirin
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• Miedema MD, Duprez DA, Misialek JR, Blaha MJ, Nasir K, Silverman MG, et al. Use of coronary artery calcium testing to guide aspirin utilization for primary prevention: estimates from the multi-ethnic study of atherosclerosis. Circ Cardiovasc Qual Outcomes [Internet]. 2014;7:453–60. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24803472. A MESA study that showed subgroup of patients with CA≥100 had a net benefit from aspirin treatment with regard to CHD prevention. On the contrary, those with CAC=0 received net harm from aspirin.
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(2014)
Circ Cardiovasc Qual Outcomes [Internet]
, vol.7
, pp. 453-460
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Miedema, M.D.1
Duprez, D.A.2
Misialek, J.R.3
Blaha, M.J.4
Nasir, K.5
Silverman, M.G.6
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24
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85004147077
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Coronary artery calcium to guide a personalized risk-based approach to initiation and intensification of antihypertensive therapy
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COI: 1:CAS:528:DC%2BC2sXkvVOrug%3D%3D, PID: 27881560, This MESA study showed that CAC could provide flexible treatment goals regarding treatment of hypertension for those with intermediate ASCVD risk and pre-hypertension or mild hypertension
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• McEvoy JW, Martin SS, Dardari ZA, Miedema MD, Sandfort V, Yeboah J, et al. Coronary artery calcium to guide a personalized risk-based approach to initiation and intensification of antihypertensive therapy. Circulation. 2017;135:153–65. This MESA study showed that CAC could provide flexible treatment goals regarding treatment of hypertension for those with intermediate ASCVD risk and pre-hypertension or mild hypertension.
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(2017)
Circulation
, vol.135
, pp. 153-165
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McEvoy, J.W.1
Martin, S.S.2
Dardari, Z.A.3
Miedema, M.D.4
Sandfort, V.5
Yeboah, J.6
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25
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85026852638
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Implications of coronary artery calcium testing for treatment decisions among statin candidates according to the ACC/AHA cholesterol management guidelines
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Available from: This paper showed that CAC scoring is recommended in the setting of clinician-patient risk discussion
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•• Hong JC, Blankstein R, Shaw LJ, Padula WV, Arrieta A, Fialkow JA, et al. Implications of coronary artery calcium testing for treatment decisions among statin candidates according to the ACC/AHA cholesterol management guidelines. JACC Cardiovasc Imaging [Internet]. 2017;10:938–52. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1936878X17305089. This paper showed that CAC scoring is recommended in the setting of clinician-patient risk discussion.
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(2017)
JACC Cardiovasc Imaging [Internet]
, vol.10
, pp. 938-952
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Hong, J.C.1
Blankstein, R.2
Shaw, L.J.3
Padula, W.V.4
Arrieta, A.5
Fialkow, J.A.6
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26
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84952690438
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Comparing the cost-effectiveness of four novel risk markers for screening asymptomatic individuals to prevent cardiovascular disease (CVD) in the US population
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Available from
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van Kempen BJH, Ferket BS, Steyerberg EW, Max W, Myriam Hunink MG, Fleischmann KE. Comparing the cost-effectiveness of four novel risk markers for screening asymptomatic individuals to prevent cardiovascular disease (CVD) in the US population. Int J Cardiol [Internet]. 2016;203:422–31. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26547049
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(2016)
Int J Cardiol [Internet]
, vol.203
, pp. 422-431
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van Kempen, B.J.H.1
Ferket, B.S.2
Steyerberg, E.W.3
Max, W.4
Myriam Hunink, M.G.5
Fleischmann, K.E.6
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27
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84897985503
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Using the coronary artery calcium score to guide statin therapy: a cost-effectiveness analysis
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Available from: Demonstrated that among patients who are at intermediate FRS risk, CAC testing is cost-effective if statins are expensive or markedly affect the quality of life. A “treat-all” strategy was not found to be cost-effective
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•• Pletcher MJ, Pignone M, Earnshaw S, McDade C, Phillips KA, Auer R, et al. Using the coronary artery calcium score to guide statin therapy: a cost-effectiveness analysis. Circ Cardiovasc Qual Outcomes [Internet]. 2014;7:276–84. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4156513&tool=pmcentrez&rendertype=abstract. Demonstrated that among patients who are at intermediate FRS risk, CAC testing is cost-effective if statins are expensive or markedly affect the quality of life. A “treat-all” strategy was not found to be cost-effective.
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(2014)
Circ Cardiovasc Qual Outcomes [Internet]
, vol.7
, pp. 276-284
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Pletcher, M.J.1
Pignone, M.2
Earnshaw, S.3
McDade, C.4
Phillips, K.A.5
Auer, R.6
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28
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84925729307
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Cost-effectiveness of coronary artery calcium testing for coronary heart and cardiovascular disease risk prediction to guide statin allocation: the multi-ethnic study of atherosclerosis (MESA)
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PID: 25786208, Demonstrated that among individuals who are at intermediate ASCVD risk, testing for CAC and treating patients with CAC≥1 is cost-effective compared with treatment based on risk assessment guidelines. Particularly, treating those who had CAC≥100 was cost-effective when accounting for statin side effects and disutility (when the patient would be willing to trade two weeks of perfect health to avoid ten years of treatment
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•• Roberts ET, Horne A, Martin SS, Blaha MJ, Blankstein R, Budoff MJ, et al. Cost-effectiveness of coronary artery calcium testing for coronary heart and cardiovascular disease risk prediction to guide statin allocation: the multi-ethnic study of atherosclerosis (MESA). PLoS One. 2015;10:e0116377. Demonstrated that among individuals who are at intermediate ASCVD risk, testing for CAC and treating patients with CAC≥1 is cost-effective compared with treatment based on risk assessment guidelines. Particularly, treating those who had CAC≥100 was cost-effective when accounting for statin side effects and disutility (when the patient would be willing to trade two weeks of perfect health to avoid ten years of treatment).
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(2015)
PLoS One
, vol.10
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Roberts, E.T.1
Horne, A.2
Martin, S.S.3
Blaha, M.J.4
Blankstein, R.5
Budoff, M.J.6
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29
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84928038840
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Cholesterol guidelines do not endorse “one size fits all”: the strategy begins with a discussion
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