Lymphopenic Community Acquired Pneumonia (L-CAP), an Immunological Phenotype Associated with Higher Risk of Mortality

EBioMedicine

Volumn 24, Issue , 2017, Pages 231-236

  Bermejo Martin, Jesus F ^a   Cilloniz, Catia ^b   Mendez, Raul ^b,c   Almansa, Raquel ^a   Gabarrus, Albert ^b   Ceccato, Adrian ^b   Torres, Antoni ^b   Menendez, Rosario ^c  

^a HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Acquired; Community; Lymphocyte; Mortality; Pneumonia

Indexed keywords

ACUTE KIDNEY FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIBIOTIC THERAPY; ARTICLE; ARTIFICIAL VENTILATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMMUNITY ACQUIRED PNEUMONIA; COUGHING; DIABETES MELLITUS; DYSPNEA; FEVER; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; LEGIONELLA PNEUMOPHILA; LEUKOCYTE COUNT; LIVER DISEASE; LOWER RESPIRATORY TRACT INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MIDDLE AGED; MORTALITY RISK; MULTICENTER STUDY; NEUTROPHIL COUNT; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPTIC SHOCK; STREPTOCOCCUS PNEUMONIAE; THORAX PAIN; THORAX RADIOGRAPHY; VACCINATION; AGED; CLINICAL TRIAL; COMMUNITY ACQUIRED INFECTION; CYTOLOGY; FEMALE; IMMUNOLOGY; LYMPHOCYTOPENIA; MALE; MORTALITY; NEUTROPHIL; PHENOTYPE; PNEUMONIA; PROGNOSIS; PROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COMMUNITY-ACQUIRED INFECTIONS; FEMALE; HOSPITALIZATION; HUMANS; LYMPHOCYTE COUNT; LYMPHOPENIA; MALE; MORTALITY; NEUTROPHILS; PHENOTYPE; PNEUMONIA; PROGNOSIS; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 85029819691     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2017.09.023     Document Type: Article

References (30)

1. Aliberti, S., Brambilla, A.M., Chalmers, J.D., Cilloniz, C., Ramirez, J., Bignamini, A., Prina, E., Polverino, E., Tarsia, P., Pesci, A., Torres, A., Blasi, F., Cosentini, R., Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis. Respir. Res., 15, 2014, 27, 10.1186/1465-9921-15-27.
2. Almansa, R., Ortega, A., Ávila-Alonso, A., Heredia-Rodríguez, M., Martín, S., Benavides, D., Martín-Fernandez, M., Rico, L., Aldecoa, C., Rico, J., López de Cenarruzabeitia, I., Beltrán de Heredia, J., Gomez-Sanchez, E., Aragón, M., Andrés, C., Calvo, D., Andaluz-Ojeda, D., Liu, P., Blanco-Antona, F., Blanco, L., Gómez-Herreras, J.I., Tamayo, E., Bermejo-Martin, J.F., Quantification of immune dysregulation by next-generation polymerase chain reaction to improve sepsis diagnosis in surgical patients. Ann. Surg., 2017, 10.1097/SLA.0000000000002406.
3. Andrijevic, I., Matijasevic, J., Andrijevic, L., Kovacevic, T., Zaric, B., Interleukin-6 and procalcitonin as biomarkers in mortality prediction of hospitalized patients with community acquired pneumonia. Ann. Thorac. Med. 9 (2014), 162–167, 10.4103/1817-1737.134072.
4. ARDS Definition Task Force, Ranieri, V.M., Rubenfeld, G.D., Thompson, B.T., Ferguson, N.D., Caldwell, E., Fan, E., Camporota, L., Slutsky, A.S., Acute respiratory distress syndrome: the berlin definition. JAMA 307 (2012), 2526–2533, 10.1001/jama.2012.5669.
5. Bellomo, R., Ronco, C., Kellum, J.A., Mehta, R.L., Palevsky, P., Acute Dialysis Quality Initiative workgroup, Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care Lond. Engl. 8 (2004), R204–212, 10.1186/cc2872.
6. Bermejo-Martín, J.F., Tamayo, E., Ruiz, G., Andaluz-Ojeda, D., Herrán-Monge, R., Muriel-Bombín, A., Fe Muñoz, M., Heredia-Rodríguez, M., Citores, R., Gómez-Herreras, J., Blanco, J., EXPRESS (Expresión Génica en Sepsis) and GRECIA (Grupo de Estudios y Análisis en Cuidados Intensivos) groups, Circulating neutrophil counts and mortality in septic shock. Crit. Care Lond. Engl., 18, 2014, 407, 10.1186/cc13728.
7. Bone, R.C., Balk, R.A., Cerra, F.B., Dellinger, R.P., Fein, A.M., Knaus, W.A., Schein, R.M., Sibbald, W.J., Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101 (1992), 1644–1655.
8. Cataudella, E., Giraffa, C.M., Di Marca, S., Pulvirenti, A., Alaimo, S., Pisano, M., Terranova, V., Corriere, T., Ronsisvalle, M.L., Di Quattro, R., Stancanelli, B., Giordano, M., Vancheri, C., Malatino, L., Neutrophil-to-lymphocyte ratio: an emerging marker predicting prognosis in elderly adults with community-acquired pneumonia. J. Am. Geriatr. Soc., 2017, 10.1111/jgs.14894.
9. Cheng, A.C., Stephens, D.P., Currie, B.J., Granulocyte-colony stimulating factor (G-CSF) as an adjunct to antibiotics in the treatment of pneumonia in adults. Cochrane Database Syst. Rev., 2007, CD004400, 10.1002/14651858.CD004400.pub3.
10. Davenport, E.E., Burnham, K.L., Radhakrishnan, J., Humburg, P., Hutton, P., Mills, T.C., Rautanen, A., Gordon, A.C., Garrard, C., Hill, A.V.S., Hinds, C.J., Knight, J.C., Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study. Lancet Respir. Med. 4 (2016), 259–271, 10.1016/S2213-2600(16)00046-1.
11. DeLong, E.R., DeLong, D.M., Clarke-Pearson, D.L., Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44 (1988), 837–845.
12. Han, D., Shang, W., Wang, G., Sun, L., Zhang, Y., Wen, H., Xu, L., Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: a meta-analysis. Int. Immunopharmacol. 29 (2015), 377–382, 10.1016/j.intimp.2015.10.026.
13. Healey, J.F., Statistics: A Tool for Social Research. 10th ed., 2014, Cengage Learning.
14. Hosmer, D.W., Lemeshow, S., Sturdivant, R.X., Applied Logistic Regression. 3rd ed., 2013, Wiley.
15. Klouche, K., Cristol, J.P., Devin, J., Gilles, V., Kuster, N., Larcher, R., Amigues, L., Corne, P., Jonquet, O., Dupuy, A.M., Diagnostic and prognostic value of soluble CD14 subtype (Presepsin) for sepsis and community-acquired pneumonia in ICU patients. Ann. Intensive Care, 6, 2016, 59, 10.1186/s13613-016-0160-6.
16. Leoni, D., Rello, J., Severe community-acquired pneumonia: optimal management. Curr. Opin. Infect. Dis. 30 (2017), 240–247, 10.1097/QCO.0000000000000349.
17. Lim, W.S., Baudouin, S.V., George, R.C., Hill, A.T., Jamieson, C., Le Jeune, I., Macfarlane, J.T., Read, R.C., Roberts, H.J., Levy, M.L., Wani, M., Woodhead, M.A., Pneumonia Guidelines Committee of the BTS Standards of Care Committee, BTS guidelines for the management of community acquired pneumonia in adults: update 2009. Thorax, 64(Suppl. 3), 2009 (iii1-55) https://doi.org/10.1136/thx.2009.121434.
18. Liu, D., Su, L.-X., Guan, W., Xiao, K., Xie, L.-X., Prognostic value of procalcitonin in pneumonia: a systematic review and meta-analysis. Respirology 21 (2016), 280–288, 10.1111/resp.12704.
19. Liu, D., Xie, L., Zhao, H., Liu, X., Cao, J., Prognostic value of mid-regional pro-adrenomedullin (MR-proADM) in patients with community-acquired pneumonia: a systematic review and meta-analysis. BMC Infect. Dis., 16, 2016, 232, 10.1186/s12879-016-1566-3.
20. Mandell, L.A., Wunderink, R.G., Anzueto, A., Bartlett, J.G., Campbell, G.D., Dean, N.C., Dowell, S.F., File, T.M., Musher, D.M., Niederman, M.S., Torres, A., Whitney, C.G., Infectious Diseases Society of America, American Thoracic Society, Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 44:Suppl. 2 (2007), S27–72, 10.1086/511159.
21. Marrie, T.J., Wu, L., Factors influencing in-hospital mortality in community-acquired pneumonia: a prospective study of patients not initially admitted to the ICU. Chest 127 (2005), 1260–1270, 10.1378/chest.127.4.1260.
22. Marshall, J.C., Charbonney, E., Gonzalez, P.D., The immune system in critical illness. Clin. Chest Med., 29(605–616), 2008, vii, 10.1016/j.ccm.2008.08.001.
23. Menéndez, R., Martínez, R., Reyes, S., Mensa, J., Filella, X., Marcos, M.A., Martínez, A., Esquinas, C., Ramirez, P., Torres, A., Biomarkers improve mortality prediction by prognostic scales in community-acquired pneumonia. Thorax 64 (2009), 587–591, 10.1136/thx.2008.105312.
24. Prina, E., Ceccato, A., Torres, A., New aspects in the management of pneumonia. Crit. Care Lond. Engl., 20, 2016, 267, 10.1186/s13054-016-1442-y.
25. Rello, J., Perez, A., Precision medicine for the treatment of severe pneumonia in intensive care. Expert Rev. Respir. Med. 10 (2016), 297–316, 10.1586/17476348.2016.1144477.
26. Shindo, Y., Unsinger, J., Burnham, C.-A., Green, J.M., Hotchkiss, R.S., Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock Augusta Ga 43 (2015), 334–343, 10.1097/SHK.0000000000000317.
27. Shindo, Y., McDonough, J.S., Chang, K.C., Ramachandra, M., Sasikumar, P.G., Hotchkiss, R.S., Anti-PD-L1 peptide improves survival in sepsis. J. Surg. Res. 208 (2017), 33–39, 10.1016/j.jss.2016.08.099.
28. Torres, A., Barberán, J., Falguera, M., Menéndez, R., Molina, J., Olaechea, P., Rodríguez, A., Grupo de la Guía Multidisciplinar para el Manejo de la Neumonía Adquirida en la Comunidad, Multidisciplinary guidelines for the management of community-acquired pneumonia. Med. Clin. (Barc.) 140 (2013), 223.e1–223.e19, 10.1016/j.medcli.2012.09.034.
29. Vasu, S., Caligiuri, M.A., Lymphocytosis and Lymphocytopenia, in: Hematology. 2015, McGraw-Hill Education.
30. Zhuang, Y., Li, W., Wang, H., Peng, H., Chen, Y., Zhang, X., Chen, Y., Gao, C., Predicting the outcomes of subjects with severe community-acquired pneumonia using monocyte human leukocyte antigen-DR. Respir. Care 60 (2015), 1635–1642, 10.4187/respcare.03953.