Modulation of retinal arteriolar central reflection by APOE genotype

Current Alzheimer Research

Volumn 14, Issue 9, 2017, Pages 916-923

  Frost, Shaun ^a   Bhuiyan, Alauddin ^a   Offerman, David ^b   Doecke, James D ^a   Macaulay, S Lance ^a   Sohrabi, Hamid R ^c   Ames, David ^d   Masters, Colin ^e   Martins, Ralph N ^c   Kanagasingam, Yogesan ^a  

^a CSIRO   (Australia)

^b Albany Regional Hospital   (Australia)

^c EDITH COWAN UNIVERSITY   (Australia)

^d NATIONAL AGEING RESEARCH INSTITUTE   (Australia)

^e FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^f AIBL   (Australia)

Author keywords

Aging; Alzheimer s; APOE; Diagnosis; Retina; Vision disorders

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; AUSTRALIAN; CARDIOVASCULAR RISK; CENTRAL REFLEX TO VESSEL WIDTH RATIO; COGNITION; COHORT ANALYSIS; DIGITAL IMAGING; EYE PHOTOGRAPHY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROMODULATION; PRIORITY JOURNAL; REFLEX; RETINAL ARTERIOLAR CENTRAL REFLEX; VISUAL SYSTEM FUNCTION; VISUAL SYSTEM PARAMETERS; AGING; ANATOMY AND HISTOLOGY; ARTERIOLE; AUTOMATED PATTERN RECOGNITION; DIAGNOSTIC IMAGING; GENETIC ASSOCIATION STUDY; GENETICS; HETEROZYGOTE; IMAGE PROCESSING; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOGRAPHY; PHYSIOLOGY; PROCEDURES; RETINA BLOOD VESSEL;

AGED; AGING; ALZHEIMER DISEASE; APOLIPOPROTEIN E4; ARTERIOLES; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HETEROZYGOTE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; ORGAN SIZE; PATTERN RECOGNITION, AUTOMATED; PHOTOGRAPHY; RETINAL VESSELS;

EID: 85029650153     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205014666170309115016     Document Type: Article

References (66)

1. Mielke R, Heiss WD. Positron emission tomography for diagnosis of Alzheimer’s disease and vascular dementia. J Neural Transm Suppl 53: 237-50 (1998).
2. Sadek JR, Hammeke TA. Functional neuroimaging in neurology and psychiatry. CNS Spectr 7(4): 286-90, 95-9 (2002).
3. Frost S, Kanagasingam Y, Sohrabi H, Vignarajan J, Bourgeat P, Salvado O, et al. Retinal vascular biomarkers for early detection and monitoring of Alzheimer’s disease. Transl Psychiatry 3: e233 (2013a).
4. Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B. Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: A rationale based on homology between cerebral and retinal microvasculatures. J Anat 206(4): 319-48 (2005).
5. Chan-Ling T, McLeod DS, Hughes S, Baxter L, Chu Y, Hasegawa T, et al. Astrocyte-endothelial cell relationships during human retinal vascular development. Invest Ophthalmol Vis Sci 45(6): 2020-32 (2004).
6. Dorrell MI, Aguilar E, Friedlander M. Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion. Invest Ophthalmol Vis Sci 43(11): 3500-10 (2002).
7. Hughes S, Yang H, Chan-Ling T. Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci 41(5): 1217-28 (2000).
8. Risau W. Mechanisms of angiogenesis. Nature 386(6626): 671-4 (1997).
9. Delaey C, Van De Voorde J. Regulatory mechanisms in the retinal and choroidal circulation. Ophthalmic research 32(6): 249-56 (2000).
10. Hardy P, Varma DR, Chemtob S. Control of cerebral and ocular blood flow autoregulation in neonates. Pediatr Clin North Am 44(1): 137-52 (1997).
11. Lassen NA. Autoregulation of Cerebral Blood Flow. Circu Res 15: 201-4 (1964).
12. Chui H. Neuropathology lessons in vascular dementia. Alzheimer Dis Assoc Disord 19(1): 45-52 (2005).
13. Wong TY, Klein R, Islam FM, Cotch MF, Folsom AR, Klein BE, et al. Diabetic retinopathy in a multi-ethnic cohort in the United States. Am J Ophthalmol 141(3): 446-55 (2006).
14. Wong TY, Mitchell P. The eye in hypertension. Lancet 369(9559): 425-35 (2007).
15. Bhuiyan A, Cheung CY, Frost S, Lamoureux EL, Mitchell P, Kanagasingam Y, et al. Development and Reliability of Retinal Arteriolar Central Light Reflex Quantification System: A New Approach for Severity Grading. Invest Ophthalmol Vis Sci 55(12): 7957-81 (2014).
16. Fowles GR. Introduction to modern optics. 2nd ed. New York: Dover Publications. 8, 328 pp (1989).
17. Keith NM, Wagener HP, Barker NW. Some different types of essential hypertension: Their course and prognosis. Am J Med Sci 197(3): 332-43 (1939).
18. Leishman R. The eye in general vascular disease: hypertension and arteriosclerosis. Br J Ophthalmol 41(11): 641-701 (1957).
19. Scheie HG. Evaluation of ophthalmoscopic changes of hypertension and arteriolar sclerosis. AMA Arch Ophthalmol 49(2): 117-38 (1953).
20. Wong TY, Mitchell P. Hypertensive retinopathy. N Engl J Med 351(22): 2310-7 (2004).
21. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261(5123): 921-3 (1993).
22. Selkoe DJ. Alzheimer’s disease: genes, proteins, and therapy. Physiol Rev 81(2): 741-66 (2001).
23. Smith JD. Apolipoprotein E4: an allele associated with many diseases. Ann Med 32(2): 118-27 (2000).
24. McCarron MO, Delong D, Alberts MJ. APOE genotype as a risk factor for ischemic cerebrovascular disease: a meta-analysis. Neurology 53(6): 1308-11 (1999).
25. Cattin L, Fisicaro M, Tonizzo M, Valenti M, Danek GM, Fonda M, et al. Polymorphism of the apolipoprotein E gene and early carotid atherosclerosis defined by ultrasonography in asymptomatic adults. Arterioscler Thromb Vasc Biol 17(1): 91-4 (1997).
26. Hixson JE. Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological determinants of atherosclerosis in youth (PDAY) research group. Arterioscler Thromb 11(5): 1237-44 (1991).
27. Humphries SE, Morgan L. Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. Lancet Neurol 3(4): 227-35 (2004).
28. Kessler C, Spitzer C, Stauske D, Mende S, Stadlmuller J, Walther R, et al. The apolipoprotein E and beta-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease. Arterioscler Thromb Vasc Biol 17(11): 2880-4 (1997).
29. de Leeuw FE, Richard F, de Groot JC, van Duijn CM, Hofman A, Van Gijn J, et al. Interaction between hypertension, apoE, and cerebral white matter lesions. Stroke 35(5): 1057-60 (2004).
30. Schmidt R, Schmidt H, Fazekas F, Schumacher M, Niederkorn K, Kapeller P, et al. Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage. Results of the Austrian stroke prevention study. Stroke 28(5): 951-6 (1997).
31. Ellis KA, Bush AI, Darby D, De Fazio D, Foster J, Hudson P, et al. The australian imaging, biomarkers and lifestyle (AIBL) study of aging: methodology and baseline characteristics of 1112 individuals recruited for a longitudinal study of Alzheimer’s disease. Int Psychogeriatr 21(4): 672-87 (2009).
32. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 34(7): 939-44 (1984).
33. Ingelsson M, Shin Y, Irizarry MC, Hyman BT, Lilius L, Forsell C, et al. Genotyping of apolipoprotein E: comparative evaluation of different protocols. Curr ProtHum Genetics: John Wiley & Sons, Inc.; 2003.
34. Hixson JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31(3): 545-8 (1990).
35. Svardsudd K, Wedel H, Aurell E, Tibblin G. Hypertensive eye ground changes. Prevalence, relation to blood pressure and prognostic importance. The study of men born in 1913. Acta Med Scand 204(3): 159-67 (1978).
36. Sun C, Wang JJ, Mackey DA, Wong TY. Retinal vascular caliber: systemic, environmental, and genetic associations. Surv Ophthalmol 54(1): 74 (2009).
37. R_Development_Core_Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing (2013).
38. Kaushik S, Tan AG, Mitchell P, Wang JJ. Prevalence and associations of enhanced retinal arteriolar light reflex: a new look at an old sign. Ophthalmology 114(1): 113-20 (2007).
39. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8(1): 1-21 (1988).
40. Eichner JE, Kuller LH, Orchard TJ, Grandits GA, McCallum LM, Ferrell RE, et al. Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am J Cardiol 71(2): 160-5 (1993).
41. Wilson PW, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. JAMA 272(21): 1666-71 (1994).
42. Isbir T, Yilmaz H, Bihorac A, Akoglu E. Mild-to-moderate hypertension and apolipoprotein E gene polymorphism. Am J Hypertens 10(7 Pt 1): 827-8 (1997).
43. Yilmaz H, Isbir T, Agachan B, Aydin M. Is epsilon4 allele of apolipoprotein E associated with more severe end-organ damage in essential hypertension? Cell Biochem Funct 19(3): 191-5 (2001).
44. Catalano M, Aronica A, Carzaniga G, Seregni R, Libretti A. Serum lipids and apolipoproteins in patients with essential hypertension. Atherosclerosis 87(1): 17-22 (1991).
45. Bhavani AB, Sastry KB, Reddy NK, Padma T. Lipid profile and apolipoprotein E polymorphism in essential hypertension. Ind Heart J 57(2): 151-7 (2005).
46. Mayet J, Hughes A. Cardiac and vascular pathophysiology in hypertension. Heart 89(9): 1104-9 (2003).
47. Pries AR, Secomb TW. Structural adaptation of microvascular networks and development of hypertension. Microcirculation 9(4): 305-14 (2002).
48. Brinchmann-Hansen O, Sandvik L. The intensity of the light reflex on retinal arteries and veins. Acta Ophthalmol (Copenh) 64(5): 547-52 (1986).
49. Brinchmann-Hansen O, Sandvik L. The width of the light reflex on retinal arteries and veins. Acta Ophthalmol (Copenh) 64(4): 433-8 (1986).
50. Patel V, Kohner EM. The eye in hypertension. In: Swales JD, editor. Textbook of Hypertension. Oxford: Blackwell Scientific Publications; 1994.
51. Walsh JB. Hypertensive retinopathy. description, classification, and prognosis. Ophthalmology 89(10): 1127-31 (1982).
52. Hui DY. Apolipoprotein E-induced cell signaling in the vessel wall. Rev Endoc Metab Disord 5(4): 335-41 (2004).
53. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240(4852): 622-30 (1988).
54. Bennet AM, Di Angelantonio E, Ye Z, Wensley F, Dahlin A, Ahlbom A, et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA 298(11): 1300-11 (2007).
55. Khan TA, Shah T, Prieto D, Zhang W, Price J, Fowkes GR, et al. Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. Int J Epidemiol 42(2): 475-92 (2013).
56. Berisha F, Feke GT, Trempe CL, McMeel JW, Schepens CL. Retinal abnormalities in early Alzheimer’s disease. Invest Ophthalmol Vis Sci 48(5): 2285-9 (2007).
57. Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer’s disease. Neuron 63(3): 287-303 (2009).
58. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/american stroke association. Stroke 42(9): 2672-713 (2011).
59. Knopman DS. Cerebrovascular pathology in cognitive impairment: new (in)sights. Neurology 78(14): 1032-3 (2012).
60. Knopman DS. Cerebrovascular disease and dementia. Brit J Radiol 80(2): S121-7 (2007).
61. Rosendorff C, Beeri MS, Silverman JM. Cardiovascular risk factors for Alzheimer’s disease. Am J Ggeriatric Cardiol 16(3): 143-9 (2007).
62. Schrijvers EM, Buitendijk GH, Ikram MK, Koudstaal PJ, Hofman A, Vingerling JR, et al. Retinopathy and risk of dementia: the Rotterdam Study. Neurology 79(4): 365-70 (2012).
63. Liew G, Shankar A, Wang JJ, Klein R, Bray MS, Couper DJ, et al. Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. Arch Ophthalmol 125(6): 813-8 (2007).
64. Wong T, Mitchell P. The eye in hypertension Lancet 369(9559): 425-35 (2007).
65. Wong TY, McIntosh R. Systemic associations of retinal microvascular signs: a review of recent population-based studies. Ophthalmic Physiol Opt 25(3): 195-204 (2005).
66. Schnabel RB, Sullivan LM, Levy D, Pencina MJ, Massaro JM, D’Agostino RBS, et al. Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet 373(9665): 739-45 (2009).