-
1
-
-
85029504106
-
Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab (MK-3475) in patients with advanced solid tumors
-
Tolcher AW, Sznol M, Hu-Lieskovan S, Papadopoulos KP, Patnaik A, Rasco DW, et al. Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab (MK-3475) in patients with advanced solid tumors. Clin Cancer Res 2017;23:5349–57.
-
(2017)
Clin Cancer Res
, vol.23
, pp. 5349-5357
-
-
Tolcher, A.W.1
Sznol, M.2
Hu-Lieskovan, S.3
Papadopoulos, K.P.4
Patnaik, A.5
Rasco, D.W.6
-
2
-
-
0031007143
-
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
-
Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997;3:682–5.
-
(1997)
Nat Med
, vol.3
, pp. 682-685
-
-
Melero, I.1
Shuford, W.W.2
Newby, S.A.3
Aruffo, A.4
Ledbetter, J.A.5
Hellström, K.E.6
-
3
-
-
79954593616
-
4-1BB signaling beyond T cells
-
Vinay DS, Kwon BS. 4-1BB signaling beyond T cells. Cell Mol Immunol 2011;8:281–4.
-
(2011)
Cell Mol Immunol
, vol.8
, pp. 281-284
-
-
Vinay, D.S.1
Kwon, B.S.2
-
4
-
-
84874909144
-
Agonist antibodies to TNFR molecules that costimulate T and NK cells
-
Melero I, Hirschhorn-Cymerman D, Morales-Kastresana A, Sanmamed MF, Wolchok JD. Agonist antibodies to TNFR molecules that costimulate T and NK cells. Clin Cancer Res 2013;19:1044–53.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1044-1053
-
-
Melero, I.1
Hirschhorn-Cymerman, D.2
Morales-Kastresana, A.3
Sanmamed, M.F.4
Wolchok, J.D.5
-
5
-
-
85018841234
-
Results from an integrated safety analysis of urelumab, an agonist anti-CD137 monoclonal antibody
-
Segal NH, Logan RF, Hodi FS, McDermott D, Melero I, Hamid O, et al. Results from an integrated safety analysis of urelumab, an agonist anti-CD137 monoclonal antibody. Clin Cancer Res 2017;23: 1929–36.
-
(2017)
Clin Cancer Res
, vol.23
, pp. 1929-1936
-
-
Segal, N.H.1
Logan, R.F.2
Hodi, F.S.3
McDermott, D.4
Melero, I.5
Hamid, O.6
-
6
-
-
77953229126
-
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ
-
Dubrot J, Milheiro F, Alfaro C, Palazón A, Martinez-Forero I, Perez-Gracia JL, et al. Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ. Cancer Immunol Immunother 2010; 59:1223–33.
-
(2010)
Cancer Immunol Immunother
, vol.59
, pp. 1223-1233
-
-
Dubrot, J.1
Milheiro, F.2
Alfaro, C.3
Palazón, A.4
Martinez-Forero, I.5
Perez-Gracia, J.L.6
-
7
-
-
78449237499
-
Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
-
Ascierto PA, Simeone E, Sznol M, Fu Y-X, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010; 37:508–16.
-
(2010)
Semin Oncol
, vol.37
, pp. 508-516
-
-
Ascierto, P.A.1
Simeone, E.2
Sznol, M.3
Fu, Y.-X.4
Melero, I.5
-
8
-
-
84867572490
-
Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
-
Fisher TS, Kamperschroer C, Oliphant T, Love VA, Lira PD, Doyonnas R, et al. Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity. Cancer Immunol Immunother 2012;61:1721–33.
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 1721-1733
-
-
Fisher, T.S.1
Kamperschroer, C.2
Oliphant, T.3
Love, V.A.4
Lira, P.D.5
Doyonnas, R.6
-
9
-
-
84923303086
-
A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer
-
Segal NH, Gopal AK, Bhatia S, Kohrt HE, Levy R, Pishvaian MJ, et al. A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer. J Clin Oncol 32, 2014 (suppl; abstr 3007).
-
(2014)
J Clin Oncol
, vol.32
-
-
Segal, N.H.1
Gopal, A.K.2
Bhatia, S.3
Kohrt, H.E.4
Levy, R.5
Pishvaian, M.J.6
-
10
-
-
84938353999
-
A phase I study of PF-05082566 (anti-4-1BB) þ rituximab in patients with CD20 þ NHL
-
Gopal AK, Bartlett NL, Levy R, Houot R, Smith SD, Segal NH, et al. A phase I study of PF-05082566 (anti-4-1BB) þ rituximab in patients with CD20 þ NHL. J Clin Oncol 33, 2015 (suppl; abstr 3004).
-
(2015)
J Clin Oncol
, vol.33
-
-
Gopal, A.K.1
Bartlett, N.L.2
Levy, R.3
Houot, R.4
Smith, S.D.5
Segal, N.H.6
-
11
-
-
84902440104
-
Dual targeting of CD137 co-stimulatoy and PD-1 co-inhibitory molecules for ovarian cancer immunotherapy
-
Wei H, Zhao L, Hellstrom I, Hellstrom KE, Guo Y. Dual targeting of CD137 co-stimulatoy and PD-1 co-inhibitory molecules for ovarian cancer immunotherapy. Oncoimmunology 2014;3:e28248.
-
(2014)
Oncoimmunology
, vol.3
, pp. e28248
-
-
Wei, H.1
Zhao, L.2
Hellstrom, I.3
Hellstrom, K.E.4
Guo, Y.5
-
12
-
-
84866335513
-
The HIF-1a hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy
-
Palazon A, Martínez-Forero I, Teijeira A, Morales-Kastresana A, Alfaro C, Sanmamed MF, et al. The HIF-1a hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy. Cancer Discov 2012;2:608–23.
-
(2012)
Cancer Discov
, vol.2
, pp. 608-623
-
-
Palazon, A.1
Martínez-Forero, I.2
Teijeira, A.3
Morales-Kastresana, A.4
Alfaro, C.5
Sanmamed, M.F.6
-
13
-
-
84886410237
-
Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model
-
Morales-Kastresana A, Sanmamed MF, Rodriguez I, Palazon A, Martinez-Forero I, Labiano S, et al. Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model. Clin Cancer Res 2013;19:6151–62.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 6151-6162
-
-
Morales-Kastresana, A.1
Sanmamed, M.F.2
Rodriguez, I.3
Palazon, A.4
Martinez-Forero, I.5
Labiano, S.6
-
14
-
-
85020385407
-
Isolation of T-cell receptors specifically reactive with mutated tumor-associated antigens from tumor-infiltrating lymphocytes based on CD137 expression
-
Parkhurst M, Gros A, Pasetto A, Prickett T, Crystal JS, Robbins P, et al. Isolation of T-cell receptors specifically reactive with mutated tumor-associated antigens from tumor-infiltrating lymphocytes based on CD137 expression. Clin Cancer Res 2017;23:2491–505.
-
(2017)
Clin Cancer Res
, vol.23
, pp. 2491-2505
-
-
Parkhurst, M.1
Gros, A.2
Pasetto, A.3
Prickett, T.4
Crystal, J.S.5
Robbins, P.6
-
15
-
-
85029535797
-
Clinical safety and efficacy assessment of the CD137 agonist urelumab alone and in combination with nivolumab in patients with hematologic and solid tumor malignancies
-
Masserelli E, Segal NH, Ribrag V, Melero I, Gangadhar TC, Urba W, et al. Clinical safety and efficacy assessment of the CD137 agonist urelumab alone and in combination with nivolumab in patients with hematologic and solid tumor malignancies. J Immunother Cancer 2016;4(Suppl 1):O7.
-
(2016)
J Immunother Cancer
, vol.4
, pp. O7
-
-
Masserelli, E.1
Segal, N.H.2
Ribrag, V.3
Melero, I.4
Gangadhar, T.C.5
Urba, W.6
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