메뉴 건너뛰기




Volumn 23, Issue 18, 2017, Pages 5326-5328

Anti-CD137 and PD-1/PD-L1 antibodies en route toward clinical synergy

Author keywords

[No Author keywords available]

Indexed keywords

NIVOLUMAB; PEMBROLIZUMAB; URELUMAB; UTOMILUMAB; ANTINEOPLASTIC AGENT; CD274 PROTEIN, HUMAN; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 9;

EID: 85029543405     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-17-1799     Document Type: Article
Times cited : (29)

References (15)
  • 1
    • 85029504106 scopus 로고    scopus 로고
    • Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab (MK-3475) in patients with advanced solid tumors
    • Tolcher AW, Sznol M, Hu-Lieskovan S, Papadopoulos KP, Patnaik A, Rasco DW, et al. Phase Ib study of utomilumab (PF-05082566), a 4-1BB/CD137 agonist, in combination with pembrolizumab (MK-3475) in patients with advanced solid tumors. Clin Cancer Res 2017;23:5349–57.
    • (2017) Clin Cancer Res , vol.23 , pp. 5349-5357
    • Tolcher, A.W.1    Sznol, M.2    Hu-Lieskovan, S.3    Papadopoulos, K.P.4    Patnaik, A.5    Rasco, D.W.6
  • 2
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, Aruffo A, Ledbetter JA, Hellström KE, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997;3:682–5.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3    Aruffo, A.4    Ledbetter, J.A.5    Hellström, K.E.6
  • 3
    • 79954593616 scopus 로고    scopus 로고
    • 4-1BB signaling beyond T cells
    • Vinay DS, Kwon BS. 4-1BB signaling beyond T cells. Cell Mol Immunol 2011;8:281–4.
    • (2011) Cell Mol Immunol , vol.8 , pp. 281-284
    • Vinay, D.S.1    Kwon, B.S.2
  • 5
    • 85018841234 scopus 로고    scopus 로고
    • Results from an integrated safety analysis of urelumab, an agonist anti-CD137 monoclonal antibody
    • Segal NH, Logan RF, Hodi FS, McDermott D, Melero I, Hamid O, et al. Results from an integrated safety analysis of urelumab, an agonist anti-CD137 monoclonal antibody. Clin Cancer Res 2017;23: 1929–36.
    • (2017) Clin Cancer Res , vol.23 , pp. 1929-1936
    • Segal, N.H.1    Logan, R.F.2    Hodi, F.S.3    McDermott, D.4    Melero, I.5    Hamid, O.6
  • 6
    • 77953229126 scopus 로고    scopus 로고
    • Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ
    • Dubrot J, Milheiro F, Alfaro C, Palazón A, Martinez-Forero I, Perez-Gracia JL, et al. Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ. Cancer Immunol Immunother 2010; 59:1223–33.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 1223-1233
    • Dubrot, J.1    Milheiro, F.2    Alfaro, C.3    Palazón, A.4    Martinez-Forero, I.5    Perez-Gracia, J.L.6
  • 7
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • Ascierto PA, Simeone E, Sznol M, Fu Y-X, Melero I. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol 2010; 37:508–16.
    • (2010) Semin Oncol , vol.37 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.-X.4    Melero, I.5
  • 8
    • 84867572490 scopus 로고    scopus 로고
    • Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
    • Fisher TS, Kamperschroer C, Oliphant T, Love VA, Lira PD, Doyonnas R, et al. Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity. Cancer Immunol Immunother 2012;61:1721–33.
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1721-1733
    • Fisher, T.S.1    Kamperschroer, C.2    Oliphant, T.3    Love, V.A.4    Lira, P.D.5    Doyonnas, R.6
  • 10
    • 84938353999 scopus 로고    scopus 로고
    • A phase I study of PF-05082566 (anti-4-1BB) þ rituximab in patients with CD20 þ NHL
    • Gopal AK, Bartlett NL, Levy R, Houot R, Smith SD, Segal NH, et al. A phase I study of PF-05082566 (anti-4-1BB) þ rituximab in patients with CD20 þ NHL. J Clin Oncol 33, 2015 (suppl; abstr 3004).
    • (2015) J Clin Oncol , vol.33
    • Gopal, A.K.1    Bartlett, N.L.2    Levy, R.3    Houot, R.4    Smith, S.D.5    Segal, N.H.6
  • 11
    • 84902440104 scopus 로고    scopus 로고
    • Dual targeting of CD137 co-stimulatoy and PD-1 co-inhibitory molecules for ovarian cancer immunotherapy
    • Wei H, Zhao L, Hellstrom I, Hellstrom KE, Guo Y. Dual targeting of CD137 co-stimulatoy and PD-1 co-inhibitory molecules for ovarian cancer immunotherapy. Oncoimmunology 2014;3:e28248.
    • (2014) Oncoimmunology , vol.3 , pp. e28248
    • Wei, H.1    Zhao, L.2    Hellstrom, I.3    Hellstrom, K.E.4    Guo, Y.5
  • 13
    • 84886410237 scopus 로고    scopus 로고
    • Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model
    • Morales-Kastresana A, Sanmamed MF, Rodriguez I, Palazon A, Martinez-Forero I, Labiano S, et al. Combined immunostimulatory monoclonal antibodies extend survival in an aggressive transgenic hepatocellular carcinoma mouse model. Clin Cancer Res 2013;19:6151–62.
    • (2013) Clin Cancer Res , vol.19 , pp. 6151-6162
    • Morales-Kastresana, A.1    Sanmamed, M.F.2    Rodriguez, I.3    Palazon, A.4    Martinez-Forero, I.5    Labiano, S.6
  • 14
    • 85020385407 scopus 로고    scopus 로고
    • Isolation of T-cell receptors specifically reactive with mutated tumor-associated antigens from tumor-infiltrating lymphocytes based on CD137 expression
    • Parkhurst M, Gros A, Pasetto A, Prickett T, Crystal JS, Robbins P, et al. Isolation of T-cell receptors specifically reactive with mutated tumor-associated antigens from tumor-infiltrating lymphocytes based on CD137 expression. Clin Cancer Res 2017;23:2491–505.
    • (2017) Clin Cancer Res , vol.23 , pp. 2491-2505
    • Parkhurst, M.1    Gros, A.2    Pasetto, A.3    Prickett, T.4    Crystal, J.S.5    Robbins, P.6
  • 15
    • 85029535797 scopus 로고    scopus 로고
    • Clinical safety and efficacy assessment of the CD137 agonist urelumab alone and in combination with nivolumab in patients with hematologic and solid tumor malignancies
    • Masserelli E, Segal NH, Ribrag V, Melero I, Gangadhar TC, Urba W, et al. Clinical safety and efficacy assessment of the CD137 agonist urelumab alone and in combination with nivolumab in patients with hematologic and solid tumor malignancies. J Immunother Cancer 2016;4(Suppl 1):O7.
    • (2016) J Immunother Cancer , vol.4 , pp. O7
    • Masserelli, E.1    Segal, N.H.2    Ribrag, V.3    Melero, I.4    Gangadhar, T.C.5    Urba, W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.