메뉴 건너뛰기




Volumn 11, Issue 6, 2017, Pages 1309-1317

Niacin and heart disease prevention: Engraving its tombstone is a mistake

Author keywords

Coronary artery disease; Food and drug administration; Heart disease; Lipoproteins; Niacin; Nicotinic acid

Indexed keywords

CATECHOLAMINE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC ACID; TRIACYLGLYCEROL;

EID: 85029480120     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2017.08.005     Document Type: Review
Times cited : (35)

References (50)
  • 1
    • 84904252744 scopus 로고    scopus 로고
    • Effects of extended-release niacin with laropiprant in high-risk patients
    • HPS2-THRIVE Collaborative Group, Landray, M.J., Haynes, R., Hopewell, J.C., et al. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med 371 (2014), 203–212.
    • (2014) N Engl J Med , vol.371 , pp. 203-212
    • Landray, M.J.1    Haynes, R.2    Hopewell, J.C.3
  • 2
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • The AIM-HIGH Investigators, Boden, W.E., Probstfield, J.L., Anderson, T., et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 365 (2011), 2255–2267.
    • (2011) N Engl J Med , vol.365 , pp. 2255-2267
    • Boden, W.E.1    Probstfield, J.L.2    Anderson, T.3
  • 3
    • 85034406532 scopus 로고    scopus 로고
    • FDA Federal Register. 2016. Available at:; Accessed April 20, 2016.
    • FDA Federal Register. 2016. Available at: https://www.federalregister.gov/articles/2016/04/18/2016-08887/abbvie-inc-et-al-withdrawal-of-approval-of-indications-related-to-the-coadministration withstatins?utm_content=previous&utm_medium=PrevNext&utm_source=Article; Accessed April 20, 2016.
  • 4
    • 85034395209 scopus 로고    scopus 로고
    • 2016 AHA CardioBrief: FDA Ends Niacin, Fibrate Combos With Statins and Other Coverage from AHA. Available at: Accessed April 17.
    • 2016 AHA CardioBrief: FDA Ends Niacin, Fibrate Combos With Statins and Other Coverage from AHA. Available at: http://cardiobrief.org/2016/04/17/fda-ends-niacin-and-fenofibric-acid-combinations-with-statins/. Accessed April 17, 2016.
    • (2016)
  • 5
    • 0029828488 scopus 로고    scopus 로고
    • Beyond LDL-C reduction
    • Superko, H.R., Beyond LDL-C reduction. Circulation 94 (1996), 2351–2354.
    • (1996) Circulation , vol.94 , pp. 2351-2354
    • Superko, H.R.1
  • 6
    • 41049092691 scopus 로고    scopus 로고
    • Lipid management to reduce cardiovascular risk: a new strategy is required
    • Superko, H.R., King, S. 3rd, Lipid management to reduce cardiovascular risk: a new strategy is required. Circulation 117 (2008), 560–568.
    • (2008) Circulation , vol.117 , pp. 560-568
    • Superko, H.R.1    King, S.2
  • 7
    • 0033596281 scopus 로고    scopus 로고
    • Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials
    • LaRosa, J.C., He, J., Vupputuri, S., Effect of statins on risk of coronary disease: a meta-analysis of randomized controlled trials. JAMA 282 (1999), 2340–2346.
    • (1999) JAMA , vol.282 , pp. 2340-2346
    • LaRosa, J.C.1    He, J.2    Vupputuri, S.3
  • 8
    • 56749106312 scopus 로고    scopus 로고
    • Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    • Ridker, P.M., Danielson, E., Fonseca, F.A., et al., JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 359 (2008), 2195–2207.
    • (2008) N Engl J Med , vol.359 , pp. 2195-2207
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 9
    • 84949462326 scopus 로고    scopus 로고
    • Atherogenic lipoprotein subfractions determined by ion mobility and first cardiovascular events after random allocation to high-intensity statin or placebo: the justification for the use of statins in prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial
    • Mora, S., Caulfield, M.P., Wohlgemuth, J., et al. Atherogenic lipoprotein subfractions determined by ion mobility and first cardiovascular events after random allocation to high-intensity statin or placebo: the justification for the use of statins in prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) Trial. Circulation 132 (2015), 2220–2229.
    • (2015) Circulation , vol.132 , pp. 2220-2229
    • Mora, S.1    Caulfield, M.P.2    Wohlgemuth, J.3
  • 10
    • 0026724433 scopus 로고
    • Differential effects of niacin in subjects with different LDL subclass patterns
    • Superko, H.R., Krauss, R.M., Differential effects of niacin in subjects with different LDL subclass patterns. Atherosclerosis 95 (1992), 69–76.
    • (1992) Atherosclerosis , vol.95 , pp. 69-76
    • Superko, H.R.1    Krauss, R.M.2
  • 11
    • 0023001772 scopus 로고
    • Fifteen year mortality in coronary drug project patients: long-term benefit with niacin
    • Canner, P.L., Berge, K.G., Wenger, N.K., et al. Fifteen year mortality in coronary drug project patients: long-term benefit with niacin. J Am Coll Cardiol 8 (1986), 1245–1255.
    • (1986) J Am Coll Cardiol , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3
  • 12
    • 22644437126 scopus 로고    scopus 로고
    • Niacin: the broad-spectrum lipid drug. A 50th anniversary review
    • Carlson, L.A., Niacin: the broad-spectrum lipid drug. A 50th anniversary review. J Intern Med 258:2 (2005), 94–114.
    • (2005) J Intern Med , vol.258 , Issue.2 , pp. 94-114
    • Carlson, L.A.1
  • 13
    • 0020988594 scopus 로고
    • Niacin and its derivatives: a short survey
    • Hotz, W., Niacin and its derivatives: a short survey. Adv Lipid Res 20 (1983), 195–217.
    • (1983) Adv Lipid Res , vol.20 , pp. 195-217
    • Hotz, W.1
  • 14
    • 84957794297 scopus 로고    scopus 로고
    • Gene expression microarray data from human microvascular endothelial cells supplemented with a low concentration of niacin
    • Hughes-Large, J.M., Borradaile, N.M., Gene expression microarray data from human microvascular endothelial cells supplemented with a low concentration of niacin. Data Brief 6 (2016), 899–902.
    • (2016) Data Brief , vol.6 , pp. 899-902
    • Hughes-Large, J.M.1    Borradaile, N.M.2
  • 15
    • 0034526290 scopus 로고    scopus 로고
    • Lipid altering drugs LDL/HDL subclass distribution. Match the treatment to the disorder
    • Superko, H.R., Lipid altering drugs LDL/HDL subclass distribution. Match the treatment to the disorder. ACC Curr J Rev 9:3 (2000), 18–24.
    • (2000) ACC Curr J Rev , vol.9 , Issue.3 , pp. 18-24
    • Superko, H.R.1
  • 16
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson, L.A., Rosenhamer, G., Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand 223 (1988), 405–418.
    • (1988) Acta Med Scand , vol.223 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 17
    • 0027513563 scopus 로고
    • Design and baseline results of the Scandinavian Simvastatin Survival Study of patients with stable angina and/or previous myocardial infarction
    • 4 S. Design and baseline results of the Scandinavian Simvastatin Survival Study of patients with stable angina and/or previous myocardial infarction. Am J Cardiol 71 (1993), 393–400.
    • (1993) Am J Cardiol , vol.71 , pp. 393-400
  • 18
    • 0035969564 scopus 로고    scopus 로고
    • Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease
    • Brown, G.B., Zhao, X.Q., Chait, A., et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 345:22 (2001), 1583–1592.
    • (2001) N Engl J Med , vol.345 , Issue.22 , pp. 1583-1592
    • Brown, G.B.1    Zhao, X.Q.2    Chait, A.3
  • 19
    • 19944426989 scopus 로고    scopus 로고
    • A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events
    • Whitney, E.J., Krasuski, R.A., Personius, B.E., et al. A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events. Ann Intern Med 142 (2005), 95–104.
    • (2005) Ann Intern Med , vol.142 , pp. 95-104
    • Whitney, E.J.1    Krasuski, R.A.2    Personius, B.E.3
  • 20
    • 85034394214 scopus 로고    scopus 로고
    • Lipoprotein metabolism and implications for atherosclerosis risk determination and treatment decisions
    • P.K. Shah Taylor & Francis Group New York, London
    • Superko, H.R., Voros, S., King, S. III, Lipoprotein metabolism and implications for atherosclerosis risk determination and treatment decisions. Shah, P.K., (eds.) Textbook on Cardiovascular Disease, 2006, Taylor & Francis Group, New York, London, 35–83.
    • (2006) Textbook on Cardiovascular Disease , pp. 35-83
    • Superko, H.R.1    Voros, S.2    King, S.3
  • 21
    • 0025183769 scopus 로고
    • Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B
    • Brown, G., Albers, J.J., Fisher, L.D., et al. Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med 323 (1990), 1289–1298.
    • (1990) N Engl J Med , vol.323 , pp. 1289-1298
    • Brown, G.1    Albers, J.J.2    Fisher, L.D.3
  • 22
    • 71649101609 scopus 로고    scopus 로고
    • Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS)
    • Zhao, X.Q., Krasuski, R.A., Baer, J., et al. Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS). Am J Cardiol 104:11 (2009), 1457–1464.
    • (2009) Am J Cardiol , vol.104 , Issue.11 , pp. 1457-1464
    • Zhao, X.Q.1    Krasuski, R.A.2    Baer, J.3
  • 23
    • 84886000801 scopus 로고    scopus 로고
    • Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes)
    • Guyton, J.R., Slee, A.E., Anderson, T., et al. Relationship of lipoproteins to cardiovascular events: the AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes). J Am Coll Cardiol 22:62 (2013), 1580–1584.
    • (2013) J Am Coll Cardiol , vol.22 , Issue.62 , pp. 1580-1584
    • Guyton, J.R.1    Slee, A.E.2    Anderson, T.3
  • 24
    • 84898899088 scopus 로고    scopus 로고
    • Effects of niacin combination therapy with statin or bile acid resin on lipoproteins and cardiovascular disease
    • Zambon, A., Zhao, X.Q., Brown, B.G., Brunzell, J.D., Effects of niacin combination therapy with statin or bile acid resin on lipoproteins and cardiovascular disease. Am J Cardiol 1:113 (2014), 1494–1498.
    • (2014) Am J Cardiol , vol.1 , Issue.113 , pp. 1494-1498
    • Zambon, A.1    Zhao, X.Q.2    Brown, B.G.3    Brunzell, J.D.4
  • 25
    • 19344370665 scopus 로고    scopus 로고
    • Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia
    • Vega, G.L., Cater, N.B., Meguro, S., Grundy, S.M., Influence of extended-release nicotinic acid on nonesterified fatty acid flux in the metabolic syndrome with atherogenic dyslipidemia. Am J Cardiol 95 (2005), 1309–1313.
    • (2005) Am J Cardiol , vol.95 , pp. 1309-1313
    • Vega, G.L.1    Cater, N.B.2    Meguro, S.3    Grundy, S.M.4
  • 26
    • 7244238303 scopus 로고    scopus 로고
    • Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes
    • Watt, M.J., Southgate, R.J., Holmes, A.G., Febbraio, M.A., Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes. J Mol Endocrinol 33 (2004), 533–544.
    • (2004) J Mol Endocrinol , vol.33 , pp. 533-544
    • Watt, M.J.1    Southgate, R.J.2    Holmes, A.G.3    Febbraio, M.A.4
  • 27
    • 79952240405 scopus 로고    scopus 로고
    • Niacin inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
    • Lukasova, M., Malaval, C., Gille, A., Kero, J., Offermanns, S., Niacin inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J Clin Invest 121 (2011), 1163–1173.
    • (2011) J Clin Invest , vol.121 , pp. 1163-1173
    • Lukasova, M.1    Malaval, C.2    Gille, A.3    Kero, J.4    Offermanns, S.5
  • 28
    • 84958252911 scopus 로고    scopus 로고
    • Niacin alternatives for dyslipidemia: Fool's gold or gold mine? Part I: alternative niacin regimens
    • Dunbar, R.L., Goel, H., Niacin alternatives for dyslipidemia: Fool's gold or gold mine? Part I: alternative niacin regimens. Curr Atheroslcer Rep, 18, 2016, 11.
    • (2016) Curr Atheroslcer Rep , vol.18 , pp. 11
    • Dunbar, R.L.1    Goel, H.2
  • 29
    • 0021828236 scopus 로고
    • Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: clues to mechanism of action of niacin
    • Knopp, R.H., Ginsberg, J., Albers, J.J., et al. Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: clues to mechanism of action of niacin. Metabolism 34 (1985), 642–650.
    • (1985) Metabolism , vol.34 , pp. 642-650
    • Knopp, R.H.1    Ginsberg, J.2    Albers, J.J.3
  • 30
    • 84958880102 scopus 로고    scopus 로고
    • Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomized controlled trials
    • Goldie, C., Taylor, A.J., Nguyen, P., McCoy, C., Zhao, X.Q., Preiss, D., Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomized controlled trials. Heart 102:3 (2015), 198–203.
    • (2015) Heart , vol.102 , Issue.3 , pp. 198-203
    • Goldie, C.1    Taylor, A.J.2    Nguyen, P.3    McCoy, C.4    Zhao, X.Q.5    Preiss, D.6
  • 32
    • 0027469834 scopus 로고
    • Prognostic significance of progression of coronary atherosclerosis
    • Waters, D., Craven, T.E., Lesperance, J., Prognostic significance of progression of coronary atherosclerosis. Circulation 87 (1993), 1067–1075.
    • (1993) Circulation , vol.87 , pp. 1067-1075
    • Waters, D.1    Craven, T.E.2    Lesperance, J.3
  • 34
    • 84948007950 scopus 로고
    • Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts
    • Blankenhorn, D.H., Nessim, S.A., Johnson, R.D., Sanmarco, M.E., Azen, S.P., Cashin-Hemphill, L., Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 257 (1987), 3233–3240.
    • (1987) JAMA , vol.257 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.D.3    Sanmarco, M.E.4    Azen, S.P.5    Cashin-Hemphill, L.6
  • 35
    • 0025685469 scopus 로고
    • Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens
    • Kane, J.P., Malloy, M.J., Ports, T.A., Phillips, N.R., Diehl, J.C., Havel, R.J., Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens. JAMA 264:23 (1990), 3007–3012.
    • (1990) JAMA , vol.264 , Issue.23 , pp. 3007-3012
    • Kane, J.P.1    Malloy, M.J.2    Ports, T.A.3    Phillips, N.R.4    Diehl, J.C.5    Havel, R.J.6
  • 36
    • 33751217682 scopus 로고    scopus 로고
    • The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3
    • Taylor, A.J., Lee, H.J., Sullenberger, L.E., The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3. Curr Med Res Opin 22 (2006), 2243–2250.
    • (2006) Curr Med Res Opin , vol.22 , pp. 2243-2250
    • Taylor, A.J.1    Lee, H.J.2    Sullenberger, L.E.3
  • 37
    • 66349105381 scopus 로고    scopus 로고
    • Advanced lipoprotein testing and subfractionation research tool or clinical utility?
    • Superko, H.R., Advanced lipoprotein testing and subfractionation research tool or clinical utility?. Circulation 119 (2009), 2383–2395.
    • (2009) Circulation , vol.119 , pp. 2383-2395
    • Superko, H.R.1
  • 38
    • 84975492237 scopus 로고    scopus 로고
    • Effect of extended-release niacin on high-density lipoprotein (HDL) functionality, lipoprotein metabolism, and mediators of vascular inflammation in statin-treated patients
    • Yadav, R., Liu, Y., Kwok, S., et al. Effect of extended-release niacin on high-density lipoprotein (HDL) functionality, lipoprotein metabolism, and mediators of vascular inflammation in statin-treated patients. J Am Heart Assoc, 4(9), 2015, e001508.
    • (2015) J Am Heart Assoc , vol.4 , Issue.9 , pp. e001508
    • Yadav, R.1    Liu, Y.2    Kwok, S.3
  • 39
    • 84859707908 scopus 로고    scopus 로고
    • Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans
    • Song, W.L., Stubbe, J., Ricciotti, E., Niacin and biosynthesis of PGD2 by platelet COX-1 in mice and humans. J Clin Invest 122 (2012), 1459–1468.
    • (2012) J Clin Invest , vol.122 , pp. 1459-1468
    • Song, W.L.1    Stubbe, J.2    Ricciotti, E.3
  • 40
    • 84939628485 scopus 로고    scopus 로고
    • Detrimental effects of niacin/laropiprant on microvascular reactivity and red cell deformability in patients with elevated lipoprotein(a) levels
    • Cioni, G., Mannini, L., Liotta, A.A., et al. Detrimental effects of niacin/laropiprant on microvascular reactivity and red cell deformability in patients with elevated lipoprotein(a) levels. J Thromb Thrombolysis 41 (2016), 433–435.
    • (2016) J Thromb Thrombolysis , vol.41 , pp. 433-435
    • Cioni, G.1    Mannini, L.2    Liotta, A.A.3
  • 41
    • 84872679028 scopus 로고    scopus 로고
    • The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression
    • Lavigne, P.M., Karas, R.H., The current state of niacin in cardiovascular disease prevention: a systematic review and meta-regression. J Am Coll Cardiol 61 (2013), 440–446.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 440-446
    • Lavigne, P.M.1    Karas, R.H.2
  • 42
    • 85034413499 scopus 로고    scopus 로고
    • The Heart and Obesity
    • R.O. Rourke R. Walsh V. Fuster 12th ed. The McGraw-Hill Companies New York, NY
    • Superko, H.R., Lakshmana, K., Pendyala, The Heart and Obesity. Rourke, R.O., Walsh, R., Fuster, V., (eds.) Hurst's The Heart Manual of Cardiology, 12th ed., 2009, The McGraw-Hill Companies, New York, NY, 618–629.
    • (2009) Hurst's The Heart Manual of Cardiology , pp. 618-629
    • Superko, H.R.1    Lakshmana, K.2    Pendyala3
  • 43
    • 84961230848 scopus 로고    scopus 로고
    • Metabolomic profiling of statin use and genetic inhibition of HMG-CoA reductase
    • Wurtz, P., Wang, Q., Soininen, P., et al. Metabolomic profiling of statin use and genetic inhibition of HMG-CoA reductase. J Am Coll Cardiol 67 (2016), 1200–1213.
    • (2016) J Am Coll Cardiol , vol.67 , pp. 1200-1213
    • Wurtz, P.1    Wang, Q.2    Soininen, P.3
  • 44
    • 4444307754 scopus 로고    scopus 로고
    • Niacin has a differential effect on low density lipoprotein subclass distribution in patients classified as LDL pattern A, B, or I
    • Superko, H.R., McGovern, M.E., Raul, E., Garrett, B., Niacin has a differential effect on low density lipoprotein subclass distribution in patients classified as LDL pattern A, B, or I. Am J Cardiol 94 (2004), 588–594.
    • (2004) Am J Cardiol , vol.94 , pp. 588-594
    • Superko, H.R.1    McGovern, M.E.2    Raul, E.3    Garrett, B.4
  • 45
    • 0031195255 scopus 로고    scopus 로고
    • Effect of HMGCoA reductase inhibitor (fluvastatin) on LDL peak particle diameter
    • Superko, H.R., Krauss, R.M., DiRicco, C., Effect of HMGCoA reductase inhibitor (fluvastatin) on LDL peak particle diameter. Am J Cardiol 80 (1997), 78–81.
    • (1997) Am J Cardiol , vol.80 , pp. 78-81
    • Superko, H.R.1    Krauss, R.M.2    DiRicco, C.3
  • 46
    • 84874548159 scopus 로고    scopus 로고
    • Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS)
    • Williams, P.T., Zhao, X.Q., Marcovina, S.M., Brown, B.G., Krauss, R.M., Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS). PLoS One, 8, 2013, e56782.
    • (2013) PLoS One , vol.8 , pp. e56782
    • Williams, P.T.1    Zhao, X.Q.2    Marcovina, S.M.3    Brown, B.G.4    Krauss, R.M.5
  • 47
    • 84896301841 scopus 로고    scopus 로고
    • Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease
    • Williams, P.T., Zhao, X.Q., Marcovina, S.M., Otvos, J.D., Brown, B.G., Krauss, R.M., Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease. Atherosclerosis 233 (2014), 713–720.
    • (2014) Atherosclerosis , vol.233 , pp. 713-720
    • Williams, P.T.1    Zhao, X.Q.2    Marcovina, S.M.3    Otvos, J.D.4    Brown, B.G.5    Krauss, R.M.6
  • 48
    • 2442425776 scopus 로고    scopus 로고
    • Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia
    • Knopp, R.H., Alagona, P., Davidson, M., et al. Equivalent efficacy of a time-release form of niacin (Niaspan) given once-a-night versus plain niacin in the management of hyperlipidemia. Metabolism 47:9 (1998), 1097–1104.
    • (1998) Metabolism , vol.47 , Issue.9 , pp. 1097-1104
    • Knopp, R.H.1    Alagona, P.2    Davidson, M.3
  • 49
    • 13644270359 scopus 로고
    • The tangled web of coronary risk factors
    • Krauss, R.M., The tangled web of coronary risk factors. Am J Med 90 (1991), 36S–41S.
    • (1991) Am J Med , vol.90 , pp. 36S-41S
    • Krauss, R.M.1
  • 50
    • 78751519853 scopus 로고    scopus 로고
    • Genetic determinants of plasma triglycerides
    • Johansen, C.T., Kathiresan, S., Hegele, R.A., Genetic determinants of plasma triglycerides. J Lipid Res 52:2 (2011), 189–206.
    • (2011) J Lipid Res , vol.52 , Issue.2 , pp. 189-206
    • Johansen, C.T.1    Kathiresan, S.2    Hegele, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.