Detrimental effects of niacin/laropiprant on microvascular reactivity and red cell deformability in patients with elevated lipoprotein(a) levels

Journal of Thrombosis and Thrombolysis

Volumn 41, Issue 3, 2016, Pages 433-435

  Cioni, Gabriele ^a   Mannini, Lucia ^a   Liotta, Alessandrello Agatina ^a   D’Alessandri, Giovanna ^b   Fatini, Cinzia ^a   Bandinelli, Brunella ^a   Costanzo, Maria ^a   Abbate, Rosanna ^a   Marcucci, Rossella ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UF Medicina del Lavoro   (Italy)

Author keywords

Microvascular reactivity; Niacin laropiprant; Peripheral arterial tonometry; Red cell deformability

Indexed keywords

FIBRINOGEN; LAROPIPRANT PLUS NICOTINIC ACID; LIPOPROTEIN A; VON WILLEBRAND FACTOR; INDOLE DERIVATIVE; MK-0524; NICOTINIC ACID;

ADULT; ARTERY THROMBOSIS; BLOOD SAMPLING; BLOOD VESSEL REACTIVITY; BLOOD VISCOSITY; CLINICAL ARTICLE; ENDOTHELIUM; ERYTHROCYTE AGGREGATION; ERYTHROCYTE DEFORMABILITY; FEMALE; FLOW KINETICS; HUMAN; ITALY; LETTER; MALE; PLASMA VISCOSITY; PRIORITY JOURNAL; UNSPECIFIED SIDE EFFECT; VENOUS BLOOD; AGED; BLOOD; CLINICAL TRIAL; DRUG EFFECTS; MICROCIRCULATION; MIDDLE AGED;

AGED; ERYTHROCYTE DEFORMABILITY; FEMALE; HUMANS; INDOLES; LIPOPROTEIN(A); MALE; MICROCIRCULATION; MIDDLE AGED; NIACIN;

EID: 84939628485     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-015-1256-9     Document Type: Letter

References (10)

1. Emerging Risk Factors Collaboration, Erqou S, Kaptoge S, Perry PL et al (2009) Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA 302(4):412–423. doi:10.1001/jama.2009.1063Review
2. Marcucci R, Liotta AA, Cellai AP et al (2003) Increased plasma levels of lipoprotein(a) and the risk of idiopathic and recurrent venous thromboembolism. Am J Med 115:601–605
3. Kamstrup PR, Tybjærg-Hansen A, Nordestgaard BG (2012) Genetic evidence that lipoprotein(a) associates with atherosclerotic stenosis rather than venous thrombosis. Arterioscler Thromb Vasc Biol 32(7):1732–1741. doi:10.1161/ATVBAHA.112.248765
4. Insull W Jr, Basile JN, Vo AN, Jiang P, Thakkar R, Padley RJ (2009) Efficacy and safety of combination therapy with niacin extended-release and simvastatin versus atorvastatin in patients with dyslipidemia: the SUPREME Study. J Clin Lipidol 3(2):109–118. doi:10.1016/j.jacl.2009.02.009
5. Toth PP, Thakker KM, Jiang P, Padley RJ (2012) Niacin extended-release/simvastatin combination therapy produces larger favorable changes in high-density lipoprotein particles than atorvastatin monotherapy. Vasc Health Risk Manag 8:39–44. doi:10.2147/VHRM.S22601
6. Ricci I, Sofi F, Liotta AA et al (2013) Alterations of haemorheological parameters in patients with peripheral arterial disease. Clin Hemorheol Microcirc 55(2):271–276. doi:10.3233/CH-2012-1633
7. Fatini C, Sticchi E, Cesari F et al (2012) Relationship among endothelial response to hyperemia, bone marrow-derived progenitor cells, and parathyroid hormone in renal transplantation. Transplantation 93(8):835–841. doi:10.1097/TP.0b013e318247a75d
8. Rubinshtein R, Kuvin JT, Soffler M et al (2010) Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events. Eur Heart J. 31(9):1142–1148. doi:10.1093/eurheartj/ehq010
9. Sandhagen B, Lind L (2012) Whole blood viscosity and erythrocyte deformability are related to endothelium-dependent vasodilation and coronary risk in the elderly. The prospective investigation of the vasculature in Uppsala seniors (PIVUS) study. Clin Hemorheol Microcirc 50(4):301–311. doi:10.3233/CH-2011-1505
10. Philpott AC, Hubacek J, Sun YC, Hillard D, Anderson TJ (2013) Niacin improves lipid profile but not endothelial function in patients with coronary artery disease on high dose statin therapy. Atherosclerosis 226(2):453–458. doi:10.1016/j.atherosclerosis.2012.10.067