Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase

Journal of the American College of Cardiology

Volumn 67, Issue 10, 2016, Pages 1200-1210

  Würtz, Peter ^a   Wang, Qin ^a,b   Soininen, Pasi ^a,b   Kangas, Antti J ^a   Fatemifar, Ghazaleh ^c   Tynkkynen, Tuulia ^a,b   Tiainen, Mika ^a,b   Perola, Markus ^d,e,f   Tillin, Therese ^g   Hughes, Alun D ^g   Mäntyselkä, Pekka ^h   Kähönen, Mika ⁱ   Lehtimäki, Terho ⁱ   Sattar, Naveed ^j   Hingorani, Aroon D ^g   Casas, Juan Pablo ^c,g   Salomaa, Veikko ^d   Kivimäki, Mika ^g,k   Järvelin, Marjo Riitta ^a,l,m   Davey Smith, George ⁿ   Vanhala, Mauno ^h,o   Lawlor, Debbie A ⁿ   Raitakari, Olli T ^p,q   Chaturvedi, Nish ^g   Kettunen, Johannes ^a,b   Ala Korpela, Mika ^a,b,m,n   more..

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

^f UNIVERSITY OF TARTU   (Estonia)

^g UNIVERSITY COLLEGE LONDON   (United Kingdom)

^h KUOPIO UNIVERSITY HOSPITAL   (Finland)

ⁱ TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^j UNIVERSITY OF GLASGOW   (United Kingdom)

^k UNIVERSITY OF HELSINKI   (Finland)

^l IMPERIAL COLLEGE LONDON   (United Kingdom)

^m OULU UNIVERSITY HOSPITAL   (Finland)

ⁿ UNIVERSITY OF BRISTOL   (United Kingdom)

^o CENTRAL FINLAND CENTRAL HOSPITAL   (Finland)

^p UNIVERSITY OF TURKU   (Finland)

^q TURKU UNIVERSITY HOSPITAL   (Finland)

more..

Author keywords

cholesterol lowering; drug development; lipoproteins; Mendelian randomization; metabolomics

Indexed keywords

APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 6 FATTY ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ALLELE; ARTICLE; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG USE; FEMALE; FINLAND; FOLLOW UP; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC INHIBITION; GENETIC VARIABILITY; GLYCOLYSIS; HMGCR GENE; HUMAN; MALE; METABOLITE; METABOLOMICS; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; UNITED KINGDOM; BLOOD; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; DRUG EFFECTS; FORECASTING; GENETICS; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; RETROSPECTIVE STUDY;

ADULT; CARDIOVASCULAR DISEASES; FEMALE; FINLAND; FORECASTING; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; METABOLOMICS; MIDDLE AGED; RETROSPECTIVE STUDIES; UNITED KINGDOM;

EID: 84961230848     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.12.060     Document Type: Article

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