Unique transcriptomic response to sepsis is observed among patients of different age groups

PLoS ONE

Volumn 12, Issue 9, 2017, Pages

  Raymond, Steven L ^a   López, María Cecilia ^a   Baker, Henry V ^a   Larson, Shawn D ^a   Efron, Philip A ^a   Sweeney, Timothy E ^b   Khatri, Purvesh ^b   Moldawer, Lyle L ^a   Wynn, James L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BONE MARROW CELL; CELL FUNCTION; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; GENE; GENE CONTROL; GENE EXPRESSION; GENOME-WIDE ASSOCIATION STUDY; GROUPS BY AGE; HUMAN; IMMUNE RESPONSE; INFANT; INFLAMMATION; INFORMATION PROCESSING; MAJOR CLINICAL STUDY; NEWBORN; SEPSIS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; AGE; AGED; BIOLOGY; CASE CONTROL STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; MALE; MICROBIOLOGY; MIDDLE AGED; PRESCHOOL CHILD; PROCEDURES; YOUNG ADULT;

TRANSCRIPTOME;

ADOLESCENT; ADULT; AGE FACTORS; AGED; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; COMPUTATIONAL BIOLOGY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; SEPSIS; TRANSCRIPTOME; YOUNG ADULT;

EID: 85029396462     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0184159     Document Type: Article

References (34)

1. Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med. 2014; 42(3):625–31. Epub 2013/11/10. https://doi.org/10.1097/CCM.0000000000000026 PMID: 24201173; PubMed Central PMCID: PMCPMC4313930.
2. Hall MJ, Williams SN, DeFrances CJ, Golosinskiy A. Inpatient care for septicemia or sepsis: a challenge for patients and hospitals. NCHS data brief. 2011;(62):1–8. Epub 2011/12/07. PMID: 22142805.
3. Kermorvant-Duchemin E, Laborie S, Rabilloud M, Lapillonne A, Claris O. Outcome and prognostic factors in neonates with septic shock. Pediatr Crit Care Med. 2008; 9(2):186–91. Epub 2008/05/15. https://doi.org/10.1097/PCC.0b013e31816689a8 PMID: 18477932.
4. Barton L, Hodgman JE, Pavlova Z. Causes of death in the extremely low birth weight infant. Pediatrics. 1999; 103(2):446–51. Epub 1999/02/02. PMID: 9925839.
5. Cohen-Wolkowiez M, Moran C, Benjamin DK, Cotten CM, Clark RH, Benjamin DK Jr., et al. Early and late onset sepsis in late preterm infants. The Pediatric infectious disease journal. 2009; 28(12):1052–6. Epub 2009/12/03. PMID: 19953725; PubMed Central PMCID: PMCPMC2798577.
6. Girard TD, Opal SM, Ely EW. Insights into severe sepsis in older patients: from epidemiology to evidence-based management. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2005; 40(5):719–27. Epub 2005/02/17. https://doi.org/10.1086/427876 PMID: 15714419.
7. Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Critical care medicine. 2006; 34(1):15–21. Epub 2005/12/24. PMID: 16374151.
8. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 2010; 126(3):443–56. Epub 2010/08/25. https://doi.org/10.1542/peds.2009-2959 PMID: 20732945; PubMed Central PMCID: PMCPMC2982806.
9. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. American journal of respiratory and critical care medicine. 2003; 167 (5):695–701. Epub 2002/11/16. https://doi.org/10.1164/rccm.200207-682OC PMID: 12433670.
10. Wynn JL, Scumpia PO, Delano MJ, O’Malley KA, Ungaro R, Abouhamze A, et al. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock. 2007; 28(6):675–83. Epub 2007/07/11. https://doi.org/10.1097/SHK.0b013e3180556d09 PMID: 17621256.
11. Wynn JL, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, et al. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol Med. 2011; 17(11–12):1146–56. Epub 2011/07/09. https://doi.org/10.2119/molmed.2011.00169 PMID: 21738952; PubMed Central PMCID: PMCPMC3321808.
12. Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, et al. Protective immunity and defects in the neonatal and elderly immune response to sepsis. J Immunol. 2014; 192(7):3156–65. Epub 2014/03/05. https://doi.org/10.4049/jimmunol.1301726 PMID: 24591376; PubMed Central PMCID: PMCPMC3967513.
13. Wynn JL, Guthrie SO, Wong HR, Lahni P, Ungaro R, Lopez MC, et al. Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis. Mol Med. 2015; 21:496–504. Epub 2015/06/09. https://doi.org/10.2119/molmed.2015.00064 PMID: 26052715; PubMed Central PMCID: PMCPMC4607623.
14. Sweeney TE, Wong HR, Khatri P. Robust classification of bacterial and viral infections via integrated host gene expression diagnostics. Sci Transl Med. 2016; 8(346):346ra91. Epub 2016/07/08. https://doi.org/10.1126/scitranslmed.aaf7165 PMID: 27384347.
15. Sweeney TE, Khatri P. Benchmarking Sepsis Gene Expression Diagnostics Using Public Data. Critical care medicine. 2017; 45(1):1–10. Epub 2016/09/30. https://doi.org/10.1097/CCM.0000000000002021 PMID: 27681387.
16. Ramasamy A, Mondry A, Holmes CC, Altman DG. Key issues in conducting a meta-analysis of gene expression microarray datasets. PLoS medicine. 2008; 5(9):e184. Epub 2008/09/05. https://doi.org/10.1371/journal.pmed.0050184 PMID: 18767902; PubMed Central PMCID: PMCPMC2528050.
17. Simon R. Microarray-based expression profiling and informatics. Curr Opin Biotechnol. 2008; 19(1):26–9. https://doi.org/10.1016/j.copbio.2007.10.008 PMID: 18053704; PubMed Central PMCID: PMCPMC2290821.
18. Simon R. Analysis of DNA microarray expression data. Best Pract Res Clin Haematol. 2009; 22 (2):271–82. https://doi.org/10.1016/j.beha.2009.07.001 PMID: 19698933; PubMed Central PMCID: PMCPMC2757654.
19. Tester AM, Cox JH, Connor AR, Starr AE, Dean RA, Puente XS, et al. LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PloS one. 2007; 2(3):e312. Epub 2007/03/22. https://doi.org/10.1371/journal.pone.0000312 PMID: 17375198; PubMed Central PMCID: PMCPMC1819564.
20. Krause PJ, Herson VC, Boutin-Lebowitz J, Eisenfeld L, Block C, LoBello T, et al. Polymorphonuclear leukocyte adherence and chemotaxis in stressed and healthy neonates. Pediatr Res. 1986; 20(4):296–300. Epub 1986/04/01. https://doi.org/10.1203/00006450-198604000-00004 PMID: 3703618.
21. Bektas S, Goetze B, Speer CP. Decreased adherence, chemotaxis and phagocytic activities of neutrophils from preterm neonates. Acta paediatrica Scandinavica. 1990; 79(11):1031–8. Epub 1990/11/01. PMID: 2267919.
22. Jones CN, Moore M, Dimisko L, Alexander A, Ibrahim A, Hassell BA, et al. Spontaneous neutrophil migration patterns during sepsis after major burns. PLoS One. 2014; 9(12):e114509. Epub 2014/12/10. https://doi.org/10.1371/journal.pone.0114509 PMID: 25489947; PubMed Central PMCID: PMCPMC4260850.
23. Atkinson SJ, Varisco BM, Sandquist M, Daly MN, Klingbeil L, Kuethe JW, et al. Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model. Molecular medicine (Cambridge, Mass). 2016; 22. Epub 2016/08/11. https://doi.org/10.2119/molmed.2016.00058 PMID: 27506554; PubMed Central PMCID: PMCPMC5072408.
24. Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, et al. Aged mice are unable to mount an effective myeloid response to sepsis. Journal of immunology (Baltimore, Md: 1950). 2014; 192(2):612–22. Epub 2013/12/18. https://doi.org/10.4049/jimmunol.1302109 PMID: 24337739; PubMed Central PMCID: PMCPMC3884685.
25. Ramchandran R, Mehta D, Vogel SM, Mirza MK, Kouklis P, Malik AB. Critical role of Cdc42 in mediating endothelial barrier protection in vivo. American journal of physiology Lung cellular and molecular physiology. 2008; 295(2):L363–9. Epub 2008/06/03. https://doi.org/10.1152/ajplung.90241.2008 PMID: 18515405; PubMed Central PMCID: PMCPMC2519844.
26. Cuenca AG, Gentile LF, Lopez MC, Ungaro R, Liu H, Xiao W, et al. Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Critical care medicine. 2013; 41(5):1175–85. Epub 2013/02/08. https://doi.org/10.1097/CCM.0b013e318277131c PMID: 23388514; PubMed Central PMCID: PMCPMC3652285.
27. Smith CL, Dickinson P, Forster T, Craigon M, Ross A, Khondoker MR, et al. Identification of a human neonatal immune-metabolic network associated with bacterial infection. Nature communications. 2014; 5:4649. Epub 2014/08/15. https://doi.org/10.1038/ncomms5649 PMID: 25120092; PubMed Central PMCID: PMCPMC4143936.
28. Mahajan P, Kuppermann N, Mejias A, Suarez N, Chaussabel D, Casper TC, et al. Association of RNA Biosignatures With Bacterial Infections in Febrile Infants Aged 60 Days or Younger. Jama. 2016; 316 (8):846–57. Epub 2016/08/24. https://doi.org/10.1001/jama.2016.9207 PMID: 27552618; PubMed Central PMCID: PMCPMC5122927.
29. Sweeney TE, Shidham A, Wong HR, Khatri P. A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set. Sci Transl Med. 2015; 7 (287):287ra71. Epub 2015/05/15. https://doi.org/10.1126/scitranslmed.aaa5993 PMID: 25972003; PubMed Central PMCID: PMCPMC4734362.
30. Hu N, Mora-Jensen H, Theilgaard-Monch K, Doornbos-van der Meer B, Huitema MG, Stegeman CA, et al. Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177. PloS one. 2014; 9(6):e99671. Epub 2014/06/14. https://doi.org/10.1371/journal.pone.0099671 PMID: 24926686; PubMed Central PMCID: PMCPMC4057222.
31. Clemmensen SN, Bohr CT, Rorvig S, Glenthoj A, Mora-Jensen H, Cramer EP, et al. Olfactomedin 4 defines a subset of human neutrophils. Journal of leukocyte biology. 2012; 91(3):495–500. Epub 2011/ 12/22. https://doi.org/10.1189/jlb.0811417 PMID: 22187488; PubMed Central PMCID: PMCPMC3289394.
32. Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA. Time for a neonatal-specific consensus definition for sepsis. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2014; 15(6):523–8. Epub 2014/04/23. https://doi.org/10.1097/pcc.0000000000000157 PMID: 24751791; PubMed Central PMCID: PMCPMC4087075.
33. Tang BM, McLean AS, Dawes IW, Huang SJ, Cowley MJ, Lin RC. Gene-expression profiling of gram-positive and gram-negative sepsis in critically ill patients. Critical care medicine. 2008; 36(4):1125–8. Epub 2008/04/02. https://doi.org/10.1097/CCM.0b013e3181692c0b PMID: 18379237.
34. Sweeney TE, Khatri P. Generalizable Biomarkers in Critical Care: Toward Precision Medicine. Critical care medicine. 2017; 45(6):934–9. Epub 2017/05/17. https://doi.org/10.1097/CCM.0000000000002402 PMID: 28509729.