Protective immunity and defects in the neonatal and elderly immune response to sepsis

Journal of Immunology

Volumn 192, Issue 7, 2014, Pages 3156-3165

  Gentile, Lori F ^a   Nacionales, Dina C ^a   Lopez, M Cecilia ^a   Vanzant, Erin ^a   Cuenca, Angela ^a   Cuenca, Alex G ^a   Ungaro, Ricardo ^a   Szpila, Ben E ^a   Larson, Shawn ^a   Joseph, Anna ^a   Moore, Frederick A ^a   Leeuwenburgh, Christiaan ^a   Baker, Henry V ^a   Moldawer, Lyle L ^a   Efron, Philip A ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE;

ADULT; AGE; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERICIDAL ACTIVITY; BONE MARROW CELL; CELL ACTIVATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; HUMAN; IMMUNE RESPONSE; LEUKOCYTE TRANSCRIPTOME; MALE; MORTALITY; MOUSE; NEWBORN; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; REGULATORY MECHANISM; RISK ASSESSMENT; SEPSIS; TRANSCRIPTOMICS; YOUNG ADULT;

ADULT; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CECUM; CELLS, CULTURED; CYTOKINES; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY; INFANT, NEWBORN; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PERITONEUM; SEPSIS; SURVIVAL ANALYSIS; TRANSCRIPTOME;

EID: 84897532158     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301726     Document Type: Article

References (27)

1. Carlet, J., J. Cohen, T. Calandra, S. M. Opal, and H. Masur. 2008. Sepsis: time to reconsider the concept. Crit. Care Med. 36: 964-966.
2. Oberholzer, A., C. Oberholzer, and L. L. Moldawer. 2001. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16: 83-96.
3. Turnbull, I. R., A. T. Clark, P. E. Stromberg, D. J. Dixon, C. A. Woolsey, C. G. Davis, R. S. Hotchkiss, T. G. Buchman, and C. M. Coopersmith. 2009. Effects of aging on the immunopathologic response to sepsis. Crit. Care Med. 37: 1018-1023.
4. Watson, R. S., J. A. Carcillo, W. T. Linde-Zwirble, G. Clermont, J. Lidicker, and D. C. Angus. 2003. The epidemiology of severe sepsis in children in the United States. Am. J. Respir. Crit. Care Med. 167: 695-701.
5. Angus, D. C., W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29: 1303-1310.
6. Martin, G. S., D. M. Mannino, and M. Moss. 2006. The effect of age on the development and outcome of adult sepsis. Crit. Care Med. 34: 15-21.
7. PrabhuDas, M., B. Adkins, H. Gans, C. King, O. Levy, O. Ramilo, and C. A. Siegrist. 2011. Challenges in infant immunity: implications for responses to infection and vaccines. Nat. Immunol. 12: 189-194.
8. Wynn, J. L., and H. R. Wong. 2010. Pathophysiology and treatment of septic shock in neonates. Clin. Perinatol. 37: 439-479.
9. Lukacs, S. L., K. C. Schoendorf, and A. Schuchat. 2004. Trends in sepsis-related neonatal mortality in the United States, 1985-1998. Pediatr. Infect. Dis. J. 23: 599-603.
10. Lawn, J. E., S. Cousens, and J. Zupan. 2005. 4 million neonatal deaths: when? Where? Why? Lancet 365: 891-900.
11. Wynn, J. L., P. O. Scumpia, M. J. Delano, K. A. O'Malley, R. Ungaro, A. Abouhamze, and K. L. Moldawer. 2007. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock 28: 675-683.
12. Wynn, J. L., P. O. Scumpia, R. D. Winfield, M. J. Delano, K. Kelly-Scumpia, T. Barker, R. Ungaro, O. Levy, and L. L. Moldawer. 2008. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood 112: 1750-1758.
13. Sands, K. E., D. W. Bates, P. N. Lanken, P. S. Graman, P. L. Hibberd, K. L. Kahn, J. Parsonnet, R. Panzer, E. J. Orav, D. R. Snydman, et al 1997. Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA 278: 234-240.
14. Weng, N. P. 2006. Aging of the immune system: how much can the adaptive immune system adapt? Immunity 24: 495-499.
15. Turnbull, I. R., J. J. Wlzorek, D. Osborne, R. S. Hotchkiss, C. M. Coopersmith, and T. G. Buchman. 2003. Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock 19: 310-313.
16. Yost, C. C., M. J. Cody, E. S. Harris, N. L. Thornton, A. M. McInturff, M. L. Martinez, N. B. Chandler, C. K. Rodesch, K. H. Albertine, C. A. Petti, et al. 2009. Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood 113: 6419-6427.
17. Cuenca, A. G., J. L. Wynn, L. L. Moldawer, and O. Levy. 2013. Role of innate immunity in neonatal infection. Am. J. Perinatol. 30: 105-112.
18. Wynn, J. L., N. Z. Cvijanovich, G. L. Allen, N. J. Thomas, R. J. Freishtat, N. Anas, K. Meyer, P. A. Checchia, R. Lin, T. P. Shanley, et al. 2011. The influence of developmental age on the early transcriptomic response of children with septic shock. Mol. Med. 17: 1146-1156.
19. Solana, R., G. Pawelec, and R. Tarazona. 2006. Aging and innate immunity. Immunity 24: 491-494.
20. Schneider, C. P., M. G. Schwacha, and I. H. Chaudry. 2007. Impact of sex and age on bone marrow immune responses in a murine model of trauma-hemorrhage. J. Appl. Physiol. 102: 113-121.
21. Mares, C. A., J. Sharma, S. S. Ojeda, Q. Li, J. A. Campos, E. G. Morris, J. J. Coalson, and J. M. Teale. 2010. Attenuated response of aged mice to respiratory Francisella novicida is characterized by reduced cell death and absence of subsequent hypercytokinemia. PLoS One 5: e14088.
22. Hinojosa, E., A. R. Boyd, and C. J. Orihuela. 2009. Age-associated inflammation and Toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J. Infect. Dis. 200: 546-554.
23. Dykstra, B., S. Olthof, J. Schreuder, M. Ritsema, and G. de Haan. 2011. Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J. Exp. Med. 208: 2691-2703.
24. Boyd, A. R., P. Shivshankar, S. Jiang, M. T. Berton, and C. J. Orihuela. 2012. Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia. Exp. Gerontol. 47: 507-518.
25. McConnell, K. W., A. C. Fox, A. T. Clark, N. Y. Chang, J. A. Dominguez, A. B. Farris, T. G. Buchman, C. R. Hunt, and C. M. Coopersmith. 2011. The role of heat shock protein 70 in mediating age-dependent mortality in sepsis. J. Immunol. 186: 3718-3725.
26. Kang, S. C., T. Matsutani, M. A. Choudhry, M. G. Schwacha, L. W. Rue, K. I. Bland, and I. H. Chaudry. 2004. Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage? Cytokine 26: 223-230.
27. Xiao, W., M. N. Mindrinos, J. Seok, J. Cuschieri, A. G. Cuenca, H. Gao, D. L. Hayden, L. Hennessy, E. E. Moore, J. P. Minei, et al 2011. A genomic storm in critically injured humans. J. Exp. Med. 208: 2581-2590.