Acute Spinal Cord Injury

Journal of Spinal Disorders and Techniques

Volumn 28, Issue 6, 2015, Pages 202-210

  Witiw, Christopher D ^a   Fehlings, Michael G ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

neuroprotection; prognosis; spinal cord injury; surgical timing

Indexed keywords

AC 105; CETHRIN; CORTICOSTEROID; MINOCYCLINE; NEUROPROTECTIVE AGENT; RILUZOLE; SUN 13837; UNCLASSIFIED DRUG;

ASSISTED VENTILATION; CERVICAL SPINE; CONVALESCENCE; FALLING; HEMODYNAMICS; HUMAN; HYPOTENSION; INTENSIVE CARE; MULTICENTER STUDY (TOPIC); NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PATIENT MONITORING; PERFUSION; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECREATION; REVIEW; SPINAL CORD DECOMPRESSION; SPINAL CORD INJURY; SURVIVAL; THORACIC SPINE; THORACOLUMBAR SPINE; TISSUE OXYGENATION; TRAFFIC ACCIDENT; VIOLENCE; ACUTE DISEASE; ADOLESCENT; ADULT; AGED; CHILD; DECOMPRESSION SURGERY; FEMALE; INFANT; MALE; MIDDLE AGED; NEUROSURGERY; NEWBORN; PATHOLOGY; PRESCHOOL CHILD; SOCIOECONOMICS; SPINAL CORD INJURIES; VERY ELDERLY; YOUNG ADULT;

ACUTE DISEASE; ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; DECOMPRESSION, SURGICAL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; NEUROSURGICAL PROCEDURES; PROGNOSIS; SOCIOECONOMIC FACTORS; SPINAL CORD INJURIES; YOUNG ADULT;

EID: 84937145702     PISSN: 15360652     EISSN: 15392465     Source Type: Journal    
DOI: 10.1097/BSD.0000000000000287     Document Type: Review

References (40)

1. Singh A, Tetreault L, Kalsi-Ryan S, et al. Global prevalence and incidence of traumatic spinal cord injury. Clin Epidemiol. 2014;6:309-331.
2. Wyndaele M, Wyndaele JJ. Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord. 2006;44:523-529.
3. Lee BB, Cripps RA, Fitzharris M, et al. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord. 2014;52:110-116.
4. Devivo MJ. Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord. 2012;50:365-372.
5. Van den Berg ME, Castellote JM, Mahillo-Fernandez I, et al. Incidence of spinal cord injury worldwide: a systematic review. Neuroepidemiology. 2010;34:184-192; discussion 192.
6. Cripps RA, Lee BB, Wing P, et al. A global map for traumatic spinal cord injury epidemiology: towards a living data repository for injury prevention. Spinal Cord. 2011;49:493-501.
7. Rowland JW, Hawryluk GW, Kwon B, et al. Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg Focus. 2008;25:E2.
8. Berlly M, Shem K. Respiratory management during the first five days after spinal cord injury. J Spinal Cord Med. 2007;30:309-318.
9. Furlan JC, Fehlings MG. Cardiovascular complications after acute spinal cord injury: pathophysiology, diagnosis, and management. Neurosurg Focus. 2008;25:E13.
10. Advanced Trauma Life Support. Student Course Manual 9E. American College of Surgeons. Committee on Trauma, Chicago, IL; 2012.
11. Vale FL, Burns J, Jackson AB, et al. Combined medical and surgical treatment after acute spinal cord injury: results of a prospective pilot study to assess the merits of aggressive medical resuscitation and blood pressure management. J Neurosurg. 1997;87:239-246.
12. Ryken TC, Hurlbert RJ, Hadley MN, et al. The acute cardiopulmonary management of patients with cervical spinal cord injuries. Neurosurgery. 2013;72(suppl 2):84-92.
13. Ploumis A, Yadlapalli N, Fehlings MG, et al. A systematic review of the evidence supporting a role for vasopressor support in acute SCI. Spinal Cord. 2010;48:356-362.
14. Theodore N, Aarabi B, Dhall SS, et al. Transportation of patients with acute traumatic cervical spine injuries. Neurosurgery. 2013;72(suppl 2):35-39.
15. Theodore N, Hadley MN, Aarabi B, et al. Prehospital cervical spinal immobilization after trauma. Neurosurgery. 2013;72(suppl 2):22-34.
16. Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med. 1990;322:1405-1411.
17. Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA. 1997;277:1597-1604.
18. Schroeder GD, Kwon BK, Eck JC, et al. Survey of cervical spine research society members on the use of high-dose steroids for acute spinal cord injuries. Spine (Phila Pa 1976). 2014;39:971-977.
19. Hurlbert RJ, Hadley MN, Walters BC, et al. Pharmacological therapy for acute spinal cord injury. Neurosurgery. 2013;72(suppl 2):93-105.
20. Pharmacological therapy after acute cervical spinal cord injury. Neurosurgery. 2002;50(suppl):S63-S72.
21. Fehlings MG, Wilson JR, Cho N. Methylprednisolone for the treatment of acute spinal cord injury: counterpoint. Neurosurgery. 2014;61(suppl 1):36-42.
22. Fehlings MG, Vaccaro A, Wilson JR, et al. Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PloS One. 2012;7:e32037.
23. Wilson JR, Arnold PM, Singh A, et al. Clinical prediction model for acute inpatient complications after traumatic cervical spinal cord injury: a subanalysis from the Surgical Timing in Acute Spinal Cord Injury Study. J Neurosurg Spine. 2012;17(suppl):46-51.
24. Wilson JR, Forgione N, Fehlings MG. Emerging therapies for acute traumatic spinal cord injury. CMAJ. 2013;185:485-492.
25. Grossman RG, Fehlings MG, Frankowski RF, et al. A prospective, multicenter, phase I matched-comparison group trial of safety, pharmacokinetics, and preliminary efficacy of riluzole in patients with traumatic spinal cord injury. J Neurotrauma. 2014;31:239-255.
26. Casha S, Zygun D, McGowan MD, et al. Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury. Brain. 2012;135(Pt 4):1224-1236.
27. Festoff BW, Ameenuddin S, Arnold PM, et al. Minocycline neuroprotects, reduces microgliosis, and inhibits caspase protease expression early after spinal cord injury. J Neurochem. 2006;97:1314-1326.
28. Kwon BK, Roy J, Lee JH, et al. Magnesium chloride in a polyethylene glycol formulation as a neuroprotective therapy for acute spinal cord injury: preclinical refinement and optimization. J Neurotrauma. 2009;26:1379-1393.
29. Rabchevsky AG, Fugaccia I, Turner AF, et al. Basic fibroblast growth factor (bFGF) enhances functional recovery following severe spinal cord injury to the rat. Exp Neurol. 2000;164:280-291.
30. Fehlings MG, Theodore N, Harrop J, et al. A phase I/IIa clinical trial of a recombinant Rho protein antagonist in acute spinal cord injury. J Neurotrauma. 2011;28:787-796.
31. Furlan JC, Noonan V, Cadotte DW, et al. Timing of decompressive surgery of spinal cord after traumatic spinal cord injury: an evidence-based examination of pre-clinical and clinical studies. J Neurotrauma. 2011;28:1371-1399.
32. Van Middendorp JJ. Letter to the editor regarding: "Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS)." Spine J. 2012;12:540; author reply 541-542.
33. Wilson JR, Singh A, Craven C, et al. Early versus late surgery for traumatic spinal cord injury: the results of a prospective Canadian cohort study. Spinal Cord. 2012;50:840-843.
34. Dahdaleh NS, Lawton CD, El Ahmadieh TY, et al. Evidence-based management of central cord syndrome. Neurosurg Focus. 2013;35:E6.
35. Bellabarba C, Fisher C, Chapman JR, et al. Does early fracture fixation of thoracolumbar spine fractures decrease morbidity or mortality? Spine (Phila Pa 1976). 2010;35(suppl):S138-S145.
36. Wilson JR, Cadotte DW, Fehlings MG. Clinical predictors of neurological outcome, functional status, and survival after traumatic spinal cord injury: a systematic review. J Neurosurg Spine. 2012;17(suppl):11-26.
37. Varma A, Hill EG, Nicholas J, et al. Predictors of early mortality after traumatic spinal cord injury: a population-based study. Spine (Phila Pa 1976). 2010;35:778-783.
38. Coleman WP, Geisler FH. Injury severity as primary predictor of outcome in acute spinal cord injury: retrospective results from a large multicenter clinical trial. Spine J. 2004;4:373-378.
39. Wilson JR, Grossman RG, Frankowski RF, et al. A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors. J Neurotrauma. 2012;29:2263-2271.
40. Ota T, Akaboshi K, Nagata M, et al. Functional assessment of patients with spinal cord injury: measured by the motor score and the Functional Independence Measure. Spinal Cord. 1996;34:531-535.