The T160A hemagglutinin substitution affects not only receptor binding property but also transmissibility of H5N1 clade 2.3.4 avian influenza virus in guinea pigs

Veterinary Research

Volumn 48, Issue 1, 2017, Pages 1-7

  Gu, Min ^a   Li, Qunhui ^a   Gao, Ruyi ^a   He, Dongchang ^a   Xu, Yunpeng ^a   Xu, Haixu ^a   Xu, Lijun ^a,b   Wang, Xiaoquan ^a   Hu, Jiao ^a   Liu, Xiaowen ^a   Hu, Shunlin ^a   Peng, Daxin ^a   Jiao, Xinan ^a   Liu, Xiufan ^a  

^a YANGZHOU UNIVERSITY   (China)

^b Yangzhou Entry Exit Inspection and Quarantine Bureau   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ; VIRUS RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL; FEMALE; GENETICS; GUINEA PIG; INFLUENZA A VIRUS (H5N1); METABOLISM; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PHYSIOLOGY; TRANSMISSION; VIROLOGY; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANIMALS; FEMALE; GUINEA PIGS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H5N1 SUBTYPE; ORTHOMYXOVIRIDAE INFECTIONS; RECEPTORS, VIRUS; VIRUS REPLICATION;

EID: 85029177496     PISSN: 09284249     EISSN: 12979716     Source Type: Journal    
DOI: 10.1186/s13567-017-0410-0     Document Type: Article

References (30)

1. Guan Y, Smith GJ (2013) The emergence and diversification of panzootic H5N1 influenza viruses. Virus Res 178:35-43
2. Watanabe Y, Ibrahim MS, Ikuta K (2013) Evolution and control of H5N1. A better understanding of the evolution and diversity of H5N1 flu virus and its host species in endemic areas could inform more efficient vaccination and control strategies. EMBO Rep 14:117-122
3. Matrosovich M, Tuzikov A, Bovin N, Gambaryan A, Klimov A, Castrucci MR, Donatelli I, Kawaoka Y (2000) Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals. J Virol 74:8502-8512
4. Shinya K, Ebina M, Yamada S, Ono M, Kasai N, Kawaoka Y (2006) Avian flu: influenza virus receptors in the human airway. Nature 440:435-436
5. Tambunan US, Ramdhan (2010) Identification of sequence mutations affecting hemagglutinin specificity to sialic acid receptor in influenza A virus subtypes. Bioinformation 5:244-249
6. Vines A, Wells K, Matrosovich M, Castrucci MR, Ito T, Kawaoka Y (1998) The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J Virol 72:7626-7631
7. Glaser L, Stevens J, Zamarin D, Wilson IA, Garcia-Sastre A, Tumpey TM, Basler CF, Taubenberger JK, Palese P (2005) A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J Virol 79:11533-11536
8. Stevens J, Blixt O, Chen LM, Donis RO, Paulson JC, Wilson IA (2008) Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. J Mol Biol 381:1382-1394
9. Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA (2006) Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. Science 312:404-410
10. Suzuki Y (2005) Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses. Biol Pharm Bull 28:399-408
11. Claes F, Morzaria SP, Donis RO (2016) Emergence and dissemination of clade 2.3.4.4 H5Nx influenza viruses-how is the Asian HPAI H5 lineage maintained. Curr Opin Virol 16:158-163
12. Zeng X, Chen P, Liu L, Deng G, Li Y, Shi J, Kong H, Feng H, Bai J, Li X, Shi W, Tian G, Chen H (2016) Protective efficacy of an H5N1 inactivated vaccine against challenge with lethal H5N1, H5N2, H5N6, and H5N8 influenza viruses in chickens. Avian Dis 60:253-255
13. Pasick J, Berhane Y, Joseph T, Bowes V, Hisanaga T, Handel K, Alexandersen S (2015) Reassortant highly pathogenic influenza A H5N2 virus containing gene segments related to Eurasian H5N8 in British Columbia, Canada, 2014. Sci Rep 5:9484
14. Chu DH, Okamatsu M, Matsuno K, Hiono T, Ogasawara K, Nguyen LT, Van Nguyen L, Nguyen TN, Nguyen TT, Van Pham D, Nguyen DH, Nguyen TD, To TL, Van Nguyen H, Kida H, Sakoda Y (2016) Genetic and antigenic characterization of H5, H6 and H9 avian influenza viruses circulating in live bird markets with intervention in the center part of Vietnam. Vet Microbiol 192:194-203
15. Butler J, Stewart CR, Layton DS, Phommachanh P, Harper J, Payne J, Evans RM, Valdeter S, Walker S, Harvey G, Shan S, Bruce MP, Rootes CL, Gough TJ, Rohringer A, Peck GR, Fardy SJ, Karpala AJ, Johnson D, Wang J, Douangngeun B, Morrissy C, Wong FY, Bean AG, Bingham J, Williams DT (2016) Novel reassortant H5N6 influenza A virus from the Lao People’s Democratic Republic is highly pathogenic in chickens. PLoS One 11:e0162375
16. Shen YY, Ke CW, Li Q, Yuan RY, Xiang D, Jia WX, Yu YD, Liu L, Huang C, Qi WB, Sikkema R, Wu J, Koopmans M, Liao M (2016) Novel reassortant avian influenza A(H5N6) viruses in humans, Guangdong, China, 2015. Emerg Infect Dis 22:1507-1509
17. Li Q, Wang X, Gu M, Zhu J, Hao X, Gao Z, Sun Z, Hu J, Hu S, Wang X, Liu X, Liu X (2014) Novel H5 clade 2.3.4.6 viruses with both alpha-2,3 and alpha-2,6 receptor binding properties may pose a pandemic threat. Vet Res 45:127
18. Li Q, Wang X, Gao Z, Sun Z, Cui Z, Duan Z, Li J, Gu M, Wang X, Hu J, Liu X, Liu X (2015) Novel reassortant H5N5 viruses bind to a human-type receptor as a factor in pandemic risk. Vet Microbiol 175:356-361
19. Li J, Gu M, Liu D, Liu B, Jiang K, Zhong L, Liu K, Sun W, Hu J, Wang X, Hu S, Liu X, Liu X (2016) Phylogenetic and biological characterization of three K1203 (H5N8)-like avian influenza A virus reassortants in China in 2014. Arch Virol 161:289-302
20. Wang X, Meng F, Wang D, Liu X, Chen S, Qin T, Peng D, Liu X (2016) Characteristics of two highly pathogenic avian influenza H5N8 viruses with different pathogenicity in mice. Arch Virol 161:3365-3374
21. Sun H, Pu J, Wei Y, Sun Y, Hu J, Liu L, Xu G, Gao W, Li C, Zhang X, Huang Y, Chang KC, Liu X, Liu J (2016) Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. J Virol 90:6235-6243
22. Bi Y, Liu H, Xiong C, Di L, Shi W, Li M, Liu S, Chen J, Chen G, Li Y, Yang G, Lei Y, Xiong Y, Lei F, Wang H, Chen Q, Chen J, Gao GF (2016) Novel avian influenza A (H5N6) viruses isolated in migratory waterfowl before the first human case reported in China, 2014. Sci Rep 6:29888
23. Zhang X, Chen S, Jiang Y, Huang K, Huang J, Yang D, Zhu J, Zhu Y, Shi S, Peng D, Liu X (2015) Hemagglutinin glycosylation modulates the pathogenicity and antigenicity of the H5N1 avian influenza virus. Vet Microbiol 175:244-256
24. Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus AD, Fouchier RA (2012) Airborne transmission of influenza A/H5N1 virus between ferrets. Science 336:1534-1541
25. Imai M, Watanabe T, Hatta M, Das SC, Ozawa M, Shinya K, Zhong G, Hanson A, Katsura H, Watanabe S, Li C, Kawakami E, Yamada S, Kiso M, Suzuki Y, Maher EA, Neumann G, Kawaoka Y (2012) Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature 486:420-428
26. Klenk HD, Wagner R, Heuer D, Wolff T (2002) Importance of hemagglutinin glycosylation for the biological functions of influenza virus. Virus Res 82:73-75
27. Teng Q, Xu D, Shen W, Liu Q, Rong G, Li X, Yan L, Yang J, Chen H, Yu H, Ma W, Li Z (2016) A single mutation at position 190 in hemagglutinin enhances binding affinity for human type sialic acid receptor and replication of H9N2 avian influenza virus in mice. J Virol 90:9806-9825
28. Wang W, Lu B, Zhou H, Suguitan AL Jr, Cheng X, Subbarao K, Kemble G, Jin H (2010) Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets. J Virol 84:6570-6577
29. Abe Y, Takashita E, Sugawara K, Matsuzaki Y, Muraki Y, Hongo S (2004) Effect of the addition of oligosaccharides on the biological activities and antigenicity of influenza A/H3N2 virus hemagglutinin. J Virol 78:9605-9611
30. Gao Y, Zhang Y, Shinya K, Deng G, Jiang Y, Li Z, Guan Y, Tian G, Li Y, Shi J, Liu L, Zeng X, Bu Z, Xia X, Kawaoka Y, Chen H (2009) Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog 5:e1000709