-
1
-
-
78649735324
-
Airway mucus function and dysfunction
-
Fahy JV, Dickey BF. Airway mucus function and dysfunction. N Engl J Med 2010; 363: 2233-47.
-
(2010)
N Engl J Med
, vol.363
, pp. 2233-2247
-
-
Fahy, J.V.1
Dickey, B.F.2
-
3
-
-
80052690031
-
The chronic bronchitic phenotype of COPD: An analysis of the COPDGene study
-
Kim V, Han MK, Vance GB, et al. The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest 2011; 140: 626-33.
-
(2011)
Chest
, vol.140
, pp. 626-633
-
-
Kim, V.1
Han, M.K.2
Vance, G.B.3
-
4
-
-
0029947193
-
Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity
-
Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Am J Respir Crit Care Med 1996; 153: 1530-5.
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 1530-1535
-
-
Vestbo, J.1
Prescott, E.2
Lange, P.3
-
5
-
-
0036794862
-
Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
-
Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57: 847-52.
-
(2002)
Thorax
, vol.57
, pp. 847-852
-
-
Donaldson, G.C.1
Seemungal, T.A.2
Bhowmik, A.3
Wedzicha, J.A.4
-
6
-
-
4344675455
-
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
-
Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004; 364: 709-21.
-
(2004)
Lancet
, vol.364
, pp. 709-721
-
-
Hogg, J.C.1
-
7
-
-
58149529356
-
Tracheobronchial air-liquid interface cell culture: A model for innate mucosal defense of the upper airways?
-
Kesimer M, Kirkham S, Pickles RJ, et al. Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways? Am J Physiol Lung Cell Mol Physiol 2009; 296: L92-L100.
-
(2009)
Am J Physiol Lung Cell Mol Physiol
, vol.296
, pp. L92-L100
-
-
Kesimer, M.1
Kirkham, S.2
Pickles, R.J.3
-
8
-
-
43549093774
-
Structure and function of the polymeric mucins in airways mucus
-
Thornton DJ, Rousseau K, McGuckin MA. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol 2008; 70: 459-86.
-
(2008)
Annu Rev Physiol
, vol.70
, pp. 459-486
-
-
Thornton, D.J.1
Rousseau, K.2
McGuckin, M.A.3
-
9
-
-
84865305392
-
A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
-
Button B, Cai LH, Ehre C, et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science 2012; 337: 937-41.
-
(2012)
Science
, vol.337
, pp. 937-941
-
-
Button, B.1
Cai, L.H.2
Ehre, C.3
-
10
-
-
85014511069
-
Contribution of mucus concentration and secreted mucins muc5ac and muc5b to the pathogenesis of mucoobstructive lung disease
-
Livraghi-Butrico A, Grubb BR, Wilkinson KJ, et al. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of mucoobstructive lung disease. Mucosal Immunol 2017; 10: 395-407.
-
(2017)
Mucosal Immunol
, vol.10
, pp. 395-407
-
-
Livraghi-Butrico, A.1
Grubb, B.R.2
Wilkinson, K.J.3
-
11
-
-
36749077948
-
Physiology of airway mucus secretion and pathophysiology of hypersecretion
-
Rogers DF. Physiology of airway mucus secretion and pathophysiology of hypersecretion. Respir Care 2007; 52: 1134-46.
-
(2007)
Respir Care
, vol.52
, pp. 1134-1146
-
-
Rogers, D.F.1
-
12
-
-
84903759350
-
Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure
-
Henderson AG, Ehre C, Button B, et al. Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure. J Clin Invest 2014; 124: 3047-60.
-
(2014)
J Clin Invest
, vol.124
, pp. 3047-3060
-
-
Henderson, A.G.1
Ehre, C.2
Button, B.3
-
13
-
-
57349134586
-
MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
-
Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton DJ. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 178: 1033-9.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1033-1039
-
-
Kirkham, S.1
Kolsum, U.2
Rousseau, K.3
Singh, D.4
Vestbo, J.5
Thornton, D.J.6
-
14
-
-
84974623218
-
Epithelial tethering of MUC5ACrich mucus impairs mucociliary transport in asthma
-
Bonser LR, Zlock L, Finkbeiner W, Erle DJ. Epithelial tethering of MUC5ACrich mucus impairs mucociliary transport in asthma. J Clin Invest 2016; 126: 2367-71.
-
(2016)
J Clin Invest
, vol.126
, pp. 2367-2371
-
-
Bonser, L.R.1
Zlock, L.2
Finkbeiner, W.3
Erle, D.J.4
-
15
-
-
84989322200
-
Characteristics and prevalence of asthma/chronic obstructive pulmonary disease overlap in the United States
-
Kumbhare S, Pleasants R, Ohar JA, Strange C. Characteristics and prevalence of asthma/chronic obstructive pulmonary disease overlap in the United States. Ann Am Thorac Soc 2016; 13: 803-10.
-
(2016)
Ann Am Thorac Soc
, vol.13
, pp. 803-810
-
-
Kumbhare, S.1
Pleasants, R.2
Ohar, J.A.3
Strange, C.4
-
16
-
-
0018068101
-
Epidemiology standardization project (American thoracic society)
-
Ferris BG. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 1978; 118: 1-120.
-
(1978)
Am Rev Respir Dis
, vol.118
, pp. 1-120
-
-
Ferris, B.G.1
-
17
-
-
84961289978
-
Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene
-
Kim V, Crapo J, Zhao H, et al. Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc 2015; 12: 332-9.
-
(2015)
Ann Am Thorac Soc
, vol.12
, pp. 332-339
-
-
Kim, V.1
Crapo, J.2
Zhao, H.3
-
18
-
-
85005773792
-
Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample: The MESA lung study
-
Hoffman EA, Ahmed FS, Baumhauer H, et al. Variation in the percent of emphysema-like lung in a healthy, nonsmoking multiethnic sample: the MESA Lung Study. Ann Am Thorac Soc 2014; 11: 898-907.
-
(2014)
Ann Am Thorac Soc
, vol.11
, pp. 898-907
-
-
Hoffman, E.A.1
Ahmed, F.S.2
Baumhauer, H.3
-
19
-
-
84898914338
-
Design of the subpopulations and intermediate outcomes in COPD study (SPIROMICS)
-
Couper D, LaVange LM, Han M, et al. Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 2014; 69: 491-4.
-
(2014)
Thorax
, vol.69
, pp. 491-494
-
-
Couper, D.1
LaVange, L.M.2
Han, M.3
-
20
-
-
84946943837
-
Excess secretion of gel-forming mucins and associated innate defense proteins with defective mucin un-packaging underpin gallbladder mucocele formation in dogs
-
Kesimer M, Cullen J, Cao R, et al. Excess secretion of gel-forming mucins and associated innate defense proteins with defective mucin un-packaging underpin gallbladder mucocele formation in dogs. PLoS One 2015; 10(9): e0138988.
-
(2015)
PLoS One
, vol.10
, Issue.9
, pp. e0138988
-
-
Kesimer, M.1
Cullen, J.2
Cao, R.3
-
21
-
-
84856557879
-
Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
-
Clunes LA, Davies CM, Coakley RD, et al. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration. FASEB J 2012; 26: 533-45.
-
(2012)
FASEB J
, vol.26
, pp. 533-545
-
-
Clunes, L.A.1
Davies, C.M.2
Coakley, R.D.3
-
22
-
-
84881494429
-
Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD
-
Dransfield MT, Wilhelm AM, Flanagan B, et al. Acquired cystic fibrosis transmembrane conductance regulator dysfunction in the lower airways in COPD. Chest 2013; 144: 498-506.
-
(2013)
Chest
, vol.144
, pp. 498-506
-
-
Dransfield, M.T.1
Wilhelm, A.M.2
Flanagan, B.3
-
23
-
-
0031977229
-
Acrolein-induced MUC5ac expression in rat airways
-
Borchers MT, Wert SE, Leikauf GD. Acrolein-induced MUC5ac expression in rat airways. Am J Physiol 1998; 274: L573-L581.
-
(1998)
Am J Physiol
, vol.274
, pp. L573-L581
-
-
Borchers, M.T.1
Wert, S.E.2
Leikauf, G.D.3
-
25
-
-
84966650988
-
Clinical significance of symptoms in smokers with preserved pulmonary function
-
Woodruff PG, Barr RG, Bleecker E, et al. Clinical significance of symptoms in smokers with preserved pulmonary function. N Engl J Med 2016; 374: 1811-21.
-
(2016)
N Engl J Med
, vol.374
, pp. 1811-1821
-
-
Woodruff, P.G.1
Barr, R.G.2
Bleecker, E.3
-
26
-
-
2942720573
-
The nature of small-airway obstruction in chronic obstructive pulmonary disease
-
Hogg JC, Chu F, Utokaparch S, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 2645-53.
-
(2004)
N Engl J Med
, vol.350
, pp. 2645-2653
-
-
Hogg, J.C.1
Chu, F.2
Utokaparch, S.3
-
27
-
-
84989323244
-
Persistent and newly developed chronic bronchitis are associated with worse outcomes in chronic obstructive pulmonary disease
-
Kim V, Zhao H, Boriek AM, et al. Persistent and newly developed chronic bronchitis are associated with worse outcomes in chronic obstructive pulmonary disease. Ann Am Thorac Soc 2016; 13: 1016-25.
-
(2016)
Ann Am Thorac Soc
, vol.13
, pp. 1016-1025
-
-
Kim, V.1
Zhao, H.2
Boriek, A.M.3
-
28
-
-
0037764092
-
COPD exacerbations: Definitions and classifications
-
Burge S, Wedzicha JA. COPD exacerbations: definitions and classifications. Eur Respir J Suppl 2003; 41: 46s-53s.
-
(2003)
Eur Respir J Suppl
, vol.41
, pp. 46-53
-
-
Burge, S.1
Wedzicha, J.A.2
-
29
-
-
84938081322
-
The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis
-
Anderson WH, Coakley RD, Button B, et al. The relationship of mucus concentration (hydration) to mucus osmotic pressure and transport in chronic bronchitis. Am J Respir Crit Care Med 2015; 192: 182-90.
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 182-190
-
-
Anderson, W.H.1
Coakley, R.D.2
Button, B.3
-
30
-
-
33750069111
-
Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction
-
Innes AL, Woodruff PG, Ferrando RE, et al. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest 2006; 130: 1102-8.
-
(2006)
Chest
, vol.130
, pp. 1102-1108
-
-
Innes, A.L.1
Woodruff, P.G.2
Ferrando, R.E.3
-
31
-
-
32544432238
-
Relation between duration of smoking cessation and bronchial inflammation in COPD
-
Lapperre TS, Postma DS, Gosman MM, et al. Relation between duration of smoking cessation and bronchial inflammation in COPD. Thorax 2006; 61: 115-21.
-
(2006)
Thorax
, vol.61
, pp. 115-121
-
-
Lapperre, T.S.1
Postma, D.S.2
Gosman, M.M.3
-
32
-
-
27744516443
-
Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers
-
Willemse BW, ten Hacken NH, Rutgers B, Lesman-Leegte IG, Postma DS, Timens W. Effect of 1-year smoking cessation on airway inflammation in COPD and asymptomatic smokers. Eur Respir J 2005; 26: 835-45.
-
(2005)
Eur Respir J
, vol.26
, pp. 835-845
-
-
Willemse, B.W.1
Ten Hacken, N.H.2
Rutgers, B.3
Lesman-Leegte, I.G.4
Postma, D.S.5
Timens, W.6
-
33
-
-
84942474807
-
The asthma-COPD overlap syndrome
-
Postma DS, Rabe KF. The asthma-COPD overlap syndrome. N Engl J Med 2015; 373: 1241-9.
-
(2015)
N Engl J Med
, vol.373
, pp. 1241-1249
-
-
Postma, D.S.1
Rabe, K.F.2
-
34
-
-
1642581818
-
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia
-
Gray T, Coakley R, Hirsh A, et al. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol 2004; 286: L320-L330.
-
(2004)
Am J Physiol Lung Cell Mol Physiol
, vol.286
, pp. L320-L330
-
-
Gray, T.1
Coakley, R.2
Hirsh, A.3
-
35
-
-
9644257234
-
Expression of ErbB receptors and mucins in the airways of long term current smokers
-
O'Donnell RA, Richter A, Ward J, et al. Expression of ErbB receptors and mucins in the airways of long term current smokers. Thorax 2004; 59: 1032-40.
-
(2004)
Thorax
, vol.59
, pp. 1032-1040
-
-
O'Donnell, R.A.1
Richter, A.2
Ward, J.3
-
36
-
-
84988698606
-
The presence of chronic mucus hypersecretion across adult life in relation to chronic obstructive pulmonary disease development
-
Allinson JP, Hardy R, Donaldson GC, Shaheen SO, Kuh D, Wedzicha JA. The presence of chronic mucus hypersecretion across adult life in relation to chronic obstructive pulmonary disease development. Am J Respir Crit Care Med 2016; 193: 662-72.
-
(2016)
Am J Respir Crit Care Med
, vol.193
, pp. 662-672
-
-
Allinson, J.P.1
Hardy, R.2
Donaldson, G.C.3
Shaheen, S.O.4
Kuh, D.5
Wedzicha, J.A.6
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