Role of the glucose-sensing receptor in insulin secretion

Diabetes, Obesity and Metabolism

Volumn 19, Issue , 2017, Pages 54-62

  Kojima, Itaru ^a   Medina, Johan ^a   Nakagawa, Yuko ^a  

^a GUNMA UNIVERSITY   (Japan)

Author keywords

glucose; glucose sensing receptor; sweet taste receptor

Indexed keywords

CELL SURFACE RECEPTOR; GLUCOSE SENSING RECEPTOR; RECEPTOR; UNCLASSIFIED DRUG; CALCIUM SENSING RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GLUCORECEPTOR; GLUCOSE; INSULIN; PROTEIN KINASE C; TASTE RECEPTORS, TYPE 1;

CALCIUM TRANSPORT; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GLUCOSE METABOLISM; HUMAN; INSULIN LIKE ACTIVITY; INSULIN RELEASE; INSULIN SYNTHESIS; PANCREAS ISLET BETA CELL; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; BIOLOGICAL MODEL; CALCIUM SIGNALING; CHEMISTRY; DIMERIZATION; ENZYMOLOGY; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; SECOND MESSENGER; SECRETION (PROCESS);

ANIMALS; CALCIUM SIGNALING; CYCLIC AMP; DIMERIZATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MODELS, BIOLOGICAL; PROTEIN KINASE C; PROTEIN MULTIMERIZATION; RECEPTORS, CALCIUM-SENSING; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SECOND MESSENGER SYSTEMS;

EID: 85029001812     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.13013     Document Type: Review

References (30)

1. Rasmussen H, Zawalich KC, Ganesan S, Calle R, Zawalich WS. Physiology and pathophysiology of insulin secretion. Diabetes Care. 1990;13:655-666.
2. Matschinsky FM. Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes. 1990;39:647-652.
3. Henquin JC. Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia. 2009;52:738-751.
4. Komatsu M, Takei M, Ishi H, Sato Y. Glucose-stimulated insulin secretion: a newer perspective. J Diabetes Investig. 2013;4:511-516.
5. Charles M, Franska R, Schmid F, Forshan P, Grodsky G. Adenosine 3′, 5′-monophosphate in pancreatic islets: glucose-induced insulin release. Science. 1973;179:569-571.
6. Furman B, Ong WK, Pyne NJ. Cyclic AMP signaling in pancreatic islets. Adv Exp Med Biol. 2010;654:281-304.
7. 2+ in the pancreatic β-cell. Biochem Biophys Res Commun. 1988;151:1299-1394.
8. 2+ in mouse islets of Langerhans. Am J Physiol. 1994;266:E852-E862.
9. 2+ in mouse pancreatic β-cells. J Physiol. 2001;530:533-540.
10. 2+-dependent activation of phospholipase C in insulin-secreting cells. J Biol Chem. 2006;281:28499-28507.
11. Miyazaki J, Araki K, Yamato E, et al. Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion. Endocrinology. 1990;127:126-132.
12. 2+ indicators, yellow Cameleon-nano. Nat Methods. 2010;7:729-732.
13. 2+ and cyclic AMP signals by activating the cell-surface glucose-sensing receptor in pancreatic β-cells. PLoS One. 2015;10:e0144053.
14. Kojima I, Nakagawa Y, Ohtsu Y, Hamano K, Medina J, Nagasawa M. Return of the glucoreceptor: glucose activates the glucose-sensing receptor T1R3 and facifitates metabolism in pancreatic β-cells. J Diabetes Investig. 2015;6:256-263.
15. Temussi P. The sweet taste receptor: a single receptor with multiple sites and modes of interaction. Adv Food Nutr Res. 2007;53:199-239.
16. Nelson G, Hoon MA, Chandrasekar J, Zhang Y, Ryba NJP, Zuker C. Mammalian sweet taste receptors. Cell. 2001;106:381-390.
17. Nakagawa Y, Nagasawa M, Yamada S, et al. Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One. 2009;4:e5106.
18. Medina A, Nakagawa Y, Ma J, et al. Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states. Endocr J. 2014;61:797-895.
19. Masubuchi Y, Nakagawa Y, Ma JH, Kojima I, Shibata H. Novel regulatory function of sweet taste-sensing receptor in adipogenic differentiation of 3T3-L1 cells. PLoS One. 2013;8:e54500.
20. Nakagawa Y, Ohtsu Y, Nagasawa M, Shibata H, Kojima I. Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3. Endocr J. 2014;61:119-131.
21. Hamano K, Nakagawa Y, Ohtsu Y, et al. Lactisole inhibits the glucose-sensing receptor in mouse pancreatic β-cells. J Endocrinol. 2015;226:57-66.
22. Tordoff MG, Alarcon LK, Valmeki S, Jiang P. T1R3: a human calcium taste receptor. Sci Rep. 2012;2:496.
23. Malaisse WJ, Louchami K, Laghmich A, et al. Possible participation of an islet B-cell calcium-sensing receptor in insulin release. Endocrine. 1999;11:293-300.
24. Medina J, Nakagawa Y, Nagasawa M, et al. Positive allosteric modulation of the calcium-sensing receptor by physiological concentrations of glucose. J Biol Chem. 2016;44:23126-23135.
25. Jiang P, Cui M, Zhao B, et al. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem. 2005;280:15238-15246.
26. Cerasi E, Luft R. Diabetes mellitus – a disorder of cellular information transmission? In: Proceeding of the 13th Nobel Symposium; September, 1969; John Wiley & Sons, Inc., New York, NY. 349-354.
27. Niki A, Niki H. Hexose anomers, insulin release and diabetes mellitus. Biomed Res. 1980;1:189-206.
28. Malaisse WJ. Insulin release: the receptor hypothesis. Diabetologia. 2014;57:1287-1290.
29. Li LF, Ohtsu Y, Nakagawa Y, Masuda K, Kojima I. Sucralose, an activator of the glucose-sensing receptor, increases ATP by calcium-dependent and independent mechanisms. Endocr J. 2016;63:715-725.
30. Kyriazis GA, Soundarapandian MM, Tyberg B. Sweet taste receptor signaling in β cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A. 2012;109:E524-E532.