New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability

Science Translational Medicine

Volumn 9, Issue 406, 2017, Pages

  Kirk, Joseph A ^a   Gebhart, Dana ^b   Buckley, Anthony M ^c   Lok, Stephen ^b   Scholl, Dean ^b   Douce, Gillian R ^c   Govoni, Gregory R ^b   Fagan, Robert P ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b AvidBiotics Corporation   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANHYDROTETRACYCLINE; ANTIINFECTIVE AGENT; AV-CD291.2; AVIOCIDIN CD; BACTERIAL PROTEIN; BACTERIOCIN; BACTERIOPHAGE RECEPTOR; BINDING PROTEIN; S LAYER PROTEIN A; UNCLASSIFIED DRUG; AVIDOCIN; MEMBRANE PROTEIN; S-LAYER PROTEINS; TOXIN;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIABILITY; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BACTERIUM MUTANT; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; INNATE IMMUNITY; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; POINT MUTATION; PRIORITY JOURNAL; SPOROGENESIS; SYRIAN HAMSTER; TOXIN SYNTHESIS; ALLELE; AMINO ACID SEQUENCE; ANIMAL; ANTIBIOTIC RESISTANCE; BACTERIAL COUNT; BACTERIAL SPORE; CHEMISTRY; DRUG EFFECT; GASTROINTESTINAL TRACT; GENETICS; HAMSTER; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; MUTATION; PATHOGENICITY; PHENOTYPE; PHYSIOLOGY; VIRULENCE;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIOCINS; CLOSTRIDIUM DIFFICILE; COLONY COUNT, MICROBIAL; CRICETINAE; DRUG RESISTANCE, BACTERIAL; GASTROINTESTINAL TRACT; IMMUNITY, INNATE; MEMBRANE GLYCOPROTEINS; MICROBIAL VIABILITY; MUTATION; PHENOTYPE; SPORES, BACTERIAL; TOXINS, BIOLOGICAL; VIRULENCE;

EID: 85028909306     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aah6813     Document Type: Article

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