RAGE maintains high levels of NFκB and oncogenic Kras activity in pancreatic cancer

Biochemical and Biophysical Research Communications

Volumn 493, Issue 1, 2017, Pages 592-597

  Azizan, Nancy ^a   Suter, Melissa A ^b   Liu, Yan ^a   Logsdon, Craig D ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Kras; NF B; Pancreatic cancer; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; KRAS PROTEIN, HUMAN; KRAS2 PROTEIN, MOUSE; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREATIC ADENOCARCINOMA CELL LINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; ANIMAL; C57BL MOUSE; CELL FRACTIONATION; GENE EXPRESSION REGULATION; METABOLISM; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; TISSUE DISTRIBUTION; TUMOR CELL LINE; UPREGULATION;

ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, INBRED C57BL; NF-KAPPA B; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS P21(RAS); SUBCELLULAR FRACTIONS; TISSUE DISTRIBUTION; UP-REGULATION;

EID: 85028849051     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2017.08.147     Document Type: Article

References (20)

1. Kierdorf, K., Fritz, G., RAGE regulation and signaling in inflammation and beyond. J. Leukoc. Biol. 94 (2013), 55–68.
2. Ostendorp, T., Leclerc, E., Galichet, A., Koch, M., Demling, N., Weigle, B., Heizmann, C.W., Kroneck, P.M., Fritz, G., Structural and functional insights into RAGE activation by multimeric S100B. Embo J. 26 (2007), 3868–3878.
3. Ahmad, S., Khan, H., Siddiqui, Z., Khan, M.Y., Rehman, S., Shahab, U., Godovikova, T., Silnikov, V., Moinuddin, AGEs, RAGEs and s-RAGE; friend or foe for cancer. Semin. Cancer Biol., 2017 Jul 13, 10.1016/j.semcancer.2017.07.001 S1044-579X(17)30032-9, [Epub ahead of print].
4. Deane, R., Wu, Z., Zlokovic, B.V., RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke 35 (2004), 2628–2631.
5. Bierhaus, A., Nawroth, P.P., Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications. Diabetologia 52 (2009), 2251–2263.
6. Byun, K., Yoo, Y., Son, M., Lee, J., Jeong, G.B., Park, Y.M., Salekdeh, G.H., Lee, B., Advanced glycation end-products produced systemically and by macrophages: a common contributor to inflammation and degenerative diseases. Pharmacol. Ther. 177 (2017 Sep), 44–55, 10.1016/j.pharmthera.2017.02.030 Epub 2017 Feb 13.
7. Kang, R., Hou, W., Zhang, Q., Chen, R., Lee, Y.J., Bartlett, D.L., Lotze, M.T., Tang, D., Zeh, H.J., RAGE is essential for oncogenic KRAS-mediated hypoxic signaling in pancreatic cancer. Cell Death Dis., 5, 2014, e1480.
8. Zeitouni, D., Pylayeva-Gupta, Y., Der, C.J., Bryant, K.L., KRAS mutant pancreatic cancer: No lone path to an effective treatment. Cancers (Basel), 8, 2016.
9. Bryant, K.L., Mancias, J.D., Kimmelman, A.C., Der, C.J., KRAS: feeding pancreatic cancer proliferation. Trends Biochem. Sci. 39 (2014), 91–100.
10. Logsdon, C.D., Lu, W., The significance of Ras activity in pancreatic cancer initiation. Int. J. Biol. Sci. 12 (2016), 338–346.
11. Huang, H., Daniluk, J., Liu, Y., Chu, J., Li, Z., Ji, B., Logsdon, C.D., Oncogenic K-Ras requires activation for enhanced activity. Oncogene 33:4 (2014 Jan 23), 532–535, 10.1038/onc.2012.619 Epub 2013 Jan 21.
12. Knickelbein, K., Zhang, L., Mutant KRAS as a critical determinant of the therapeutic response of colorectal cancer. Genes Dis. 2 (2015), 4–12.
13. Gukovsky, I., Li, N., Todoric, J., Gukovskaya, A., Karin, M., Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology 144 (2013), 1199–1209 e1194.
14. Sirois, C.M., Jin, T., Miller, A.L., Bertheloot, D., Nakamura, H., Horvath, G.L., Mian, A., Jiang, J., Schrum, J., Bossaller, L., Pelka, K., Garbi, N., Brewah, Y., Tian, J., Chang, C., Chowdhury, P.S., Sims, G.P., Kolbeck, R., Coyle, A.J., Humbles, A.A., Xiao, T.S., Latz, E., RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA. J. Exp. Med. 210 (2013), 2447–2463.
15. Tian, J., Avalos, A.M., Mao, S.Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., Hua, J., An, L.L., Audoly, L., La Rosa, G., Bierhaus, A., Naworth, P., Marshak-Rothstein, A., Crow, M.K., Fitzgerald, K.A., Latz, E., Kiener, P.A., Coyle, A.J., Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat. Immunol. 8 (2007), 487–496.
16. Hingorani, S.R., Wang, L., Multani, A.S., Combs, C., Deramaudt, T.B., Hruban, R.H., Rustgi, A.K., Chang, S., Tuveson, D.A., Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7 (2005), 469–483.
17. Huang, H., Daniluk, J., Liu, Y., Chu, J., Li, Z., Ji, B., Logsdon, C.D., Oncogenic K-Ras requires activation for enhanced activity. Oncogene 33 (2014), 532–535.
18. Daniluk, J., Liu, Y., Deng, D., Chu, J., Huang, H., Gaiser, S., Cruz-Monserrate, Z., Wang, H., Ji, B., Logsdon, C.D., An NF-kappaB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. J. Clin. investigation 122 (2012), 1519–1528.
19. Kwak, T., Drews-Elger, K., Ergonul, A., Miller, P.C., Braley, A., Hwang, G.H., Zhao, D., Besser, A., Yamamoto, Y., Yamamoto, H., El-Ashry, D., Slingerland, J.M., Lippman, M.E., Hudson, B.I., Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis. Oncogene 36 (2017), 1559–1572.
20. Kang, R., Loux, T., Tang, D., Schapiro, N.E., Vernon, P., Livesey, K.M., Krasinskas, A., Lotze, M.T., Zeh, H.J. 3rd, The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 7031–7036.